A 64-year-old female receiving clopidogrel and aspirin antiaggregation therapy after percutaneous coronary intervention for non-STEMI myocardial infarction developed nontraumatic bilateral subdural ...hematoma with dizziness, vertigo and headache. Craniotomy had to be postponed because of reduced ADP platelet aggregability. Four days after clopidogrel withdrawal and transfusion of 12 platelet concentrate units, ADP aggregation transiently normalized and bilateral trepanation with hematoma evacuation was performed. The procedure was followed by excellent neurologic and clinical recovery; however, decreased platelet aggregability was recorded by postoperative day 12 despite strict clopidogrel and other platelet inhibitor withdrawal. Suspicion of Glanzmann thrombastenia was excluded by flow cytometry. Two weeks after neurosurgery, the right femoral vein thrombosis was detected by color doppler ultrasonography and therapy with fractionated heparin was initiated, followed by warfarin. The risk and incidence of hemorrhagic complications of antiaggregation and anticoagulation therapy are discussed. Caution is warranted on prescribing this potentially harmful therapy to older patients, generally burdened with other chronic comorbidities.
The objective of the paper is to research if the specificities of insurance business influence the fact that in insurance companies more components of other comprehensive income occur, as well as if ...in insurance companies different components of other comprehensive income are represented compared to the companies from the real sector. Furthermore, the paper should show if net income and net comprehensive income of insurance companies are significantly different, and which one of them is more volatile over time. The results of the research suggest that in the insurance companies more components of other comprehensive income are represented than in the companies from the real sector, as well as that that the most represented components of other comprehensive income in insurance companies are not different from the real sector companies, but that their frequency of appearance is higher. Statistical analysis conducted at the level of population has shown that net income and net comprehensive income are not significantly different. Also, it was established that net comprehensive income of insurance companies was more volatile over time than net income. However, by segmentation of total population according to types of insurance dealt with by insurance companies to life insurance companies, non-life insurance companies and those doing activities of both life and non-life insurance, it was established that in certain cases net income and net comprehensive income are statistically significantly different, as well as that net income was more volatile than net comprehensive income.
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The basic objective of the paper is the examination of mutual interdependence of the parameters on insurance market and the economic growth at the specific area of ex-Yugoslavia. Time horizon of the ...observation encompasses the period 2005-2019, and as the appropriate methodological framework, the econometrics of panel data was used. The accompanying co-integration tests and tests of long-term effects have shown that the insurance sector and economic growth are long-term related, as well as that the insurance sector exerts positive and statistically significant influence on the economic growth. Additionally, it was shown that non-life insurance realizes more significant effects on growth. To confirm robustness, causality test has shown that changes in insurance sector cause the changes in economic growth. Economic policy makers have an important task ahead of them, which consists in promoting insurance markets, improvement of regulation, and legislation framework that should contribute to the growth of economic activity in analyzed countries.
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The objective of the paper is to research if the specificities of insurance business influence the fact that in insurance companies more components of other comprehensive income occur, as well as if ...in insurance companies different components of other comprehensive income are represented compared to the companies from the real sector. Furthermore, the paper should show if net income and net comprehensive income of insurance companies are significantly different, and which one of them is more volatile over time. The results of the research suggest that in the insurance companies more components of other comprehensive income are represented than in the companies from the real sector, as well as that that the most represented components of other comprehensive income in insurance companies are not different from the real sector companies, but that their frequency of appearance is higher. Statistical analysis conducted at the level of population has shown that net income and net comprehensive income are not significantly different. Also, it was established that net comprehensive income of insurance companies was more volatile over time than net income. However, by segmentation of total population according to types of insurance dealt with by insurance companies to life insurance companies, non-life insurance companies and those doing activities of both life and non-life insurance, it was established that in certain cases net income and net comprehensive income are statistically significantly different, as well as that net income was more volatile than net comprehensive income.
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Pancreatic endocrine tumors are rare, and among them large non-functioning tumors of uncertain behavior are extremely infrequent. Non-functioning pancreatic endocrine tumors originate from the ...endocrine part of the pancreas but are not associated with a distinct hormonal syndrome. A rare case is presented of a 49-year-old woman with a well-differentiated endocrine tumor of uncertain behavior that presented with intermittent pain in the epigastrium radiating to the right subcostal region. Computed tomography showed a well-defined and circumscribed solid mass in the pancreas head. The pancreatic mass was surgically removed and submitted for histopathologic analysis. Microscopically, the tumor had relatively uniform cells with oval nuclei that coated trabecular and pseudoglandular structures, which also showed 1 mitosis per 10 VVP and proliferation activity measured with Ki67 of less than 2%. A focus of intravascular invasion was seen on one slide. Immunohistochemical analyses for NSE, chromogranin and synapthophysin were positive, which along with its size (over 2 cm in diameter) and reported angioinvasion indicated the diagnosis of pancreatic endocrine tumor of uncertain behavior. Although mostly considered as malignant, large non-functioning pancreatic endocrine tumors can sometimes express benign or uncertain behavior; therefore, a large number of factors should always be considered when determining the biological nature of these tumors.
This paper examines the applicability of the CAPM (Capital Asset Pricing Model) and conditional CAPM in the Belgrade Stock Exchange (BSE) in order to determine whether both the CAPM and conditional ...CAPM can be reliably applied to this emerging market. The returns were collected from the official BSE website for the period from January 2010 to December 2014. Time-series data were then collected for 60 monthly returns of the selected stocks, which is a common practice in model testing. The time-series data were observed for 60 months, which is long enough for all short-term shocks to be neutralized and for beta coefficients to be adjusted to their long-term values. The results of this study indicate that both the CAPM and conditional CAPM cannot be reliably applied in the BSE. The paper suggests that beta cannot be reliably used as a tool for explaining cross-sectional differences in the returns in the BSE and as a measure of market risk.
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Information about the financial status and performance of a company, which are presented in financial statements, has been of great importance for users since it represents the basis for resource ...allocation decision making. Accordingly, reliable and transparent financial reporting, which results in truthful and honest representation of a company’s financial achievements, is a vital determinant of financial system reliability and stability. Numerous financial frauds and scandals at the turn of this century revealed the risks of numerous users and economic decision-makers’ losing trust in the reliability of financial information withinfinancial statements. Only by revealing financial statement fraud causes and methods can the accounting profession regain the credibility of information in financial statements. Numerous financial scandals that happened in the previous period showed that the role of auditors (both internal and external) cannot be enough for fraud prevention. Consequently, the accounting profession began to utilize forensic accounting. The main task of forensic accounting is to detect and investigate financial statement frauds in accordance with legal procedures and methods. The role of forensic accounting in investigating and preventing financial statement frauds is the subject of this paper.
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The Coagulation Section at Laboratory of Hematology, Sestre milosrdnice University Hospital, Zagreb, was founded in 1955 by Ljubomir Popović, hematologist and assistant at School of Medicine, ...University of Zagreb, in cooperation with hard-working laboratory technicians. Apart from papers on hematologic neoplasms, plasmacytoma and lymphoma, Ljubomir Popović published a number of papers in the field of anticoagulant therapy with heparin and oral anticoagulants, some of which are also in use today. After Ljubomir Popović left the Hospital in 1964, the Laboratory was run by Professor Nedjeljko Milić, head of the newly founded Division of Hematology. In 1968, the management of the Laboratory of Hematology was taken over by Biserka Raić, MS, medical biochemist, until her retirement in 2007. Great development in morphological and cytometric studies of blood and blood cells has been paralleled by continuous progress and almost dominating activities in the diagnosis of hemostasis disorders. In the 1970s, Marko Koprcina, hematologist, and Biserka Raić introduced the then latest tests in practice at all Hospital departments. In that golden age of the Coagulation Section, M. Koprcina, B. Raić and their associates transferred their knowledge to all colleagues in the Hospital. Through that collaboration, high standards in the diagnosis of hemostasis disorders were achieved, from which the currently high level of clinical knowledge about coagulation disorders and their treatment has derived, making Sestre milosrdnice University Hospital one of the leading hospitals in this field in the country. By describing development of the Coagulation Section and the life of its founder Ljubomir Popović, the authors tried to provide an answer to the following question: can today's clinicians still have a deciding role in laboratory development, considering that assessments of different phenomena are always initiated by an interested clinician who is trying to interpret and understand the nature of the disorder? This means that the clinician's place may still be in the laboratory, or else, it will become clear that the laboratory, as well as knowledge in general, has undergone such an expansion that the clinician is no longer able to run it by himself. It is our belief that the answer will assert itself through the survey of the history of the Coagulation Section at Laboratory of Hematology, Division of Hematology, and the lives of its founders and beneficiaries.
Koagulacijski odsjek Hematološkog laboratorija u Kliničkoj bolnici “Sestre milosrdnice” osnovao je davne 1955. godine hematolog Ljubomir Popović, uza svesrdno zalaganje suradnika laboratorijskih ...tehničara. Doktor Popović je tada bio asistent na Medicinskom fakultetu i voditelj Odsjeka hematologije na internom odjelu. U novoosnovanom laboratoriju doktor Popović traži rješenja i odgovore na pitanja koja se javljaju u kliničkoj praksi uz bolesnički krevet. Stručni napredak praćen je objavljivanjem niza članaka o hemoblastozama i protuzgrušavajućoj terapiji, koje postavke vrijede i danas. Ujesen 1964. godine Popović u naponu snage napušta Bolnicu, a Koagulacijski laboratorij dalje vodi profesor Nedjeljko Milić, pročelnik novostvorenoga Zavoda za hematologiju. Godine 1968. dolazi inženjerka medicinske biokemije magistra Biserka Raić i vodi Hematološki laboratorij do svog umirovljenja 2007. godine. Golem napredak bilježi dijagnostika poremećaja hemostaze, ali i citometrijske i morfološke analize krvnih stanica. Sedamdesetih i osamdesetih godina prošloga stoljeća, u zlatno doba razvoja i rada Koagulacijskog laboratorija, hematolog Marko Koprčina sa suradnicima te inženjeri biokemije Biserka Raić i Biserka Getaldić uvode niz novih koagulacijskih i viskozimetrijskih testova u kliničku praksu Bolnice. Ovaj hematološko-koagulacijski klinički rad čini Zavod za hematologiju naše bolnice, s liječnicima i inženjerima, jedinstvenim i prepoznatljivim. Uz opis razvoja Koagulacijskog laboratorija te života njegova osnivača Ljubomira Popovića autori pokušavaju odgovoriti na pitanje može li i mora li danas, kao prije pedeset godina, kliničar imati odlučujuću ulogu u razvoju i radu laboratorija. Autori smatraju da je kliničaru internistu i dalje mjesto u laboratoriju, ali uz gotovo neispunjiv uvjet sinteze bazičnih znanja iz biologije, tehnologije s kliničkom praksom. Razvoj Koagulacijskog laboratorija te životni put njegova osnivača doktora Ljubomira Popovića pokazuju kako bi njemu ova sinteza, isto kao i prije 55 godina, možda uspjela i danas.
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