The deterioration process and deterioration mechanism of magnesium oxychloride cement (MOC) in an alkaline environment were studied using a scanning electron microscope (SEM), an X-ray diffractometer ...(XRD), a Fourier transform infrared spectrometer (FT-IR) and a micro-electro-hydraulic servo pressure testing machine to investigate the effects of soaking time in 10 wt.% NaOH solution on the macro- and micro-morphology, phase composition and compressive strength of MOC samples. The results show that the deterioration of MOC samples under an alkaline environment is mainly caused by the alkaline environment providing more OH− ions, which can react with 5Mg(OH)2·MgCl2·8H2O (P 5) in the sample. The resulting reaction gives rise to a faster decomposition of 5Mg(OH)2·MgCl2·8H2O (P 5) and a substantial reduction in the strength of the sample, and finally leads to a gradual deterioration of MOC samples. Meanwhile, immersion time exhibits a significant effect on MOC samples. The extension of immersion time coincides with more OH− ions entering the sample, and the greater presence of OH ions increases the likelihood that more P 5 will produce a hydrolysis reaction, further resulting in the increased deterioration of the sample. After soaking for 6 h in alkaline media, the main phase composition of the surface layer of an MOC sample changes to MgO and Mg(OH)2, and its microscopic morphology is also dominated by round sheets, giving rise to a sharp decrease in its compressive strength (52.2%). When the immersion time is prolonged to 72 h, OH− ions have already immersed into the inner core of the sample, causing the disappearance of P 5 from the whole sample. At the same time, both the surface and inner core of the sample exhibit a disc-shaped morphology, and chalking phenomena also appear on the surface of the sample. This reduces the compressive strength of the sample to 13.5 MPa, only 20% of its compressive strength in water. The compressive strength of the sample after 120 h of immersion is as low as 8.6 MPa, which is lower than that of the sample dipped in water for 21 days (9.5 MPa). As a result, the MOC samples studied in alkaline environments exhibit a faster deterioration rate, mainly because of a faster hydrolysis reaction by P 5, caused by more OH− ions.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Resistance to chemotherapy remains the major cause of treatment failure in patients with colorectal cancer (CRC). Here, we identified TRIM25 as an epigenetic regulator of oxaliplatin (OXA) resistance ...in CRC. The level of TRIM25 in OXA-resistant patients who experienced recurrence during the follow-up period was significantly higher than in those who had no recurrence. Patients with high expression of TRIM25 had a significantly higher recurrence rate and worse disease-free survival than those with low TRIM25 expression. Downregulation of TRIM25 dramatically inhibited, while overexpression of TRIM25 increased, CRC cell survival after OXA treatment. In addition, TRIM25 promoted the stem cell properties of CRC cells both in vitro and in vivo. Importantly, we demonstrated that TRIM25 inhibited the binding of E3 ubiquitin ligase TRAF6 to EZH2, thus stabilizing and upregulating EZH2, and promoting OXA resistance. Our study contributes to a better understanding of OXA resistance and indicates that inhibitors against TRIM25 might be an excellent strategy for CRC management in clinical practice.
FeVO
4
is considered to be a potential anode material for alkaline ion batteries due to its abundant resources, low price, and high specific capacity. To enhance the energy storage performance of ...FeVO
4
, carbon coated FeVO
4
(FeVO
4
@C) growing on carbon cloth (CC) (FeVO
4
@C/CC) was prepared by a hydrothermal method in this work. The needle-like FeVO
4
grew obliquely on CC, forming a 3D structure. This 3D structure was beneficial to shortening the Li-ion diffusion distance, buffering the strain caused by the volumetric change of FeVO
4
during phase transition process and improving the conductivity of the material. Profiting from the morphology and component, FeVO
4
@C/CC demonstrated superior electrochemical performance as an anode for alkaline ion batteries. It delivered specific capacities of 835 mAh/g, 239 mAh/g, 306 mAh/g, and 211 mAh/g after 120 cycles at the current density of 0.1 A/g for Li-ion battery, K-ion battery, Na-ion battery, and LiNi
0.8
Co
0.1
Mn
0.1
O
2
full battery, respectively.
Graphical abstract
Carbon coated FeVO
4
growing on carbon cloth is prepared by hydrothermal method. The needle-like FeVO
4
grows obliquely on carbon cloth, forming a 3D structure. This 3D structure is beneficial for shortening the Li-ion diffusion distance, buffering the strain of volume change, and improving the conductivity of the material. The prepared materials demonstrate superior electrochemical performance as the anodes for Li-ion battery, K-ion battery, Na-ion battery, and LiNi
0.8
Co
0.1
Mn
0.1
O
2
full battery.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Abstract
Background
Metabolic reprograming have been associated with cancer occurrence and progression within the tumor immune microenvironment. However, the prognostic potential of ...metabolism-related genes in colorectal cancer (CRC) has not been comprehensively studied. Here, we investigated metabolic transcript-related CRC subtypes and relevant immune landscapes, and developed a metabolic risk score (MRS) for survival prediction.
Methods
Metabolism-related genes were collected from the Molecular Signatures Database and metabolic subtypes were identified using an unsupervised clustering algorithm based on the expression profiles of survival-related metabolic genes in GSE39582. The ssGSEA and ESTIMATE methods were applied to estimate the immune infiltration among subtypes. The MRS model was developed using LASSO Cox regression in the GSE39582 dataset and independently validated in the TCGA CRC and GSE17537 datasets.
Results
We identified two metabolism-related subtypes (cluster-A and cluster-B) of CRC based on the expression profiles of 539 survival-related metabolic genes with distinct immune profiles and notably different prognoses. The cluster-B subtype had a shorter OS and RFS than the cluster-A subtype. Eighteen metabolism-related genes that were mostly involved in lipid metabolism pathways were used to build the MRS in GSE39582. Patients with higher MRS had worse prognosis than those with lower MRS (HR 3.45,
P
< 0.001). The prognostic role of MRS was validated in the TCGA CRC (HR 2.12,
P
= 0.00017) and GSE17537 datasets (HR 2.67,
P
= 0.039). Time-dependent receiver operating characteristic curve and stratified analyses revealed the robust predictive ability of the MRS in each dataset. Multivariate Cox regression analysis indicted that the MRS could predict OS independent of TNM stage and age.
Conclusions
Our study provides novel insight into metabolic heterogeneity and its relationship with immune landscape in CRC. The MRS was identified as a robust prognostic marker and may facilitate individualized therapy for CRC patients.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract
Objective
We investigated the different life styles among the diet structures and exercise patterns of 100 patients with refractory gout and 79 healthy volunteers; of these, we selected 39 ...patients and 20 healthy volunteers for serum proton magnetic resonance (
1
H-NMR) metabolic network detection. We determined the potential biomarkers of refractory gout and attempted to explore the relation between potential biomarkers and diet structures and exercise patterns.
Methods
The study employed a questionnaire survey to analyze diet structures and exercise patterns from 100 patients of refractory gout and 79 healthy volunteers. At the same time, using
1
H-NMR metabolic technology to analyze the metabolites present in the serum samples obtained from 39 patients of refractory gout (group B) and 20 healthy subjects (group A). Employing MestReNova (Version 8.0.1) to analyze the metabolites maps, collecting the NMR results, further importing into SIMCA-P+ 14.0 software (Umetrics, Sweden) for principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA) statistical analysis. Combining patterns recognition and multivariate statistics, potential biomarkers were searched. Other experimental data, including creatinine and adiponectin, were counted by the SPSS21.0. The measurement data were expressed by X ± S and
t
test. The counting data were expressed in percent and performed by
X
2
test.
Results
Our results revealed that patients with gout tended to be obese, and there were differences in their lifestyle with exercise, sleep, and smoking, as well as in their preference for fructose drinks, alcohol, and total and structural distribution of meat, milk, eggs, and so on when compared with the healthy volunteers. Importantly, we found the adiponectin in the gout group was lower as compared to the healthy group. Further, metabolomics in combination with KEGG analysis revealed that the biosynthesis of aminoacyl tRNA, biosynthesis of valine, leucine, and isoleucine, metabolism of alanine, aspartic, and glutamate, metabolism of glycine, serine, and threonine, phenylalanine, glycolysis/gluconeogenesis, ketone body synthesis and degradation, metabolism of
d
‐glutamine, citric acid cycle (TCA cycle), triglyceride metabolism, and others could be used as specific biomarkers of this disease.
Conclusion
Recurrent refractory gout and formation of tophus may be related to the diet structures and lifestyles between the patients and the healthy people, and their abnormal metabolic network may be related to the disorder of mitochondrial energy metabolism, which further results in abnormal metabolism of glucose, lipids, amino acids, and deposition of uric acid in joints, peripheral connective tissue, and kidney, inducing an inflammatory response.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Binary chromium carbides display excellent wear resistance, extreme stiffness and oxidation resistance under high temperature. The influence of applied pressure on electronic structure, elastic ...behavior, Debye temperature and hardness of Cr7C3, Cr3C2 and Cr23C6 have been investigated by the density functional theory (DFT) method. The results reveal that lattice parameters and formation enthalpy display an inverse relationship with applied pressure, and Cr3C2 exhibited optimal structural stability. Moreover, Cr-C orbital hybridization tends to be stronger due to the decreased partial density of states (PDOS) of the Cr atom. The difference in electronic distribution of binary carbides has also been investigated, which confirmed that overall orbital hybridization and covalent characteristics has been enhanced. The theoretical hardness was elevated according to the higher bond strength and bond density. In accordance with structural stability data, Cr3C2 has shown maximum theoretical hardness. Furthermore, the anisotropic nature of hardness has been evaluated with external pressure. Cr3C2, and the highest isotropic hardness behavior along with an increase in hardness values with increasing pressure has been observed. In addition, the variation in Debye temperatures of binary chromium carbides under applied pressure has also been predicted. The results provide a theoretical insight into electronic, mechanical and thermodynamic behavior of three binary chromium carbides and show the potential of these novel carbides in a wide range of applications.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
We analyzed data from 917 patients with a self-reported history of stroke from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The total magnesium intake was calculated by ...summing the magnesium intake from dietary and dietary supplements, and then adjusting for total energy intake according to the nutrient density method. Mortality status was determined using public-use linked mortality files from 2019. Cox regression model and restricted cubic splines were used to explore the relationship between magnesium intake and all-cause mortality. The average total magnesium intake across all patients was 251.0 (184.5-336.5) mg/d, and 321 (70.2%) males and 339 (73.7%) females had insufficient magnesium intake. During a median follow-up period of 5.3 years, 277 deaths occurred. After fully adjusting for confounding factors, total magnesium intake levels were inversely associated with all-cause mortality risk (HR per 1-mg/(100 kcal*d) increase, 0.97; 95% CI, 0.94-1.00; p = 0.017). Participants with the highest quartile of total magnesium intake (greater than or equal to 18.5 mg/(100 kcal*d)) had a 40% reduction in all-cause mortality risk compared to those with the lowest quartile (less than or equal to 12.0 mg/(100 kcal*d)) (HR, 0.60; 95% CI, 0.38-0.94; p = 0.024). Stratified analyses showed that this inverse association was statistically significant in those who were older, female, without hypertension, and had smoking, normal renal function, and adequate energy intake. Dietary magnesium intake alone might be not related to all-cause mortality. Stroke survivors who consumed adequate amounts of magnesium from diet and supplements had a lower risk of all-cause mortality.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Coaxial fiber-shaped supercapacitors with short charge carrier diffusion paths are highly desirable as high-performance energy storage devices for wearable electronics. However, the traditional ...approaches based on the multistep fabrication processes for constructing the fiber-shaped energy device still encounter persistent restrictions in fabrication procedure, scalability, and mechanical durability. To overcome this critical challenge, an all-in-one coaxial fiber-shaped asymmetric supercapacitor (FASC) device is realized by a direct coherent multi-ink writing three-dimensional printing technology via designing the internal structure of the coaxial needles and regulating the rheological property and the feed rates of the multi-ink. Benefitting from the compact coaxial structure, the FASC device delivers a superior areal energy/power density at a high mass loading, and outstanding mechanical stability. As a conceptual exhibition for system integration, the FASC device is integrated with mechanical units and pressure sensor to realize high-performance self-powered mechanical devices and monitoring systems, respectively.
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