Background
Recent studies revealed that various inflammatory and nutritional indexes were associated with prognosis in esophageal cancer (EC). However, these studies only evaluated one or two ...indexes, and the prognostic value of these indexes individually or in combination is unclear. This study aimed to construct an integrative score based on various inflammatory and nutritional indexes for prognosis in resectable esophageal squamous cell carcinoma (ESCC).
Methods
A total of 421 consecutive patients were randomly divided into either a training or validation cohort at a ratio of 7:3 for retrospective analysis. Using logic regression analyses, independent risk factors from peripheral blood indexes were screened to construct an integrative score. The associations regarding the integrative score, clinical characteristics, cancer-specific survival (CSS), and overall survival (OS) were analyzed.
Results
Out of 20 indexes, hemoglobin (HB), C-reactive protein to albumin ratio (CAR), and platelet to lymphocyte ratio (PLR) were independent risk factors based on logical regression analyses. Then, an integrative score with the optimal cut-off value of .67 was established according to the Combination Of HB, CAR, and PLR (COHCP). The area under the curve (AUC) indicated higher predictive ability of COHCP on prognosis than other indicators. Multivariate analyses revealed that COHCP serves as an independent prognostic score. Patients with COHCP low group (≤.67) had better 5-year CSS (57.3% vs 13.5%, P < .001) and OS (51.1% vs 12.3%, P < .001) than those with high group, respectively. Finally, the nomogram based on COHCP was established and validated regarding CSS and OS, which can accurately and effectively predict individual survival in resected ESCC.
Conclusion
The COHCP was a novel, simple, and useful predictor in resectable ESCC. The COHCP-based nomogram may accurately and effectively predict survival.
Hierarchical chestnut-like manganese cobalt oxide (MnCo2O4) nanoneedles (NNs) are successfully grown on nickel foam using a facile and cost-effective hydrothermal method. High resolution TEM image ...further verifies that the chestnut-like MnCo2O4 structure is assembled by numerous 1D MnCo2O4 nanoneedles, which are formed by numerous interconnected MnCo2O4 nanoparticles with grain diameter of ∼10 nm. The MnCo2O4 electrode exhibits high specific capacitance of 1535 F g−1 at 1 A g−1 and good rate capability (950 F g−1 at 10 A g−1) in a 6 M KOH electrolyte. An asymmetric supercapacitor is fabricated using MnCo2O4 NNs on Ni foam (MnCo2O4 NNs/NF) as the positive electrode and graphene/NF as the negative electrode. The device shows an operation voltage of 1.5 V and delivers a high energy density of ∼60.4 Wh kg−1 at a power density of ∼375 W kg−1. Moreover, the device exhibits an excellent cycling stability of 94.3% capacitance retention after 12000 cycles at 30 A g−1. This work demonstrates that hierarchical chestnut-like MnCo2O4 NNs could be a promising electrode for the high performance energy storage devices.
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•Hierarchical chestnut-like MnCo2O4 nanoneedles are grown on Ni foam.•MnCo2O4 nanoneedles are formed by numerous interconnected MnCo2O4 nanoparticles.•MnCo2O4 NNs electrode shows a specific capacitance of 1535 F g−1 at 1 A g−1.•MnCo2O4 NNs//G ASC delivers a high energy density of 60.4 Wh kg−1.•MnCo2O4 NNs//G ASC shows excellent cycle stability at 30 A g−1.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various cancers. The aim of this study was to determinate the prognostic value of the neutrophil ...lymphocyte ratio (NLR) and the platelet lymphocyte ratio (PLR) in patients with esophageal squamous cell carcinoma (ESCC).
Preoperative NLR and PLR were evaluated in 483 patients undergoing esophagectomy for ESCC from January 2005 to December 2008. The prognostic significance of both markers was then determined by both uni- and multivariate analytical methods. Receiver operating characteristic (ROC) curves were also plotted to verify the accuracy of NLR and PLR for survival prediction.
High preoperative NLR (≥3.5 versus < 3.5, P = 0.039) and PLR (≥150 versus < 150, P < 0.001) were significantly associated with poor overall survival in multivariate analysis. However, our study demonstrated a better discrimination for the PLR in terms of hazard ratio(HR) than the NLR (HR = 1.840 versus HR = 1.339). Patients with NLR ≥3.5 had significantly poorer overall survival compared to NLR <3.5 (35.4% versus 57.7%, P < 0.001). Patients with PLR ≥150 also had significantly poorer overall survival compared to patients with PLR <150 (32.7% versus 63.5%, P < 0.001). The area under the curve (AUC) was 0.658 (95% confidence interval (CI): 0.610 to 0.706, P < 0.001) for NLR and 0.708 (95% CI: 0.662 to 0.754, P < 0.001) for PLR, indicating that PLR was superior to NLR as a predictive factor in ESCC.
Preoperative NLR and PLR were significant predictors of overall survival in patients with ESCC. However, PLR is superior to NLR as a predictive factor in patients with ESCC.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Since the discovery of two-dimensional (2D) graphene, a new class of 2D materials with excellent electrical conductivity has recently been attracting attention in studying promising electrode ...materials in energy storage applications. Herein, bismuth oxychloride nanosheets-immobilised Ti3C2Tx MXene material (TCBOC) is synthesised by a facile and cost-effective chemical bath deposition (CBD) route. The bismuth oxychloride (BiOCl) nanosheets are grown and immobilised on surfaces of Ti3C2Tx-MXene flakes. An electrode based on the TCBOC nanocomposite exhibited a remarkably volumetric specific capacitance of 396.5 F cm-3 at 1 A g−1 and 228.0 F cm-3 at 15 A g−1. Furthermore, a symmetric supercapacitor (SSC) assembled using TCBOC material proves to have a high energy density of 15.2 Wh kg−1 at a power density of 567.4 W kg−1 compared to SSCs using previously reported Ti3C2Tx MXene materials. The SSC shows cycle life retention of 85.0% after 5000 cycles (at 5 A g−1). The enhanced capacitive performance is attributed to the increased surface area due to BiOCl nanosheets anchored on a 2D MXene surface, the activities of BiOCl sheets, and the excellent conductivity of a Ti3C2Tx MXene material.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
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Porous microspheres copper cobalt carbonate hydroxides (CuxCo2⿿xCH) pseudocapacitive electrode material comprised of nanoplates via a facile hydrothermal method were presented. ...Significantly, the crystalline structure, morphology and electrochemical performance of the CuxCo2⿿xCH can be readily manipulated by varying the Cu/Co molar ratios. Among various stoichiometries of CuxCo2⿿xCH porous microspheres studied, Cu1.79Co0.21CH consisted of nanoplates with a mean thickness of ⿼35nm showed a high specific capacitance of 789Fg⿿1 at a current destiny of 1Ag⿿1 and good rate ability. Furthermore, the optimized Cu1.79Co0.21CH electrode also exhibited remarkable high cycling stability, ca 77.5% after 3000 charge/discharge cycles at current density of 5Ag⿿1. An asymmetric device was constructed from optimized Cu1.79Co0.21CH materials on nickel foam (NF) as cathode electrode and graphene on NF as anode electrode in a 6M KOH electrolyte. The asymmetric Cu1.79Co0.21CH/NF//graphene/NF supercapacitor device delivered a specific capacitance of 60.5Fg⿿1 in a potential range of 0⿿1.6V. A high energy density of 21.5Whkg⿿1 was achieved at the power density of 200Wkg⿿1. More significantly, the designed device exhibited excellent cycling stability with 73.3% capacity retention after 5000 cycles.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
•By adding cobalt compound, NiCo(CO)3(OH)2 nanowires are separately grown without agglomeration.•The nano-scale Co2(CO3)(OH)2 is distributed in NiCo(CO3)(OH)2 nanowire arrays.•The NiCo(CO)3(OH)2 ...electrode shows a great specific capacity of 1288.2mAhg−1 at a current density of 3Ag−1.
Binder-free mesoporous NiCo(CO3)(OH)2 nanowire arrays were grown using a facile hydrothermal technique. The Co2(CO3)(OH)2 in NiCo(CO3)(OH)2 nanowire arrays was well-decorated as nano-dot scale (a few nanometer). In addition, increasing cobalt content in nickel compound matrix, NiCo(CO3)(OH)2 nanowire arrays were separately uniformly grown without agglomeration on Ni foam, providing a high specific surface area to help electrolyte access and ion transfer. The enticing composition and morphology of the NiCo(CO3)(OH)2 nanowire exhibit a superior specific capacity of 1288.2mAhg−1 at a current density of 3Ag−1 and excellent cycling stability with the capacity retention of 80.7% after 10,000 cycles. Furthermore, an asymmetric supercapacitor composed of the NiCo(CO3)(OH)2 composite as a positive electrode and the graphene as a negative electrode presented a high energy density of 35.5Whkg−1 at a power density of 2555.6Wkg−1 and satisfactory cycling stability with 71.3% capacity retention after 10,000 cycles. The great combination of the active nano-dot Co2(CO3)(OH)2 and the individually grown NiCo(CO3)(OH)2 nanowires made it a promising electrode material for asymmetric supercapacitors. A well-developed nanoarchitecture of the nano-dot Co2(CO3)(OH)2 decorated NiCo(CO3)(OH)2 composite could pave the way for an excellent electrode design for high-performance supercapacitors.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
The objective of this study was to investigate the prognostic and predictive significance of tumor length in patients with esophageal squamous cell carcinoma undergoing radical resection.
Tumor ...length and other clinicopathological variables were retrospectively evaluated in 1435 patients with squamous cell carcinoma treated with radical resection between 2003 and 2010. Tumor length was analyzed as categorical and continuous variable. Associations with overall survival were assessed with Cox proportional hazards models. Model-based nomograms were constructed. Predictive accuracy was measured with C-index. Decision curve analysis was used to evaluate clinical usefulness of prediction models.
Both categorically and continuously coded tumor length were independent prognostic factors in multivariable analysis. Adding categorically and continuously coded tumor length to TNM staging model increased predictive accuracy by 0.2 and 0.4 % respectively. Decision curve analysis revealed that the models built by the addition of categorically or continuously coded tumor length did not perform better than TNM staging model.
Tumor length is an independent prognostic factor in patients with esophageal squamous cell carcinoma treated with radical resection. It increases predictive accuracy of TNM staging system for overall survival in these patients. But it does not increase clinical usefulness of TNM staging system as a prediction model.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Phase-only nulling with low sidelobe level is a problem of interest in array synthesis which is a tedious problem without an analytical solution. In this communication, a novel framework for the ...phase-only nulling based on radial basis function neural network (RBFNN) is proposed to predict the phase adjustment for the array pattern nulling with sidelobe control. In the process of network training, the parameters of the RBFNN are optimized simultaneously based on the self-adaptive differential evolution (SADE) algorithm, which aims to improve the approximation ability and reduce the complexity of the network. Simulation results of the optimized RBFNN models show compact network structure and form the array pattern under desired performance with good generalization capability.
A Ti 3 C 2 T x MXene electrode decorated with NiO nanosheets was synthesized by a facile and cost-effective hydrothermal method. The NiO nanosheets were grown and immobilized on the carbon-supported ...TiO 2 layer which was derived from Ti 3 C 2 T x -MXene during a thermal annealing process. An electrode based on the NiO-grown derived-TiO 2 /C-Ti 3 C 2 T x -MXene nanocomposite (Ni-dMXNC) exhibited a remarkable maximum specific capacity of 92.0 mA h cm −3 at 1 A g −1 and 53.9 mA h cm −3 at 10 A g −1 . Furthermore, an asymmetric supercapacitor (ASC) device composed of Ni-dMXNC as the positive electrode and Ti 3 C 2 T x MXene as the negative electrode was demonstrated to be better with a high energy density of 1.04 × 10 −2 W h cm −3 at a power density of 0.22 W cm −3 , and cycling stability with 72.1% retention after 5000 cycles, compared to ASCs using previously reported Ti 3 C 2 T x MXene materials. The enhanced capacitive performance is attributed to the newly formed high-surface-area multilayers of the Ni-dMXNC architecture, the active surface of NiO layer, and a favourable synergetic behaviour of the Ti 3 C 2 T x MXene negative electrode.
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IJS, KILJ, NUK, UL, UM, UPUK
Abstract
The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is ...formed by one of two sphingosine kinases (SphKs), SphK1 and SphK2. These enzymes largely exert their various biological and pathophysiological actions through one of five G protein-coupled receptors (S1PR1–5), with receptor activation setting in motion various signaling cascades. Considerable evidence has been accumulated on S1P signaling and its pathogenic roles in diseases, as well as on novel modulators of S1P signaling, such as SphK inhibitors and S1P agonists and antagonists. S1P and ceramide, composed of sphingosine and a fatty acid, are reciprocal cell fate regulators, and S1P signaling plays essential roles in several diseases, including inflammation, cancer, and autoimmune disorders. Thus, targeting of S1P signaling may be one way to block the pathogenesis and may be a therapeutic target in these conditions. Increasingly strong evidence indicates a role for the S1P signaling pathway in the progression of cancer and its effects. In the present review, we discuss recent progress in our understanding of S1P and its related proteins in cancer progression. Also described is the therapeutic potential of S1P receptors and their downstream signaling cascades as targets for cancer treatment.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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