A search for dark matter linelike signals iss performed in the vicinity of the Galactic Center by the H.E.S.S. experiment on observational data taken in 2014. An unbinned likelihood analysis iss ...developed to improve the sensitivity to linelike signals. The upgraded analysis along with newer data extend the energy coverage of the previous measurement down to 100 GeV. The 18 h of data collected with the H.E.S.S. array allow one to rule out at 95% C.L. the presence of a 130 GeV line (at l=-1.5°, b=0° and for a dark matter profile centered at this location) previously reported in Fermi-LAT data. This new analysis overlaps significantly in energy with previous Fermi-LAT and H.E.S.S.
No significant excess associated with dark matter annihilations was found in the energy range of 100 GeV to 2 TeV and upper limits on the gamma-ray flux and the velocity weighted annihilation cross section are derived adopting an Einasto dark matter halo profile. Expected limits for present and future large statistics H.E.S.S. observations are also given.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
The aim of this study was to evaluate the incremental benefit of biomarkers for prediction of Alzheimer's disease dementia (ADD) in patients with mild cognitive impairment (MCI) when added stepwise ...in the order of their collection in clinical routine. The model started with cognitive status characterized by the ADAS-13 score. Hippocampus volume (HV), cerebrospinal fluid (CSF) phospho-tau (pTau), and the FDG t-sum score in an AD meta-region-of-interest were compared as neurodegeneration markers. CSF-Aβ1-42 was used as amyloidosis marker. The incremental prognostic benefit from these markers was assessed by stepwise Kaplan-Meier survival analysis in 402 ADNI MCI subjects. Predefined cutoffs were used to dichotomize patients as 'negative' or 'positive' for AD characteristic alteration with respect to each marker. Among the neurodegeneration markers, CSF-pTau provided the best incremental risk stratification when added to ADAS-13. FDG PET outperformed HV only in MCI subjects with relatively preserved cognition. Adding CSF-Aβ provided further risk stratification in pTau-positive subjects, independent of their cognitive status. Stepwise integration of biomarkers allows stepwise refinement of risk estimates for MCI-to-ADD progression. Incremental benefit strongly depends on the patient's status according to the preceding diagnostic steps. The stepwise Kaplan-Meier curves might be useful to optimize diagnostic workflow in individual patients.
Summary A major threat to tuberculosis (TB) control programs is the emergence of drug resistant Mycobacterium tuberculosis strains that cause TB that cannot be cured by standard anti-TB drug ...regimens. Because few data exist on MDR-TB in this region of the country, we performed an epidemiologic study that combined conventional and molecular analysis of MDR-TB cases from Rio Grande do Sul (RS) that were diagnosed in this period and included cases that were under treatment with second line drug schemes. Included were 121 MDR cases and sequencing of rpo B and kat G showed that 106 (87.6%) strains were mutated in rpo B and 97 (80.2%) in kat G. Spoligotyping demonstrated that the LAM genotype was predominant ( n = 70, 57.8%) and included the largest group composed by 22 (18.1%) strains with the LAM5 ST93 genotype. Other main genotypes belonged to the families T ( n = 22, 18.2%), U family ( n = 16, 13.2%), Haarlem ( n = 5, 4.1%) and X ( n = 1, 0.8%). Genotyping by IS 6110- RFLP analysis showed 51 distinct fingerprints, 38 (31.4%) of these observed only once and the other 13 patterns being shared among the rest of the isolates ( n = 83, 68.6%). Among the 22 strains that were LAM5 ST93, only two had different IS 6110 -RFLP genotypes. In conclusion, there exists a high degree of M. Tuberculosis genotype clustering among MDR-TB cases in Rio Grande do Sul. Moreover, we observed a large MDR-TB outbreak.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
We present the first observation of K^{-} and ϕ absorption within nuclear matter by means of π^{-}-induced reactions on C and W targets at an incident beam momentum of 1.7 GeV/c studied with HADES ...at SIS18/GSI. The double ratio (K^{-}/K^{+})_{W}/(K^{-}/K^{+})_{C} is found to be 0.319±0.009(stat)_{-0.012}^{+0.014}(syst) indicating a larger absorption of K^{-} in heavier targets as compared to lighter ones. The measured ϕ/K^{-} ratios in π^{-}+C and π^{-}+W reactions within the HADES acceptance are found to be equal to 0.55±0.04(stat)_{-0.07}^{+0.06}(syst) and to 0.63±0.06(stat)_{-0.11}^{+0.11}(syst), respectively. The similar ratios measured in the two different reactions demonstrate for the first time experimentally that the dynamics of the ϕ meson in nuclear medium is strongly coupled to the K^{-} dynamics. The large difference in the ϕ production off C and W nuclei is discussed in terms of a strong ϕN in-medium coupling. These results are relevant for the description of heavy-ion collisions and the structure of neutron stars.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UL, UM
The circadian rhythm of clinical symptoms in rheumatoid arthritis (RA) has been primarily attributed to circadian variations in humoral factors and hormones. In this study, we investigated circadian ...rhythms of cellular immunity in RA (CiRA study).
Peripheral blood of female postmenopausal patients with active RA (DAS 28 ≥ 4.2) (n=5) and female postmenopausal non-RA controls (n=5) was collected every 2 hours for 24 hours and analysed by flow cytometry, cytokine multiplex suspension array and quantitative RT-PCR of clock gene expression in isolated CD14+ monocytes. Endogenous circadian rhythms of macrophages were investigated by BMAL1-luciferase bioluminescence. Significance of circadian rhythms was tested by Cosinor analysis.
We found (i) circadian rhythms in the relative frequency of peripheral blood cell populations that were present in postmenopausal non-RA controls but absent in patients with active RA, (ii) circadian rhythms that were absent in non-RA controls but present in patients with RA and (iii) circadian rhythms that were present in both groups but with differences in peak phase or amplitude or amplitude/magnitude. The circadian rhythm in expression of the clock genes PER2 and PER3 in CD14+ monocytes was lost in patients with RA. The amplitude of BMAL1-luciferase bioluminescence tended to be lower in patients with RA than in non-RA controls.
We conclude that (i) in RA some immune cell populations lose their normal circadian rhythms whereas others establish new 'inflammatory' circadian rhythms and (ii) these findings provide a good basis for further identifying pathophysiological aspects of RA chronobiology with potential therapeutic implications.
Background
The aim was to analyse the association between severity of complications up to 30 days after surgery and pre‐operative nutritional and physical performance parameters.
Methods
The ...participants were a subsample of the previously published PERATECS study (ClinicalTrials.gov: NCT01278537) and included 517 onco‐geriatric patients aged ≥ 65 years, undergoing thoracoabdominal, gynaecological, or urological surgery. Post‐operative complications were classified according to the Clavien Classification System (CCS). Independent risk factors related to the severity of complications, defined as major complications (CCS IIIa‐V) and graded complications (CCS grade 0‐V), were analysed using logistic and ordinal regression, respectively.
Results
In total, 132 patients suffered major post‐operative complications. The development of major post‐operative complications was independently associated with body mass index (BMI) < 20 kg/m2, hypoalbuminaemia (< 30 g/l), longer duration of surgery, and specific tumour sites (upper gastrointestinal, gynaecological, colorectal) (all P < 0.05). Higher‐grade complications were predicted by Timed Up and Go (TUG) > 20 s, hypoalbuminaemia (< 30 g/l), higher American Society of Anesthesiologists (ASA) status III‐IV, longer duration of surgery (> 165 min), and specific tumour sites (upper gastrointestinal, gynaecological) (all P < 0.05). Mini Nutritional Assessment (MNA) scores and weight loss were not independent risk factors for the severity of complications.
Conclusions
Nutritional and physical performance risk factors that predicted the severity of complications differed between major and higher‐grade post‐operative complications, but hypoalbuminaemia independently predicted both. The results support the need for pre‐operative risk screening. Due to the explorative nature of the study, further research is required in larger cohorts to corroborate these findings.
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BFBNIB, DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UILJ, UKNU, UL, UM, UPUK
The stimulatory NKG2D lymphocyte receptor together with its tumor-associated ligands enable the immune system to recognize and destroy cancer cells. However, with dynamic changes unfolding, cancers ...exploit NKG2D and its ligands for immune evasion and suppression. Recent findings have added yet another functional dimension, wherein cancer cells themselves co-opt NKG2D for their own benefit to complement the presence of its ligands for self-stimulation of parameters of tumorigenesis. Those findings are here extended to in vivo tumorigenicity testing by employing orthotopic xenotransplant breast cancer models in mice. Using human cancer lines with ectopic NKG2D expression and RNA interference (RNAi)-mediated protein depletion among other controls, we show that NKG2D self-stimulation has tumor-promoting capacity. NKG2D signals had no notable effects on cancer cell proliferation and survival but acted at the level of angiogenesis, thus promoting tumor growth, tumor cell intravasation and dissemination. NKG2D-mediated effects on tumor initiation may represent another factor in the observed overall enhancement of tumor development. Altogether, these results may have an impact on immunotherapy approaches, which currently do not account for such NKG2D effects in cancer patients and thus could be misdirected as underlying assumptions are incomplete.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Tree seedling establishment and growth were studied in experimental canopy gaps to assess the effect of heterogeneity of regeneration microsites within and among gaps in mature conifer forests. ...Seedlings were studied for two years in closed-canopy areas and in recently created gaps ranging in size from 40 to 2000 m2 in four stands of mature (90-140 yr) and old-growth ($>$400 yr) Douglas-fir forest in the western Cascade Range of central Oregon and southern Washington, USA. We examined the relative importance of substrate type, shade from logs and shade cloth, density of understory vegetation, gap size, and forest age on the success of Pacific silver fir (Abies amabilis), Douglas-fir (Pseudotsuga menziesii), and western hemlock (Tsuga heterophylla). Seedlings originating from seed sown on experimental microsites were compared with seedlings regenerating naturally on a range of microsites. Seedling establishment was greater on decayed wood than on forest floor or mineral soil in closed-canopy areas, particularly for Tsuga. Differences in establishment among substrates declined with increasing gap size, although establishment on the forest floor tended to be low in portions of large gaps exposed to direct solar radiation. In exposed areas, shade from woody debris and shade cloth facilitated establishment for all species, while shade from understory vegetation aided the establishment of Pseudotsuga but not that of Tsuga. Establishment in shaded portions of gaps declined with vegetation and shade-cloth cover. Seedling size increased with gap size, decreased with level of shade, and tended to be greatest on forest floor and lowest on decayed wood. Establishment and growth of the different species was related to differences in seed mass and tolerance of environmental extremes. Heterogeneity at the seedling scale ($<$10 cm) often overrode larger-scale environmental gradients ($>$2 m) associated with gap size and within-gap position. Thus the gap partitioning hypothesis, which emphasizes gap size and within-gap position, may be too simple to account for the role of microsite heterogeneity and species' regeneration traits on the development of mature forests.
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BFBNIB, FZAB, GIS, IJS, INZLJ, KILJ, NLZOH, NMLJ, NUK, OILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK, ZRSKP
Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it is critical to identify factors that underlie impaired social functioning as well ...as processes that mediate the beneficial health effects of positive relationships in individuals exposed to CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations in specific inter- and intrapersonal processes (e.g., regulation of closeness and distance) that underlie problems in broader domains of social functioning (e.g., lack of perceived social support) in individuals affected by CM; (2) identifying internal (e.g., current emotional state) and external situational factors (e.g., cultural factors, presence of close others) that modulate alterations in specific social processes; and (3) identifying mechanisms that explain the positive health effects of intact social functioning. Methodological recommendations include: (1) assessing social processes through interactive and (close to) real-life assessments inside and outside the laboratory; (2) adopting an interdisciplinary, lifespan perspective to assess social processes, using multi-method assessments; (3) establishing global research collaborations to account for cultural influences on social processes and enable replications across laboratories and countries. The proposed line of research will contribute to globally develop and refine interventions that prevent CM and further positive relationships, which – likely through buffering the effects of chronic stress and corresponding allostatic load – foster resilience and improve mental and physical health, thereby reducing personal suffering and the societal and economic costs of CM and its consequences. Interventions targeting euthymia and psychological well-being are promising therapeutic concepts in this context.
A Burning Problem Charnley, Susan; Poe, Melissa R.; Ager, Alan A. ...
Human organization,
12/2015, Volume:
74, Issue:
4
Journal Article
Peer reviewed
Disasters result from hazards affecting vulnerable people. Most disasters research by anthropologists focuses on vulnerability; this article focuses on natural hazards. We use the case of wildfire ...mitigation on United States Forest Service lands in the northwestern United States to examine social, political, and economic variables at multiple scales that influence fire hazard and risk reduction treatments and their effectiveness. Variables highlighted include policy direction to prioritize wildfire risk reduction in the wildland-urban interface, laws and policies that make treating fuels in some national forest land management allocations challenging, social and political constraints on using prescribed fire, agency budget and target pressures, and integrating fire hazard reduction into forest management projects having multiple objectives. These variables compromise the effectiveness of wildfire mitigation treatments. Understanding the social dynamics of natural hazard mitigation is important because they affect its outcomes, creating differential exposure to natural hazards—one component of social vulnerability. Interdisciplinary research to identify how the social dynamics of natural hazard mitigation influence hazard reduction outcomes can contribute to more informed and effective approaches to disaster risk reduction.
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BFBNIB, CEKLJ, NMLJ, NUK, ODKLJ, PNG, UL, UM, UPUK
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