We present a 1024-element near-infrared imaging array of superconducting nanowire single photon detectors (SNSPDs) using a 32×32 row-column multiplexing architecture. The array has an active area of ...0.96 × 0.96 mm, making it the largest SNSPD array reported to date in terms of both active area and pixel count. Using a 64-channel time-tagging readout, we have characterized the array's yield, efficiency, and timing resolution. Large arrays of SNSPDs are desirable for applications such as imaging, spectroscopy, or particle detection.
Diabetes: a 21st century challenge Zimmet, Paul Z; Magliano, Dianna J; Herman, William H ...
The lancet. Diabetes & endocrinology
2, Issue:
1
Journal Article
Peer reviewed
The number of people with diabetes worldwide has more than doubled during the past 20 years. One of the most worrying features of this rapid increase is the emergence of type 2 diabetes in children, ...adolescents, and young adults. Although the role of traditional risk factors for type 2 diabetes (eg, genetic, lifestyle, and behavioural risk factors) has been given attention, recent research has focused on identifying the contributions of epigenetic mechanisms and the effect of the intrauterine environment. Epidemiological data predict an inexorable and unsustainable increase in global health expenditure attributable to diabetes, so disease prevention should be given high priority. An integrated approach is needed to prevent type 2 diabetes, taking into account its many origins and heterogeneity. Thus, research needs to be directed at improved understanding of the potential role of determinants such as the maternal environment and other early life factors, as well as changing trends in global demography, to help shape disease prevention programmes.
Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer ...metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We show that mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn releases c-Myc from a suppressive miR-34c-dependent network. These central features of activated mTORC2 signaling, acetylated FoxO, and c-Myc levels are highly intercorrelated in clinical samples and with shorter survival of GBM patients. These results identify a specific, Akt-independent role for mTORC2 in regulating glycolytic metabolism in cancer.
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•mTORC2 is required for the growth of GBM cells in glucose•mTORC2 controls glycolytic metabolism by regulating the cellular level c-Myc•mTORC2 signaling acetylates FoxO1 and FoxO3 to upregulate c-Myc•mTORC2, acetylated FoxO, and c-Myc axis confer shorter survival in patients
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Natural climate solutions are not enough Anderson, Christa M; DeFries, Ruth S; Litterman, Robert ...
Science (American Association for the Advancement of Science),
03/2019, Volume:
363, Issue:
6430
Journal Article
Peer reviewed
Decarbonizing the economy must remain a critical priority
Stabilizing Earth's climate and limiting temperature increase to well below 2°C per the Paris Agreement requires a dramatic uptick in the ...rate of progress on reducing greenhouse gas (GHG) emissions. Natural climate solutions (NCS) can be a substantial contributor, while also providing valuable cobenefits for people and ecosystems. Although analyses of NCS have some differences in the GHG fluxes they consider, all include emissions sources (such as deforestation, land-use change, and agricultural practices), emissions sinks (such as reforestation and restoring degraded lands), and non–carbon dioxide (CO
2
) agricultural emissions (such as methane from livestock). Some of us have contributed to among the most optimistic assessments of the potential of NCS (
1
), whereas others have been more pessimistic (
2
,
3
). But one thing on which we agree, and which technical literature generally acknowledges, is that the benefits of NCS do not decrease the imperative for mitigation from the energy and industrial sectors (
2
,
4
,
5
). Yet this point sometimes gets lost in public-facing conversations for example, are forests “our best weapon for fighting carbon emissions” or, more realistically, just one “piece of the puzzle”? (
6
). Strategies for incorporating NCS with energy and industrial mitigation in the climate portfolio should not be “either/or” but “yes, and.”
Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to ...end-stage kidney disease (ESKD) is unknown.
Multicenter prospective cohort study.
We included 1,908 participants with diabetes and reduced GFR enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study in the United States.
Urinary albumin and protein excretion.
Incident ESKD, CKD progression (ESKD or ≥50% reduction in estimated GFR eGFR from baseline), and annual rate of decline in kidney function.
ESKD was ascertained by self-report and by linkage to the US Renal Data System. We used Cox proportional hazards modeling to estimate the association of albuminuria and proteinuria with incident ESKD or CKD progression and linear mixed-effects models to assess differences in eGFR slopes among those with and without albuminuria.
Mean eGFR at baseline was 41.2mL/min/1.73m2. Normal or mildly increased 24-hour urinary albumin excretion (<30mg/d) at baseline was present in 28% of participants, but in only 5% of those progressing to ESKD. For those with baseline normal or mildly increased albuminuria, moderately increased albuminuria (albumin excretion, 30-299mg/d), and 2 levels of severely increased albuminuria (albumin excretion, 300-999 and ≥1,000mg/d): crude rates of ESKD were 7.4, 34.8, 78.7, and 178.7 per 1,000 person-years, respectively; CKD progression rates were 17.0, 61.4, 130.5, and 295.1 per 1,000 person-years, respectively; and annual rates of eGFR decline were −0.17, −1.35, −2.74, and −4.69mL/min/1.73m2, respectively.
We were unable to compare the results with healthy controls.
In people with diabetes with reduced eGFRs, the absence of albuminuria or proteinuria is common and carries a much lower risk for ESKD, CKD progression, or rapid decline in eGFR compared with those with albuminuria or proteinuria. The rate of eGFR decline in normoalbuminuric CKD was similar to that reported for the general diabetic population.
Travel time uncertainty has significant impacts on individual activity-travel scheduling, but at present these impacts have not been considered in most accessibility studies. In this paper, an ...accessibility evaluation framework is proposed for urban areas with uncertain travel times. A reliable space-time service region (RSTR) model is introduced to represent the space-time service region of a facility under travel time uncertainty. Based on the RSTR model, four reliable place-based accessibility measures are proposed to evaluate accessibility to urban services by incorporating the effects of travel time reliability. To demonstrate the applicability of the proposed framework, a case study using large-scale taxi tracking data is carried out. The results of the case study indicate that the proposed accessibility measures can evaluate large-scale place-based accessibility well in urban areas with uncertain travel times. Conventional place-based accessibility indicators ignoring travel time reliability can significantly overestimate the accessibility to urban services.
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BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
7.
Strong Loophole-Free Test of Local Realism Shalm, Lynden K; Meyer-Scott, Evan; Christensen, Bradley G ...
Physical review letters,
2015-Dec-18, Volume:
115, Issue:
25
Journal Article
Peer reviewed
Open access
We present a loophole-free violation of local realism using entangled photon pairs. We ensure that all relevant events in our Bell test are spacelike separated by placing the parties far enough apart ...and by using fast random number generators and high-speed polarization measurements. A high-quality polarization-entangled source of photons, combined with high-efficiency, low-noise, single-photon detectors, allows us to make measurements without requiring any fair-sampling assumptions. Using a hypothesis test, we compute p values as small as 5.9×10^{-9} for our Bell violation while maintaining the spacelike separation of our events. We estimate the degree to which a local realistic system could predict our measurement choices. Accounting for this predictability, our smallest adjusted p value is 2.3×10^{-7}. We therefore reject the hypothesis that local realism governs our experiment.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
In a retrospective review to assess neuroanatomical targets of radiation-induced cognitive decline, dose volume histogram (DVH) analyses of specific brain regions of interest (ROI) are correlated to ...neurocognitive performance in 57 primary brain tumor survivors.
Neurocognitive assessment at baseline included Trail Making Tests A/B, a modified Rey-Osterreith Complex Figure, California or Hopkins Verbal Learning Test, Digit Span, and Controlled Oral Word Association. DVH analysis was performed for multiple neuroanatomical targets considered to be involved in cognition. The %v10 (percent of ROI receiving 10 Gy), %v40, and %v60 were calculated for each ROI. Factor analysis was used to estimate global cognition based on a summary of performance on individual cognitive tests. Stepwise regression was used to determine which dose volume predicted performance on global factors and individual neurocognitive tests for each ROI.
Regions that predicted global cognitive outcomes at doses <60 Gy included the corpus callosum, left frontal white matter, right temporal lobe, bilateral hippocampi, subventricular zone, and cerebellum. Regions of adult neurogenesis primarily predicted cognition at %v40 except for the right hippocampus which predicted at %v10. Regions that did not predict global cognitive outcomes at any dose include total brain volume, frontal pole, anterior cingulate, right frontal white matter, and the right precentral gyrus.
Modeling of radiation-induced cognitive decline using neuroanatomical target theory appears to be feasible. A prospective trial is necessary to validate these data.
The purpose of this study was to 1) examine whether frequency of positive and negative interactions (manipulated via reliability) with a computer agent had an impact on an individual's trust ...resilience after a major error occurs and 2) empirically test the notion of relationship equity, which encompasses the total accumulation of positive and negative interactions and experiences between two actors, on user trust on a separate transfer task. Participants were randomized into one of four groups, differing in agent positivity and frequency of interaction, and completed both a pattern recognition task and transfer task with the aid of the same computer agent. Subjective trust ratings, performance data, compliance, and agreement were collected and analyzed. Results demonstrated that frequency of positive and negative interactions did have an impact on user trust and trust resilience after a major error. Additionally, it was shown that relationship equity has an impact on user trust and trust resilience. This is the first empirical demonstration of relationship equity's impact on user trust in an automated teammate.
•Relationship equity has an impact on level of trust in an agent.•Frequent positive engagement with an agent can carry over to a separate task.•Frequent positive engagement yielded greater trust resilience.•Agent positivity impacted trust greater than frequency of interaction.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Many existing accessibility studies ignore human mobility due to the lack of large-scale human mobility data. This study investigates the impacts of human mobility on accessibility using massive ...mobile phone tracking data collected in Shenzhen, China. In this study, human mobility information is extracted from mobile phone tracking data using a time-geographic approach. The accessibility of each phone user is evaluated using fine spatial resolution across the entire city. The impacts of human mobility on accessibility are quantified by using relative accessibility ratios between phone users and a virtual stationary user in the same residential location. Results of this study enrich understandings of how land use influences relationships between human mobility and accessibility. For resource-poor regions with sparse service facilities, human mobility can greatly enhance individual accessibility. In contrast, for resource-rich regions with dense service facilities, human mobility can even reduce individual accessibility. Overall, human mobility can reduce spatial inequity of accessibility for people living in different regions of the city. The results of this study also have several important methodological implications for including human mobility and time dimension in accessibility evaluations.
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BFBNIB, DOBA, INZLJ, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, ZRSKP
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