Models for strongly interacting fermions in disordered clusters forming an array, with electron hopping between sites, reproduce the linear dependence on temperature of the resistivity, typical of ...the strange metal phase of high temperature superconducting materials extended Sachdev-Ye-Kitaev (SYK) models. We identify the low energy collective excitations as neutral energy excitations, diffusing in the lattice of the thermalized non-Fermi liquid phase. However, the diffusion is heavily hindered by coupling to the pseudo-Goldstone modes of the conformal broken symmetry SYK phase, which are local in space. The imaginary time evolution of the extended model in the strong interaction and 1/N expansion limit is presented in the incoherent nonchaotic regime. On the other hand, a Fermi electronic liquid at low energy becomes marginal when perturbed by the SYK dots. A critical temperature for superconductivity is derived, which is not BCS-like, in case the collective excitations are assumed to mediate an attractive Cooper pairing.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM, UPUK
The Author remarks the interstitial lung involvement in systemic lupus erythematosus. This secondary respiratory manifestation is infrequent as well as the consequent pulmonary hypertension making it ...possible to miss or delay the diagnosis. Therefore the interdisciplinary evaluation of the multisystemic disease lupus erythematosus needs. In this context the role of the pneumologists is relevant for the global treatment of the patients with LES in particular as concerns the early detection of the clinical and functional respiratory symptoms as well as the appropriate treatment plan within their specialistic competence.
. The Monte Carlo simulation software is a valuable tool in radiation therapy, in particular to achieve the needed accuracy in the dose evaluation for the treatment plans optimisation. The current ...challenge in this field is the time reduction to open the way to many clinical applications for which the computational time is an issue. In this manuscript we present an innovative GPU-accelerated Monte Carlo software for dose valuation in electron and photon based radiotherapy, developed as an update of the FRED (Fast paRticle thErapy Dose evaluator) software.
. The code transports particles through a 3D voxel grid, while scoring their energy deposition along their trajectory. The models of electromagnetic interactions in the energy region between 1 MeV-1 GeV available in literature have been implemented to efficiently run on GPUs, allowing to combine a fast tracking while keeping high accuracy in dose assessment. The FRED software has been bench-marked against state-of-art full MC (FLUKA, GEANT4) in the realm of two different radiotherapy applications: Intra-Operative Radio Therapy and Very High Electron Energy radiotherapy applications.
. The single pencil beam dose-depth profiles in water as well as the dose map computed on non-homogeneous phantom agree with full-MCs at 2% level, observing a gain in processing time from 200 to 5000.
. Such performance allows for computing a plan with electron beams in few minutes with an accuracy of ∼%, demonstrating the FRED potential to be adopted for fast plan re-calculation in photon or electron radiotherapy applications.
The Author remarks the dispute about the adjuvant chemotherapy in patients with completely resected NSCLC stage IA. The tendency to overcoming all these disputes on the basis of relevant data ...published in the pneumological literature, is taking shape. The most active role in this field of research is played by the pathologists as well as by thoracic surgeons in the interdisciplinary perspective concerning the new changed “scenario” after the 7th Edition 2009 of TNM Staging System.
Management of hypernatremias Salvati, F.
Italian journal of medicine,
05/2013, Volume:
1, Issue:
2
Journal Article
Peer reviewed
Open access
BACKGROUND The hypernatremias (serum sodium concentration value exceeding 145 mMol per Liter) are common electrolyte disorders, frequently developing in hospitalized patients, sometimes as an ...iatrogenic condition. Hypernatremia often causes cellular dehydratation and the resultant morbidity may be serious or even life-threatening. Some of its major complications result not from the disorder itself but from the inappropriate treatment of it.
CONCLUSIONS In this article we focus on the pathophysiology of these electrolyte disorders (hypovolemic, euvolemic and hypervolemic hypernatremias) and on the management of the sodium and water derangement and of the clinical complications.
Intrinsic permeability is crucial to assess gases and volatile compounds transport through soil. In situ measurements of this parameter are based on Darcy equation, an empirical relation that ...describes the flow of a fluid through a porous medium. A new technique for in situ measurement of soil gas permeability was developed and deeply tested in several terrains. The new instrument was successfully calibrated against RADON JOK, a permeameter which is widely employed all over the world. The new device provides rapid responses and is easy to carry in the field. It can be employed in the range of 3×10−13–8.0×10−11m2, extending the upper detection limit of RADON JOK (1.8×10−11). Its use is recommended to investigate radon and other gas transfer through the soil and to map radon or CO2 potentials of a given site. It could be also employed in environmental studies where the transfer of volatile pollutants is of primary concern.
•A new device for in situ measurement of soil gas permeability has been developed.•It has been tested against RADON JOK, a permeameter broadly used all over the world.•The new device provides rapid responses and is easy to carry in the field.•It extends the upper detection limit of RADON JOK.•It may be used in the evaluation of gas hazard and volatile pollutants remediation.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
The adjuvant therapy in NSCLC Stage IA still remains a controversial issue even in the interdisciplinary decision making after limited resections of the neoplasm as an alternative to lobectomy. The ...Authors accept from literature that this mainly concerns specific sub-group of patients, the istopathological post-resection diagnosis of whom highlights linfovascular o perineural as well as visceral pleura invasion. There is confidence that the presently depersonalizing rigidity in the guidelines implementation is overcome in the presence of clear istological signs of invasion. As a consequence the interdisciplinary team should reasonably consider as correct the adjuvant treatment.
The nucleoside analog, gemcitabine, has shown activity as a single agent in the treatment of metastatic non-small-cell lung cancer (NSCLC). Its combination with cisplatin in preclinical models ...suggested synergy between the two drugs. The aim of the study was to evaluate the clinical efficacy and toxicity of the cisplatin-gemcitabine combination in advanced NSCLC.
Forty-eight consecutive previously untreated NSCLC patients entered the trial from January to June 1994. The median age was 60 years (range, 37 to 70) and performance status (PS) was 0 or 1; 22 patients had unresectable stage III disease (21 stage IIIB and one stage IIIA) and 26 had stage IV disease. Gemcitabine 1 g/m2 was administered weekly (days 1, 8, and 15) followed by a 1-week rest and cisplatin 100 mg/m2 on day 2 of each 28-day cycle. Survival and response were determined in accordance with the intention-to-treat principle in all enrolled patients.
Of 48 assessable patients, one (stage IV) had a complete response (CR) and 25 achieved a partial response (PR). The overall response rate was 54% (95% confidence interval CI, 40% to 68%). Thrombocytopenia was the main side effect, with 52% of patients experiencing grade III to IV toxicity, which was usually short-lived and responsible for the omission of gemcitabine administration on day 15 in 50% of chemotherapy courses. The median survival time was 61.5 weeks (95% CI, 40 to 71).
The combination of gemcitabine and cisplatin induced a high response rate in both stage IIIB and IV NSCLC, with modest side effects. The regimen deserves further careful evaluation in a phase III prospective randomized trial.
The Authors fully share cricitisms voiced in international literature to NSCLC longsurvivors, in particular those remarkes related to advanced disease patients following various anti-tumor treatments ...( mostly multimodal). To this point, even the NCCN version 3.2014 guidelines prove inadequate as they mostly focus on longsurvivors post-NSCLC early stage surgical resection. Although AIOM Working Group's recommendations for follow-up seem to be more adequate, still they lack depth with respect to advanced-stage bronchogenic carcinoma. The Authors quote a number of case report related to advanced disease longsurvivors, and draws his attention on the peculiar role of pneumologists in the follow-up for such patients: in particular, as regards respiratory pathologies prior or subsequent to different anti-tumor treatments (i.e., BPCO, interstitial lung diseases, pulmonary thromboembolism, etc.).
Mucoid degeneration of the anterior cruciate ligament (ACL) is a pathological state not yet well morphologically defined, involving people without history of knee instability or significant trauma, ...and causing important pain. The aim of this study was to define the histopathological and radiographic features of this pathological condition.
Analysis of 1 215 knee magnetic resonance (MR) examinations found 64 cases (5.3%) of ACL mucoid metaplastic-degeneration (MMD), subsequently all subjects underwent surgical and arthroscopic validation. MR examinations have been performed using a dedicate system provided with a permanent magnet of 0.18 T and with a dedicate coil of 12 cm of field of view (FOV) or an high field instrument with 1.5 T. Radiological criteria to define ACL MMD were based essentially on increased signal intensity in T2W sequences and in STIR ones, as in T1W scans the ligament showed an intermediate signal.
ACL MMD was diagnosed in 36 males and 28 females, with a mean age of 44 years. ''Segmentary MMD'' was found in 11 subjects (17.2%) commonly affecting the postero-lateral bundle of the ligament without femoral or tibial spongious mucoid intrusion. ''Total MMD'' (involving the entire ligament and accompanied with femoral or tibial intrusion) was found in 53 subjects (82.8%).
The comparison between histopathological and MR findings suggests that the commonly called ACL mucoid degeneration (ACL MD) should be better defined as mucoid metaplastic degeneration (MMD).
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