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  • Reward and motivation in pa... Reward and motivation in pain and pain relief
    Navratilova, Edita; Porreca, Frank Nature neuroscience, 10/2014, Volume: 17, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well ...
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2.
  • Reward, motivation, and emo... Reward, motivation, and emotion of pain and its relief
    Porreca, Frank; Navratilova, Edita Pain (Amsterdam), 04/2017, Volume: 158 Suppl 1, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    The experience of pain depends on interpretation of context and past experience that guide the choice of an immediate behavioral response and influence future decisions of actions to avoid harm. The ...
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3.
  • Mechanisms of craniofacial ... Mechanisms of craniofacial pain
    Chichorro, Juliana Geremias; Porreca, Frank; Sessle, Barry Cephalalgia, 06/2017, Volume: 37, Issue: 7
    Book Review, Journal Article
    Peer reviewed

    Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight peripheral and central adaptations that may promote chronification of pain in craniofacial pain states such as ...
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4.
  • Brain Circuits Encoding Rew... Brain Circuits Encoding Reward from Pain Relief
    Navratilova, Edita; Atcherley, Christopher W; Porreca, Frank Trends in neurosciences (Regular ed.), 11/2015, Volume: 38, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Relief from pain in humans is rewarding and pleasurable. Primary rewards, or reward-predictive cues, are encoded in brain reward/motivational circuits. While considerable advances have been made in ...
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5.
  • Pathophysiology, prevention... Pathophysiology, prevention, and treatment of medication overuse headache
    Diener, Hans-Christoph; Dodick, David; Evers, Stefan ... Lancet neurology, September 2019, 2019-Sep, 2019-09-00, 20190901, Volume: 18, Issue: 9
    Journal Article
    Peer reviewed

    Regular or frequent use of analgesics and acute antimigraine drugs can increase the frequency of headache, and induce the transition from episodic to chronic headache or medication overuse headache. ...
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6.
  • The Jak/STAT pathway: A foc... The Jak/STAT pathway: A focus on pain in rheumatoid arthritis
    Simon, Lee S.; Taylor, Peter C.; Choy, Ernest H. ... Seminars in arthritis and rheumatism, February 2021, 2021-02-00, 20210201, Volume: 51, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase 3 clinical ...
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7.
  • Unmasking the tonic-aversiv... Unmasking the tonic-aversive state in neuropathic pain
    Vera-Portocarrero, Louis; Vanderah, Todd W; Dussor, Gregory ... Nature neuroscience, 11/2009, Volume: 12, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding, analgesic agents that are not rewarding in the absence of pain should become rewarding only when there is ...
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8.
  • Biocompatible PEDOT:Nafion ... Biocompatible PEDOT:Nafion Composite Electrode Coatings for Selective Detection of Neurotransmitters in Vivo
    Vreeland, Richard F; Atcherley, Christopher W; Russell, Wilfred S ... Analytical chemistry (Washington), 03/2015, Volume: 87, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    A Nafion and poly­(3,4-ethylenedioxythiophene) (PEDOT) containing composite polymer has been electropolymerized on carbon-fiber microelectrodes with the goal of creating a mechanically stable, ...
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9.
  • Selective modulation of ton... Selective modulation of tonic aversive qualities of neuropathic pain by morphine in the central nucleus of the amygdala requires endogenous opioid signaling in the anterior cingulate cortex
    Navratilova, Edita; Nation, Kelsey; Remeniuk, Bethany ... Pain (Amsterdam), 03/2020, Volume: 161, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    The amygdala is a key subcortical region believed to contribute to emotional components of pain. As opioid receptors are found in both the central (CeA) and basolateral (BLA) nuclei of the amygdala, ...
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10.
  • Endogenous opioid activity ... Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain
    Navratilova, Edita; Xie, Jennifer Yanhua; Meske, Diana ... The Journal of neuroscience, 2015-May-06, 2015-05-06, 20150506, Volume: 35, Issue: 18
    Journal Article
    Peer reviewed
    Open access

    Pain is aversive, and its relief elicits reward mediated by dopaminergic signaling in the nucleus accumbens (NAc), a part of the mesolimbic reward motivation pathway. How the reward pathway is ...
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