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  • Persistence of Plasmodium f... Persistence of Plasmodium falciparum HRP-2 antigenaemia after artemisinin combination therapy is not associated with gametocytes
    Oulton, Tate; Mahamar, Almahamoudou; Sanogo, Koualy ... Malaria journal, 12/2022, Volume: 21, Issue: 1
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    In some settings, sensitive field diagnostic tools may be needed to achieve elimination of falciparum malaria. To this end, rapid diagnostic tests (RDTs) based on the detection of the Plasmodium ...
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  • Naturally acquired immunity... Naturally acquired immunity to sexual stage P. falciparum parasites
    Stone, Will J R; Dantzler, Kathleen W; Nilsson, Sandra K ... Parasitology, 02/2016, Volume: 143, Issue: 2
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    Gametocytes are the specialized form of Plasmodium parasites that are responsible for human-to-mosquito transmission of malaria. Transmission of gametocytes is highly effective, but represents a ...
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3.
  • Naturally acquired immunity against immature Plasmodium falciparum gametocytes
    Dantzler, Kathleen W; Ma, Siyuan; Ngotho, Priscilla ... Science translational medicine, 06/2019, Volume: 11, Issue: 495
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    Open access

    The recent decline in global malaria burden has stimulated efforts toward elimination. Understanding the biology of malaria transmission stages may provide opportunities to reduce or prevent onward ...
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  • Two-Faced Immunity? The Evi... Two-Faced Immunity? The Evidence for Antibody Enhancement of Malaria Transmission
    Stone, Will; Bousema, Teun; Sauerwein, Robert ... Trends in parasitology, February 2019, 2019-02-00, 20190201, Volume: 35, Issue: 2
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    Plasmodium gametocytes can induce an immune response in humans that interferes with the development of sexual-stage parasites in the mosquito gut. Many early studies of the sexual-stage immune ...
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  • An inter-laboratory compari... An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines
    Miura, Kazutoyo; Stone, Will J R; Koolen, Karin M ... Malaria journal, 09/2016, Volume: 15, Issue: 1
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    An effective malaria transmission-blocking vaccine may play an important role in malaria elimination efforts, and a robust biological assay is essential for its development. The standard ...
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  • Immunity against sexual sta... Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
    Jong, Roos M.; Tebeje, Surafel K.; Meerstein‐Kessel, Lisette ... Immunological reviews, January 2020, Volume: 293, Issue: 1
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    Summary The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to ...
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  • A semi-automated luminescen... A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes
    Vos, Martijn W; Stone, Will J R; Koolen, Karin M ... Scientific reports, 12/2015, Volume: 5, Issue: 1
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    Current first-line treatments for uncomplicated falciparum malaria rapidly clear the asexual stages of the parasite, but do not fully prevent parasite transmission by mosquitoes. The standard ...
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  • Examining the human infecti... Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity
    Gonçalves, Bronner P; Kapulu, Melissa C; Sawa, Patrick ... Nature communications, 10/2017, Volume: 8, Issue: 1
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    A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide ...
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  • The relevance and applicabi... The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays
    Stone, Will J R; Eldering, Maarten; van Gemert, Geert-Jan ... Scientific reports, 12/2013, Volume: 3, Issue: 1
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    Mosquito feeding assays are important in evaluations of malaria transmission-reducing interventions. The proportion of mosquitoes with midgut oocysts is commonly used as an outcome measure, but in ...
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  • The acquisition of humoral ... The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections
    de Jong, Roos M; Alkema, Manon; Oulton, Tate ... Frontiers in immunology, 07/2022, Volume: 13
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    Individuals infected with develop antibody responses to intra-erythrocytic gametocyte proteins and exported gametocyte proteins present on the surface of infected erythrocytes. However, there is ...
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