The Premonitory Urge for Tics Scale (PUTS) is a common self-report measure of premonitory urges for patients with tic disorders. This study aims to evaluate the Chinese version of the PUTS (PUTS-C) ...and to explore its association with psychiatric symptoms in Chinese children diagnosed with tic disorders.
The psychometric evaluation involved 204 outpatients with tic disorders, aged 7-16 years, who were divided into two age groups: (7-10 years, n = 103; 11-16 years, n = 95).
The PUTS-C demonstrated good internal consistency (McDonald'sω = 0.84) and two-week test-retest reliability (0.76). We observed a statistically significant correlation between the total PUTS-C score and various Yale Global Tic Severity Scale (YGTSS) subscales and total tic severity scores. The PUTS-C score also showed significant correlations with the Children Yale-Brown Obsessive Compulsive Scale (CY-BOCS), Screening Child Anxiety-Related Emotional Disorders (SCARED), and Children's Depression Inventory (CDI). Notably, premonitory urges independently predicted tic severity, beyond the influence of comorbid symptoms. A two-factor structure of the PUTS-C was identified in the total sample through factor analysis.
The PUTS-C possesses acceptable validity and good reliability. It appears that premonitory urges in Chinese patients with tic disorders are associated with obsessive-compulsive symptoms, anxiety, and depression, but can independently predict tic severity. Specific PUTS-C factors possibly related to motor and vocal tics. Future research should continue to investigate age-related differences and the association with tics and other sensory symptoms.
Aims
An improved left ventricular ejection fraction (HFiEF) was observed across heart failure (HF) patients with a reduced or mid‐range ejection fraction (HFrEF or HFmrEF, respectively). We ...postulated that HFiEF patients are clinically distinct from non‐HFiEF patients.
Methods and results
A total of 447 patients hospitalized due to a clinical diagnosis of HF (LVEF <50% at baseline) were enrolled from September 2017 to September 2019. Echocardiogram re‐evaluation was conducted repeatedly over 6 months of follow‐up after discharge. The primary endpoint included the composite of HF hospitalization and all‐cause mortality. Subjects (n = 184) with HFiEF (defined as an absolute LVEF improvement≥10%) were compared with 263 non‐HFiEF (defined by <10% improvement in LVEF) subjects. Multivariable Cox regression was performed and identified younger age, smaller left ventricular end diastolic dimension (LVEDD), beta‐blocker use, AF ablation and cardiac resynchronization therapy (CRT) as independent predictors of HFiEF. According to Kaplan–Meier analysis, HFiEF subjects had lower cardiac composite outcomes (P = 0.002) and all‐cause mortality (P = 0.003) than non‐HFiEF subjects. Multivariate Cox survival analysis revealed that non‐HFiEF (compared with HFiEF) was an independent predictor of both the primary endpoints (HR = 0.679, 95% CI: 0.451–0.907, P = 0.012), which was driven by all‐cause mortality (HR = 0.504, 95% CI: 0.256–0.991, P = 0.047).
Conclusions
These data confirm that compared with non‐HFiEF, HFiEF is a distinct HF phenotype with favourable clinical outcomes.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Farm size plays a critical role in agricultural sustainability. This may have far-reaching consequences for the economic and environmental performance of agricultural production, resulting, for ...instance, in an excessive use of mineral fertilizers. However, the magnitude of such effects and their main causes are not well understood, while being essential for effective policy development, especially for countries like China where the agricultural sector is still largely dominated by smallholder farms. In this paper, we review the current understanding of how farm size affects agricultural sustainability using China's crop farming as an example from economic, environment and social aspects. We analyze impacts from both a Chinese and a global perspective to identify intervention points to improve agricultural performance. We found that increasing farm size has a positive impact on farmer's net profit, as well as economic, technical and labor efficiency with mean coefficients of 0.005, 0.02 and 2.25, respectively. Nevertheless, the relationships between farm size and overall productivity, total factor productivity and allocative efficiency are still not well understood and therefore require more research. Meanwhile, increase in farm size is associated with statistically significant decrease in fertilizer and pesticide use per hectare, showing clear benefits for environmental protection. In line with the experiences documented for the evolution of agricultural practices in developed countries, the expansion of large-scale farming is a critical path for modernizing agricultural production and ensuring sustainable food production from the social perspective. Measures concerning farm size should be implemented in an interaction between farmers and the government to promote the green development of agriculture.
•Farm size plays an important role in the performance of agriculture.•Increasing farm size shows clear benefits for environmental protection.•Large-scale farming is a critical path for modernizing and sustaining agriculture.•Smallholders prefer to use more non-fixed inputs to increase yields.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•Functional ACM-based composites facilitate the photocatalytic process in both aqueous/gaseous condition.•Abundant surface properties of ACM provide the high capability of adsorption, the ...distribution of photocatalysts, and the transfer of photo-generated electrons.•Surface activating and interlayered modification on ACM benefit combination of the photocatalysts and the support.•Compared with type 1:1 ACM, type 2:1 ACM exhibits more flexible structure that provides more space for photocatalysts loading.
Aluminosilicate clay mineral (ACM) is a kind of typical raw materials that used widely in manufacturing industry owing to the abundant reserve and low-cost exploring. In past two decades, in-depth understanding on unique layered structure and abundant surface properties endows ACM in the emerging research and application fields. In field of solar-chemical energy conversion, ACM has been widely used to support various semiconductor photocatalysts, forming the composites and achieving efficient conversion of reactants under sunlight irradiation. To date, classic ACM such as kaolinite and montmorillonite, loaded with semiconductor photocatalysts has been widely applied in photocatalysis. This review summaries the recent works on ACM-based composites in photocatalysis. Focusing on the properties of surface and layered structure, we elucidate the different features in the composition with various functional photocatalysts on two typical kinds of ACM, i.e., type 1:1 and type 2:1. Not only large surface area and active surface hydroxyl group assist the substrate adsorption, but also the layered structure provides more space to enlarge the application of ACM-based photocatalysts. Besides, we overview the modifications on ACM from both external surface and the inter-layer space that make the formation of composites more efficiently and boost the photo-chemical process. This review could inspire more upcoming design and synthesis for ACM-based photocatalysts, leading this kind of economic and eco-friendly materials for more practical application in the future.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
•An “economic-social-ecological” ILU value accounting system was developed and applied.•Significant differences were found generated by the ILU value in different projects.•The integrated value of ...ILU in the TLGP was 177,189,300 yuan.•The integrated value of ILU in the Xinmeng River project is significantly higher than other projects.•The ILU at different stages basically showed the law of diminishing marginal utility.
Assessing the value of land resources is a prerequisite for resource management, as well as for resolving the conflict between supply and demand. In the realm of intensive land use (ILU), a standardized framework for accounting methods from a project perspective has yet to be established. Therefore, taking the Taihu Lake governance project (TLGP) (which includes the Xingou River project, Xinmeng River project and Zoumatang River project) as a case study, this paper firstly constructs an integrated value accounting system based on economic, social and ecological frameworks. Furthermore, with consideration of physical parameters, we incorporated the integrated land section price method, income reduction method, alternative market method, and equivalent factor method are all incorporated to assess the value of ILU at distinct stages within the research area. This approach serves to elucidate the evolving dynamics of ILU valuation. The results showed that: (1) There were significant differences in the values generated by the ILU in different projects. The integrated value of the TLGP brought about by ILU was 177,189,300 yuan, and the ILU of the Xinmeng River project was significantly higher than the Zoumatang River project and the Xingou River project. (2) The ILU at different stages basically displayed the law of diminishing marginal utility. Consistent with changes in the different stages of the TLGP, the value of ILU in Stage I of the Zoumatang River project and the Xingou River project was significantly higher than that in Stage II. Additionally, the accounting system proposed in this study has the advantages of reasonable index setting and simple process operability. This helps to realize the comparison of ILU values across projects and stages. The results of this study can provide a reference for the management and sustainable use of land resources during the construction of water conservancy and other projects.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The use of reduced graphene oxide (rGO) as an environmentally friendly, multi-functional conductive binder is proposed as a novel strategy for manufacturing free-standing, flexible, high-performance ...hard carbon anodes for sodium ion batteries (NIBs). Compared with the conventional electrodes fabricated with insulating, fluorine-containing polymer binder (PVDF), the unique two-dimensional structure enable rGO can act as a strong binder and flexible backbone, resulting in free-standing, flexible hard carbon film, which can be directly used as anode for sodium ion batteries without any current collector. What's more, rGO also acts as active material, providing Na-storage capacity, as well as conductive addition to construct 3D conductive network, improving the rate performance of hard carbon. The obtained rGO-bonded hard carbon film with excellent flexibility can deliver a high reversible electrode capacity up to 372.4 mA h g−1. After 200 charging/discharging cycles, the capacity loss is only 9%. The good electrochemical performance and excellent flexibility, combined with its facile fabrication approach make it to be a promising electrode candidate for developing next-generation flexible and environmentally friendly energy storage devices.
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An increasing disconnect between livestock production and croplands has been observed in many world regions, including China, which has the world’s largest livestock production ...sector. Here we propose a cropland-based livestock production system to rebuild the linkage between livestock and cropland from both agriculture production and human consumption perspectives for China. In 2015, the total excretion nitrogen (N) generated by livestock production operations was 14.6 Tg N, and it would grow to 15.0 Tg in 2030 by extrapolating current trends. The optimal demand of total N by crops in China was estimated to be 23.0 Tg N in 2030, suggesting that Chinese livestock would be within the carrying capacity of cropland on national level, but substantial variations were found across provinces. The carrying capacity of cropland with regard to N input from manure would be exceeded in 74% provinces, under the assumption that manure providing half of the N supply for crops. Furthermore, from the perspective of domestic feed supply for livestock production, about 51% of feed N needs to be imported. If following the optimized dietary structure of China to manage livestock sector, livestock production could be reduced by 37% in excretion nitrogen, which would not only benefit the food security and human health, but also mitigate the agricultural pollution. Accordingly, policy regulations on reduction and spatially reallocation of livestock production on a regional scale could substantially reduce manure N loss from 10.5 Tg yr−1 to 1–1.2 Tg yr−1 under different recoupled scenarios.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The pH value of subcellular organelles in living cells is a significant parameter in the physiological activities of cells. Its abnormal fluctuations are commonly believed to be associated with ...cancers and other diseases. Herein, a series of surface-enhanced Raman scattering (SERS) nanosensors with high sensitivity and targeting function was prepared for the quantification and monitoring of pH values in mitochondria, nucleus, and lysosome. The nanosensors were composed of gold nanorods (AuNRs) functionalized with a pH-responsive molecule (4-mercaptopyridine, MPy) and peptides that could specifically deliver the AuNRs to the targeting subcellular organelles. The localization of our prepared nanoprobes in specific organelles was confirmed by super-high resolution fluorescence imaging and bio-transmission electron microscopy (TEM) methods. By the targeting ability, the pH values of the specific organelles can be determined by monitoring the vibrational spectral changes of MPy with different pH values. Compared to the cases of reported lysosome and cytoplasm SERS pH sensors, more accurate pH values of mitochondria and nucleus, which could be two additional intracellular tracers for subcellular microenvironments, were disclosed by this SERS approach, further improving the accuracy of discrimination of related diseases. Our sensitive SERS strategy can also be employed to explore crucial physiological and biological processes that are related to subcellular pH fluctuations.
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•Microwave heating has the potential to enhance the saltiness perception of meat.•PFG-STE 23Na NMR could be a potent tool to determine sodium mobility.•The enhanced salty taste was ...due to water and sodium mobility in the meat matrix.•The water and sodium mobility were related to the conformational changes of protein.
A saltiness perception enhancement method of grass carp meat conducted by microwave heating was investigated. Ion chromatographic results demonstrated that all samples had the same sodium level retained in matrices after being treated by water bath (WBV) and microwave with different power of 2.5, 7.5, 10, and 12.5 W/g (MWV). However, the meat treated by microwave exhibited a higher salty intensity than that of WBV, particularly MWV-10 W/g and MWV-12.5 W/g. The enhanced saltiness perception of meat treated by microwave was attributed to the facilitated water and sodium mobility demonstrated by low field-NMR and pulse-field-gradient stimulated echo (PFG-STE) 23Na NMR experiments. Furthermore, the enhancement was also related to the formation of microstructure favorable for sodium diffusion, originating from the insufficient denaturation and less exposure of hydrophobic groups of proteins induced by microwave heating. Therefore, microwave heating has the potential to enhance the saltiness perception of meat in the food industry.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Subcellular organelles, for example, nucleus, mitochondria, and lysosome, are the vital organelles with responsibilities that maintain cell operation and metabolism. Owing to their roles in energy ...production and programmed cell death, these organelles have become prime therapeutic targets in different diseases and states. In this study, biocompatible, organelle-targeting nanoprobes were developed by modifying gold nanorods (AuNRs) with specific targeting peptides. These nanoprobes were employed to directly profile subcellular biomolecules and vital organelles by surface-enhanced Raman scattering (SERS) spectroscopy. Macromolecular spectral profiles of subcellular organelles were achieved and compared. Further, these organelle-targeting AuNRs were used for the photothermal treatment of cancer cells (HepG2, HeLa, and MCF-7 cell lines). The cell viability assays show that the nucleus- and mitochondria-targeting AuNRs provide higher photothermal efficiencies under an 808 nm laser relative to the lysosome-targeting ones. This study makes critical insights into the spectral profiles of subcellular organelles and also inspires people in the development of high-efficacy cancer therapeutic strategies by subcellular organelle-targeting drugs.
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IJS, KILJ, NUK, PNG, UL, UM
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