Background
Robot-assisted laparoscopic pancreaticoduodenectomy is a novel minimally invasive surgery technique, and its effectiveness and safety remain unknown in patients with borderline malignant ...or malignant diseases. This study aimed to prospectively evaluate the effectiveness and safety of RLPD versus open PD (OPD).
Methods
Between January 2010 and December 2013, 180 eligible patients were prospectively hospitalized for elective RLPD (
n
= 60) or OPD (
n
= 120). They were matched for tumor location, tumor type, tumor size, ASA classification, age, and sex. The main outcome measures included demographics, intraoperative variables, morbidity, postoperative recovery, and mid-term evaluation.
Results
Over the study period, the RLPD group had a significantly longer but decreasing operative time (median 410 vs. 323 min;
P
< 0.001), less blood loss (median 400 vs. 500 mL;
P
= 0.005), better nutritional status recovery, expedited off-bed return to activity (3.2 vs. 4.8 d;
P
< 0.001), faster resumption of bowel movement (3.6 vs. 5.2 d;
P
< 0.001), and shorter hospital stay (20 vs. 25 d;
P
= 0.002) compared to the OPD group. The two groups had similar surgical morbidities and mortality as well as R0 resection rate and number of lymph nodes resected. Among patients with pancreatic adenocarcinoma, the two groups had similar overall and disease-free survival (ACTRN12614000299606).
Conclusions
This first largest, prospective matched study demonstrated that for treating selected borderline and malignant pathologies, RLPD was associated with a significant learning curve effect and expedited postoperative recovery, but had a surgical and oncological safety profile similar to OPD.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
CdSe/CdS core/shell quantum dots (QDs) can be used as stable and highly active photoredox catalysts for efficient transfer hydrogenation of imines to amines with thiophenol as a hydrogen atom donor. ...This reaction proceeds via a proton-coupled electron transfer (PCET) from the QDs conduction band to the protonated imine followed by hydrogen atom transfer from the thiophenol to the α-aminoalkyl radical. This precious metal free transformation is easy to scale up and can be carried out by a one-pot protocol directly from aldehyde, amine, and thiophenol. Additional advantageous features of this protocol include a wide substrate scope, high yield of the amine products, extremely low catalyst loading (0.001 mol %), high turnover number (105), and the mild reaction conditions of using visible light or sun light at room temperature in neutral media.
Full text
Available for:
IJS, KILJ, NUK, PNG, UL, UM
Objective
To evaluate the effect of art therapy on cancer patients' quality of life and physical and psychological symptoms.
Methods
The databases PubMed, Embase, Web of Science, The Cochrane ...Library, Clinical Trial.gov, the China National Knowledge Infrastructure (CNKI), Wanfang and the Chinese Biomedical Literature Database (CBM) were searched from their inception up to 20 August 2019. Trials examining the effects of art therapy on physical and psychological symptoms and quality of life versus a control group were included. The methodological quality of the included randomised controlled trials was assessed using the risk of bias tool of Cochrane Handbook. Meanwhile, the Newcastle‐Ottawa Quality Assessment Scale (NOS) was used to evaluate the methodological quality of the non‐randomised studies.
Results
Twelve studies involving 587 cancer patients were included. The results revealed that art therapy significantly reduced anxiety symptoms (standard mean difference SMD = −0.46, 95% confidence interval CI −0.90, 0.02, p = .04), depression symptoms (SMD = −0.47, 95% CI −0.72, 0.21, p < .01), and fatigue (SMD = −0.38, 95% CI −0.68, −0.09, p = .01) in cancer patients. Art therapy also significantly improved the quality of life of cancer patients (SMD = 0.43, 95% CI 0.18, 0.68, p < .01).
Conclusions
Art therapy had a positive effect on quality of life and symptoms in cancer patients and can be used as a complementary treatment for cancer patients.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Pericarp structure and permeability in
Tilia miqueliana
were explored using anatomy, paraffin section detection, scanning electron microscopy, and magnetic resonance imaging. The pericarp of intact
...T. miqueliana
seeds comprised an exocarp, mesocarp, and endocarp. The exocarp was densely covered with villi and consisted of irregular thin-walled cells. The mesocarp was highly lignified and impermeable, with slender, thick-walled, round and irregularly polygonal cells. The endocarp consisted of spherical parenchyma cells. The water gap provided an entry point for free water in intact seeds. The impermeable and highly lignified mesocarp creates a mechanical and permeability barrier, inhibiting germination in
T. miqueliana.
Liquid chromatography–mass spectrometry was used to identify the chemical composition of the pericarp. Identified compounds included phenols, esters, organic acid, lipids, aldehydes, as well as unsaturated fatty acids, which likely play a role in suppressing germination.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
A compact all-fiber optical anemometer based on a fiber Bragg grating inscribed in a metal-filled microstructured optical fiber (MOF) is presented. Six-hole MOF (SHMOF) with a suspended core is ...fabricated to engineer the evanescent field of the fundamental guided mode, and low-melting-point alloy is filled in the micro-holes to achieve highly efficient light-heat conversion. Such a metal-filled SHMOF can strongly absorb pumping light at 1450 nm to generate heat and forms a fiber-optic "hot wire." The Bragg grating at 850 nm is inscribed in the core of SHMOF and acts as an in-fiber sensor for monitoring wind-speed dependent temperature of the "hot wire." Experimental results show the sensitivity of the fiber-optic anemometer is as high as ~0.091 nm/(m/s) at wind speed of around 2 m/s. Such a compact anemometer is promising as a low-power-consumption optical flow-meter for remote sensing and on-chip integration.
ETHNOPHARMACOLOGICAL RELEVANCEBioactive substance identification is always the focal point and the main challenge in Chinese herbal medicine (CHM). Most CHM present multiple efficacies and multiple ...tropisms, which has improved the application accuracy of CHM, and is worthy of further study. In this article, the concept of "multi-tropism efficacy of CHM" has been proposed for the first time. In addition, it is hypothesized that the different components in CHM can be classified based on their efficacy status. AIM OF THE STUDYThe spectrum-effect relationship between the fingerprint and efficacy was established to identify the efficacy status of components. This provided a practical, efficient and accurate way to identify the bioactive substances from a complex CHM system. MATERIALS AND METHODSThe network pharmacology approach was applied to preliminarily analyze the potential antibacterial compounds and mechanisms of HQ. Furthermore, its chemical fingerprint was established and the characteristic peaks were identified by LC-MS/MS. The antibacterial and anti-inflammatory bioactivities of HQ were determined to evaluate its pharmacological effect of heat-clearing and detoxification, and its anticoagulation activity was determined to evaluate its heat-clearing and tocolysis effects. The spectrum-effect relationships were assessed by gray correlation analysis to discriminate the status of active components in HQ with different efficacies. RESULTSNetwork pharmacology analysis revealed apigenin, wogonin, baicalein, acacetin, β-sitosterol, baicalin, eugenol, moslosooflavone, palmitic acid, oroxylin-A 7-O-glucuronide, and scutevulin as the potential active compounds responsible for the efficacy of HQ against both E. coli and S. aureus. The spectrum-effect relationship was utilized to reveal the orientation activities, with the results as follows: 1) The main basic-efficacy components in HQ with antibacterial, anti-inflammatory, and anticoagulant effects were P5, P8, P9, P15, P18, P19, P20; while the general basic-efficacy components were P2, P3, P6, P7, P11, P14, P21, P22, P28. 2) The main efficacy-oriented components in HQ with antibacterial effects on E. coli were P1, P12, P17, while the general efficacy-oriented compound was P10, P24, P25, P26, P27; the main efficacy-oriented in HQ with antibacterial effects on S. aureus were P14 and the general efficacy-oriented components were P1, P12, P26, P29, P30, respectively. 3) The main efficacy-oriented components with anti-inflammatory activity were P14, P24, P25, P27, and P30, while the general efficacy-oriented components were P13, P23, P26. 4) The main efficacy-oriented compounds in HQ with effects on anticoagulation were P6 and P22; these acted by prolonging APTT through the intrinsic coagulation pathway and PT through the extrinsic coagulation pathway, respectively. 5) The pharmacodynamic status classification of Scutellaria baicalensis ingredients were confirmed by nine reference compounds exemplarily. CONCLUSIONThis work established a novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis, the method is scientific feasible and can be applied to the effective substances identification and quality control of other CHM.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
PIWI (P element induced wimpy testis) integrating RNAs (piRNAs) are small non-coding RNAs with the length of approximately 30 nucleotides that plays crucial roles in germ cells and adult stem cells. ...Recently, accumulating data have shown that piRNA and PIWI proteins are involved in tumorigenesis. However, the roles of PIWI proteins and piRNAs in pancreatic cancer are still elusive. Here, we showed that piR-017061 is significantly downregulated in pancreatic cancer patients’ samples and pancreatic cancer cell lines. Furthermore, we studied the function of piR-017061 in pancreatic cancer and our data revealed that piR-017061 inhibits pancreatic cancer cell growth in vitro and in vivo. Moreover, we analyzed the genomic loci around piR-017061 and identified EFNA5 as a novel target of piR-017061. Importantly, our data further revealed a direct binding between piR-017061 and EFNA5 mRNA mediated by PIWIL1. Mechanically, piR-017061 cooperates with PIWIL1 to facilitate EFNA5 mRNA degradation and loss of piR-017061 results in accumulation of EFNA5 which facilitates pancreatic cancer development. Hence, our data provided novel insights into PIWI/piRNA-mediated gene regulation and their function in pancreatic cancer. Since PIWI proteins and piRNA predominately express in germline and cancer cells, our study provided novel therapeutic strategy for pancreatic cancer treatment.
Full text
Available for:
EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The hydrodynamics and water quality evolutions in response to the land reclamations in Bohai Bay were investigated by developing a coupled hydrodynamics-water quality model. Simulated results ...indicate reclamations considerably change the residual current fields and decrease the tidal prisms. After 1990–2006 reclamations, salinity isolines in the west of the bay obviously move towards open sea, and cause the decrease of salinity value. Compared with the 2006 reclamation scenario, the 2022 reclamation scenario generates larger salinity concentration, thereby intensifying salinity intrusion. Besides, a large amount of dissolved inorganic nitrogen (DIN) is retained in the bay and increases its concentration value due to 1990–2006 reclamations, which almost presents opposite variation in the 2022 reclamation scenario. 1990–2006 reclamations increase phytoplankton carbon concentrations in the most bay areas, with a maximum increased value of 53.37 μg/L. With the further construction of reclamations (2006–2022), phytoplankton carbon concentrations increase within several estuarine areas, nevertheless the decreases appear in the large areas from estuarine mouths to bay's center. Statistically, the averaged salinity concentration slightly changes in the whole bay, while the averaged DIN and phytoplankton carbon concentrations significantly increase by 14.92% and 13.33% during 1990–2006, then they decrease by 16.02% and 20.68% during 2006–2022, respectively.
Display omitted
•A coupled hydrodynamics-water quality model is established in Bobai Bay.•Land reclamations change residual current fields and decreases tidal prisms.•Land reclamations affect spatial distributions of water quality parameters.•Averaged dissolved inorganic nitrogen and phytoplankton carbon increase by 14.92% and 13.33% after 1990–2006 reclamations.•Nevertheless they decrease by 16.02% and 20.68% due to 2006–2022 reclamations.
Full text
Available for:
GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Background. The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible biological marker that has been reported to represent disease severity. The aim of this study is to investigate the ...association between NLR and mortality in patients with sepsis. Methods. A total of 333 consecutive adult patients with sepsis were screened for eligibility in this prospective, observational study cohort. Severity scores and leukocyte counts were prospectively recorded upon entry to the intensive care unit (ICU). Receiver operating characteristic (ROC) curves and binary logistic regression models were used to assess the performance of NLR in predicting unfavorable outcome. Correlations between variables and disease severity were analyzed through Spearman correlation tests. Results. Median NLR levels were significantly higher in patients who died than in survivors. NLR had a modest power for predicting poor outcome as suggested by area under the curve (AUC) of 0.695 ± 0.036 . Multivariate linear regression indicated that increased NLR levels were related to unfavorable outcome independently of the effect of possible confounders. Spearman correlation tests showed that there was a positive correlation between NLR levels and disease severity. Conclusions. Increased NLR levels were independently associated with unfavorable clinical prognosis in patients with sepsis. Further investigation is required to increase understanding of the pathophysiology of this relationship.
Full text
Available for:
DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
An unusual alkylidyne homologation Han, Yong-Shen; Hill, Anthony F; Kong, Richard Y
Chemical communications,
01/2018, Volume:
54, Issue:
18
Journal Article
Peer reviewed
Open access
The reaction of W(triple bond, length as m-dashCH)Br(CO)
(dcpe) (dcpe = 1,2-bis(dicyclohexylphosphino)ethane) with
BuLi and SiCl
affords the trichlorosilyl ligated neopentylidyne complex W(triple ...bond, length as m-dashC
Bu)(SiCl
)(CO)
(dcpe). This slowly reacts with H
O to afford W(triple bond, length as m-dashCCH
Bu)Cl
(dcpe) and ultimately H
Cdouble bond, length as m-dashCH
Bu via an unprecedented alkylidyne homologation in which coordinated CO is the source of the additional carbon atom with potential relevance to the Fischer-Tropsch process.
PDF
