The main goal and promise of comparative genomics has been to create a comprehensive catalog of genomic information and function across the phenomenal diversity of living systems. A recent study has ...demonstrated the evolutionary insights possible by generating high-quality whole-genome assemblies from multiple species of a clade.
The complexity and diversity of primate behavior have long attracted the attention of ethologists, psychologists, behavioral ecologists, and neuroscientists. Recent studies have advanced our ...understanding of the nature of genetic influences on differences in behavior among individuals within species. A number of analyses have focused on the genetic analysis of behavioral reactions to specific experimental tests, providing estimates of the degree of genetic control over reactivity, and beginning to identify the genes involved. Substantial progress is also being made in identifying genetic factors that influence the structure and function of the primate brain. Most of the published studies on these topics have examined either cercopithecines or chimpanzees, though a few studies have addressed these questions in other primate species. One potentially important line of research is beginning to identify the epigenetic processes that influence primate behavior, thus revealing specific cellular and molecular mechanisms by which environmental experiences can influence gene expression or gene function relevant to behavior. This review summarizes many of these studies of non‐human primate behavioral genetics. The primary focus is on analyses that address the nature of the genes and genetic processes that affect differences in behavior among individuals within non‐human primate species. Analyses of between species differences and potential avenues for future research are also discussed.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Advances in genome sequencing technologies have created new opportunities for comparative primate genomics. Genome assemblies have been published for various primate species, and analyses of several ...others are underway. Whole-genome assemblies for the great apes provide remarkable new information about the evolutionary origins of the human genome and the processes involved. Genomic data for macaques and other non-human primates offer valuable insights into genetic similarities and differences among species that are used as models for disease-related research. This Review summarizes current knowledge regarding primate genome content and dynamics, and proposes a series of goals for the near future.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Early and accurate identification of factors that predict post-stroke cognitive outcome is important to set realistic targets for rehabilitation and to guide patients and their families accordingly. ...However, behavioral measures of cognition are difficult to obtain in the acute phase of recovery due to clinical factors (e.g. fatigue) and functional barriers (e.g. language deficits). The aim of the current study was to test whether single channel wireless EEG data obtained acutely following stroke could predict longer-term cognitive function.
Resting state Relative Power (RP) of delta, theta, alpha, beta, delta/alpha ratio (DAR), and delta/theta ratio (DTR) were obtained from a single electrode over FP1 in 24 participants within 72 hours of a first-ever stroke. The Montreal Cognitive Assessment (MoCA) was administered at 90-days post-stroke. Correlation and regression analyses were completed to identify relationships between 90-day cognitive function and electrophysiological data, neurological status, and demographic characteristics at admission.
Four acute qEEG indices demonstrated moderate to high correlations with 90-day MoCA scores: DTR (r = -0.57, p = 0.01), RP theta (r = 0.50, p = 0.01), RP delta (r = -0.47, p = 0.02), and DAR (r = -0.45, p = 0.03). Acute DTR (b = -0.36, p < 0.05) and stroke severity on admission (b = -0.63, p < 0.01) were the best linear combination of predictors of MoCA scores 90-days post-stroke, accounting for 75% of variance.
Data generated by a single pre-frontal electrode support the prognostic value of acute DAR, and identify DTR as a potential marker of post-stroke cognitive outcome. Use of single channel recording in an acute clinical setting may provide an efficient and valid predictor of cognitive function after stroke.
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•Kratom was often used to self-treat opioid withdrawal or as an opioid substitute.•Polydrug use that included kratom and at least one other substance was common.•Kratom was perceived as lifesaving, ...but also potentially addictive.•Kratom dependence and withdrawal symptoms were described in detail.•Most used kratom for pragmatic health reasons, rather than to achieve euphoria.
Mitragyna speciosa, referred to as “kratom”, is increasingly used in the United States for self-treating pain, psychiatric, and substance use disorder symptoms. It is used by some to attenuate opioid withdrawal and as a longer-term drug substitute. Most self-report data have come from online surveys, small in-person surveys, and case reports. These may not be representative of the broader kratom-using population.
Analyze user-generated social media posts to determine if independent, descriptive accounts are generally consistent with prior U.S. kratom survey findings and gain a more nuanced understanding of kratom use patterns.
Reddit posts mentioning kratom from 42 subreddits between June 2019–July 2020 were coded by two independent raters.
Relevant posts (number of comments, upvotes, and downvotes) from 1274 posts comprised the final sample (n = 280). Of the 1521 codes applied, 1273 (83.69%) were concordant. Desirable kratom effects were described among a majority, but so too were adverse effects. Reports of kratom as acute self-treatment for opioid withdrawal were more prominent compared to longer-term opioid substitution. Quantitative analysis found higher kratom doses associated (p < .001) with greater odds of reported kratom addiction (OR = 3.56) or withdrawal (OR = 5.88), with slightly lower odds of desirable effects (OR = 0.53, p = .014). Despite perceived therapeutic benefits, kratom was characterized by some in terms of addiction that, in some cases, appeared dose-dependent. Polydrug use was also prominently discussed.
Results validated many prior survey findings while illustrating complexities of kratom use that are not being fully captured and require continued investigation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Summary
Objective
The aim of this study was to evaluate the impact of mindfulness‐based interventions on psychological and physical health outcomes in adults who are overweight or obese.
Methods
We ...searched 14 electronic databases for randomized controlled trials and prospective cohort studies that met eligibility criteria. Comprehensive Meta‐analysis software was used to compute the effect size estimate Hedge's g.
Results
Fifteen studies measuring post‐treatment outcomes of mindfulness‐based interventions in 560 individuals were identified. The average weight loss was 4.2 kg. Overall effects were large for improving eating behaviours (g = 1.08), medium for depression (g = 0.64), anxiety (g = 0.62) and eating attitudes (g = 0.57) and small for body mass index (BMI; g = 0.47) and metacognition (g = 0.38) outcomes. Therapeutic effects for BMI (g = 0.43), anxiety (g = 0.53), eating attitudes (g = 0.48) and eating behaviours (g = 0.53) remained significant when examining results from higher quality randomized control trials alone. There was no efficacy advantage for studies exceeding the median dose of 12 h of face‐to‐face intervention. Studies utilizing an Acceptance and Commitment Therapy approach provided the only significant effect for improving BMI (g = 0.66), while mindfulness approaches produced great variation from small to large (g = 0.30–1.68) effects across a range of psychological health and eating‐related constructs. Finally, the limited longitudinal data suggested maintenance of BMI (g = 0.85) and eating attitudes (g = 0.75) gains at follow‐up were only detectable in lower quality prospective cohort studies.
Conclusions
Mindfulness‐based interventions may be both physically and psychologically beneficial for adults who are overweight or obese, but further high‐quality research examining the mechanisms of action are encouraged.
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Virtual-reality based rehabilitation (VR) shows potential as an engaging and effective way to improve upper-limb function and cognitive abilities following a stroke. However, an updated synthesis of ...the literature is needed to capture growth in recent research and address gaps in our understanding of factors that may optimize training parameters and treatment effects.
Published randomized controlled trials comparing VR to conventional therapy were retrieved from seven electronic databases. Treatment effects (Hedge's g) were estimated using a random effects model, with motor and functional outcomes between different protocols compared at the Body Structure/Function, Activity, and Participation levels of the International Classification of Functioning.
Thirty-three studies were identified, including 971 participants (492 VR participants). VR produced small to medium overall effects (g = 0.46; 95% CI: 0.33-0.59, p < 0.01), above and beyond conventional therapies. Small to medium effects were observed on Body Structure/Function (g = 0.41; 95% CI: 0.28-0.55; p < 0.01) and Activity outcomes (g = 0.47; 95% CI: 0.34-0.60, p < 0.01), while Participation outcomes failed to reach significance (g = 0.38; 95% CI: -0.29-1.04, p = 0.27). Superior benefits for Body Structure/Function (g = 0.56) and Activity outcomes (g = 0.62) were observed when examining outcomes only from purpose-designed VR systems. Preliminary results (k = 4) suggested small to medium effects for cognitive outcomes (g = 0.41; 95% CI: 0.28-0.55; p < 0.01). Moderator analysis found no advantage for higher doses of VR, massed practice training schedules, or greater time since injury.
VR can effect significant gains on Body Structure/Function and Activity level outcomes, including improvements in cognitive function, for individuals who have sustained a stroke. The evidence supports the use of VR as an adjunct for stroke rehabilitation, with effectiveness evident for a variety of platforms, training parameters, and stages of recovery.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Portions of the southern and southeastern United States, primarily Mississippi, Alabama, and Georgia, have experienced century-long (1895–2007) downward air temperature trends that occur in all ...seasons. Superimposed on them are shifts in mean temperatures on decadal scales characterized by alternating warm (1930s–1940s, 1990s) and cold (1900s; 1960s–1970s) regimes. Regional atmospheric circulation and SST teleconnection indices, station-based cloud cover and soil moisture (Palmer drought severity index) data are used in stepwise multiple linear regression models. These models identify predictors linked to observed winter, summer, and annual Southeastern air temperature variability, the observed variance (r
2
) they explain, and the resulting prediction and residual time series. Long-term variations and trends in tropical Pacific sea temperatures, cloud cover, soil moisture and the North Atlantic and Arctic oscillations account for much of the air temperature downtrends. Soil moisture and cloud cover are the primary predictors of 59.6 % of the observed summer temperature variance. While the teleconnections, cloud cover and moisture data account for some of the annual and summer Southeastern cooling trend, large significant downward trending residuals remain in winter and summer. Comparison is made to the northeastern United States where large twentieth century upward air temperature trends are driven by cloud cover increases and Atlantic Multidecadal Oscillation (AMO) variability. Differences between the Northeastern warming and the Southeastern cooling trends in summer are attributable in part to the differing roles of cloud cover, soil moisture, the Arctic Oscillation and the AMO on air temperatures of the 2 regions.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
This systematic review and meta-analysis aimed to investigate whether cognition is associated with activity and participation outcomes in adult stroke survivors. Five databases were systematically ...searched for studies investigating the relationship between general- and domain-specific cognition and longer-term (>3 months) basic activities of daily living (ADL), instrumental ADLs, and participation outcomes. Eligibility for inclusion, data extraction, and study quality was evaluated by 2 reviewers using a standardized protocol. Effect sizes (
) were estimated using a random-effects model. Sixty-two publications were retained for review, comprising 7817 stroke survivors (median age 63.57 years, range:18-96 years). Median length of follow-up was 12 months (range: 3 months-11 years). Cognition (all domains combined) demonstrated a significant medium association with all 3 functional outcomes combined,
=0.37 (95% CI, 0.33-0.41),
<0.001. Moderator analyses revealed these effects persisted regardless of study quality, order in which outcomes were collected (sequential versus concurrent), age, sample size, or follow-up period. Small to medium associations were also identified between each individual cognitive domain and the separate ADL, instrumental ADL, and participation outcomes. In conclusion, poststroke cognitive impairment is associated with early and enduring activity limitations and participation restrictions, and the association is robust to study design factors, such as sample size, participant age, follow-up period, or study quality. Cognitive assessment early poststroke is recommended to facilitate early detection of disability, prediction of functional outcomes, and to inform tailored rehabilitation therapies.
Soil moisture shortages adversely affecting agriculture are significantly associated with meteorological drought. Because of limited soil moisture observations with which to monitor agricultural ...drought, characterizing soil moisture using drought indices is of great significance. The relationship between commonly used drought indices and soil moisture is examined here using Chinese surface weather data and calculated station-based drought indices. Outside of northeastern China, surface soil moisture is more affected by drought indices having shorter time scales while deep-layer soil moisture is more related on longer index time scales. Multiscalar drought indices work better than drought indices from two-layer bucket models. The standardized precipitation evapotranspiration index (SPEI) works similarly or better than the standardized precipitation index (SPI) in characterizing soil moisture at different soil layers. In most stations in China, theZindex has a higher correlation with soil moisture at 0–5 cm than the Palmer drought severity index (PDSI), which in turn has a higher correlation with soil moisture at 90–100-cm depth than theZindex. Soil bulk density and soil organic carbon density are the two main soil properties affecting the spatial variations of the soil moisture–drought indices relationship. The study may facilitate agriculture drought monitoring with commonly used drought indices calculated from weather station data.
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