Understanding ancient deep‐water sedimentary systems that accumulated at complex plate boundaries requires confronting the stratigraphic record of deformed sedimentary successions by tracking ...sand‐fairways and identifying original relationships in later deformed sequences. Here, we investigate the Numidian turbidite system (early to mid‐Miocene) of Central‐East Sicily to explore a deep‐water sedimentary system deposited at an active thrust belt on the Central Mediterranean. Turbidites include multi‐metre thick‐bedded, ultra‐mature quartz sandstones that were sourced from North Africa and are now deformed and dismembered within the Apennine‐Maghrebian orogen. To date, much research has focused on the little‐deformed sections that sample discrete parts of the original turbidite pathways. Yet the bulk of these systems are represented by deformed successions and these have attracted little modern sedimentological and stratigraphic investigation. We present new data based on field mapping, sedimentological/structural fieldwork, and biostratigraphy (planktonic foraminifera and nannofossils) that focus on the Numidian turbidites of Central‐East Sicily. Thickness and facies variations, together with evidence of large‐scale sediment bypass and local substrate reworking, characterize the Numidian turbidites of the study area, consistent with a partially confined turbidite system. Our work demonstrates that the Numidian turbidite system accumulated across active structures and these provided tortuous, evolving corridors through which turbidity currents were routed, transporting coarse sand over many hundreds of km. These results provide insight on structurally confined turbidites in analogous tectonic settings and demonstrate the need to seek sedimentological and stratigraphic data from deformed and dismembered parts of deep‐water systems.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Understanding whether a system was unconfined, and deposited on a relatively unstructured basin-floor, or was confined by actively deforming substrate is important for the prediction of turbidite ...stratigraphy. Here we consider the Numidian turbidite system (Oligocene-Miocene) of Sicily - for many the type example of thick structureless submarine sandstones. New mapping and detailed sedimentology in the Nebrodi and Madonie Mountains (northern Sicily), allied to existing and new biostratigraphic data, challenge conventional interpretations for the Numidian system as a whole. Rather than having been deposited within an unstructured foredeep by relatively unconfined flows, we show that Numidian deposition was confined by active structures. These governed the routing of turbidity currents to create sand fairways and associated facies variations. The controlling structures include thrust-related folds together with inherited basin-floor faults. Existing models suggest that facies variations between adjacent outcrops on Sicily (and elsewhere) result from long-range stratigraphic variations being juxtaposed by later large-displacement thrusts. Our research reveals a much simpler tectonic structure but a more complex stratigraphic arrangement for the Numidian on Sicily - a characteristic of confined turbidite systems.
•New mapping, sedimentology and biostratigraphy data for Numidian of northern Sicily.•Numidian turbidite system of northern Sicily is Burdigalian in age.•Numidian system confined by active thrusts and inherited structures.•System shows short-range facies variations related to confining basin geometry.•Degree of post-Numidian thrust disruption in N Sicily previously over-estimated.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPUK, ZRSKP
Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse ...is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in their enhancer landscape. Clinical data revealed that two genes (JAK1 and FGF10), which gained large enhancer clusters in resistant EOC cell lines, could provide novel biomarkers for early patient stratification with statistical independence for JAK1. To modulate the enhancer remodeling process and prevent the acquisition of cPt resistance in EOC cells, we performed a chromatin-focused RNAi screen in the presence of cPt. We identified subunits of the Nucleosome Remodeling and Deacetylase (NuRD) complex as critical factors sensitizing the EOC cell line A2780 to platinum treatment. Suppression of the Methyl-CpG Binding Domain Protein 3 (MBD3) sensitized cells and prevented the establishment of resistance under prolonged cPt exposure through alterations of H3K27ac at enhancer regions, which are differentially regulated in cPt-resistant cells, leading to a less aggressive phenotype. Our work establishes JAK1 as an independent prognostic marker and the NuRD complex as a potential target for combinational therapy.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
PURPOSE:The combination of power and conflict is frequently reported to have a detrimental impact on communication and on patient care, and it is avoided and perceived negatively by health care ...professionals. In view of recent recommendations to explicitly address power and conflict in health professions education, adopting more constructive approaches toward power and conflict may be helpful.
METHOD:The authors used social bases of power (positional, expert, informational, reward, coercive, referent) identified in the literature to examine the role of power in conflicts between health care professionals in different cultural settings. They drew upon semistructured interviews conducted from 2013 to 2016 with 249 health care professionals working at health centers in the United States, Switzerland, and Hungary, in which participants shared stories of conflict they had experienced with coworkers. The authors used a directed approach to content analysis to analyze the data.
RESULTS:The social bases of power tended to be comparable across sites and included positional, expert, and coercive power. The rigid hierarchies that divide health care professionals, their professions, and their specialties contributed to negative experiences in conflicts. In addition, the presence of an audience, such as supervisors, coworkers, patients, and patients’ families, prevented health care professionals from addressing conflicts when they occurred, resulting in conflict escalation.
CONCLUSIONS:These findings suggest that fostering more positive approaches toward power and conflict could be achieved by using social bases of power such as referent power and by addressing conflicts in a more private, backstage, manner.
The present study reports field data of ticks infesting wild carnivores captured from July 1998 to September 2004 in Brazil. Additional data were obtained from one tick collection and from previous ...published data of ticks on carnivores in Brazil. During field work, a total of 3437 ticks were collected from 89 Cerdocyon thous (crab-eating fox), 58 Chrysocyon brachyurus (maned wolf), 30 Puma concolor (puma), 26 Panthera onca (jaguar), 12 Procyon cancrivorus (crab-eating raccoon), 4 Speothos venaticus (bush dog), 6 Pseudalopex vetulus (hoary fox), 6 Nasua nasua (coati), 6 Leopardus pardalis (ocelot), 2 Leopardus tigrinus (oncilla), 1 Leopardus wiedii (margay), 1 Herpailurus yagouaroundi (jaguarundi), 1 Oncifelis colocolo (pampas cat), 1 Eira barbara (tayara), 1 Galictis vittata (grison), 1 Lontra longicaudis (neotropical otter), and 1 Potus flavus (kinkajou). Data obtained from the Acari Collection IBSP included a total of 381 tick specimens collected on 13 C. thous, 8 C. brachyurus, 3 P. concolor, 10 P. onca, 3 P. cancrivorus, 4 N. nasua, 1 L. pardalis, 1 L. wiedii, 4 H. yagouaroundi, 1 Galictis cuja (lesser grison), and 1 L. longicaudis. The only tick-infested carnivore species previously reported in Brazil, for which we do not present any field data are Pseudalopex gymnocercus (pampas fox), Conepatus chinga (Molina's hog-nosed skunk), and Conepatus semistriatus (striped hog-nosed skunk). We report the first tick records in Brazil on two Felidae species (O. colocolo, H. yagouaroundi), two Canidae species (P. vetulus, S. venaticus), one Procyonidae species (P. flavus) and one Mustelidae (E. barbara). Tick infestation remains unreported for 5 of the 26 Carnivora species native in Brazil: Oncifelis geoffroyi (Geoffroy's cat), Atelocynus microtis (short-eared dog), Pteronura brasiliensis (giant otter), Mustela africana (Amazon weasel), and Bassaricyon gabbii (olingo). Our field data comprise 16 tick species represented by the genera Amblyomma (12 species), Ixodes (1 species), Dermacentor (1 species), Rhipicephalus (1 species), and Boophilus (1 species). Additional 5 tick species (3 Amblyomma species and 1 species from each of the genera Ixodes and Ornithodoros) were reported in the literature. The most common ticks on Carnivora hosts were Amblyomma ovale (found on 14 host species), Amblyomma cajennense (10 species), Amblyomma aureolatum (10 species), Amblyomma tigrinum (7 species), Amblyomma parvum (7 species), and Boophilus microplus (7 species).
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
To characterize a purified panel of monoclonal antibodies (MAb) to epitopes in HIV-1 envelope V3, CD4-binding region, C4 and gp41.
Neutralization and/or binding activity data were obtained from 21 ...laboratories on a coded panel consisting of seven human MAb, seven mouse MAb, recombinant human CD4 immunoadhesin CD4-immunoglobulin G (IgG), normal human and normal murine Ig.
Laboratories performed a variety of neutralization assays and antigen binding assays with HIVIIIB, HIVMN and other laboratory strains of HIV-1.
For a single MAb, there was up to a 10(3) range of neutralizing antibody titers between laboratories. The range in titers appeared to depend on the sensitivity of the neutralization assay. Two methods were used to consolidate the data from all laboratories, the geometric mean titer (GMT) and the median neutralizing titer (MNT). The panel of MAb were also analyzed by a variety of assays that measure binding activity to native or denatured epitopes. The relative binding activity of the MAb did not appear to correlate with neutralizing activity.
Neutralization results from any single laboratory did not correlate with the collective data. The relative potency (rank order) of the MAb in the panel were equivalent when determined by GMT or MNT. These values may be useful to individual laboratories for estimating the sensitivity of their neutralization assays. The study also identified potential reference reagents with which neutralizing activity could be compared.
The Endophthalmitis Vitrectomy Study Sternberg, Paul; Nolte, Frederick S.; Schwalbe, Richard S. ...
Ophthalmology (Rochester, Minn.),
February 1997, 1997-02-00, Volume:
104, Issue:
2
Journal Article
Peer reviewed
Purpose: The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlate with the microbiologic culture results.
Methods: A total of 420 ...patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens implantation were evaluated as part of a randomized clinical trial. Results of cultures performed on aqueous and vitreous specimens obtained at presentation were categorized as follows: gram-positive coagulase-negative micrococci, "other" gram-positive, gram-negative, and equivocal/no growth.
Results: Eleven features of the initial clinical presentation were associated with significant differences in the microbiologic spectrum (P < 0.05). Baseline factors correlating with higher rates of both gram-negative and other gram-positive isolates were: corneal infiltrate, cataract wound abnormalities, afferent pupillary defect, loss of red reflex, initial light perception-only vision, and symptom onset within 2 days of surgery. Gram-negative organisms did not grow in any eyes in which a retinal vessel could be visualized, and 61.9% of these eyes had equivocal or no growth. Diabetes mellitus was associated with a higher yield of gram-positive, coagulase-negative micrococci. Eye pain was not a discriminator for culture results.
Conclusions: The presenting characteristics of acute endophthalmitis after cataract surgery may be helpful in predicting the most likely culture results. Such predictions do not appear sufficiently strong to guide the initial empiric choice of intravitreal antibiotics.
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