The Surrounding Field Compensation (SFC) system described in this work is installed around the four-layer Mu-metal magnetic shield of the neutron electric dipole moment spectrometer located at the ...Paul Scherrer Institute. The SFC system reduces the DC component of the external magnetic field by a factor of about 20. Within a control volume of approximately 2.5m x 2.5m x 3m disturbances of the magnetic field are attenuated by factors of 5 to 50 at a bandwidth from \(10^{-3}\) Hz up to 0.5 Hz, which corresponds to integration times longer than several hundreds of seconds and represent the important timescale for the nEDM measurement. These shielding factors apply to random environmental noise from arbitrary sources. This is achieved via a proportional-integral feedback stabilization system that includes a regularized pseudoinverse matrix of proportionality factors which correlates magnetic field changes at all sensor positions to current changes in the SFC coils.
Malondialdehyde Levels In Wilson′s Disease Sinha Sanjib; Christopher R; Prashanth L K ...
Annals of the Indian Academy of Neurology,
01/2004, Volume:
7, Issue:
4
Journal Article
Peer reviewed
Open access
Background: Copper ion is a pro-oxidant metal and may be responsible for free radical mediated damage in Wilson′s disease (WD). Estimation of serum malondialdehyde (MDA), a standard test to detect ...oxidative damage, may support this pathogenesis. Aim: The aim of the study was to analyze the serum levels of MDA and correlate with clinical status in patients of WD. Patients and Methods: Forty five patients, from a large cohort of proven WD at various stages of treatment were evaluated. Their clinical parameters were noted and assessment of disability and handicap were done. The laboratory tests were carried out using standard methods. Results: The mean age of patients was 21.1+9.1 years (range: 6-50 years) with M: F ratio of 1.6:1. The mean age at presentation was 14.4+6.9 years (range: 6-42 years) and the mean duration of treatment was 14.4+6.9 years (range: 0-24 years). Their mean serum copper and ceruloplasmin levels were 41.4+22.9 g/d1 (range: 4 -103 g/dl) and 5.8+3.4 mg/dl (range: 2-18 mg/dl) respectively. Thirty eight of them had neurological involvement, four had hepatic form, two had both hepatic and neurological involvement while one was presymptomatic sibling. Patients were assessed using CHU staging (mean: 1.5+0.6), modified schwab and England Activities of Daily Living (MSEADL) scale (mean: 94.44+19.55) and Neurologic symptom Score (NSS) (mean: 3.96+5.2). The mean serum MDA level was 0.65 + 0.34 moles/1 and only four (9.4%) patients had increased levels of MDA (mean: 1.32 + 0.05 moles/1), compared to control (mean: 0.56 + 0.36 moles/1) but it was not statistically significant. No significant correlation was noted between MDA levels and NSS, CHU score, MSEADL score and serum copper level. Conclusion: Increased levels of MDA were detected in only 4 out of 45 patients but those with or without increased MDA levels were not different in their clinical status. These patients were on long term treatment, which might alter the oxidative state. Mechanisms other than oxidative damage may underlie WD. Further studies, especially on newly diagnosed patients, need to be done to validate the mechanism of copper induced damage.
This paper presents an approach to high power THz generation that uses a Switched Oscillator (SwO) as a photoconductively-switched antenna. A simplified model is used to demonstrate the SwO as an ...effective THz radiator. Numerical simulations are used to optimize various parameters of interest with the primary objective of maximizing the radiated energy and minimizing lossess. The radiation Q and resonant frequency are obtained as function of each parameter.
Parkinsonian syndromes Chaudhuri, K. Ray; Ondo, William G
Handbook of Movement Disorders,
2011, 20100415
Book Chapter
A variety of conditions may cause parkinsonian syndromes independent of the idiopathic loss of substantia nigra neurons and deafferentation of the striatum; these include degenerative conditions, ...infections, drugs, toxins and structural lesions (Figure 2.1). The clinical pictures of these degenerative conditions overlap but are usually recognized by the presence of subtle “red flags” in the earlier stage of the illness. Over the period of a few years a distinctive atypical clinical picture, separate to that of Parkinson’s disease, emerges and is typically characterized by a poorer response to dopaminergic therapy. However, it may be impossible to distinguish idiopathic Parkinson’s disease from other parkinsonian syndromes by clinical features alone, although review of the patient’s medical history and diagnostic tests, such as sophisticated neuroimaging, can aid diagnosis 1.
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A genetic algorithmic fixing of attack points in a moving target Rajan, E.G.; Krishna, M.V.; Rrashanth, N. ...
1995 IEEE International Conference on Systems, Man and Cybernetics. Intelligent Systems for the 21st Century,
1995, Volume:
1
Conference Proceeding
The authors previously (1994) introduced a novel technique for identifying a target in a combat space, and for setting the seeker head of a homing system to lock on to it. The central idea on which ...this technique has been developed is that of identifying a wanted target using a syntactic pattern recognition algorithm, and of tracking it with the help of a high-throughput cellular logic locking algorithm. This algorithm ensures fast real time updating of skeleton information about an identified target, and the seeker head is locked on to what is called an attack point. The term attack point refers to a node in a skeleton which has a maximum number of branches in a specific neighborhood. In this paper, we discuss an important issue of fixing this attack point using genetic algorithmic principles.
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