U radu se tretira problematika u vezi sa tržištem investicionih hartija od vrednosti, a u funkciji uloge banaka u tom procesu. Naglasak se stavlja na iskustva razvijenih zemalja, a posebno SAD. ...Poslednjih godina, banke i druge deponentne institucije pokazuju tendenciju da prihvate veći rizik i složenije investicije u svom portfelju. Pojavili su se novi instrumenti čija je svrha više od jednostavnog obezbeđivanja likvidnosti i prihoda, a, posebno, u slučajevima slabe potražnje zajmova. Banke i druge institucije-zajmodavci bave se zamenom portfelja svojih investicionih hartija od vrednosti imajući u vidu kako poreze tako i veće prihode.
This paper describes the issues related to the investment securities market, and the function of the role of banks in the process. Here, the emphasis is on the experiences of developed countries, especially the U.S.A. In recent years, banks and other deponent institutions have had a tendency to accept higher risks and more complex investments in their portfolio. There have appeared new instruments whose purpose is more than just provision of liquidity and income, especially, in cases of poorloan demand. An instrument for swap of the bank portfolio and other institutions- lenders mostly practice replacing the portfolios of their investment securities,bearing in mind tax,as well as higher revenues
This paper describes the issues related to the investment securities market, and the function of the role of banks in the process. Here, the emphasis is on the experiences of developed countries, ...especially the U.S.A. In recent years, banks and other deponent institutions have had a tendency to accept higher risks and more complex investments in their portfolio. There have appeared new instruments whose purpose is more than just provision of liquidity and income, especially, in cases of poorloan demand. An instrument for swap of the bank portfolio and other institutions-lenders mostly practice replacing the portfolios of their investment securities,bearing in mind tax,as well as higher revenues.
Finding an effective drug to prevent or treat COVID-19 is of utmost importance in tcurrent pandemic. Since developing a new treatment takes a significant amount of time, drug repurposing can be an ...effective option for achieving a rapid response. This study used a combined in silico virtual screening protocol for candidate SARS-CoV-2 PLpro inhibitors. The Drugbank database was searched first, using the Informational Spectrum Method for Small Molecules, followed by molecular docking. Gramicidin D was selected as a peptide drug, showing the best in silico interaction profile with PLpro. After the expression and purification of PLpro, gramicidin D was screened for protease inhibition in vitro and was found to be active against PLpro. The current study’s findings are significant because it is critical to identify COVID-19 therapies that are efficient, affordable, and have a favorable safety profile.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The dose-response relationship of sildenafil effects on cardiac function is not completely elucidated. The aim of this study was to assess the effects of different doses of sildenafil on coronary ...flow and oxidative stress in isolated rat hearts. Coronary flow and markers of oxidative stress, including nitrite outflow, and superoxide anion production in coronary effluent, were determined for isolated rat hearts. The experiments were performed during control conditions and in the presence of sildenafil (10, 20, 50, 200 nM) alone or with Nω-nitro-L-arginine monomethyl ester (L-NAME) (30 μM). Sildenafil was shown to result in a significant increase in coronary flow at lower coronary perfusion pressure (CPP) values at all administered doses, whereas, with an increase in CPP, a reduction in coronary flow was observed. An increase in nitric oxide (NO) was most pronounced in the group treated with the lowest dose of sildenafil at the highest CPP value. After the inhibition of the NO-cyclic guanosine monophosphate (cGMP) signaling (NOS) system by L-NAME, only a dose of 200 nM sildenafil was high enough to overcome the inhibition and to boost release of O
. That effect was CPP-dependent, with statistical significance reached at 80, 100 and 120 mmHg. Our findings indicate that sildenafil causes changes in heart vasculature in a dose-dependent manner, with a shift from a vasodilatation effect to vasoconstriction with a pressure increase. The highest dose administered is capable of producing superoxide anion radicals in terms of NOS system inhibition.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Finding an effective drug to prevent or treat COVID-19 is of utmost importance in tcurrent pandemic. Since developing a new treatment takes a significant amount of time, drug repurposing can be an ...effective option for achieving a rapid response. This study used a combined in silico virtual screening protocol for candidate SARS-CoV-2 PL
inhibitors. The Drugbank database was searched first, using the Informational Spectrum Method for Small Molecules, followed by molecular docking. Gramicidin D was selected as a peptide drug, showing the best in silico interaction profile with PL
. After the expression and purification of PL
, gramicidin D was screened for protease inhibition in vitro and was found to be active against PL
. The current study's findings are significant because it is critical to identify COVID-19 therapies that are efficient, affordable, and have a favorable safety profile.
Full text
Available for:
IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This study aimed to assess the influence of different doses of tadalafil on coronary flow and oxidative stress in isolated rat hearts.
The hearts of male Wistar albino rats (n = 48) were retrogradely ...perfused according to the Langendorff technique at gradually increased constant perfusion pressure (CPP) (40-120 mm Hg). Coronary flow and oxidative stress markers: nitrite oxide (NO) outflow and superoxide anion production in coronary effluent were measured. The experiments were performed during control conditions and in the presence of tadalafil (10, 20, 50, and 200 nM) alone or with Nω-nitro-L-arginine monomethyl ester (L-NAME) (30 μM).
Tadalafil administration significantly increased coronary flow at all CPP values at all administered doses. Tadalafil led to an increase in the NO levels, but a statistically significant NO release increase was found only at the highest dose and highest CPP. Tadalafil did not significantly affect the release of O2-. After inhibiting the nitrite oxide synthase system by L-NAME, tadalafil-induced changes in cardiac flow and NO levels were reversed. L-NAME administration had no pronounced effect on the O2- release.
Tadalafil causes changes in the heart vasculature in a dose-dependent manner. It does not lead to a significant increase in the production of superoxide anion radicals.
Unintentional electromagnetic (EM) emissions often include information about the data processed by electronic devices. Intrusion based on an unintentional EM emission leaves no evidence of an ...attacker’s activity, while the data owner is unaware that it has been lost. EM attacks can be performed without physically damaging a device that operates regularly. The most typical intrusion activities involve sensitive data exfiltration using various methods that do not require the physical connection of devices to the computer network or communication channels. This research examines EM emissions from computer monitors, wireless keyboards and mice, printers, scanners, conductors, piezoelectric sensors (PES), and radio frequency identification (RFID) devices. The telecommunication electronics material protected from emanating spurious transmissions (TEMPEST) profiling as a performance engineering of the EM footprint is discussed. This study also presents different TEMPEST standards and highlights their importance concerning unintentional EM radiation.
The quality of DEMs is especially being considered based on the spatial resolution of the created digital models and the type of terrain of the interest area. DEM analysis was performed specifically ...for LiDAR-based DEMs, as well as a comparison with results obtained using the radar recording method (Shuttle Radar Topography Mission). The application of DEM data for security-sensitive systems requires the fulfillment of security requirements, such as authenticity, integrity, confidentiality, and non-repudiation. For this purpose, the authors have developed a model for non-repudiation and protecting DEM data. The model simulation shows it is possible to detect even the smallest changes made in the transmission or the DEM location, as well as proving the data authenticity and non-repudiation of the sender. DEM data security testing has shown that DEM data is effectively protected from the source of origin to the end entity location.
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