Este relato de caso possui o objetivo de relatar o tratamento da espasticidade de dois pacientes com o uso de fitocanabinoides. O caso 1 é de um paciente portador de hérnia discal cervical e lombar, ...evoluindo com espasticidade, principalmente em período noturno. Após o tratamento com fitocanabinoides, o paciente apresentou redução dos movimentos involuntários e redução dos despertares noturnos. O caso 2 é de uma paciente portadora de fibromialgia, associado a espasticidade de membros superiores, insônia e transtorno de humor. Após o tratamento com fitocanabinoides, a paciente evoluiu com cessação dos movimentos involuntários, melhora da qualidade de sono e melhora do quadro álgico. Conclui-se que os fitocanabinoides foram capazes de reduzir a espasticidade dos pacientes, e também auxiliou no tratamento de transtornos associados.
In SARSCoV-2 infections, excessive activation of the immune system dramatically elevates reactive oxygen species levels, harms cell structures, and directly increases disease severity and mortality. ...We aimed to evaluate whether plasma oxidative stress biomarker levels could predict mortality in adults admitted with Coronavirus Disease 2019 (COVID-19), considering potential confounders. We conducted a cohort study of 115 adults (62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Serum levels of α-tocopherol, glutathione, superoxide dismutase, 8-hydroxy-2′-deoxyguanosine, malondialdehyde, and advanced oxidation protein products were quantified at COVID-19 diagnosis using real-time polymerase chain reaction. Serum levels of α-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products differed significantly between survivors and non-survivors. Serum glutathione levels below 327.2 μmol/mL were associated with a significant risk of death in COVID-19 patients, even after accounting for other factors (adjusted hazard ratio = 3.12 95% CI: 1.83–5.33).
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•COVID-19 leads to an imbalance in the production of ROS and antioxidants.•Oxidative biomarkers can forecast the odds of death in severe COVID-19 patients.•GSH and SOD have shown the highest accuracy in predicting death.•COVID-19 patients with GSH <327.2 μmol/mL face three times the mortality risk.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
In this randomized open-label trial pilot study we assessed the antiviral effects and safety of various doses of ivermectin in patients with mild clinical symptoms of COVID-19.
Patients were randomly ...assigned to receive standard of care (SOC) treatment at hospital admission; SOC plus ivermectin 100 mcg/kg; SOC plus ivermectin 200 mcg/kg; or SOC plus ivermectin 400 mcg/kg. The primary assessed endpoint was the proportion of patients who achieved two consecutive negative SARS-CoV-2 RT PCR tests within 7 days of the start of the dosing period. This study was registered at ClinicalTrials.gov (NCT04431466).
A total of 32 patients were enrolled and randomized to treatment. SOC treatment together with ivermectin did not result in any serious adverse events. All patients exhibited a reduction in SARS-CoV-2 viral load within 7 days; however, those who received ivermectin had a more consistent decrease as compared to the SOC alone group, characterized by a shorter time for obtaining two consecutive negative SARS-CoV-2 RT PCR tests.
Ivermectin is safe in patients with SARS-CoV-2, reducing symptomatology and the SARS-CoV-2 viral load. This antiviral effect appears to depend on the dose used, and if confirmed in future studies, it suggests that ivermectin may be a useful adjuvant to the SOC treatment in patients with mild COVID-19 symptoms.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
The essential oil from
Rosmarinus officinalis
L. (OERO) has bioactive compounds with anti-inflammatory activity. The objective of this study was to evaluate the anti-inflammatory potency of ...nanoemulsions containing essential oil of
Rosmarinus officinalis
L. (NOERO, NECHA, NECULT, and NECOM) in vitro and in vivo. This study was accomplished in a quantitative format through tests with diphenyl picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cellular antioxidant activity (CCA), determination of nitric oxide production, cellular viability and anti-inflammatory activity in zebrafish. OERO’s were submitted to the analysis-coupled gas chromatography–mass spectrometry (GC–MS), which highlighted 1,8-cineol and camphor as major compounds. NOEROs were obtained by a low-energy method and presenting the medium size smaller than 200 nm. The efficiency of encapsulation by spectrometry and gas chromatographic analysis was 67.61 and 75.38%, respectively. In the CCA assay, all of the samples presented percentage values of inhibition similar to the quercetin pattern, indicating antioxidant activity. In the test for determination of NO·, all of the samples inhibited the production of NO· when compared to LPS, and NOEROS were more effective than OEROS to 5 µg/mL. In the cell viability assay, the cells remained viable after contact with the samples, demonstrating an absence of cytotoxicity. This study showed that all nanoemulsions (NECHA, NECULT, and NECOM) showed no toxicity to macrophages, besides demonstrating antioxidant activity and potentiation of the essential oil effect in the proliferation of viable fibroblasts. Nanoemulsions has also shown the ability to potentiate the anti-inflammatory action of essential oils by exerting immunomodulatory activity by inhibiting the production of the pro-inflammatory mediator nitric oxide. The results obtained with NECHA in zebrafish confirm the hypothesis that prominent terpenic compounds, alpha-pinene, 1,8-cineole, and camphor, became more available at the target sites, inhibiting the inflammatory process in this animal species.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Several studies have shown conflicting results for the relationship between vitamin D deficiency and COVID-19 outcomes. Here, we aimed to evaluate whether plasma 25(OH)D levels predict mortality in ...adults admitted with COVID-19, considering potential confounders.
We conducted a retrospective cohort study that included 115 adults (age 62.1 ± 17.6 years, 65 males) admitted to a Brazilian public hospital for severely symptomatic COVID-19. Subjects were classified into two groups according to their plasma levels of 25(OH)D: sufficiency (≥50 nmol/L) and the deficiency (<50 nmol/L). The diagnosis of COVID-19 was performed using real-time polymerase chain reaction (qPCR). In addition, direct competitive chemiluminescence immunoassay assessed serum 25(OH)D levels.
The all-cause 30-day mortality was 13.8% (95% CI: 6.5%–21%) in the group of patients with sufficient plasma 25(OH)D levels and 32.1% (95% CI: 14.8%–49.4%) among those with deficient plasma 25(OH)D levels. Cox regression showed that plasma 25(OH)D levels remained a significant predictor of mortality even after adjusting for the covariates sex, age, length of the delay between symptom onset and hospitalization, and disease severity (HR = 0.98, 95% CI: 0.96–1.00; p = 0.02).
Vitamin D deficiency predicts higher mortality risk in adults with COVID-19.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A presente pesquisa justifica-se pela necessidade de conhecimento quantitativo e qualitativo, oportunidades e limitações referentes aos empreendimentos que atuam no ramo da reciclagem em ...Castanhal-PA. O método utilizado nesta pesquisa foi o dedutivo. A abrangência da pesquisa constituiu a observativa, sistemática e direta, associada ao levantamento de dados documentais. Para complementar os dados do diagnóstico referente as questões de gestão/gerenciamento de RS no município de Castanhal-PA, realizou-se um levantamento das principais empresas que atuam no ramo da triagem e reciclagem de RS no município. Referente a identificação de empresas que atuam no ramo da reciclagem em Castanhal-PA, os dados obtidos indicaram um total de 36 (trinta e seis) empreendimentos com CNPJ registrado, sendo que 19 (dezenove) estão em operação e 17 (dezessete) com baixa no CNPJ ou inativa. Neste contexto, é importante destacar a representatividade dos empreendimentos regularizados nos últimos cinco anos, aproximadamente (58%). Os dados obtidos também indicaram que a maior proporção de resíduos produzidos são: papel, papelão, plástico de diversas densidades, vidro e metais. Em relação às 11 (onze) empresas que não possuem licenciamento ambiental, a amostragem enumerou como fatores que justificam esta situação como sendo: ausência de incentivo por parte do setor público; altas taxas públicas administrativas (Documento de Arrecadação Municipal (DAM); taxas para emissão da licença prévia, licença de instalação e licença de operação; e, valores aplicados para solicitação de declaração de dispensa de outorga, quando a atividade utiliza este recurso no processo produtivo. Apenas 5 (cinco) empresas estão devidamente licenciadas pela SEMMA de Castanhal-PA, tendo como fatores limitantes no processo de licenciamento, a demasiada burocracia citada pela amostragem e taxas administrativas elevadas. Portanto, foi identificado que tal seguimento de atividades corrobora com a redução de materiais que seriam encaminhados ao vazadouro a céu aberto municipal e pode servir como subsídios para a tomada de decisão do poder público, além de permitir sintetizar as informações municipal de empreendimentos recicladores.
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).
The article has been retracted at the ...request of the Founding Editor, Prof. Lawrence H. Lash, on the basis that there is clear evidence that the findings are unreliable: https://publicationethics.org/files/retraction-guidelines-cope.pdf.
Additional external review of this published paper raised several concerns. While a properly conducted clinical trial is certainly welcome, the experimental design of this study lacks sufficient details for some of the methods and approaches, uses inappropriate or inadequate statistical analysis, and presents unclear data interpretation.
The conclusions and statements of the authors cannot be readily supported by the information presented in the paper.
Additionally, no reference is made to the well-known controversies that surrounded the recommended use of ivermectin to treat infections with COVID-19. https://www.nature.com/articles/d41586-020-01695-w; https://www.the-scientist.com/news-opinion/surgisphere-sows-confusion-about-another-unproven-covid19-drug-67635 The omission of any discussion of these controversies in the present paper makes the paper misleading and unacceptable.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
O esgotamento sanitário é um processo essencial à manutenção da saúde pública da população de um município. Nesse sentido, a falta de tratamento do esgoto resulta em problemas como o surgimento de ...doenças endêmicas e contaminação de recursos naturais. O objetivo desta pesquisa foi verificar e analisar a destinação e disposição final dos resíduos, gases e rejeitos oriundos do tratamento de efluentes das estações de tratamento de esgoto - ETE do município de Paragominas-PA. O método aplicado foi o dedutivo, pois, com tal processo de raciocínio é possível, partindo de uma ou mais premissas a obtenção de uma conclusão imprescindível e evidente. Esta é uma pesquisa de caráter exploratório, com aplicação de formulário semiestruturado para obtenção de respostas esclarecedoras sobre a quantidade, tipo e disposição/destinação final de resíduos gerados e retirados das estações de tratamento de esgoto em funcionamento no município de Paragominas-PA. A análise dos dados obtidos indicou a presenta em maiores proporções de efluentes, lodos e resíduos sólidos. Os resíduos sólidos juntamente com o lodo são dispostos no aterro controlado municipal, os gases passam por filtros e são dispostos na atmosfera, já os efluentes são lançados em um corpo hídrico receptor, após condições adequadas. Entretanto não se tem dados quantitativos precisos e com proposições para mitigação dos impactos a partir do quantitativo de gases, efluentes e resíduos sólidos gerados.
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