Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and cellular signal transduction under physiological conditions of the central nervous system (CNS). In response ...to acute or chronic brain injuries, these ion transporters can be activated and differentially regulate glial functions, which has subsequent impact on brain injury or tissue repair and functional recovery. In this review, we summarized the current knowledge about major glial ion transporters, including Na+/H+ exchangers (NHE), Na+/Ca2+ exchangers (NCX), Na+–K+–Cl− cotransporters (NKCC), and Na+–HCO3− cotransporters (NBC). In acute neurological diseases, such as ischemic stroke and traumatic brain injury (TBI), these ion transporters are rapidly activated and play significant roles in regulation of the intra‐ and extracellular pH, Na+, K+, and Ca2+ homeostasis, synaptic plasticity, and myelin formation. However, overstimulation of these ion transporters can contribute to glial apoptosis, demyelination, inflammation, and excitotoxicity. In chronic brain diseases, such as glioma, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), glial ion transporters are involved in the glioma Warburg effect, glial activation, neuroinflammation, and neuronal damages. These findings suggest that glial ion transporters are involved in tissue structural and functional restoration, or brain injury and neurological disease development and progression. A better understanding of these ion transporters in acute and chronic neurological diseases will provide insights for their potential as therapeutic targets.
Main points
Glial ion transporters are involved in acute brain injury via glial apoptosis, demyelination, inflammation and excitotoxicity.
Glioma and neurodegenerative diseases stimulate glial ion transporters in tumor growth, inflammation, and neuronal damage.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Sewer sediments contain various hazardous compounds, leading to significant pollution risks when combined sewer overflows (CSOs) occur without appropriate controls. This paper presents a ...comprehensive review of the issues associated with particles in sewers, specifically focusing on the non-negligible contribution of particulate matter to CSOs, which leads to pollution in urban rivers. Therefore, the sources of particulate matter in sewers, their contributions to the overflow particles, and the specific areas of concern when it comes to managing particulate matter during particle transportation are outlined. Overall, carefully considering the goal of avoiding sedimentation during the drainage system design is the most effective prevention and control method for pipeline sediment, where minimum velocity and minimum shear stress are the core parameters. The establishment of a flexible and adaptive particle simulation method in drainage pipelines requires reliable simulation of particle sedimentation and erosion, the development of sediment prevention facilities with strong adaptability, and a comprehensive evaluation of economic and environmental benefits. With the ongoing enhancement of urbanization in developing countries, such studies will have more practical significance.
Policy Points
Social policies might not only improve economic well‐being, but also health. Health policy experts have therefore advocated for investments in social policies both to improve population ...health and potentially reduce health system costs.
Since the 1960s, a large number of social policies have been experimentally evaluated in the United States. Some of these experiments include health outcomes, providing a unique opportunity to inform evidence‐based policymaking.
Our comprehensive review and meta‐analysis of these experiments find suggestive evidence of health benefits associated with investments in early life, income support, and health insurance interventions. However, most studies were underpowered to detect health outcomes.
Context
Insurers and health care providers are investing heavily in nonmedical social interventions in an effort to improve health and potentially reduce health care costs.
Methods
We performed a systematic review and meta‐analysis of all known randomized social experiments in the United States that included health outcomes. We reviewed 5,880 papers, reports, and data sources, ultimately including 61 publications from 38 randomized social experiments. After synthesizing the main findings narratively, we conducted risk of bias analyses, power analyses, and random‐effects meta‐analyses where possible. Finally, we used multivariate regressions to determine which study characteristics were associated with statistically significant improvements in health outcomes.
Findings
The risk of bias was low in 17 studies, moderate in 11, and high in 33. Of the 451 parameter estimates reported, 77% were underpowered to detect health outcomes. Among adequately powered parameters, 49% demonstrated a significant health improvement, 44% had no effect on health, and 7% were associated with significant worsening of health. In meta‐analyses, early life and education interventions were associated with a reduction in smoking (odds ratio OR = 0.92, 95% confidence interval CI 0.86‐0.99). Income maintenance and health insurance interventions were associated with significant improvements in self‐rated health (OR = 1.20, 95% CI 1.06‐1.36, and OR = 1.38, 95% CI 1.10‐1.73, respectively), whereas some welfare‐to‐work interventions had a negative impact on self‐rated health (OR = 0.77, 95% CI 0.66‐0.90). Housing and neighborhood trials had no effect on the outcomes included in the meta‐analyses. A positive effect of the trial on its primary socioeconomic outcome was associated with higher odds of reporting health improvements. We found evidence of publication bias for studies with null findings.
Conclusions
Early life, income, and health insurance interventions have the potential to improve health. However, many of the included studies were underpowered to detect health effects and were at high or moderate risk of bias. Future social policy experiments should be better designed to measure the association between interventions and health outcomes.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NMLJ, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
A semi-quantitative and quantitative multi-immunochromatographic (ICA) strip detection assay was developed for the simultaneous detection of twenty types of mycotoxins from five classes, including ...zearalenones (ZEAs), deoxynivalenols (DONs), T-2 toxins (T-2s), aflatoxins (AFs), and fumonisins (FBs), in cereal food samples. Sensitive and specific monoclonal antibodies were selected for this assay. The semi-quantitative results were obtained within 20 min by the naked eye, with visual limits of detection for ZEAs, DONs, T-2s, AFs and FBs of 0.1-0.5, 2.5-250, 0.5-1, 0.25-1 and 2.5-10 μg kg(-1), and cut-off values of 0.25-1, 5-500, 1-10, 0.5-2.5 and 5-25 μg kg(-1), respectively. The quantitative results were obtained using a hand-held strip scan reader, with the calculated limits of detection for ZEAs, DONs, T-2s, AFs and FBs of 0.04-0.17, 0.06-49, 0.15-0.22, 0.056-0.49 and 0.53-1.05 μg kg(-1), respectively. The analytical results of spiked samples were in accordance with the accurate content in the simultaneous detection analysis. This newly developed ICA strip assay is suitable for the on-site detection and rapid initial screening of mycotoxins in cereal samples, facilitating both semi-quantitative and quantitative determination.
Purpose/Significance With the rapid development of information technology and the arrival of the era of big data, big data has become a key production factor and a strategic fundamentally resource ...for a country. Big data governance has become an important way to fully release data value and realize the modernization of national governance system and governance capacity. This study reviews the related research on big data governance, in order to better play its positive role as a new production factor and a means of social governance. Method/Process On the basis of bibliometrics and content analysis, this study systematically reviews the relevant research on big data governance in China, and finds that the research on big data governance has been rising in recent years. The relevant research topics have also displayed characteristics such as wide diversity and multidisciplinary integration. The core topics involved in the research include big data governance, social governance, government governance, big d
The durability of concrete is critical for the service life of concrete structures, and it is influenced by various factors. This paper investigates the impact of the relative humidity (RH) of the ...curing environment on the durability of five different concrete types. The aim is to determine a suitable approach for designing concrete that is well-suited for use in the salt lake region of Inner Mongolia. The concrete types comprise ordinary Portland cement (OPC), high-strength expansive concrete (HSEC), high-strength expansive concrete incorporating silica fume, fly ash, and blast furnace slag (HSEC-SFB), steel fiber-reinforced high-strength expansive concrete (SFRHSEC), and high elastic modulus polyethylene fiber-reinforced high-strength expansive concrete (HFRHSEC). All these concrete types underwent a 180-day curing process at three distinct relative humidities (RH = 30%, 50%, and 95%) before being subjected to freeze-thaw cycles in the Inner Mongolia salt lake brine. The curing environment with a 95% RH is referred to as the standard condition. The experimental results reveal that the durability of OPC and HSEC decreases significantly with increasing relative humidity. In comparison with the control sample cured in 95% RH, the maximum freeze-thaw cycles for concrete cured in lower RHs are only 31% to 76% for OPC and 66% to 77% for HSEC. However, the sensitivity of the durability of HSEC-SFB, SFRHSEC, and HFRHSEC to variations in RH in the curing environment diminishes. In comparison with the corresponding reference value, the maximum freeze-thaw cycles for samples cured in dry conditions increase by 14% to 17% for HSEC-SFB and 21% for SFRHSEC. Specifically, the service life of HFRHSEC cured in a low RH is 25% to 46% higher than the reference value. The durability of HSEC-SFB, SFRHSEC, and HFRHSEC has been proven to be appropriate for structures located in the salt lake region of Inner Mongolia.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Abstract Due to the presence of non-line-of-sight (NLOS) obstacles, the localization accuracy in ultra-wideband (UWB) wireless indoor localization systems is typically substantially lower. To ...minimize the influence of these environmental factors and improve the accuracy of indoor wireless positioning, this paper proposes a density clustering with noise combined with particle swarm optimization (DCNPSO) to improve UWB positioning. Which exploits the advantages of the density-based spatial clustering algorithm with noise (DBSCAN) and particle swarm optimization (PSO) algorithm. The experimental results show that the DCNPSO algorithm achieves 45.25% and 36.14% higher average positioning accuracy than the DBSCAN and PSO algorithms, respectively. The positioning error of this algorithm remains stable within 3 cm in static positioning and can achieve high accuracy in NLOS environments.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Previous studies have shown a bidirectional relationship between diabetes and pancreatic cancer (PC). In particular, new-onset diabetes might be induced by PC, and people with long-term diabetes ...might be at increased risk for the development of PC. The purpose of our study was to examine whether long-term diabetes represented an independent risk factor for PC development.
A literature search was performed by searching electronic databases for studies published before July 1, 2014, and relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated. Data pertaining to diabetes were recorded at both individual and study levels, with RRs calculated separately to analyze the relationship between the duration of diabetes and the development of PC.
Forty-four studies were included in this meta-analysis, including 18 studies with a case-control design, 5 with a nested case-control design and 21 with a cohort design. The overall summary estimate for the relationship between the population with a duration of diabetes ≥2 years and PC was 1.64 (1.52-1.78). The pooled RR (95% CI) of PC for the population with a duration of diabetes ≥5 years was 1.58 (1.42-1.75). For the population with a duration of diabetes ≥10 years, the RR (95% CI) of PC was 1.50 (1.28-1.75).
Our study suggests that long-term diabetes mellitus is associated with an increased risk of PC. However, the level of risk is negatively correlated with increasing diabetes mellitus duration.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Studies suggest that clonal plants' ability to select habitats and forage in a heterogeneous environment is influenced by their past environment, with stress legacy potentially playing a crucial ...role. In this study, we examined parental ramets of
Focke that were subject to either a control or lead-contaminated environment (past environment), and their newborn offspring were then transplanted into control, homogeneous lead or heterogeneous lead environment (present environment). We analysed how past and present environments affect plant growth and DNA methylation in offspring. The result shown that the DNA methylation loci composition of offspring was affected by the interaction of parental environment and offspring environment, and DNA methylation levels were higher in heterogeneous environments. Moreover, our findings indicate that offspring would thrive in the heterogeneous lead environment if they did not experience lead pollution in the past, their progeny will avoid lead toxicity by reducing underground biomass allocation. However, when the parents experienced lead stress environment, their biomass allocation strategies disappeared, and they prefer to grow in favourable patches to avoid lead-contaminated patches. We concluded that the integration of historical parental exposure to lead-contaminated and current information about their offspring's environment are impacting plant phenotypes. It is possible that the stress legacy from the parents has been transmitted to their offspring ramets, and the stress legacy is at least partly based on heritable epigenetic variation. The phenotypic variation regulated by the stress legacy affects the growth performance, biomass allocation strategy, and even the behaviour of
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A surface-enhanced Raman scattering (SERS) sensor based on gold nanostar (Au NS) core-silver nanoparticle (Ag NP) satellites was fabricated for the first time to detect aflatoxinB1 (AFB1). We ...constructed the SERS sensor using AFB1 aptamer (DNA1)-modified Ag satellites and a complementary sequence (DNA2)-modified Au NS core. The Raman label (ATP) was modified on the surface of Ag satellites. The SERS signal was enhanced when the satellite NP was attached to the Au core NS. The AFB1 aptamer on the surface of Ag satellites would bind to the targets when AFB1 was present in the system, Ag satellites were then removed and the SERS signal decreased. This SERS sensor showed superior specificity for AFB1 and the linear detection range was from 1 to 1000 pg mL(-1) with the limit of detection (LOD) of 0.48 pg mL(-1). The excellent recovery experiment using peanut milk demonstrated that the sensor could be applied in food and environmental detection.
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