Abstract During the last 25 yr, hundreds of binary stars and planets have been discovered toward the Galactic bulge by microlensing surveys. Thanks to a new generation of large-sky surveys, it is now ...possible to regularly detect microlensing events across the entire sky. The OMEGA Key Projet at the Las Cumbres Observatory carries out automated follow-up observations of microlensing events alerted by these surveys with the aim of identifying and characterizing exoplanets as well as stellar remnants. In this study, we present the analysis of the binary lens event Gaia20bof. By automatically requesting additional observations, the OMEGA Key Project obtained dense time coverage of an anomaly near the peak of the event, allowing characterization of the lensing system. The observed anomaly in the lightcurve is due to a binary lens. However, several models can explain the observations. Spectroscopic observations indicate that the source is located at ≤2.0 kpc, in agreement with the parallax measurements from Gaia. While the models are currently degenerate, future observations, especially the Gaia astrometric time series as well as high-resolution imaging, will provide extra constraints to distinguish between them.
MOA-2006-BLG-074 was selected as one of the most promising planetary candidates in a retrospective analysis of the MOA collaboration: its asymmetric high-magnification peak can be perfectly explained ...by a source passing across a central caustic deformed by a small planet. However, after a detailed analysis of the residuals, we have realized that a single lens and a source orbiting with a faint companion provides a more satisfactory explanation for all the observed deviations from a Paczynski curve and the only physically acceptable interpretation. Indeed the orbital motion of the source is constrained enough to allow a very good characterization of the binary source from the microlensing light curve. The case of MOA-2006-BLG-074 suggests that the so-called xallarap effect must be taken seriously in any attempts to obtain accurate planetary demographics from microlensing surveys.
A paramyxovirus virus termed Nipah virus has been identified as the etiologic agent of an outbreak of severe encephalitis in people with close contact exposure to pigs in Malaysia and Singapore. The ...outbreak was first noted in late September 1998 and by mid-June 1999, more than 265 encephalitis cases, including 105 deaths, had been reported in Malaysia, and 11 cases of encephalitis or respiratory illness with one death had been reported in Singapore. Electron microscopic, serologic, and genetic studies indicate that this virus belongs to the family Paramyxoviridae and is most closely related to the recently discovered Hendra virus. We suggest that these two viruses are representative of a new genus within the family Paramyxoviridae. Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans.
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Context . Gravitational microlensing is a method that is used to discover planet-hosting systems at distances of several kiloparsec in the Galactic disk and bulge. We present the analysis of a ...microlensing event reported by the Gaia photometric alert team that might have a bright lens. Aims . In order to infer the mass and distance to the lensing system, the parallax measurement at the position of Gaia21blx was used. In this particular case, the source and the lens have comparable magnitudes and we cannot attribute the parallax measured by Gaia to the lens or source alone. Methods . Since the blending flux is important, we assumed that the Gaia parallax is the flux-weighted average of the parallaxes of the lens and source. Combining this assumption with the information from the microlensing models and the finite source effects we were able to resolve all degeneracies and thus obtained the mass, distance, luminosities and projected kinematics of the binary lens and the source. Results . According to the best model, the lens is a binary system at 2.18 ± 0.07 kpc from Earth. It is composed of a G star with 0.95 ± 0.17 M ⊙ and a K star with 0.53 ± 0.07 M ⊙ . The source is likely to be an F subgiant star at 2.38 ± 1.71 kpc with a mass of 1.10 ± 0.18 M ⊙ . Both lenses and the source follow the kinematics of the thin-disk population. We also discuss alternative models, that are disfavored by the data or by prior expectations, however.
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Following the clinical diagnosis of the first case of mumps on September 22, 2006 at the University of Virginia (UVA), 52 suspected cases were identified through active surveillance for mumps by the ...end of December 2006. Samples were collected from 47 students who presented with parotitis despite a documented history of two doses of measles, mumps, and rubella (MMR) vaccine. Six of 47 serum samples (13%) were positive for mumps IgM, and 46/47 specimens were positive for mumps IgG. Endpoint titration of acute phase serum samples from laboratory-confirmed cases did not provide evidence that elevated serum IgG is a consistent marker for infection among cases due to secondary vaccine failure. Buccal swab samples from 39 of the 47 students were tested by real-time reverse transcription-polymerase chain reaction (RT-PCR) and/or viral culture. Mumps virus or mumps RNA was detected in 12 of 39 buccal samples (31%). Genetic analysis of the virus from the outbreak at UVA indicated that the outbreak was not linked to the large mumps outbreak in the Midwestern US that occurred earlier in 2006. Our findings support the use of viral detection to improve laboratory diagnosis of mumps among persons who have received two doses of MMR. J. Med. Virol. 81:1819-1825, 2009.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Background. On 12 February 2008, an infected Swiss traveler visited hospital A in Tucson, Arizona, and initiated a predominantly health care-associated measles outbreak involving 14 cases. We ...investigated risk factors that might have contributed to health care-associated transmission and assessed outbreak-associated hospital costs. Methods. Epidemiologie data were obtained by case interviews and review of medical records. Health care personnel (HCP) immunization records were reviewed to identify non— measles-immune HCP. Outbreakassociated costs were estimated from 2 hospitals. Results. Of 14 patients with confirmed cases, 7 (50%) were aged > 18 years, 4 (29%) were hospitalized, 7 (50%) acquired measles in health care settings, and all (100%) were unvaccinated or had unknown vaccination status. Of the 11 patients (79%) who had accessed health care services while infectious, 1 (9%) was masked and isolated promptly after rash onset. HCP measles immunity data from 2 hospitals confirmed that 1776 (25%) of 7195 HCP lacked evidence of measles immunity. Among these HCPs, 139 (9%) of 1583 tested seronegative for measles immunoglobulin G, including 1 person who acquired measles. The 2 hospitals spent US$ 799,136 responding to and containing 7 cases in these facilities. Conclusions. Suspecting measles as a diagnosis, instituting immediate airborne isolation, and ensuring rapidly retrievable measles immunity records for HCPs are paramount in preventing health care—associated spread and in minimizing hospital outbreak-response costs.
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Molecular Epidemiology of Measles Virus Rota, P. A.; Featherstone, D. A.; Bellini, W. J.
Current topics in microbiology and immunology,
2009, Volume:
330
Book Chapter, Journal Article
Peer reviewed
Genetic characterization of wild-type measles viruses provides a means to study the transmission pathways of the virus and is an essential component of laboratory-based surveillance. Laboratory-based ...surveillance for measles and rubella, including genetic characterization of wild-type viruses, is performed throughout the world by the WHO Measles and Rubella Laboratory Network, which serves 166 countries in all WHO regions. In particular, the genetic data can help confirm the sources of virus or suggest a source for unknown-source cases as well as to establish links, or lack thereof, between various cases and outbreaks. Virologic surveillance has helped to document the interruption of transmission of endemic measles in some regions. Thus, molecular characterization of measles viruses has provided a valuable tool for measuring the effectiveness of measles control programs, and virologic surveillance needs to be expanded in all areas of the world and conducted during all phases of measles control.
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FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
BackgroundThe most severe sequela of measles virus infection is subacute sclerosing panencephalitis (SSPE), a fatal disease of the central nervous system that generally develops 7–10 years after ...infection. From 1989 through 1991, a resurgence of measles occurred in the United States, with 55,622 cases of measles reported. The purpose of the present study was to identify cases of SSPE that were associated with the resurgence of measles and to calculate the risk of developing SSPE MethodsBrain tissue samples obtained from 11 patients with a presumptive diagnosis of SSPE were tested for the presence of measles virus RNA. Measles virus genotypes were determined by reverse-transcription polymerase chain reaction (RT-PCR) and by analysis of the sequences of the PCR products. A search of the literature was conducted to identify reports of cases of SSPE in persons residing in the United States who had measles during 1989–1991 ResultsThe measles virus sequences derived from brain tissue samples obtained from 11 patients with SSPE confirmed the diagnosis of SSPE. For 5 of the 11 patients with SSPE who had samples tested by RT-PCR and for 7 patients with SSPE who were identified in published case reports, it was determined that the development of SSPE was associated with the measles resurgence that occurred in the United States during 1989–1991. The estimated risk of developing SSPE was 10-fold higher than the previous estimate reported for the United States in 1982 ConclusionsVaccination against measles prevents more cases of SSPE than was originally estimated
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The problem of the automatic determination of the first and second ventilatory thresholds (VT1 and VT2) from cardiopulmonary exercise test (CPET) still leads to controversy. The reliability of the ...gold standard methodology (i.e. expert visual inspection) feeds into the debate and several authors call for more objective automatic methods to be used in the clinical practice. In this study, we present a framework based on a collaborative approach, where a web-application was used to crowd-source a large number (1245) of CPET data of individuals with different aerobic fitness. The resulting database was used to train and test an artificial intelligence (i.e. a convolutional neural network) algorithm. This automatic classifier is currently implemented in another web-application and was used to detect the ventilatory thresholds in the available CPET. A total of 206 CPET were used to evaluate the accuracy of the estimations against the expert opinions. The neural network was able to detect the ventilatory thresholds with an average mean absolute error of 178 (198) mlO
2
/min (11.1%, r = 0.97) and 144 (149) mlO
2
/min (6.1%, r = 0.99), for VT1 and VT2 respectively. The performance of the neural network in detecting VT1 deteriorated in case of individuals with poor aerobic fitness. Our results suggest the potential for a collective intelligence system to outperform isolated experts in ventilatory thresholds detection. However, the inclusion of a larger number of VT1 examples certified by a community of experts will be likely needed before the abilities of this collective intelligence can be translated into the clinical use of CPET.
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FSPLJ, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
For the purposes of regeneration of the consolidated city it is increasingly important to have the knowledge of the micro-scale distribution of the vulnerability of the population to the consequences ...of climate change and increasing urbanization. The work to be presented starts with the creation of maps of the risk classification induced by the heat islands in the city of Parma, and aims to investigate which are the most effective strategies that a Public Administration can adopt. The maps that have been created allow to assess the risk for the fragile population at the level of the single building. They relate the climatic datum of thermal variation with the population residing within each building, and verify the causal relationship with the soil sealing and with the morphology of the urban fabric. The results of the study can help to identify the thermal hot spot, receivers of specific mitigation actions. The risk map is itself a tool to develop multilevel actions, designed according to the peculiarities of the sites, where the possible adaptive solutions are compared with the physical and morphological characteristics of the places. The positive function of green infrastructures (contrast of overheating, flood mitigation, creation of places and services with a recreational function) is acquired by research and urban planning practice. It is equally well known the difficulty faced by Local Authorities in the maintenance and increase of unbuilt public areas, fundamental for the connection of ecological networks.
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