Bioceramics are versatile materials for hard tissue engineering. Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA ...allows for a wide range of substitutions, which allows for tailoring materials properties. Transition metals and lanthanides are of interest since substitution in HA can result in magnetic properties. In this study, experimental results were compared to theoretical calculations of HA substituted with a transition metal. Calculation of a 10 atomic percent substitution of a transition metal ion Mn
2+
, Fe
2+
, and Co
2+
substituted HA samples lead to magnetic moments of 5, 4, and 3 Bohr magnetons, respectively. Hydroxyapatite substituted by transition metals (MHA) was fabricated through an ion exchange procedure and characterized with X-ray diffraction, Fourier transform infra-red spectroscopy (FTIR), X-ray photoelectron spectroscopy, and vibrating sample magnetometer, and results were compared to theoretical calculations. All the substitutions resulted in phase-pure M
2+
HA with lattice parameters and FTIR spectra in good agreement with calculations. Magnetic measurements revealed that the substitution of Mn
2+
has the greatest effect on the magnetic properties of HA followed by the substitution of Fe
2+
and then Co
2+
. The present work underlines the power of synergistic theoretical-experimental work in guiding the rational design of materials.
Experimental studies and theoretical predictions have been conducted to investigate magnetic properties of transition metal-substituted hydroxyapatite.
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This article is linked to Partap Mouli et al papers. To view these articles visit https://doi.org/10.1111/apt.13840 and https://doi.org/10.1111/apt.14535.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
Parameterized pattern matching is a string searching variant that was initially defined to detect duplicate code but later proved to support several other applications. In particular, two ...equal-length strings X andY are a parameterized-match if there exists a bijective function g for which every text symbol in X is equal to g(Y). Baker was the first researcher to have addressed this problem (Baker, 1993) and, since then, many others have followed her work. She did, indeed, open up a wide field of extensive research. Over the years, many variants and extensions that have been pursued include: parameterized matching under edit and Hamming distances, parameterized multi-pattern matching, two dimensional parameterized matching, structural matching, function matching, and the very recent developments in succinct and streaming models. This accelerated research could only be justified by the usefulness of its practical applications such as in software maintenance, image processing and bioinformatics to name some. Even though the problem was posed about 25 years ago, research on parameterized matching is still very active. Its extensive study over the years and its current relevance motivate us to review the most notorious contributions as road map for current and future research.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The possibility that neutrinos may be their own antiparticles, unique among the known fundamental particles, arises from the symmetric theory of fermions proposed by Ettore Majorana in 1937
. Given ...the profound consequences of such Majorana neutrinos, among which is a potential explanation for the matter-antimatter asymmetry of the universe via leptogenesis
, the Majorana nature of neutrinos commands intense experimental scrutiny globally; one of the primary experimental probes is neutrinoless double beta (0νββ) decay. Here we show results from the search for 0νββ decay of
Te, using the latest advanced cryogenic calorimeters with the CUORE experiment
. CUORE, operating just 10 millikelvin above absolute zero, has pushed the state of the art on three frontiers: the sheer mass held at such ultralow temperatures, operational longevity, and the low levels of ionizing radiation emanating from the cryogenic infrastructure. We find no evidence for 0νββ decay and set a lower bound of the process half-life as 2.2 × 10
years at a 90 per cent credibility interval. We discuss potential applications of the advances made with CUORE to other fields such as direct dark matter, neutrino and nuclear physics searches and large-scale quantum computing, which can benefit from sustained operation of large payloads in a low-radioactivity, ultralow-temperature cryogenic environment.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
•Experiments are undertaken with SiO2 nanofluid up to 4% concentration.•The heat transfer coefficient increased up to 3% and decreased thereafter.•The friction factor is higher than values from ...Blasius equation for Re<25,000.•The property relations developed explain the conditions of heat transfer enhancement.•The concentration, material and temperature influence heat transfer coefficients.
The heat transfer coefficients and friction factor with SiO2/water nanofluid up to 4% particle volume concentration are determined for flow in a circular tube under constant heat flux boundary condition. Experiments are undertaken in the Reynolds number range of 5000–27,000 at a bulk temperature of 30°C. The Nusselt number and friction factor at 3.0% nanofluid particle concentration is respectively greater than the values of water by 32.7% and 17.1%. The pressure drop increases with particle concentration up to 3.0% and decreases thereafter. The nanofluid friction factor decreases with increase in Reynolds number at any concentration. The particle concentration at which SiO2 nanofluid gives maximum heat transfer has been experimentally determined.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Longitudinal symptoms of post-traumatic stress disorder (PTSD) are often characterized by heterogeneous trajectories, which may have unique pre-, peri- and post-trauma risk and protective factors. To ...date, however, no study has evaluated the nature and determinants of predominant trajectories of PTSD symptoms in World Trade Center (WTC) responders.
A total of 10835 WTC responders, including 4035 professional police responders and 6800 non-traditional responders (e.g. construction workers) who participated in the WTC Health Program (WTC-HP), were evaluated an average of 3, 6 and 8 years after the WTC attacks.
Among police responders, longitudinal PTSD symptoms were best characterized by four classes, with the majority (77.8%) in a resistant/resilient trajectory and the remainder exhibiting chronic (5.3%), recovering (8.4%) or delayed-onset (8.5%) symptom trajectories. Among non-traditional responders, a six-class solution was optimal, with fewer responders in a resistant/resilient trajectory (58.0%) and the remainder exhibiting recovering (12.3%), severe chronic (9.5%), subsyndromal increasing (7.3%), delayed-onset (6.7%) and moderate chronic (6.2%) trajectories. Prior psychiatric history, Hispanic ethnicity, severity of WTC exposure and WTC-related medical conditions were most strongly associated with symptomatic trajectories of PTSD symptoms in both groups of responders, whereas greater education and family and work support while working at the WTC site were protective against several of these trajectories.
Trajectories of PTSD symptoms in WTC responders are heterogeneous and associated uniquely with pre-, peri- and post-trauma risk and protective factors. Police responders were more likely than non-traditional responders to exhibit a resistant/resilient trajectory. These results underscore the importance of prevention, screening and treatment efforts that target high-risk disaster responders, particularly those with prior psychiatric history, high levels of trauma exposure and work-related medical morbidities.
One of the challenging task in agriculture is mapping of crops using satellite images as spectral properties of the crops looks similar to each other, and there are many complexities which are there ...in the field such as small land holdings, heterogeneous and often distinct field patterns. In past, mapping with high resolution satellite images was not possible due to the non-availability of data and even they were costlier. However, with the free availability of PlanetScope dataset having 8 spectral bands, with daily revisit cycle and resolution of 3m, it is now possible to carry out mapping and monitoring of agriculture crops. The objective of the study is to classify major crops of rabi (December-April) season using single date PlanetScope imagery in the Haridwar district, Uttarakhand, India. Classification of crops has been carried out using an ensemble based machine learning algorithms within Google earth engine. Off late, Google Earth Engine (GEE), a cloud based platform has attracted the attention of remote sensing analyst since it expediates the classification yielding good results of high quality. In this study, Random Forest (RF) and Gradient Tree Boosting algorithm (GTB) have been used after performing hyper-parameter tuning and results shows that overall accuracy obtained by RF and GTB are 88% and 86.5% respectively. According to the results, both classifier performed well but RF achieved 1.5% high accuracy over GTB. Analysis of the results show that highest accuracy was attained by agriculture class (wheat) while other crops class exhibited lower accuracy. In this study, RF was found to be more competent as compared to GTB in classifying the crops and PlanetScope 8 band dataset has also proved its potential in classifying crops in heterogeneous fields.
Conventional agriculture is energy and carbon intensive. Single and double-crop basis residue-mulching in zero-tilled crop-sequences may minimize carbon-footprint with improved crop and energy ...productivity in water-scarce ecologies. Zn-fertilization is also vital for drought-stress tolerance besides enhanced productivity and quality in Zn-deficient arid-soils. Hence, we compared the single and double-crop basis residue-mulching alongwith Hydrogel and Zn-fertilization in zero-tilled pigeonpea-wheat system. Results showed that double-crop residue-mulching + Hydrogel exhibited ∼22.3 and 17.1% higher system-productivity over no-residue and single-crop residue-mulching plots while maintaining higher net-returns (1315 US$/ha). Crop-residue covering consumed considerable energy (77.3–89.1% of total consumption) and carbon (5–10 folds). Thick residue-cover (8 t/ha/year) under double-crop residue-mulching + Hydrogel exhibited significantly higher energy-output (238,328 MJ ha−1), energy-intensiveness (107.3 MJ/US$) and specific energy (20.15 MJ kg−1) compared to single-crop residue-mulching; whereas energy-use efficiency, energy productivity and profitability were higher under no-residue cover. Zn-fertilization (5 kg ha−1) alongwith Zn-solubilizer in both crops also enhanced the biomass and energy productivity over sole-Zn or no-Zn. Interestingly, carbon footprints increased with residue-covering (4–8 t/ha/year) while least under no-residues. Therefore, farmers should preserve a balance while mulching the residues in single or both crops besides necessitating Zn-fertilization in Zn-deficient arid and semi-arid regions where livestock equally competes for residues as quality fodder.
•Higher yield, energy output and profits in double-crop residue mulching in zero-tilled (ZT) sequence.•Zn plus Zn-solubilizer enhanced yield, profits and energy-use over sole use or no-Zn.•Crop residue covering consumed higher energy and carbon input and production costs.•Single-crop residue mulching more carbon and energy-use efficient over double-crop mulched plots.•Higher energy and carbon use efficiency in no-residue plots in ZT system.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
X-ray and gamma-ray polarization measurements of the prompt emission of gamma-ray bursts (GRBs) are believed to be extremely important for testing various models of GRBs. So far, the available ...measurements of hard X-ray polarization of GRB prompt emission have not significantly constrained the GRB models, particularly because of the difficulty of measuring polarization in these bands. The CZT Imager (CZTI) on board AstroSat is primarily an X-ray spectroscopic instrument that also works as a wide-angle GRB monitor due to the transparency of its support structure above 100 keV. It also has experimentally verified polarization measurement capability in the energy range 100-300 keV and thus provides a unique opportunity to attempt spectropolarimetric studies of GRBs. Here we present the polarization data for the brightest 11 GRBs detected by CZTI during its first year of operation. Among these, five GRBs show polarization signatures with ⪆3 , and one GRB shows 2 detection significance. We place upper limits for the remaining five GRBs. We provide details of the various tests performed to validate our polarization measurements. While it is difficult yet to discriminate between various emission models with the current sample alone, the large number of polarization measurements that CZTI expects to gather in its minimum lifetime of five years should help to significantly improve our understanding of the prompt emission.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used medications in the world for their analgesic, antipyretic, and anti-inflammatory actions, despite a well-known incidence ...of a wide spectrum of their adverse effects. To a great extent, beneficial action and side effects of NSAIDs are associated with the interaction of these drugs at the cell membrane level. Here, we use neutron scattering to combine elastic intensity scans, quasielastic and neutron spin echo (NSE) measurements to understand the effect of aspirin, a commonly used NSAID, on the dynamical and phase behavior of the membrane of dimyristoylphosphatidylcholine (DMPC), a prominent representative of phospholipids residing in the outer leaflet of the human erythrocyte membrane. Elastic intensity scans reveal that addition of aspirin not only eliminates the pre-transition (solid gel to ripple phase), but also broadens the main phase transition (ripple to fluid phase) in the membrane. Moreover, the main phase transition becomes shifted toward a lower temperature. These results are found to be consistent with our differential scanning calorimetry measurements. Elastic intensity scans further suggest that aspirin inhibits the membrane from going into the ordered phase and overall induces disorder in the membrane, thus indicating enhancement in the fluidity of the membrane. Quasielastic neutron scattering (QENS) data show that aspirin affects both lateral lipid motion within the leaflet and the localized internal motion of the lipid. Aspirin accelerates both lateral and internal motions, with the more pronounced effect observed for the ordered phase of the neat membrane. Intermediate scattering function as observed by NSE has been analyzed using the Zilman Granek model, which indicates that addition of aspirin alters the bending modulus of the membrane to make the membrane softer. Our study provides a quantitative description of the effect of an archetypal NSAID, aspirin, on the various physical properties of the model biological membrane, which is essential for understanding the complex drug-membrane interaction.
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