Over the last 20 years, Hepatitis C virus (HCV) infection prevalence has dramatically increased among HIV-infected men who have sex with men (MSM) in many countries worldwide. It is suspected that ...this increase is primarily driven by sexual behaviours linked to blood exposure. Monitoring these behaviours is crucial to understand the drivers of the epidemic. This study assessed the prevalence of chronic HCV infection among MSM attending gay venues and associated chronic HCV risk factors. HCV screening and associated factors were described.
The cross-sectional survey PREVAGAY, based on time-location sampling, was conducted in 2015 among MSM attending gay venues in 5 French metropolitan cities. A self-administered questionnaire was completed and capillary whole blood on dried blood spots (DBS) collected. Possible factors associated with chronic HCV prevalence and with HCV screening in the previous year were investigated using Poisson regression.
Chronic HCV infection prevalence from DBS analysis was 0.7% IC95%: 0.3-1.5 in the study's 2645 participants and was 3.0% 1.5-5.8 in HIV-positive MSM. It was significantly higher in those who reported the following: (lifetime) slamming (with or without the sharing of injection equipment); (during the previous year) fisting and chemsex, unprotected anal intercourse with casual partners, using gay websites and/or of mobile-based GPS applications, and having more than 10 sexual partners. Only 41.3% 38.2-44.5 of the participants reported HCV screening during the previous year. Screening was significantly more frequent in MSM under 30 years of age, those who were HIV-positive, those vaccinated against hepatitis B and meningococcus C, and those who reported the following (during the previous year): more than 10 sexual partners, at least one sexually transmitted infection and fisting.
Chronic HCV infection prevalence in MSM attending gay venues was significantly higher in HIV-positive MSM and in those with risky sexual behaviours. Reflecting current screening recommendations for specific populations, previous HCV screening was more frequent in HIV-positive individuals and those with risky sexual behaviours. Nevertheless, HCV screening coverage needs to be improved in these populations. Comprehensive medical management, which combines screening and linkage to care with prevention strategies, is essential to control HCV among MSM.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Goal, Scope and Background Efficient and environmentally friendly technologies for soil reclamation require efforts to develop innovative processes. Alternative technologies to drastic techniques ...(containment, total removal of soil) are receiving increasing interest. They are based either on the use of ameliorants (e.g. lime, fertilizer, organic mulch) and more recently on the spreading of organic wastes (e.g. compost, sewage sludge). This paper presents a new process of soil construction using wastes and industrial by-products which are formulated and stacked in layers to build a new soil profile over in situ degraded substrates. Work was conducted to assess the feasibility of the ecological reclamation, focusing on the major functions of constructed Technosols. Materials and Methods Two large lysimetric plots (10 x 10 m) were built on a former coking plant, and two strategies of constructed soil profiles were compared: i) a control soil using thermally treated industrial soil available in situ, and ii) a constructed soil with a combination of thermally treated industrial soil mixed with exogenous materials such as green waste compost and paper mill sludge. Rainfall was measured periodically, drainage effluent was collected, and aliquots were sampled per plot. Plants were collected in 8 replicates for each plot. Results Water balance data showed that about 10% of the rain water percolated through the constructed soil profiles. Drainage effluent contained a low concentration of contaminants, below the French water drinking standards. Plants grew without any deficiency symptoms on both plots. Apart from the sowed plants, indigenous species developed on the constructed Technosols. Discussion The experimental set-up was representative of the real conditions for the implementation of such reclamation technologies. In spite of the significant concentrations of trace elements in the parent materials, the fluxes in the drainage effluent were very low because of the high pH. Significantly higher biomass values were recorded on the constructed soil than on the control, as well as a better development of indigenous plants. Conclusions The constructed soils are examples of Technosols as they are made exclusively of technogenic parent materials. Our results showed that they can behave like natural soils (water cycle, trace elements filtration, biomass production). The process of soil construction is not only an efficient way to reclaim derelict lands, but also a safe alternative for the recycling of wastes and by-products with a minimum use of unpolluted and fertile agricultural soil. Recommendations The restoration of soil functions, thanks to the soil construction process, must be considered as a primary step for the ecological reclamation of derelict lands. In this way, the pedo-engineering approach should be considered as an essential part of the global ecological engineering for the reclamation of derelict lands. Perspectives Two major outlooks appear: i) testing a larger variety of wastes and by-products as parent materials for different constructed soils, ii) generalize the results on constructed soils to the characterization of Technosols.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
AbstractActive transportation to school (ATS) is a recognized way to increase physical activity (PA). However, girls and young women do not regularly use ATS despite the many documented physical, ...mental, and community health benefits. Social Marketing (SM) may provide a framework for understanding girls' perspectives of and experience with ATS and inform messages for use in a public health marketing campaign. Focus groups with 79 girls between the ages of 7 and 15 were conducted in Spring 2017 in Victoria, Canada. Transcripts and poster data were initially categorized using the ‘4Ps’ from social marking (Product, Price, Place and Promotion). Participant groups were segmented into three age categories for designing tailored messaging. Thematic analysis revealed elementary school aged participants identified health and fun while middle school participants valued socializing and helping the environment as reasons for engaging in ATS. For secondary school students, ATS was seen as a way to become more independent. All three highlighted fun and enjoyment as important benefits of ATS, and suggested positive and lighthearted messaging. Segmenting into different audiences highlighted how campaign segmentation would resonate with different audiences based on core values and beliefs. Further segmentation of the audience could result in different core values and beliefs held by diverse groups.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The emergence of SARS-CoV-2 variant 20I/501Y.V1 (VOC-202012/1 or GR/501Y.V1) is concerning given its increased transmissibility. We reanalysed 11,916 PCR-positive tests (41% of all positive tests) ...performed on 7-8 January 2021 in France. The prevalence of 20I/501Y.V1 was 3.3% among positive tests nationwide and 6.9% in the Paris region. Analysing the recent rise in the prevalence of 20I/501Y.V1, we estimate that, in the French context, 20I/501Y.V1 is 52-69% more transmissible than the previously circulating lineages, depending on modelling assumptions.
Background and Objectives
Since the advent of AIDS, men who have sex with men (MSM) have often been deferred from blood donation. In France, quarantine plasma donation by MSM donors with the same ...deferral rules as for other donors was introduced in July 2016 and continued up to March 2022. At this time, MSM‐specific deferral criteria were lifted for all blood or plasma donation. The donor deferral, as well as rate of infectious markers in plasma donors who would have been otherwise deferred for MSM activity, was evaluated and compared with those of the other donors during the same time period from June 2016 to March 2022.
Results
A total of 8843 MSM donors made 12,250 plasma donation applications. The overall deferral rate was very high (75.2%), mainly due to the absence of apheresis capacity at the donation site. The deferral criteria for sexual risk were present in 12.1% of MSM donors compared with 1.0% in other plasma and blood donors (p < 0.001). Overall, 994 MSM donors made 2880 plasma donations. Of these, one donation was HIV positive (34.7 vs. 0.6/105 donations by other donors, relative risk RR: 61.0 95% confidence interval CI: 8.5–437.7), one was HBV positive (34.7 vs. 4.5/105, RR: 7.7 95% CI: 1.1–54.6) and none were HCV positive (0 vs. 2.4/105). Additionally, 21 donations were syphilis positive (729.2 vs. 10.7/105, RR: 67.9 95% CI: 44.2–104.4). A post hoc analysis of eligible MSM donors who were unable to donate plasma due to logistic constraints yielded similar findings.
Conclusion
Plasma donation by donors who would have been otherwise deferred for MSM activity was associated with both an increased deferral rate for sexual risk and an increased rate of infectious markers, notably syphilis.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
Background and Objectives
Data from 21 years (2000–2020) of haemovigilance were used to assess human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) ...incidence rates in repeat blood donors and the occurrence of transfusion‐transmitted (TT) viral infections.
Materials and Methods
Blood donors who converted for HIV, HCV or HBV markers within serial three‐year analysis periods were included. Epidemiological and virological data were retrieved from the national epidemiological donor database and were supplemented with information on blood components and the infection status of recipients of the previous negative donation (D.N‐1) of donors who seroconverted.
Results
Incidence rates declined from 1.27 to 0.35/100,000 person‐years for HIV, from 0.59 to 0.19 for HCV and from 1.66 to 0.18 for HBV. Risk factors and lookback for 232 HIV, 90 HCV and 74 HBV seroconversions were investigated. The main risk factor identified at post‐donation interview was having sex with men (47.8% of males) for HIV and a sexual risk for HCV (30.6%) and HBV (37.1%). The viral loads and sequences were retrospectively tested in 191 HIV, 74 HCV and 62 HBV D.N‐1 archived samples. Six (five HBV and one HIV‐1) were positive all low viral loads. Two recipients were infected by red blood cells from two HBV seroconverting donors before the introduction of HBV‐nucleic acid testing.
Conclusion
HIV, HCV and HBV incidence rates in blood donors declined over the two past decades in France. There is a very small risk of a blood component that tests negative entering the blood supply resulting in TT infections, especially after introduction of molecular assays in donor screening.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
7.
L-05 VIH et don de sang : actualités Laperche, Syria; Gallian, Pierre; Sauvage, Claire ...
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine,
November 2022, 2022-11-00, Volume:
29, Issue:
4
Journal Article
Peer reviewed
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
BACKGROUND
Blood donation deferral for men who have sex with men (MSM) in France was reduced from permanent to 12 months in July 2016. To inform a further reduction of the deferral period, an HIV ...risk assessment was conducted with two scenarios: S1, 4‐month deferral; S2, 4‐month deferral only in the case of more than one sexual partner (i.e., similar to other blood donors).
METHODS
Baseline HIV residual risk (RR) was calculated from July 2016 to December 2017, using the Incidence Rate–Window Period method. The impact of both scenarios on RR was assessed using data from surveys on MSM and blood donors, to estimate 1) the number of additional MSM expected to donate in each scenario and 2) HIV incidence among these donors.
RESULTS
Baseline HIV RR was estimated at 1 in 6,380,000 donations. For S1, an additional 733 MSM donors, and an additional 0.09 HIV‐positive donations were estimated, yielding an unchanged RR of 1 in 6,300,000. For S2, these numbers were estimated at 3102 and 3.92, respectively, yielding an RR of 1 in 4,300,000. Sensitivity analyses showed that, under worst‐case assumptions, the RR would equal 1 in 6,225,000 donations for S1 and 1 in 3,000,000 for S2.
CONCLUSION
For both scenarios, the HIV RR remains very low. For S1, the risk is identical to the baseline RR. For S2, it is 1.5 times higher, and sensitivity analysis shows that this estimate is less robust than for S1. The French Minister of Health announced that S1 will be implemented in April 2020.
See editorial on page 437–440, in this issue
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
In the last decade, European cities saw the development of “slamming,” a practice related to chemsex that combines three elements: a sexual context, psychostimulant drug use, and injection practices. ...Epidemiological data on this practice is still sparse and media attention might have unintentionally distorted the size of this phenomenon. Therefore, we aimed to estimate the prevalence of men practicing slam and to identify factors associated with this practice.
We used data from the Prevagay 2015 bio-behavioral survey to estimate the prevalence of slamming practices. A time-location sampling was performed among gay-labeled venues in five French cites. Behavioral information was recorded using a self-administered questionnaire. The HIV and HCV serostatus were investigated using ELISA tests on dried blood spots. The factors associated with slamming were assessed using a multiple logistic regression. We applied a weighting mechanism to enhance the generalizability of the estimates.
Among the 2646 men who have sex with men (MSM) included in our study, 3.1% reported slamming at least once during their lifetime (95% confidence interval (CI) = 2.2–4.3) and 1.6% (95% CI = 1–2.3) said they participated in a slamming session in the last 12 months. In the multivariate analysis, both HCV and HIV biological status were strongly associated with practicing “slam” in the last 12 months (OR = 13.37 (95% CI = 3.26–54.81) and 4.73 (95% CI = 1.58–14.44), respectively). Furthermore, a ten-point decrease in mental health scores was linked with the practice with an OR of 1.37 (95% CI = 1.08–1.73), indicating poorer mental health.
Even though slamming seems to involve a relatively small proportion of MSM, the vulnerability of this sub-group is high enough to justify setting up harm reduction measures and specific care. Training health professionals and creating services combining sexual health and drug dependence could be an effective response.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
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