The Madín Dam is a reservoir located in the municipalities of Naucalpan and Atizapán, in the metropolitan area adjacent to Mexico City. The reservoir supplies drinking water to nearby communities and ...provides an area for various recreational activities, including kayaking, sailing and carp fishing. Over time, the number of specimens of common carp has notably diminished in the reservoir, which receives direct domestic drainage from two towns as well as numerous neighborhoods along the Tlalnepantla River. Diverse studies have demonstrated that the pollutants in the water of the reservoir produce oxidative stress, genotoxicity and cytotoxicity in juvenile Cyprinus carpio, possibly explaining the reduction in the population of this species; however, it is necessary to assess whether these effects may also be occurring directly in the embryos. Hence, surface water samples were taken at five sites and pharmaceutical drugs, personal care products (especially sunscreens), organophosphate and organochlorine pesticides, and other persistent organic pollutants (e.g., polychlorinated biphenyls and polycyclic aromatic hydrocarbons) were identified. Embryos of C. carpio were exposed to the water samples to evaluate embryolethality, modifications in embryonic development, lipoperoxidation, the quantity of hydroperoxide and oxidized proteins, and antioxidant enzyme activity (superoxide dismutase, catalase and glutathione peroxidase). It was found that the polluted water of the Madín Dam gave rise to embryolethality, embryotoxicity, congenital abnormalities, and oxidative stress on the common carp embryos.
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•The water of the Madin dam contains hydrocarbons of various types.•These hydrocarbons in combination with other contaminants from the site produce embryotoxicity in the common carp.•Cyprinus carpio is at risk in the Madín reservoir.
The water of the Madín dam contains a complex mixture of pollutants, including hydrocarbons, which produce oxidative stress and embryotoxicity on Cyprinus carpio.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Neuroinflammation contributes to neuronal degeneration in Parkinson's disease (PD). However, how brain inflammatory factors mediate the progression of neurodegeneration is still poorly understood. ...Experimental models of PD have shed light on the understanding of this phenomenon, but the exploration of inflammation-driven models is necessary to better characterize this aspect of the disorder. The use of lipopolysaccharide (LPS) to induce a neuroinflammation-mediated neuronal loss is useful to induce reliable elimination of dopaminergic neurons. Nevertheless, how this model parallels the PD-like neuroinflammation is uncertain. In the present work, we used the direct LPS injection as a model inductor to eliminate dopaminergic neurons of the substantia nigra pars compacta (SNpc) in rats and reevaluated the inflammatory reaction. High-resolution 3D histological examination revealed that, although LPS induced a reliable elimination of SNpc dopaminergic neurons, it also generated a massive inflammatory response. This inflammation-mediated injury was characterized by corralling, a damaged parenchyma occupied by a vast population of lesion-associated microglia and macrophages (LAMMs) undertaking wound compaction and scar formation, surrounded by highly reactive astrocytes. LAMMs tiled the entire lesion and engaged in long-standing phagocytic activity to resolve the injury. Additionally, modeling LPS inflammation in a cell culture system helped to understand the role of phagocytosis and cytotoxicity in the initial phases of dopaminergic degeneration and indicated that LAMM-mediated toxicity and phagocytosis coexist during LPS-mediated dopaminergic elimination. However, this type of severe inflammatory-mediated injury, and subsequent resolution appear to be different from the ageing-related PD scenario where the architectural structure of the parenchyma is mostly preserved. Thus, the necessity to explore new experimental models to properly mimic the inflammatory compound observed in PD degeneration.
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•LPS-induced mesencephalic injury causes corralling of microglia/macrophages•LPS-mediated lesion in SNpc triggers microglia/macrophages tiling and honeycomb structures•Microglia/macrophages tiling contributes to promote interactions with remnant dopaminergic neurons and debris•Corralled lesion shows high phagocytic capacity of dopaminergic remains
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In the TRITIUM project, an on-site monitoring system is being developed to measure tritium (3H) levels in water near nuclear power plants. The quite low-energy betas emitted by 3H have a very short ...average path in water (5 μm as shown by simulations for 18 keV electrons). This path would be further reduced by impurities present in the water, resulting in a significant reduction of the detection efficiency. Therefore, one of the essential requirements of the project is the elimination of these impurities through a filtration process and the removal of salts in solution. This paper describes a water treatment system developed for the project that meets the following requirements: the water produced should be of near-pure water quality according to ISO 3696 grade 3 standard (conductivity < 10 μS/cm); the system should operate autonomously and be remotely monitored.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Introduction
Electroconvulsive therapy is a highly effective treatment for severe psychopharmacological resistant patients but it is also a procedure that involves open airway management and has been ...considered as an aerosol generating procedure. The COVID-19 pandemic, has resulted in reduction in ECT services internationally. The COVID-19 pandemic has dramatically and rapidly transformed hospitals in heavily affected areas, decreasing mental health services. The need to locate critical patients in spaces intended for anesthesia, where we usually administered ECT, has forced us to decrease the number of procedures and be highly selective. In the same way, continuation and maintenance ECT (m-ECT) have also been dramatically reduced. The risk of contagion urged us to develop a protocol involving other areas of the hospital
Objectives
To create a safe circuit from admission to the hospital to the ECT including emergency room and psychiatric Ward
Methods
Review of the tliterature and published protocols Workshops with Preventive Medicine, Anaesthesia and Emergency Service to elaborate a protocol Submission of the protocol to Management of the Hospital
Results
The protocol (Figure 1) began with the screening for COVID-19 in every patient. If the PCR was (+) the patient was not excluded. We moved treatment from the PACU into the OR and if a patient tested positive It was determined that the ECT was administered in the OR
That was provided with negative pressure. Circuits were established within the Psychiatric Ward and in the areas of the hospital involved to reduce risks and patients remained isolated until negative test was confirmed The number of persons present in the treatment room was kept to the absolute minimum required and appropriate personal protective equipment was used, as prescribed by the WHO
Conclusions
We must keep in mind treating the most vulnerable of our patients. ECT should be seen as an essential medical procedure and made available
Disclosure
No significant relationships.
Introduction
A considerable percentage of Health Care Workers (HCW) have experienced psychological distress during the COVID-19 pandemic. Data from previous pandemics suggest that HCW might develop ...psychiatric disorders. Psychosocial and workplace measures can improve mental wellbeing of the MHW. As part of the program of the Hospital to give support to the HCW, five support weekly open dynamic groups have been carried out with HCW from the COVID Areas of our Hospital including the ICU
Objectives
Identify recurrent contents in the group that express areas ofconcern Identify HCW in risk of develop a psuchiatric disorder and refer them to their apropiate level o
Methods
The sessions were carried out in a freely open group and the contents expressed in the sessions were recorded and analyzed ina narrative way. Special attention was given to the the more stresfull activities identified, to Signs of overload and to the ability to seek relief, as well as signs of disruption of personal life outside of work. Four sessions of 90 minutes, with staff of the same area were established and after these four sessions booster sessions was offered through continuity groups to members with need of more long term care as well as individual care.
Results
The recurrent areas identified were Concern about inadequite Personal Protective Equipment Concern about spreading the infection in their own families Need for relief and avoid double turn Uncertainty about the course of the illness Exposure to patients suffering and dying
Conclusions
HCW need nor only psychological support but also pragmatic measures
Disclosure
No significant relationships.
Simulation results of a real-time in water tritium monitor Azevedo, C.D.R.; Baeza, A.; Chauveau, E. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2020, Volume:
982
Journal Article
Peer reviewed
Open access
In this work we present simulation results for a modular tritium in-water real-time monitor. The system allows for scalability in order to achieve the required sensitivity. The modules are composed ...by 340 uncladed scintillating fibers immersed in water and 2 photosensors in coincidence for light readout. Light yield and Birks’ coefficient uncertainties for low energy beta particles is discussed. A study of the detection efficiency according to the fiber length is presented. Discussion on the system requirements and background mitigation for a device with sensitivity of 100Bq/L, required to comply with the European directive 2013/51/Euratom, is presented. Due to the low energetic beta emission from tritium a detection efficiency close to 3.3% was calculated for a single 2 mm round fiber.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Tritium is released abundantly to the environment by nuclear power plants (NPP), as a product of neutron capture by hydrogen and deuterium. In normal running conditions, released cooling waters may ...contain levels of tritium close to or even larger than the maximum authorised limit for human consumption (drinking and irrigation). The European Council Directive 2013/51/Euratom requires a maximum level of tritium in water for human consumption lower than 100 Bq=L. Current monitoring of tritium activity in water by liquid scintillating method takes about two days and can only be carried out in a dedicated laboratory. This system is not appropriate for real time monitoring. At present, there exists no available detector device with enough sensitivity to monitor waters for human consumption with high enough sensitivity. The goal of the TRITIUM project is to build a tritium monitor capable to measure tritium activities with detection limit close to 100Bq=L, using instrumentation technique developed in recent years for Nuclear and Particle Physics, such as scintillating fibres and silicon photomultipliers (SiPM). In this paper the current status of the TRITIUM project is presented and he results of first prototypes are discussed. A detector system based on scintillating fibers read out either photomultiplier tubes (PMTs) or silicon photomultiplier (SiPM) arrays is under development and will be installed in the vicinity of Almaraz nuclear power plant (Cáceres, Spain) by the fourth term of 2019.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract
In this paper, we report the development and performance of
a detector module envisaging a tritium-in-water real-time activity
monitor. The monitor is based on modular detection units whose
...number can be chosen according to the required sensitivity. The full
system is being designed to achieve a
Minimum Detectable
Activity
(
MDA
) of 100 Bq/L of tritium-in-water activity
which is the limit established by the E.U. Council Directive
2013/51/Euratom for water intended for human consumption. The same
system can be used as a real-time pre-alert system for nuclear power
plant regarding tritium-in water environmental surveillance. The
first detector module was characterized, commissioned and installed
immediately after the discharge channel of the Arrocampo dam
(Almaraz nuclear power plant, Spain) on the Tagus river. Due to the
high sensitivity of the single detection modules, the system
requires radioactive background mitigation techniques through the
use of active and passive shielding. We have extrapolated a
MDA
of 3.6 kBq/L for a single module being this value
limited by the cosmic background. The obtained value for a single
module is already compatible with a real-time environmental
surveillance and pre-alert system. Further optimization of the
single-module sensitivity will imply the reduction of the number of
modules and the cost of the detector system.
Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances in early diagnosis and postnatal management have increased survival in CHD ...children, worrying long-term outcomes, particularly neurodevelopmental disability, have emerged as a key prognostic factor in the counseling of these pregnancies.
Eligible participants are women presenting at 20 to < 37 weeks of gestation carrying a fetus with CHD. Maternal/neonatal recordings are performed at regular intervals, from the fetal period to 24 months of age, and include: placental and fetal hemodynamics, fetal brain magnetic resonance imaging (MRI), functional echocardiography, cerebral oxymetry, electroencephalography and serum neurological and cardiac biomarkers. Neurodevelopmental assessment is planned at 12 months of age using the ages and stages questionnaire (ASQ) and at 24 months of age with the Bayley-III test. Target recruitment is at least 150 cases classified in three groups according to three main severe CHD groups: transposition of great arteries (TGA), Tetralogy of Fallot (TOF) and Left Ventricular Outflow Tract Obstruction (LVOTO).
The results of NEURO-HEART study will provide the most comprehensive knowledge until date of children's neurologic prognosis in CHD and will have the potential for developing future clinical decisive tools and improving preventive strategies in CHD.
NCT02996630 , on 4th December 2016 (retrospectively registered).
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