Cordycepin has good antitumor activity, but its clinical application is limited due to the easy deamination of N6 in structure. In this study, a large lipolysis group was introduced at the cordycepin ...N6 to improve the problem, cordycepin derivatives (
-
) were synthesized, and biological evaluation of compounds was studied. In this study, the vitro antitumor activity of the compounds against MCF7 cells, HepG2 cells and SGC-7901 cells was evaluated by MTT assay. In the results, compound
showed the most obvious inhibitory effect on MCF7 cells with an IC
value of 27.57 ± 0.52 μM, which was much lower than cordycepin. Compound
showed high selectivity between MCF7 and normal MCF-10A cells. Further biological evaluation showed that compound
promoted apoptosis and blocked the cell cycle in the G0/G1 phase. Then, Western Blot was used to detect related apoptotic proteins. It was found that Compound
could down-regulate the expression of Bcl-2 protein and up-regulate the expression of p53, Bax, Caspase-3 and Caspase-9 proteins. The mitochondrial membrane potential decreased continuously and the positive expression rate decreased. It was speculated that compound
induced the apoptosis of MCF7 cells through the mitochondrial pathway.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
A series of celastrol derivatives were synthesized and evaluated as hypoxia-inducible factor-1α (HIF-1α) inhibitors. Among these compounds,
4b
and
4d
appeared to have high HIF-1α inhibitory activity ...of 2.97 and 2.99 μM IC
50
values respectively. The cytotoxicity of these compounds was also assessed in Hep3B cells using the MTT assay, and no compounds showed any appreciable cytotoxic activity (IC
50
> 50 μmol/L).
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
A series of celastrol derivatives were synthesized and evaluated as hypoxia-inducible factor-1alpha (HIF-1alpha) inhibitors. Among these compounds, 4b and 4d appeared to have high HIF-1alpha ...inhibitory activity of 2.97 and 2.99 muM IC.sub.50 values respectively. The cytotoxicity of these compounds was also assessed in Hep3B cells using the MTT assay, and no compounds showed any appreciable cytotoxic activity (IC.sub.50 > 50 mumol/L).
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Amine-functionalized adsorbents offer substantial potential for CO2 capture owing to their selectivity and diverse application scenarios. However, their effectiveness is hindered by low efficiency ...and unstable cyclic performance. Here we introduce an amine-support system designed to achieve efficient and stable CO2 capture. Through atom-level design, each polyethyleneimine (PEI) molecule is precisely impregnated into the cage-like pore of MIL–101(Cr), forming stable composites via strong coordination with unsaturated Cr acid sites within the crystal lattice. The resulting adsorbent demonstrates a low regeneration energy (39.6 kJ/molCO2), excellent cyclic stability (0.18% decay per cycle under dry CO2 regeneration), high CO2 adsorption capacity (4.0 mmol/g), and rapid adsorption kinetics (15 min for saturation at 30 °C). These properties stem from the unique electron-level interaction between the amine and the support, effectively preventing carbamate products’ dehydration. This work presents a feasible and promising cost-effective and sustainable CO2 capture strategy.An amine-support system has been introduced through atom-level design, achieving low regeneration energy, excellent cyclic stability, high capacity, and rapid kinetics, stemming from electron-level interactions preventing carbamate dehydration.
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•A novel tri-solvent amine absorbent was synthesized for efficient CO2 capture.•The absorbent exhibited a high CO2 loading and cyclic capacity.•The absorbent exhibited a reduced ...regeneration heat duty of 2.14 GJ/tCO2.•The reaction products of the absorbent mainly included bicarbonates and unstable carbamates.
Blended amine scrubbing is considered as a promising alternative to the monoamine scrubbing process due to the potential for enhanced CO2 capture efficiency and reduced energy consumption. However, striking a balance between absorption rate and regeneration energy consumption in blended amine systems by establishing suitable interactions between activated amines and proton-acceptor amines remains a significant challenge. In this study, a novel blended amine system, involving tertiary amine diethanolamine (DEEA) as the main agent and several monoamines as promoters, was first proposed to achieve highly effective CO2 capture. The designed tri-solvent amine system of DEEA combined with piperazine (PZ) and 4-amino-1-methylpiperidine (PD) (denoted as DEEA + PZ + PD) exhibited exceptional CO2 loading (0.988 mol CO2/mol amine), superior cyclic capacity (0.788 mol CO2/mol amine), and reduced regeneration heat duty (2.14 GJ/t), surpassing monoethanolamine (MEA) by 79.6 %, 277 %, and decreasing by 43.7 %, respectively. Furthermore, the performance improvement mechanism of DEEA + PZ + PD was systematically elucidated, showcasing the swift CO2 absorption facilitated by PD or PZ in the initial reaction phase, and the subsequent formation of bicarbonate from PDCOO− and DEEA in the later stage, enhancing CO2 absorption capacity. The predominant reaction products, bicarbonate and unstable carbamate (PZ(COO−)2, PDCOO−), contribute to the high regeneration efficiency and minimal energy consumption during regeneration for DEEA + PZ + PD. Consequently, this facilely prepared tri-solvent amine system, characterized by high capture efficiency and low energy consumption, holds promise for achieving carbon–neutral operations in coal-fired power plants.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Chinese cabbage (Brassica pekinensis L.) is a leafy green vegetable, which is widely grown and consumed worldwide. Rapidly determining chlorophyll content is crucial for the effective and efficient ...breeding and cultivation of Chinese cabbage. Hyperspectral techniques have been widely used for studies concerning chlorophyll content; however, few studies have been conducted for different periods and species of Chinese cabbage leaves. In the present study, we used a Chinese cabbage translocation line material with rich variation. Samples were acquired for covering all periods of Chinese cabbage nutritional growth. In this study, a hyperspectral data preprocessing method was combined with a genetic algorithm for feature wavelength extraction. A self-adjusted prediction model based on a One-Dimensional Convolutional Neural Network (1D-CNN) was designed to predict four chlorophyll contents: Chlorophyll a (Chla), Chlorophyll b (Chlb), total Chlorophyll (Chl), and SPAD. Compared to the traditional machine learning model, partial least squares regression (PLSR), the self-adjusted model exhibited optimal performance. In the test set, the R2 of the SA-1DCNN model was 0.65, 0.64, 0.71 and 0.34 for each Chlorophyll (included Chla, Chlb, Chl and SPAD), respectively. The experimental results showed that hyperspectral preprocessing methods combined with a genetic algorithm (GA) and Self-adjusted One-Dimensional Convolutional Neural Network (SA-1DCNN) were effective for chlorophyll content prediction. This study provides new theoretical framework for determining the nutritional status of Chinese cabbage.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•The X5 resin had a large pore volume (1.90 cm3/g) and bimodal porous networks.•Polyethylenimine was impregnated into X5 for CO2 capture from ambient air.•The 50 %PEI@X5 achieved a high CO2 uptake of ...118 mg/g at 400 ppm CO2 and 25 °C.•The adsorbent exhibited superb cyclic stability with no decay observed.•Introducing 25 % H2O (relative humidity) significantly improved the CO2 uptake.
Direct air capture (DAC) by solid amine adsorbents is a promising technology to curb the increasing atmospheric CO2 level. Despite extensive efforts, there are still limited improvements for this type of materials in their CO2 uptake and adsorption kinetics under ultra-dilute conditions. And most current research focuses on powdered adsorbents, which need to be granulated or fabricated into devices for DAC application, resulting in a further decline in CO2 uptake. Herein, a series of commercial resin particles (1.0 mm) were used as supports, and it was found that X5 exhibited favorable support characteristics in the preparation of solid amine adsorbents. Notably, X5 possessed a large pore volume of 1.90 cm3/g and featured a hierarchical bimodal porous network comprising mesopores and macropores. The prepared adsorbents (PEI@X5) had considerable polyethyleneimine (PEI) dispersion even at PEI content up to 50 %, and thus demonstrated excellent CO2 adsorption performances with high CO2 uptakes of 118 or 108 mg/g in TGA or fixed bed under simulated ambient air conditions (25 °C, 400 ppm CO2). Additionally, the adsorbents exhibited superb cyclic stability with no decay observed over 10 adsorption-regeneration cycles. The introduction of 25 % relative humidity (RH) of water vapor significantly improved the CO2 uptake of the adsorbent to 130 mg/g, with a lifting efficiency of 20.4 %. However, further increases in RH reduced the CO2 uptake and adsorption rate due to the excessive adsorption water, which leached part of PEI from the pores of 50 %PEI@X5. Considering the commercial production of raw materials, the facile synthesis of 50 %PEI@X5, and its superior CO2 capture efficiency, these findings open up new avenues for DAC technology.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Heading is one of the most important agronomic traits for Chinese cabbage crops. During the heading stage, leaf axial growth is an essential process. In the past, most genes predicted to be involved ...in the heading process have been based on leaf development studies in
Arabidopsis
. No genes that control leaf axial growth have been mapped and cloned via forward genetics in Chinese cabbage. In this study, we characterize the inward curling mutant
ic1
in
Brassica rapa
ssp.
pekinensis
and identify a mutation in the
OCTOPUS
(
BrOPS
) gene by map-based cloning. OPS is involved in phloem differentiation in
Arabidopsis
, a functionalization of regulating leaf curvature that is differentiated in Chinese cabbage. In the presence of brassinosteroid (BR) at the early heading stage in
ic1
, the mutation of BrOPS fails to sequester brassinosteroid insensitive 2 (BrBIN2) from the nucleus, allowing BrBIN2 to phosphorylate and inactivate BrBES1, which in turn relieves the repression of
BrAS1
and results in leaf inward curving. Taken together, the results of our findings indicate that BrOPS positively regulates BR signaling by antagonizing BrBIN2 to promote leaf epinastic growth at the early heading stage in Chinese cabbage.
The industrial applications of CaO-based adsorbents for CO2 capture are limited by the challenges of serious sintering in a realistic regeneration condition and elutriation in the fluidized-bed ...reactors. Although the granulation of CaO-based adsorbents has been extensively investigated, the key indexes such as mechanical strength, adsorption performance, and cyclic stability were investigated independently rather than united for practical applications. Here, we systematically investigated the impacts of binders on the mechanical properties and CO2 capture performance of CaO-based particles granulated using the extrusion method. Among different commercial binders (cement, kaolin, and bentonite), only cement yielded calcined CaO-based particles with the required mechanical strength. At the optimal cement proportion (10%) and particle diameter (3 mm), the “CaO+Cement” particle achieved a compressive strength of ≥20 N and an attrition rate of ≤5%. After granulating, the “CaO+Cement” particle retained a favorable CO2 uptake of 458 mg/g within 10 min, and also exhibited excellent cyclic performance in a realistic regeneration condition (calcination at 920 °C in a CO2 atmosphere), with a decay rate of 0.9% per cycle during long-term cycles. After 50 cycles, the cumulative CO2 uptake for “CaO+Cement” particle was 9.44 g/g, representing a marked increase of 42.9% compared with that of the pure CaO particle. Owing to those multiple advantages of excellent mechanical strength, CO2 adsorption performance, cyclic stability and economic cost, the “CaO+Cement” particle (with a cement proportion of 10% and a diameter of 3 mm) appears to be a promising material for CO2 capture from industrial flue gas at large-scale.
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•A systematic and comprehensive evaluation of CaO-based pellets is presented.•Preparation parameters in binder types, proportion and pellet size were studied.•The kaolin and bentonite reduced the mechanical strength of CaO-based pellets.•The “CaO+Cement” pellet possessed high compressive strength and low attrition rate.•The “CaO+Cement” pellet exhibited excellent CO2 uptake and cyclic performance.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
