Quantum dots (QDs) are nanocrystals of semiconducting material possessing quantum mechanical characteristics with capability to get conjugated with drug moieties. The particle size of QDs varies from ...2 to 10 nm and can radiate a wide range of colours depending upon their size. Their wide and diverse usage of QDs across the world is due to their adaptable properties like large quantum yield, photostability, and adjustable emission spectrum. QDs are nanomaterials with inherent electrical characteristics that can be used as drug carrier vehicle and as a diagnostic in the field of nanomedicine. Scientists from various fields are aggressively working for the development of single platform that can sense, can produce a microscopic image and even be used to deliver a therapeutic agent. QDs are the fluorescent nano dots with which the possibilities of the drug delivery to a targeted site and its biomedical imaging can be explored. This review is mainly focused on the different process of synthesis of QDs, their application especially in the areas of malignancies and as a theranostic tool. The attempt is to consolidate the data available for the use of QDs in the biomedical applications.
•QDs are nonmaterial's that can be used for drug delivery, imaging and diagnostic tool in the field of nanomedicine.•The various approaches to synthesize the QDs were explored.•QDs are accepted in the treatment strategies due to their biocompatibility with human physiology.•QDs posses' several biomedical application particularly in the area of cancer theranostics.•Fluorescents dots (QDs) can illuminate the complicated terrain of oncology sciences, novel biomarkers and a patient compliant treatment regimens.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Pesticides are widely used chemical compounds in agriculture to destroy insects, pests and weeds. In modern era, they form an indispensable part of agricultural and health practices. Globally, nearly ...3 billion kg of pesticides are used every year with a budget of ~40 billion USD. This extensive usage has increased the crop yield as well as led to significant reduction in harvest losses and thereby, enhanced food availability. On the other hand, indiscriminate usage of these chemicals has led to several environmental implications and caused adverse effects on human health. Epidemiological evidences have revealed the harmful effects of pesticides exposure on various organs including liver, brain, lungs and colon. Recent investigations have shown that pesticides can also lead to fatal consequences such as cancer among individuals. These chemicals enter ecosystem, thus hampering the sensitive environmental equilibrium through bio-accumulation. Due to their non-biodegradable nature, they can persist in nature for years and are regarded as potent biohazard. Worldwide, very few surveillance methods have been considered, which can bring awareness among the individuals, therefore the present review is an attempt to delineate consequences induced by various types of pesticide exposure on the environment. Further, the prospective of biopesticides use could facilitate the increase of crop production without compromising human health.
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•Pesticides are abundantly used in agriculture and health sectors.•These chemicals can be classified into natural and synthetic.•Pesticides target essential metabolic pathways of physiological system.•They are non-biodegradable and toxic chemicals.•Bio-pesticides and integrated pest management practices are need of an hour.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We report here the design and syntheses of a naphthalenediimide (NDI)-N functionalized organic fluorophore, 1 , and its supramolecular CT complexes ( 1 ·2H) 2+ ·(PA − ) 2 ( 2 ) and ( 1 ·2H) 2+ ...·(3,5-DNSA − ) 2 ( 3 ), self-assembled from 1 as an electron acceptor (A) and picric acid (PA) or 3,5-dinitrosalicylic acid (3,5-DNSA) as a donor (D), with a very large Stokes shift (>170 nm) and significant fluorescence lifetime (∼1.55 ns). NDI is functionalized with phenylpyridyl units (chromophore) to extend the π-conjugation and thus provide a suitable platform for strong C–H---π and π⋯π stacking interactions, which are the prime requirements for any compound to be used as a fluorescent probe. The organic fluorophore, 1 , and its supramolecular CT complexes 2 and 3 exhibit decent electronic properties as suggested by DFT, cyclic voltammetry, and fluorescence studies. Moreover, compounds 1–3 were also exploited as fluorescent probes for cell imaging under normal cell isolation and with time-bound exposure.
In an era characterized by rapid technological advancements, the ability to communicate instantly with others has become an integral part of our daily lives. With the ubiquity of mobile devices, ...tablets, and laptops, staying informed about the latest events and news has never been easier. This research article explores the development and impact of an Android news application that connects users to the latest news from over 120 reputable news organizations across India. The primary objective of this innovative application is to amalgamate global news sources and present information to users in an engaging and visually compelling format with minimal delay. One of the distinguishing features of this Android news app is its user-centric approach, allowing individuals to filter live news based on their preferences. Upon selecting a news article, users are seamlessly redirected to the corresponding news source, ensuring the integrity of the original reporting. The app is designed to deliver frequent updates on a wide range of topics, leveraging the capabilities of the NEWS API to source information from renowned news outlets worldwide, including BBC, CNN, The Guardian, and NDTV. This research anticipates a substantial increase in the speed at which information reaches the average person, thanks to the seamless integration of multiple news sources through this Android news application. This technological advancement promises to revolutionize the way individual's access and consume news, ensuring they stay well-informed in an increasingly fast-paced world.
Background: The objectives of the study were to identify the psychological impact of lockdown on medical students due to COVID-19 and to discover the educational perplexities being faced by these ...students during the lockdown due to COVID-19.
Methods: A cross-sectional study was conducted at Sir Seewoosagur Ramgoolam Medical College (SSRMC), Mauritius. Questions were designed after extensive review of the literature, so that they were relevant to meet the objectives of the study.
Results: Out of 700 undergraduate medical students, 663 students participated in the study, this equates to a substantial response rate of 95%. Due to the pandemic 348 (52.5 %) of the students were stationed in their hometown and the remaining 315 (47.5 %) were stationed in Mauritius. 464(70%) of the students suffered from the psychological impact of lockdown whereas 634(95.6%) of the students suffered from the educational impact of lockdown. Mauritian students suffered from a greater educational impact aOR4.2361.606-11.173. Psychological impact aOR 1.280 0.917-1.789 and educational impact aOR 2.464 1.076-5.647 was found more in students those who were at their hometown.
Conclusion: Lockdown triggered both educational and psychological impact on medical students. On a psychological basis it was proven that the lockdown induced a feeling of guilt and had subsequent psychological impacts in certain students. The COVID-19 situation was simultaneously indicated to be a motivator in the majority of students; however, juxtaposed to this was the fact that various students felt as if they could not study at the same level that they are accustomed to due to the uncertainty of the situation.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
This narrative review of the literature aims to assess the impact of COVID-19 on the younger age group in terms of the Global mortality of COVID-19 in comparison to Nepal. An extensive literature ...survey of English literature was conducted using Pubmed, Medline, Google Scholar, Embase, WHO Nepal Situation Updates on COVID-19, Situation update report, Ministry of Health and Population-Nepal from January 25, 2020 to June20, 2020. According to the Ministry of Health and population of The Government of Nepal, as of June 20 , 2020, out of a total of 8,605 laboratory confirmed cases reported to date, the pattern shows that most of the cases fell into the cohort of 21-30 years (37.72%), followed by 11-20 years (24.35 %), 31-40 years (21.97%) and 41-50 years (9.2%). To date Nepal has recorded a total of twenty-two deaths. At first evaluation thesefigures may not strike one as alarming, but on further investigation it is noted that the mean age is 42. 32 ± 19.632 SD years, and out of which male patients accounted for 77.3% and female accounted for 22.7%. The current situation of COVID-19 and how it develops in Nepal should be closely monitored and could be of international concern as it may be the early indicator of a changing pattern in COVID-19 infections. Nepal maytherefore act as a global watch dog, due to the fact that the world could very possibly expose the younger age group under the notion that they are more resilient to the virus, when in reality that notion may be changing. This trend must be monitored and further investigated in order to establish the risk of the events unfolding in Nepal.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract
Color patterns in nonavian reptiles are beautifully diverse, but little is known about the genetics and development of these patterns. Here, we investigated color patterning in pet ball ...pythons (Python regius), which have been bred to show color phenotypes that differ dramatically from the wildtype form. We report that several color phenotypes in pet animals are associated with putative loss-of-function variants in the gene encoding endothelin receptor EDNRB2: (1) frameshift variants in EDNRB2 are associated with conversion of the normal mottled color pattern to skin that is almost fully white, (2) missense variants affecting conserved sites of the EDNRB2 protein are associated with dorsal, longitudinal stripes, and (3) substitutions at EDNRB2 splice donors are associated with subtle changes in patterning compared to wildtype. We propose that these phenotypes are caused by loss of specialized color cells (chromatophores), with loss ranging from severe (fully white) to moderate (dorsal striping) to mild (subtle changes in patterning). Our study is the first to describe variants affecting endothelin signaling in a nonavian reptile and suggests that reductions in endothelin signaling in ball pythons can produce a variety of color phenotypes, depending on the degree of color cell loss.
Pet ball pythons (Python regius) have been bred to exhibit color morphs that differ dramatically from the wildtype form. This study describes an allelic series of morphs that converts the normal mottled color pattern to stripes or all-white skin. The authors show that these morphs are associated with variants in an endothelin receptor gene. This study belongs to a course-based research experience for undergraduates and showcases the ability of undergraduates to contribute to real discoveries in a classroom setting.
We report here the design and syntheses of a naphthalenediimide (NDI)-N functionalized organic fluorophore,
1
, and its supramolecular CT complexes (
1
·2H)
2+
·(PA
−
)
2
(
2
) and (
1
·2H)
2+
...·(3,5-DNSA
−
)
2
(
3
), self-assembled from
1
as an electron acceptor (A) and picric acid (PA) or 3,5-dinitrosalicylic acid (3,5-DNSA) as a donor (D), with a very large Stokes shift (>170 nm) and significant fluorescence lifetime (∼1.55 ns). NDI is functionalized with phenylpyridyl units (chromophore) to extend the π-conjugation and thus provide a suitable platform for strong C-H---π and π π stacking interactions, which are the prime requirements for any compound to be used as a fluorescent probe. The organic fluorophore,
1
, and its supramolecular CT complexes
2
and
3
exhibit decent electronic properties as suggested by DFT, cyclic voltammetry, and fluorescence studies. Moreover, compounds
1-3
were also exploited as fluorescent probes for cell imaging under normal cell isolation and with time-bound exposure.
Two new intermolecular CT complexes having large Stokes shift (>170 nm) and significant fluorescence life-time (∼1.55 ns) have been prepared and exploited for cell imaging application.
Abstract : Many people lose their life when a natural disaster such as earthquake, tsunamis, windstorms occur. Similarly, in war-fields soldiers lose their life when they put their foot ...incidentallyon landmines. This paper focuses on investigating, analyzing, and exploring the previous research papers on the alive human detection robot. The further modifications that have been done in the past arecompared extensively in this paper. A quantitative analysis of the various technologies used in the past such as microcontrollers (Arduino UNO, Raspberry pi), sensors (PIR sensor for detecting the motion in the body, IR sensor) and other wireless technologies for data and instruction transmission (Bluetooth) is done in this paper. Further, methods have been devised in order to make the robotmoreeffective. Keywords : PIR, Arduino, IR sensor.
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