Tissue factor (TF) is a transmembrane glycoprotein and an essential component of the factor VIIa‐TF enzymatic complex that triggers activation of the coagulation cascade. Formation of TF‐FVIIa ...complexes on cell surfaces not only trigger the coagulation cascade but also transduce cell signaling via activation of protease‐activated receptors. Tissue factor is expressed constitutively on cell surfaces of a variety of extravascular cell types, including fibroblasts and pericytes in and surrounding blood vessel walls and epithelial cells, but is generally absent on cells that come into contact with blood directly. However, TF expression could be induced in some blood cells, such as monocytes and endothelial cells, following an injury or pathological stimuli. Tissue factor is essential for hemostasis, but aberrant expression of TF leads to thrombosis. Therefore, a proper regulation of TF activity is critical for the maintenance of hemostatic balance and health in general. TF‐FVIIa coagulant activity at the cell surface is influenced not only by TF protein expression levels but also independently by a variety of mechanisms, including alterations in membrane phospholipid composition and cholesterol content, thiol‐dependent modifications of TF allosteric disulfide bonds, and other post‐translational modifications of TF. In this article, we critically review the key literature on mechanisms by which TF coagulant activity is regulated at the cell surface in the absence of changes in TF protein levels with specific emphasis on recently published data and provide the authors’ perspective on the subject.
Full text
Available for:
FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
1 Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
2 Microbial Type Culture Collection (MTCC), Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India
...3 Microbial Culture Collection, National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007, India
4 ISRO Headquarters, Department of Space, Bangalore 560 023, India
5 Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India
6 Anveshna, 12-13-100, Lane No. 1, Street No. 3, Tarnaka, Hyderabad 500 017, India
7 Inter-University Centre for Astronomy and Astrophysics, Ganeshkhind, Post Bag 4, Pune 411 007, India
Correspondence S. Shivaji shivas{at}ccmb.res.in
Three novel bacterial strains, PVAS-1 T , B3W22 T and B8W22 T , were isolated from cryotubes used to collect air samples at altitudes of between 27 and 41 km. Based on phenotypic characteristics, chemotaxonomic features, DNA–DNA hybridization with the nearest phylogenetic neighbours and phylogenetic analysis based on partial 16S rRNA gene sequences (PVAS-1 T , 1196 nt; B3W22 T , 1541 nt; B8W22 T , 1533 nt), the three strains were identified as representing novel species, and the names proposed are Janibacter hoylei sp. nov. (type strain PVAS-1 T =MTCC 8307 T =DSM 21601 T =CCUG 56714 T ), Bacillus isronensis sp. nov. (type strain B3W22 T =MTCC 7902 T =JCM 13838 T ) and Bacillus aryabhattai sp. nov. (type strain B8W22 T =MTCC 7755 T =JCM 13839 T ).
The GenBank/EMBL/DDBJ accession numbers for the 16S rRNA gene sequences of strains PVAS-1 T , B3W22 T and B8W22 T are DQ317608 , EF114311 and EF114313 .
Polar lipid profiles of the novel strains and related type strains and results of UV-sensitivity experiments are available as supplementary material with the online version of this paper.
Introduction: Undiagnosed hypertension (HTN) increases the risk of severe consequences such as chronic kidney disease (CKD), hypertensive retinopathy, heart failure, and stroke. Population-based ...screening can be used to expose the hidden diseased mass with active disease. Thus, a screening survey was conducted to estimate the proportion of people with HTN among apparently healthy adults of age ≥30 years residing at the urban field practice area (UHTC) of AIIMS, Raipur, and also determine the predictors of undiagnosed HTN among the study participants. Methodology: This was a community-based cross-sectional study conducted over 2 months duration in the Ramnagar area, which comes under the urban field practice area of AIIMS Raipur using the STEPS tool is an acronym of study tool provided by WHO i.e. STEPwise approach to NCD risk factor surveillance consisting of three steps viz. questionnaire for behavioural risk factors, physical measurements and biochemical measurements. Results: In this study, 24.2% (95%, confidence interval CI: 20.1-28.2) of participants screened positive for HTN. The proportion of males who screened positive for HTN was 28.8% (95% CI: 22.6-35), whereas the proportion of females who screened positive for HTN was 19.6% (95% CI: 14.3-25). In this study, elderly (>60 years), male gender, daily tobacco use, greater waist circumference (male >90 cm and female >80 cm), and daily salt intake of more than 5 g were found to have higher odds of having HTN. Conclusion: The prevalence of undiagnosed HTN in the UHTC of AIIMS Raipur was quite high.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Recent years have seen a significant growth in Internet of Things (IoT) technology consisting of a large number of devices embedded with sensors and deployed to perform monitoring and actuation ...tasks. The IoT devices collect large volumes of data that is usually uploaded to cloud to perform analytics and predictions. One of the main challenges in IoT is the transportation of large-scale data collected over a period of time at a remote site. Cellular networks are already facing explosive growth of mobile data traffic due to the proliferation of smart devices and traffic-intensive applications. An alternate solution is to perform the data offloading, where a portion of data can be offloaded from primary links and transferred using opportunistic terminal-to-terminal (T2T) network that relies on direct communication between mobile users, without any need for an infrastructure backbone. However, such approach may lead to data loss and delay if dynamics of time-varying topology and mobility of nodes is not taken care of. To address this challenge, we propose three prediction-based offloading schemes that exploit the mobility patterns and temporal contacts of nodes to predict future data transfer opportunities. We have utilized the High-level Petri Nets to model and formally analyzed the communication processes of the proposed schemes. The new symbolic model verifier (NuSMV) has been employed for the verification of the three schemes against the identified constraints. The verification results affirm the correctness and scalability of the models. The protocols are evaluated with performance metrics, such as the delivery ratio, latency, and overhead. Our results indicate significant improvement in performance compared to existing approaches.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Introduction: Acute surge in coronavirus disease-2019 (COVID)-associated mucormycosis (CAM) cases was reported during mid-May 2021, which was later declared an epidemic in various states of India ...including Bihar. Objective: We carried out a rapid investigation of CAM cases to describe the epidemiological and clinical profiles and find plausible predictors to guide the initiation of public health actions. Methods: A team of public health specialists contacted all the CAM cases reported to our hospital to collect relevant information using a case-investigation-form. In addition, the team visited the Flu Clinic and Ear, Nose, and Throat (ENT) outpatient department (OPD) to capture CAM cases on daily basis during the period of the acute surge of CAM cases. Results: About 88% of 130 CAM cases reported during the period of the acute surge were in the advanced stage of mucormycosis. The majority of the CAM cases were younger (less than 60 years) 76.2%, diabetics 65.4%, un-vaccinated 86.9%, and had used steroids for management of COVID-19 64.6%. Other findings of public health importance were summarized and possible public health actions were recommended for the prevention of outbreaks in future. Conclusion: Optimum management of diabetes including screening for each COVID case, rational use of steroids only when necessary, strict adherence to COVID appropriate behavior by health professionals as well as the public, increasing COVID vaccine coverage, CAM awareness, and setting up a CAM surveillance mechanism may be the key to prevent and control CAM outbreaks in future.
Full text
Available for:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
7.
Heat flow in the Indian shield Roy, Sukanta; Rao, R. U. M.
Journal of Geophysical Research,
10 November 2000, Volume:
105, Issue:
B11
Journal Article
Peer reviewed
Open access
Seventy new heat flow values have been determined for the Indian shield. The new sites include 28 from the Archaean Dharwar craton, one from the Proterozoic Cuddapah basin of southern India, four ...from the southern part of the Proterozoic Aravalli mobile belt of northwestern India, and 37 from the southern part of the Cretaceous‐Eocene Deccan Volcanic Province (DVP) of central India. Existing and new data lead to the following inferences: (1) The Dharwar craton, in common with other Archaean cratons is characterized by low heat flow values generally ranging from 25 to 50 mW m−2. (2) The western part of the Cuddapah basin and the DVP to the south of the Son‐Narmada‐Tapti megalineament zone are characterized by low heat flow values in the range 31 to 50 mW m−2. (3) There is no evidence for thermal transients associated with the K‐T Deccan volcanism on the present‐day heat flow regime in the southern part of the DVP. (4) In contrast to the southern Indian shield, the Aravalli mobile belt is characterized by significantly higher heat flow from 56 to 96 mW m−2. (5) Observations in the Aravalli and Singbhum Proterozoic belts show that some parts of the Precambrian shield are characterized by high as well as variable heat flow. With no evidence for recent tectonothermal events the variations in heat flow in the Indian shield can be mostly explained on the basis of radioactive heat production of the crustal rocks.
Tissue Factor–Factor VIIa Signaling Rao, L Vijaya Mohan; Pendurthi, Usha R
Arteriosclerosis, thrombosis, and vascular biology,
2005-January, Volume:
25, Issue:
1
Journal Article
Peer reviewed
Open access
How does tissue factor (TF), whose principle role is to support clotting factor VIIa (FVIIa) in triggering the coagulation cascade, affect various pathophysiological processes? One of the answers is ...that TF interaction with FVIIa not only initiates clotting but also induces cell signaling via activation of G-protein–coupled protease activated receptors (PARs). Recent studies using various cell model systems and limited in vivo systems are beginning to define how TF–VIIa-induced signaling regulates cellular behavior. Signaling pathways initiated by both TF–VIIa protease activation of PARs and phosphorylation of the TF–cytoplasmic domain appear to regulate cellular functions. In the present article, we review the emerging data on the mechanism of TF-mediated cell signaling and how it regulates various cellular responses, with particular focus on TF–VIIa protease-dependent signaling.
This study aims to enhance the latent heat storage properties of the microcapsules by altering the amount of crosslinking agent from 3 to 20%w/w, the core-to-shell ratio from 1:1 to 2:1, and the ...amount of initiator from 1 to 3%. The phase change material n-tetradecane (C-14) was microencapsulated by using poly (methyl methacrylate -co- methacrylic acid) as a shell material through an oil by water-seeded emulsion polymerisation technique. The structural, morphological, and thermal properties of microcapsules were evaluated by using Fourier transform infrared spectroscopy, optical microscopy, scanning electron microscopy, differential scanning calorimetry analysis, and thermogravimetric analysis. The average particle size of the microcapsules ranges from 01 to 15 µm. The results showed that the microcapsules have a higher melting enthalpy value of 127.3 ± 0.06 J/g with a microencapsulation efficiency of 66.72% when a 20% w/w crosslinker was used. The thermal stability of the phase change material (PCM) was increased by ∼30 ± 2 °C by encapsulation.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Aim
Rheumatoid arthritis (RA) can lead to severe disability. This literature review assessed the descriptive epidemiology, comorbidities and extra‐articular manifestations, functioning abilities and ...quality of life, and treatment patterns of RA patients in India.
Method
A literature review of all observational studies published from 1985 to 2012 was conducted using MEDLINE and Embase. Quantitative and qualitative findings were summarized.
Results
Twenty‐eight studies were identified for data extraction. Seven described the descriptive epidemiology of RA, 14 described comorbidities and extra‐articular manifestations, nine described the functioning abilities and quality of life among patients, and 10 provided information on treatments.
Conclusion
This review is confined to studies with small sample sizes, cross‐sectional designs, and/or clinical settings that may not be representative of the entire Indian population. There is a need for more robust studies, as conclusions for the entire Indian RA population cannot be drawn from only the current observational studies.
Full text
Available for:
DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
PDF
