A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9.3 +/- 4.5 years), with predominantly ...focal forms of epilepsy treated with trileptal (oxcarbazepine). The observation period was 31 weeks. Efficacy and safety of therapy was assessed in 3 visits: screening and assignment to therapy (visit 1), the end of titration and achievement of maintenance dose (visit 2), assessment of maintenance therapy (visit 3). The percentage of patients with a positive response to the trileptal therapy (the decrease of seizure frequency by 50% and more) was 91.1%. The complete reduction of seizures was achieved in 59.4% of patients. Most of patients (95.3%) continued to receive trileptal until the end of the trial. The significant decrease (p < 0.001) of seizure frequency from visit 1 to visit 3, the reduction of epileptiform activity (p < 0.05) on the awake EEG in visit 3 were found. The mean effective dose of trileptal was 902.4 +/- 442.7 mg/day, i.e. was less than 30 mg/kg/day, daily doses did not exceed 600 mg. Adverse effects were observed in 11.2% of patients but in 40% of cases they seemed not be related to the drug. The adverse effects were from mild to moderate extent. In conclusion, trileptal as the monotherapy is effective and well-tolerated in the treatment of focal epilepsies in the age groups studied.
The study aimed to differentiate, according to clinical and electroencephalographical criteria, between the most frequent types of myoclonus epilepsy--Unverricht-Lundborg disease (ULD) and Lafora ...disease (LD). Two patients with ULD and two with LD, aged 13-16 years, have been examined. In all cases, the diagnosis of myoclonus epilepsy has been verified by using molecular genetic analysis. The differential diagnostic criteria have been ascertained for ULD and LD: the earlier age-of-onset in ULD comparing to LD (8.8 and 12.5 years, respectively); tonic clonic paroxysms in ULD and partial ones with visual aura in LD; a presence of nonepileptical subcortical myoclonus, according to EEG data (visual monitoring); negative myoclonus emerging in manifested stage of LD; appearing of regional epileptiform activity for posterior regions on EEG in LD; more rapid progressiveness of extra pyramidal disturbances with organic dementia outcome in myoclonus LD.
In this paper we describe the operation and performance of the HERA-B Outer Tracker, a 112
674 channel system of planar drift tube layers. The performance of the HERA-B Outer Tracker system ...fullfilled all requirements for stable and efficient operation in a hadronic environment, thus confirming the adequacy of the honeycomb drift tube technology and of the front-end readout system. The detector was stably operated with a gas gain of
3
×
10
4
in an
Ar
/
CF
4
/
CO
2
(65:35:5) gas mixture, yielding a good efficiency for triggering and track reconstruction, larger than 95% for tracks with momenta above
5
GeV
/
c
. The hit resolution of the drift cells was 300–
320
μ
m
and the relative momentum resolution can be described as:
σ
(
p
)
/
p
%
=
(
1.61
±
0.02
)
+
(
0.0051
±
0.0006
)
·
p
GeV
/
c
. At the end of the HERA-B running no aging effects in the Outer Tracker cells were observed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Йоддефицитные заболевания (ЙДЗ) являются серьезной проблемой здравоохранения практически во всем мире. Наиболее тяжелые из них напрямую связаны с нарушениями репродуктивной функции или развиваются ...перинатально: врожденные аномалии, эндемический кретинизм, неонатальный зоб, гипотиреоз, снижение фертильности. Широкое внедрение на всей территории России программы антенатальной и постнатальной йодной профилактики, подразумевающей прием беременными и кормящими женщинами препаратов йода в суточной дозе 200 мкг/сут, позволит значительно снизить патологию беременности и улучшить психическое и физическое здоровье подрастающего населения.
The proton structure function F-2(x, Q(2)) is measured in inelastic QED Compton scattering using data collected with the H1 detector at HERA. QED Compton events are used to access the kinematic range ...of very low virtualities of the exchanged photon, Q(2), down to 0.5 GeV2, and Bjorken x up to similar to 0.06, a region which has not been covered previously by inclusive measurements at HERA. The results are in agreement with the measurements from fixed target lepton-nucleon scattering experiments. (C) 2004 Published by Elsevier B.V.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The H1 Collaboration reports the first measurement of the 1-jettiness event shape observable \(\tau_1^b\) in neutral-current deep-inelastic electron-proton scattering (DIS). The observable ...\(\tau_1^b\) is equivalent to a thrust observable defined in the Breit frame. The data sample was collected at the HERA \(ep\) collider in the years 2003-2007 with center-of-mass energy of \(\sqrt{s}=319\,\text{GeV}\), corresponding to an integrated luminosity of \(351.1\,\text{pb}^{-1}\). Triple differential cross sections are provided as a function of \(\tau_1^b\), event virtuality \(Q^2\), and inelasticity \(y\), in the kinematic region \(Q^2>150\,\text{GeV}^{2}\). Single differential cross section are provided as a function of \(\tau_1^b\) in a limited kinematic range. Double differential cross sections are measured, in contrast, integrated over \(\tau_1^b\) and represent the inclusive neutral-current DIS cross section measured as a function of \(Q^2\) and \(y\). The data are compared to a variety of predictions and include classical and modern Monte Carlo event generators, predictions in fixed-order perturbative QCD where calculations up to \(\mathcal{O}(\alpha_s^3)\) are available for \(\tau_1^b\) or inclusive DIS, and resummed predictions at next-to-leading logarithmic accuracy matched to fixed order predictions at \(\mathcal{O}(\alpha_s^2)\). These comparisons reveal sensitivity of the 1-jettiness observable to QCD parton shower and resummation effects, as well as the modeling of hadronization and fragmentation. Within their range of validity, the fixed-order predictions provide a good description of the data. Monte Carlo event generators are predictive over the full measured range and hence their underlying models and parameters can be constrained by comparing to the presented data.
The H1 Collaboration at HERA reports the first measurement of groomed event shape observables in deep inelastic electron-proton scattering (DIS) at \(\sqrt{s}=319\) GeV, using data recorded between ...the years 2003 and 2007 with an integrated luminosity of \(351\) pb\(^{-1}\). Event shapes provide incisive probes of perturbative and non-perturbative QCD. Grooming techniques have been used for jet measurements in hadronic collisions; this paper presents the first application of grooming to DIS data. The analysis is carried out in the Breit frame, utilizing the novel Centauro jet clustering algorithm that is designed for DIS event topologies. Events are required to have squared momentum-transfer \(Q^2 > 150\) GeV\(^2\) and inelasticity \( 0.2 < y < 0.7\). We report measurements of the production cross section of groomed event 1-jettiness and groomed invariant mass for several choices of grooming parameter. Monte Carlo model calculations and analytic calculations based on Soft Collinear Effective Theory are compared to the measurements.
The Breit frame provides a natural frame to analyze lepton-proton scattering events. In this reference frame, the parton model hard interactions between a quark and an exchanged boson defines the ...coordinate system such that the struck quark is back-scattered along the virtual photon momentum direction. In Quantum Chromodynamics (QCD), higher order perturbative or non-perturbative effects can change this picture drastically. As Bjorken-\(x\) decreases below one half, a rather peculiar event signature is predicted with increasing probability, where no radiation is present in one of the two Breit-frame hemispheres and all emissions are to be found in the other hemisphere. At higher orders in \(\alpha_s\) or in the presence of soft QCD effects, predictions of the rate of these events are far from trivial, and that motivates measurements with real data. We report on the first observation of the empty current hemisphere events in electron-proton collisions at the HERA collider using data recorded with the H1 detector at a center-of-mass energy of 319 GeV. The fraction of inclusive neutral-current DIS events with an empty hemisphere is found to be \(0.0112 \pm 3.9\,\%_\text{stat} \pm 4.5\,\%_\text{syst} \pm 1.6\,\%_\text{mod}\) in the selected kinematic region of \(150< Q^2<1500\) GeV\(^2\) and inelasticity \(0.14< y<0.7\). The data sample corresponds to an integrated luminosity of 351.1 pb\(^{-1}\), sufficient to enable differential cross section measurements of these events. The results show an enhanced discriminating power at lower Bjorken-\(x\) among different Monte Carlo event generator predictions.
A setup for measuring complex coupling parameters in a ring optical cavity of the laser gyro is described. Using the results of measurements, it is possible to predict the lock-in threshold and ...nonlinear scale factor distortions associated with the influence of the ring cavity mirrors backscattering at the stage of laser gyro assembly.
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