This paper shows the course designed by COPEC - Science and Education Research Council education research team, for engineering students what is called "working with communities course", which ...provides the students of engineering in 3rd year the chance to work with consultancy for the entrepreneurial community, in the region. It is for an engineering school of a private university and the goal is provide the needed resources to enable interdisciplinary efforts to prepare engineering students to tackle real-world challenges in engineering, entrepreneurship and new business ventures as professionals. The process is designed in order to offer a space that has been named after "innovative office", where local entrepreneurs go with a problem or project to discuss and to find sustainable solutions under the consultancy of young engineers. So far the program has been working well and is opening doors for young engineers.
An organometallic Lewis base adduct of methyltrioxorhenium(VII) (MTO), comprising the ligand 4-ferrocenylpyridine, has been isolated and characterized. The binuclear complex and also the precursor ...free ligand have been immobilized in β-cyclodextrin (CD) to give inclusion complexes with a one-to-one stoichiometry. Powder X-ray diffraction (XRD) indicates that the microcrystalline powders obtained are true homogeneous inclusion complexes. This is corroborated by thermogravimetric analysis (TGA), which indicates that the ferrocenylpyridine ligand gains an additional thermal stability upon encapsulation. FTIR and
13C- solid-state CP MAS NMR spectroscopy confirm that the Re–N ligation is intact for the included binuclear complex. The NMR results also support the conclusion that the monosubstituted ferrocene derivatives adhere to an inclusion model in which the ferrocene penetrates deeply into the CD cavity in axial mode while the substituent protrudes out.
A 1:1 inclusion compound between β-cyclodextrin (CD) and a Lewis base adduct comprising 4-ferrocenylpyridine and methyltrioxorhenium has been prepared and characterized in the solid-state by powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), FTIR and
13C- CP MAS NMR spectroscopy.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Radiation therapy is routinely used in the management of primary central nervous system malignancies. However, the efficacy of this therapeutic modality is limited by the occurrence of resistance. In ...the present study, we investigated whether modulation of oxidative stress might underlie glioma cell radioresistance. Superoxide dismutase activity in irradiated M059J cells was two-fold higher than that in untreated controls, but did not significantly change in U-87 and U-138 cells. This is accompanied by an increase in reactive oxygen species content and decreases in cells viability. Pharmacological or genetic modulation of oxidative stress could be associated with an enhancement in the susceptibility of tumor cells to radiation therapy.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Following the new trend in education, more focused on a global perspective, COPEC - Science and Education Research Council is offering an MBA, online, in Social Engineering for all Countries of CPLP ...- Portuguese Language Countries Community. The goal is to cover these countries' engineers, which are also seeking for opportunities, as the majority are countries of growing economy based on their very rich resources. The idea of an online program is the possibility of reaching a broader audience and at the same time of enriching the experience of offering and implementing a program that can disseminate ideas and concepts, which fits the needs of the target audience. The Education Research Team of COPEC is convinced that Engineers with proper knowledge and skills can take action in order to solve social problems, as engineers are problem solvers.
Rheumatic Heart Disease (RHD) is well known to be an active inflammatory process which develops progressive calcification and leaflet thickening over time. The potential for statin therapy in slowing ...the progression of valvular heart disease is still controversial. Retrospective studies have shown that medical therapy is beneficial for patients with calcific aortic stenosis and recently for rheumatic valve disease. However, the prospective randomized clinical trials have been negative to date. This article discusses the epidemiologic risk factors, basic science, retrospective and prospective studies in valvular heart disease and a future clinical trial to target RHD with statin therapy to slow the progression of this disease. Recent epidemiological studies have revealed the risk factors associated with valvular disease include male gender, smoking, hypertension and elevated serum cholesterol and are similar to the risk factors for vascular atherosclerosis. An increasing number of models of experimental hypercholesterolemia demonstrate features of atherosclerosis in the aortic valve (AV), which are similar to the early stages of vascular atherosclerotic lesions. Calcification, the end stage process of the disease, must be understood as a prognostic indicator in the modification of this cellular process before it is too late. This is important in calcific aortic stenosis as well as in rheumatic valve disease. There are a growing number of studies that describe similar pathophysiologic molecular markers in the development of rheumatic valve disease as in calcific aortic stenosis. In summary, these findings suggest that medical therapies may have a potential role in patients in the early stages of this disease process to slow the progression of RHD affecting the valves. This review will summarize the potential for statin therapy for this patient population.
Exact mathematical derivation of the moment generating function for an optically preamplified receiver output current is carried out. Amplified spontaneous emission noise as well as Poisson ...shot-noise and thermal noise originated at the receiver front-end are considered. Optical bandpass filter is also taken into account. This new global description of the stochastic processes involved in optical signal detection enables analytical assessment of the overall receiver performance without restrictions on the optical input pulse and the electronic filter response. Various bit error rate evaluation methods such as Chernoff bound, modified Chernoff bound, Gaussian approximation and saddlepoint approximation are developed based on the moment generating function and their precision compared.< >
Color matching in the anterior superior incisor region (ASIR) is very difficult when using a rubber dam during restorative procedures. This study measured temperature/relative humidity parameters in ...the ASIR and evaluated the influence of the inhalation/downtime/exhalation mouth-breathing cycle on microleakage in composite resin restorations performed in the region, using three different adhesive systems. Sixty bovine incisors were randomly assigned to six groups (n=10) according to environmental conditions (laboratory environment or intraoral conditions) and the three adhesive systems being tested (Prime & Bond NT (PB), Single Bond (SB) and Clearfil SE Bond (CL)). The composite resin restored specimens were thermocycled (800 cycles, 5-55 degrees C), immersed in a 2% methylene blue-buffered solution and sectioned longitudinally The dye penetration on the margin of the restoration was evaluated and non-parametric statistical analyses were performed. The temperature and humidity parameters in the ASIR showed significant differences when compared to the laboratory environment. Restorations performed in the ASIR environment showed no increases in microleakage. As it was shown that temperature/humidity in ASIR do not affect marginal sealing in direct composite resin restorations negatively, better color matching can be safely achieved without the use of a rubber dam.
Platinum-based doublets are recommended as treatment for advanced or metastatic non-small-cell lung cancer (NSCLC); however, chemotherapy must be tailored to limit side effects. A phase II study was ...conducted to evaluate the efficacy and safety of oxaliplatin combined with docetaxel for NSCLC.
Patients with stage IIIB or IV, chemotherapy-naive NSCLC received docetaxel 70
mg/m
2, oxaliplatin 130
mg/m
2, and pegfilgrastim 6
mg every 21 days for up to six cycles. Primary endpoint was overall response rate (ORR), secondary endpoints were progression-free (PFS) and overall survival (OS), and safety.
Twenty-nine patients were treated; 93% had stage IV disease and 28% had brain metastases. In 27 evaluable patients with follow-up, there were 10 partial responses for an ORR of 37% (90% confidence interval CI, 22–55%). Median PFS was 4.6 months (95% CI, 2.6–6.5 months); 12-month PFS was 14.8% (95% CI, 3.4–34.0%). Median OS was 10.9 months (95% CI, 8.9–16.8 months); 12-month OS was 40% (95% CI, 19–61%) and 18-month OS was 16% (95% CI, 1–46%). In 29 treated patients, there were no unusual or unexpected adverse events. The most common grade 3 and 4 toxicities were anemia (14% of patients) and hyperglycemia (10%); there were only two reports of neutropenia; both were grade 1 or 2.
These phase II findings suggest that the combination of oxaliplatin and docetaxel is active and well tolerated, and should be further investigated as a feasible treatment alternative for patients with advanced or metastatic NSCLC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The increase in productivity is a demand for modern industries that need to be competitive in the actual business scenario. To face these challenges, companies are increasingly using robotic systems ...for end-of-line production tasks, such as wrapping and palletizing, as a mean to enhance the production line efficiency and products traceability, allowing human operators to be moved to more added value operations. Despite this increasing use of robotic systems, these equipments still present some inconveniences regarding the programming procedure, as the time required for its execution does not meet the current industrial needs. To face this drawback, offline robot programming methods are gaining great visibility, as their flexibility and programming speed allows companies to face the need of successive changes in the production line set-up. However, even with a great number of robots and simulators that are available in market, the efforts to support several robot brands in one software did not reach the needs of engineers. Therefore, this paper proposes a translation library named AdaptPack Studio Translator, which is capable to export proprietary codes for the ABB, Fanuc, Kuka, and Yaskawa robot brands, after their offline programming has been performed in the Visual Components software. The results presented in this paper are evaluated in simulated and real scenarios.
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