CLL is considered to be an accumulation of matured lymphocytes.
In blood, bone marrow, spleen, and lymph nodes, we aimed to assess the correlation of initial hematological features with advanced ...stage in CLL.
A retrospective study was conducted on 138 patients with CLL, confirmed by flow cytometry of peripheral blood collected in the Hiwa Hematological and Oncological Hospital in Sulaimani, Nanakaly Hospital in Hawler, and Azadi Hematology - Oncology Center in Duhok, Kurdistan Region of Iraq, from January 1, 2010, to December 31, 2020.
The mean age of patients was 63.07±11 years, with male predominance. The majority of patients at presentation were Rai stage II and Binet stage A. The frequency of direct antiglobulin test (DAT) positivity was 6.5%, which also established an appositive relationship with advanced stage. There also were statistically significant relationships between hemoglobin levels, platelet counts, and lactose dehydrogenase (LDH) levels and Rai stage and Binet stage disease (P<0.001). No association was noted between different age groups and initial laboratory findings, and there also was no relationship between gender and stage.
In the present study, there was a significant relationship between laboratory findings (hemoglobin levels, platelet counts, and LDH levels) and stage. In addition, DAT positivity demonstrated a significant correlation with advanced stage and high LDH levels were associated with more advanced Rai stage.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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