Measles virus (MeV) is a highly contagious human pathogen. Despite the success of measles vaccination programs, measles is still responsible for an estimated 245,000 deaths each year. There are ...currently no antiviral compounds available for the treatment of measles. Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) are antisense compounds that enter cells readily and can interfere with mRNA function by steric blocking. A panel of PPMO was designed to target various sequences of MeV RNA that are known to be important for viral replication. Five PPMO, targeting MeV genomic RNA or mRNA, inhibited the replication of MeV, in a dose-responsive and sequence-specific manner in cultured cells. One of the highly active PPMO (PPMO 454), targeting a conserved sequence in the translation start site of the mRNA coding for the nucleocapsid protein, inhibited multiple genotypes of MeV. This report provides evidence that PPMO treatment represents a promising approach for developing antiviral agents against measles and other paramyxoviruses.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
22.
Surveillance and Prevention of Residential-Fire Injuries Mallonee, Sue; Istre, Gregory R; Rosenberg, Mark ...
New England journal of medicine/The New England journal of medicine,
07/1996, Volume:
335, Issue:
1
Journal Article
Peer reviewed
Open access
Burns are the fourth leading cause of death from unintentional injury in the United States and result in 1.4 million injuries each year.
1,2
Residential fires cause over 75 percent of all deaths from ...fires and burns.
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The southern part of the United States, including Oklahoma, has the highest regional rate of death from fires (2.5 deaths per 100,000 population)
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; this high rate may be due to rural poverty, a lower prevalence of smoke alarms, and greater use of portable heating equipment.
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Although the absence of functional smoke alarms in residential dwellings is a risk factor for subsequent injury or . . .
