It is notable that along the N=Z line in the nuclear chart, extremely large collectivity emerges suddenly in the mass-80 region. By applying the Monte Carlo shell model (MCSM) and the ...Hartree-Fock-Bogolyubov plus generator coordinate method (HFB+gcm), we study this problem to find the origin. On the basis that both calculations reproduce the experimental data of the N≈Z nuclei with A=64∼88, we identify the backbone from full shell-model calculations that can explain the strong prolate deformation. We find that inclusion of the 2d5/2 orbit in the model space to cooperate with 1g9/2 is the key ingredient to describe the rapid increase of collectivity from 70Se to 76Sr and to produce the observed large B(E2) values in 76Sr, 78Sr and 80Zr. The quadrupole-quadrupole (QQ) interaction acting between the quasi-SU(3) partner orbits, 1g9/2−2d5/2, is the driving force that changes the nuclear shape from oblate- to prolate-deformed. We further suggest that the quasi-SU(3) effect is particularly amplified in the N≈Z nuclei because these are the unique examples where quasi-SU(3) partner orbits can be formed, like the nuclear pairing, simultaneously in three different types: neutron-neutron (n-n), proton-proton (p-p), and neutron-proton (n-p), which respectively interact through the n-n, p-p, and n-p components of the QQ force to enhance the quadrupole collectivity coherently.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Exosomes can mediate a dynamic method of communication between malignancies, including those sequestered in the central nervous system and the immune system. We sought to determine whether exosomes ...from glioblastoma (GBM)-derived stem cells (GSCs) can induce immunosuppression. We report that GSC-derived exosomes (GDEs) have a predilection for monocytes, the precursor to macrophages. The GDEs traverse the monocyte cytoplasm, cause a reorganization of the actin cytoskeleton, and skew monocytes toward the immune suppresive M2 phenotype, including programmed death-ligand 1 (PD-L1) expression. Mass spectrometry analysis demonstrated that the GDEs contain a variety of components, including members of the signal transducer and activator of transcription 3 (STAT3) pathway that functionally mediate this immune suppressive switch. Western blot analysis revealed that upregulation of PD-L1 in GSC exosome-treated monocytes and GBM-patient-infiltrating CD14
+
cells predominantly correlates with increased phosphorylation of STAT3, and in some cases, with phosphorylated p70S6 kinase and Erk1/2. Cumulatively, these data indicate that GDEs are secreted GBM-released factors that are potent modulators of the GBM-associated immunosuppressive microenvironment.
Energy storage systems are necessary for renewable energy sources such as solar power in order to stabilize their output power, which fluctuates widely depending on the weather. Since 'flywheel ...energy storage systems' (FWSSs) do not use chemical reactions, they do not deteriorate due to charge or discharge. This is an advantage of FWSSs in applications for renewable energy plants. A conventional FWSS has capacity limitation because of the mechanical bearings used to support the flywheel. Therefore, we have designed a superconducting magnetic bearing composed of a superconducting coil stator and a superconducting bulk rotor in order to solve this problem, and have experimentally manufactured a large scale FWSS with a capacity of 100 kWh and an output power of 300 kW. The superconducting magnetic bearing can levitate 4 tons and enables the flywheel to rotate smoothly. A performance confirmation test will be started soon. An overview of the superconducting FWSS is presented in this paper.
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR1
. Deficiency in the LUBAC ...components SHARPIN or HOIP in mice results in severe inflammation in adulthood or embryonic lethality, respectively, owing to deregulation of TNFR1-mediated cell death
. In humans, deficiency in the third LUBAC component HOIL-1 causes autoimmunity and inflammatory disease, similar to HOIP deficiency, whereas HOIL-1 deficiency in mice was reported to cause no overt phenotype
. Here we show, by creating HOIL-1-deficient mice, that HOIL-1 is as essential for LUBAC function as HOIP, albeit for different reasons: whereas HOIP is the catalytically active component of LUBAC, HOIL-1 is required for LUBAC assembly, stability and optimal retention in the TNFR1 signalling complex, thereby preventing aberrant cell death. Both HOIL-1 and HOIP prevent embryonic lethality at mid-gestation by interfering with aberrant TNFR1-mediated endothelial cell death, which only partially depends on RIPK1 kinase activity. Co-deletion of caspase-8 with RIPK3 or MLKL prevents cell death in Hoil-1
(also known as Rbck1
) embryos, yet only the combined loss of caspase-8 with MLKL results in viable HOIL-1-deficient mice. Notably, triple-knockout Ripk3
Casp8
Hoil-1
embryos die at late gestation owing to haematopoietic defects that are rescued by co-deletion of RIPK1 but not MLKL. Collectively, these results demonstrate that both HOIP and HOIL-1 are essential LUBAC components and are required for embryogenesis by preventing aberrant cell death. Furthermore, they reveal that when LUBAC and caspase-8 are absent, RIPK3 prevents RIPK1 from inducing embryonic lethality by causing defects in fetal haematopoiesis.
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KISLJ, NUK, SBMB, UL, UM, UPUK
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