Based on the seasonal bottom trawl surveys in the Minjiang River Estuary in 2015, the breadth and overlap of ecological niche of major fish species were analyzed. Those fish species were identified ...based on the index of relative importance (IRI). A total of 137 species belonging to 37 families and 16 orders were collected. Fifteen major fish species were determined by the IRI, including six dominant species Polydactylus sextarius, Harpadon nehereus, Pennahia argentata, Secutor ruconius, Cynoglossus abbreviates, Coilia mystus, and nine important species Collichthys lucidus, Amblychaeturichthys hexanema, Upeneus japonicas, Lagocephalus spadiceus, Pampus argenteus, Larimichthys crocea, Thryssa kammalensis, Takifugu oblongus, Lepturacanthus savala. Seven species whose spatio-temporal niche breadth was higher than 1 in a declining order were C. abbreviates, C. lucidus, S. ruconius, A. hexanema, T. kammalensis, C. mystus, H. nehereus. The ecological niche of major fish species in the Minjiang River Estuary showed obvious seasonal dynamics. The percentage of species pairs with spatio-temporal niche overlap at the meaningful level was as high as 81.9%. Six species pairs reached significant ecological niche overlap, indicating that major fish species had similar distribution at the spatial and temporal scales and the existence of resource utilization competition. The species pairs of U. japonicus-L. savalawas had the highest spatio-temporal niche overlap value, whereas U. japonicus-C. lucidus had the lowest niche overlap value. The spatio-temporal niche overlap of major fish species in the Minjiang River Estuary had substantial seasonal variation.
Serum chemokine CXC Ligand 16 (CXCL16) concentration is associated with atherosclerosis and
CXCL16 expression may be influenced by the polymorphism, A181V. We established whether serum CXCL16 ...concentration or the A181V genotype is more strongly associated with atherosclerotic stroke and its associated risk factor, carotid atherosclerosis.
PCR–RFLP was used to genotype 244 atherosclerotic stroke patients (AS group), 153 stroke-free controls (patient controls) and 167 healthy controls. Serum CXCL16 concentration was determined for a subset of patients (n
=
135) and all controls. The same subset of patients was then examined using ultrasound to evaluate their carotid atherosclerotic lesions, including intima-media thickness (IMT), plaque stability and carotid plaque area (CPA).
Compared with the patient controls and healthy controls, serum CXCL16 concentration was significantly increased in the AS group (
P
<
0.05, and 0.01). It was also strongly associated with increased IMT, vulnerable plaque and increased CPA (
P
<
0.05, <
0.001, and <
0.01). However, the
CXCL16 A181V genotype distribution and allele frequencies showed no differences between AS and control groups, nor did it influence serum CXCL16 concentration.
Serum CXCL16 concentration is significantly associated with atherosclerotic stroke and carotid atherosclerosis, suggesting that this biochemical test may be useful to identify patients at increased risk of atherosclerosis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
AIM: To determine the validity of the non-invasive method of CT perfusion (CTP) in rat model of hepatic diffuse disease.METHODS: Twenty-eight Wistar rats were divided into two groups. Uver diffuse ...lesions were induced by diethylnitrosamine in 14 rats of test group. Rats in control group were bred with pure water. From the 1^st to 12^th wk after the test group was intervened, both groups were studied every week with CTP. CTP parameters of liver parenchyma in different periods and pathologic changes in two groups were compared and analyzed.RESULTS: The process of hepatic diffuse lesions in test groups was classified into three stages or periods according to the pathologic alterations, namely hepatitis, hepatic fibrosis,and cirrhosis. During this period, hepatic artery flow (HAF) of control group declined slightly, mean transit time (MTT),blood flow (BF) and volume (BV) increased, but there were no significant differences between different periods. In test group, HAF tended to increase gradually, MTr prolonged obviously, BV and BF decreased at the same time. The results of statistical analysis revealed that the difference in the HAF ratio of test group to control group was significant.The ratio of BV and BF in test group to control group in stage of hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis was significantly different, but there was no significant difference between hepatitis and hepatic fibrosis. The main pathological changes in stage of hepatitis were swelling of hepatic cells, while sinusoid capillarization and deposition of collagen aggravated gradually in the extravascular Disse's spaces in stage of fibrosis and early stage of cirrhosis.CONCLUSION: The technique could reflect some early changes of hepatic blood perfusion in rat with liver diffuse disease and is valuable for their early diagnosis.
A series of novel derivatives of phenyl substituted tetramethoxy xanthone were synthesized and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor ...hepatic cells. Among these derivatives, compound 6 was more potent than positive control 5-fluorouracil (5-Fu) on QGY-7703 and SMMC-7721 cells with IC50 values of 6.27 μM, 7.50 μM and 15.56 μM, 14.55 μM, respectively. Furthermore, compounds 6, 14, 16, and 29 exhibited much better selectivity toward the normal hepatic cell line QSG-7701 than 5-Fu. Additionally, compound 6 significantly induced cell apoptosis in QGY-7703 cells. Our findings suggested that these phenylxanthone derivatives may hold promise as chemotherapeutic agents for the treatment of human HCC.
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•Derivatives of phenyl substituted tetramethoxy xanthone were synthesized.•Compound 6 showed more potent activity against HCC cells than 5-Fu.•Compound 6 presented better cytotoxic selectivity.•The structure–activity relationships of compounds have been discussed.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Background
Human adenovirus type 55 is a re‐emerging human respiratory pathogen that is associated with several respiratory infections outbreaks in military and school populations. In this study, we ...describe the first HAdV55‐associated hospital outbreak documented in Guangdong, China.
Methods
Active surveillance was conducted in the involved neurosurgical inpatient department. All staff and patients in the involved neurosurgical department were surveyed for any symptoms of fever (≥38°C) and enlarged tonsils during the outbreak period. Throat swabs and demographic information were collected for all cases. For each specimen, assays for common respiratory viruses were performed using one‐step reverse transcription‐polymerase chain reaction. HAdV‐positive samples were inoculated onto Hep‐2 cells for isolation. Hexon genes, fiber genes, penton genes, and whole genomes were sequenced. A phylogenetic tree was constructed.
Results and Conclusions
Forty‐three cases, including 24 laboratory‐confirmed cases and 19 possible cases, were identified. Nurses had the highest attack rate of infection, with a rate of 36.4%. The attack rate for doctors and inpatients was 20.0% and 16.7%, respectively. HAdV55 was the sole pathogen identified during this outbreak. The hexon, fiber, and penton genes from seven isolated HAdV55 stains were sequenced. All these genes showed 100% homology and fell into the HAdV55 P14H11F14 cluster, indicating that HAdV55 was the single viral strain for the outbreak. While not conclusive, the epidemic investigation revealed that the outbreak was introduced by nurses from sources outside the hospital. It was likely that a transmission from staff to inpatients had occurred.
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FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
In order to evaluate the effects of the implementation of emission reduction measures and the revolution of air quality of Beijing during APEC, the evolution characteristics of air quality was ...analyzed based on the hourly monitored readings of Olympic Sports Center from 1 to 15 November 2014 released by Environmental Monitoring Station of China, and compared with that in 2013. The results showed that: (1) PM₂.₅ was the main pollutant in Beijing. The air quality was good during the period of APEC with three obvious pollution events, and it was better than that in the same period in 2013, indicating that the implementation of emission reduction measures had made significant contribution to the improvement of air quality. (2) During the period of APEC, the concentrations of PM₂.₅ of 5 days were below the World Health Organization (WHO) standard (25 µg · m⁻³), and the concentration of SO₂ met the WHO standard during this time. (3) During the period of APEC, the ratio of PM₂.₅, and PM₁₀ was less than 0.5 when the
We demonstrate a controllable dual-wavelength fiber laser which contains a master laser and a slave laser. The master laser is a kind of ring cavity laser which can be injected into by the slave ...laser. The output laser wavelength is controlled by injected power of the slave laser; both single- and dual-wavelength operation can be achieved. Under free running, the master laser generates 1064nm laser output. Here the slave laser is a 1072nm fiber laser. The 1064 nm and 1072nm laser coexist in output spectrum for relatively low injected power. Dual-wavelength and power-ratio-tunable operation can be achieved. If the injected power of the slave laser is high enough, the 1064 nm laser is extinguished automatically and there is only 1072nm laser output.
A recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, a key component in the regulation of inflammatory ...inhibition, to be significantly associated with PCa risk in a Chinese population. Because inflammation may be a common etiological risk factor between PCa and benign prostatic hyperplasia (BPH), the current study was conducted to investigate the association of rs103294 with BPH risk. rs103294 was genotyped in a Chinese population of 426 BPH cases and 1,008 controls from Xinhua Hospital in Shanghai, China. Association between rs103294, BPH risk and clinicopathological traits were tested with adjustment for age. rs103294 was significantly associated with BPH risk with a p-value of 0.0067. Individuals with risk allele "C" had increased risk for BPH (OR = 1.34, 95% CI: 1.09-1.66). Stratified analysis revealed a stronger association risk for younger patients who are below 72 years old (OR = 1.51, 95% CI: 1.06-2.16). Our study represents the first effort to demonstrate that LILRA3 gene is significantly associated with BPH risk in a Chinese population. Our results support a common role of inflammation in the development of PCa and BPH. Additional studies are needed to further evaluate our results.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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