stoplasmosis is a deep cosmopolitan mycosis due to dimorphic fungi belonging to the genus Histoplasma. We distinguish the American histoplasmosis, with small form due to Histoplasma capsulatum var. ...capsulatum (H. capsulatum), and large-form African histoplasmosis, due to H. duboisii. The latter is endemic in West and Central Africa and Madagascar. African histoplasmosis is a rare deep mycosis, due to Histoplasma Capsulatum var.duboisii. Clinical presentation may be localized with isolated infections of the skin, bones or lymph nodes or disseminated with multiple skin lesions present throughout the body, subcutaneous abscesses, enlarged lymph nodes, liver and spleen, and enlargement of visceral organs. It has diagnostic similarities with pathologies such as lymph node tuberculosis, cutaneous cryptococcosis and certain malignant diseases of the skeleton. The disease sometimes poses therapeutic difficulties. We report a histoplasmosis case at Histoplasma Capsulatum var.duboisii, with multiple localization in a 22-year-old student.
