Medical sealant devices for in vivo hemostasis are far from satisfactory in the aged society. A major challenge is effective integration of quick hemorrhage control of the increased anticoagulated ...patients, high safety, and facile accessibility. Here, a well‐defined ammonolysis‐based Tetra‐PEG hydrogel sealant is developed with rapid gelation speed, strong tissue adhesion, and high mechanical strength. Introduction of cyclized succinyl ester groups into a hydrogel matrix endows the sealant with fast degradable and controllably dissolvable properties. The hydrogel possesses outstanding hemostatic capabilities even under the anticoagulated conditions while displaying excellent biocompatibility and feasibility. These results reveal that the optimized hydrogel may be a facile, effective, and safe sealant for hemorrhage control in vivo.
A PEG sealant with fast and controllable degradation properties is constructed for in vivo visceral organ hemostasis, which possesses high hemostatic efficacy even under anticoagulated situations and which, even more remarkably, does not hinder the tissue healing and cause side effects.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Electronic skin, a class of wearable electronic sensors that mimic the functionalities of human skin, has made remarkable success in applications including health monitoring, human-machine ...interaction and electronic-biological interfaces. While electronic skin continues to achieve higher sensitivity and faster response, its ultimate performance is fundamentally limited by the nature of low-frequency AC currents. Herein, highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers (MNFs) in thin layers of polydimethylsiloxane (PDMS). Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli, the skin-like optical sensors show ultrahigh sensitivity (1870 kPa-1), low detection limit (7 mPa) and fast response (10 μs) for pressure sensing, significantly exceeding the performance metrics of state-of-the-art electronic skins. Electromagnetic interference (EMI)-free detection of high-frequency vibrations, wrist pulse and human voice are realized. Moreover, a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated. These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins.
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FFLJ, NUK, ODKLJ, UL, UM, UPUK
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► Reconstitution of AquaporinZ into polymerized lipid vesicles for pressure-driven water purification purposes is demonstrated. ► Immobilization of the polymerized vesicles on porous ...substrates is achieved via robust amine-catechol reactions. ► The polymerized vesicles on porous substrates could sustain high pressure and surface shear in the nanofiltration tests.
Aquaporins are water channel proteins in biological membranes that have extraordinary water permeability and selectivity. In this work, we have demonstrated that one of their family members, AquaporinZ (AqpZ), can be possibly applied in a pressure-driven water purification process. A nanofiltration membrane was designed and fabricated by immobilization of AqpZ-reconstituted liposomes on a polydopamine (PDA) coated microporous membrane. Amine-functionalized proteoliposomes were first deposited via gentle vacuum suction and subsequently conjugated on the PDA layer via an amine-catechol adduct formation. Due to the existence of a polymer network within the lipid bilayers, the membrane could sustain hydraulic pressure of 5bar as well as the strong surface agitation in nanofiltration tests, indicating a relatively stable membrane structure. In comparison with membrane without AqpZ incorporation, the membrane with AqpZ-to-lipid weight ratio of 1:100 increased the water flux by 65% with enhanced NaCl and MgCl2 rejections of 66.2% and 88.1%, respectively. With AqpZ incorporation, the vesicle immobilized membrane exhibits a promising strategy for high productivity water purification.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
After the founding of the People’s Republic of China, the state formulated the first five-year plan for national economic development with the development of heavy industry as the core. The ...assistance of the Soviet Union completely opened the prelude to China’s large-scale industrial construction. With the continuous increase of urban energy consumption in China and the huge pressure it brings to the environment, urban planning and design aiming at energy conservation and climate adaptability has attracted more and more attention. Residential building layout is an important part of urban planning and design, which is closely related to building environmental energy consumption and urban microclimate. Therefore, it is necessary to study the energy saving and climate adaptive design strategy of residential building layout. Yichun is a cold city, located in the northernmost part of the three northeastern provinces, with a population of about 1 million. Its climate is characterized by continuous low temperature in winter, and the extreme value of daily lowest air temperature in Yichun City since 1981 is -42.2°C. The highest temperature in summer is 35°C. The unique geographical location and climate have created Yichun’s unique urban quality, and outdoor cultural activities are also unique. Yichun is a place with four distinct seasons, and each season has its own characteristics. The beauty of the four seasons contrasts greatly. The best travel time in Yichun is from June to September. In this study, the scientific nature of environment numerical simulation software is verified. Taking the surrounding residential open space as the research object, reasonable grid simulation size and initial boundary conditions are set. The quantitative relationship between design elements and thermal comfort level is established through software simulation. After repeated and a large number of hourly simulation verification, combined with the spatial distribution map and numerical distribution map of thermal comfort, the design elements and open space are established. On this basis, the optimization strategies of open space in residential areas in extreme weather areas are put forward, including the reasonable layout of activity areas, careful selection of open positions, attention to the proportion of open space, attention to plane enclosure and corner units, encouragement of secondary restrictions of activity space, reasonable selection of underlying surface materials, and reasonable layout of water bodies. This paper mainly studies the design of outdoor communication space in Yichun residential area in winter. The average temperature in winter is -14°C ~ -2°C. Through the study of design methods and countermeasures, an operable Yichun residential area design method is found.
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
To improve the ecological and economic benefits of Korean pine (Pinus koraiensis), we analysed and evaluated its germplasm resources. This promotes in-depth research and utilisation of germplasm ...resources, providing excellent genetic resources for Korean pine breeding. We performed genetic analysis based on morphological and physiological traits and nuclear SSR molecular marker data was performed by collecting 314 clones (5 ramets of each clone) of Korean pine from eight (8) locations within the Korean pine range. The core collection underwent testing and evaluation for representativeness using variable rate (VR), coincidence rate (CR), variance difference percentage (VD), mean difference percentage (MD), Shannon index (I), and other indicators. The results indicated significant differences in morphological and physiological traits among the populations. All traits had a coefficient of variation (CV) greater than 10%, except for the water content of the needles (WC), which had an average CV of 17.636%. The populations showed high overall genetic diversity, with the HL (Helong) population exhibiting the highest genetic diversity, with an Ne (number of effective alleles), I, and He (expected heterozygosity) of 3.171, 1.103, and 0.528, respectively. Genetic variation mainly originated from individuals within populations, while the variation between populations was relatively small, at only 3%. The population did not exhibit any distinct subpopulation structures and was mainly derived from two admixed gene pools. Six core sets were obtained using different sampling strategies, and subset 6 was identified as the core collection, consisting of 114 individuals, representing a selection rate of 36.31%. In conclusion, the most appropriate method for constructing the core collection of Korean pines is the M-strategy (maximizing the number of alleles), based on both phenotypic and molecular data. The resulting core collection effectively represents the genetic diversity of the entire population effectively.
Abstract
The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit tumor growth and recurrence, but also to ...repair the defect and preserve the limb function. Hence, it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation. Based on the previous stage, we successfully prepared hydroxyapatite (HAP) composite poly(lactic-co-glycolic acid) (PLGA) scaffolds and verified its good osteogenic properties, in this study, we produced an HAP composite PLGA scaffolds modified with MNPs. The composite scaffold showed appropriate porosity and mechanical characteristics, while MNPs possessed excellent magnetic and thermal properties. The cytological assay indicated that the MNPs have antitumor ability and the composite scaffold possessed good biocompatibility. In vivo bone defect repair experiment revealed that the composite scaffold had good osteogenic capacity. Hence, we could demonstrate that the composite scaffolds have a good effect in bone repair, which could provide a potential approach for repairing bone defect after bone tumor excision.
The creation of improvised dancing choreographies is an important research field of cross-modal analysis. A key point of this task is how to effectively create and correlate music and dance with a ...probabilistic one-to-many mapping, which is essential to create realistic dances of various genres. To address this issue, we propose a GAN-based cross-modal association framework, DeepDance, which correlates two different modalities (dance motion and music) together, aiming at creating the desired dance sequence in terms of the input music. Its generator is to predictively produce the dance movements best-fit to current music piece by learning from examples. In another hand, its discriminator acts as an external evaluation from the audience and judges the whole performance. The generated dance movements and the corresponding input music are considered to be well-matched if the discriminator cannot distinguish the generated movements from the training samples according to the estimated probability. By adding motion consistency constraints in our loss function, the proposed framework is able to create long realistic dance sequences. To alleviate the problem of expensive and inefficient data collection, we propose an effective approach to create a large-scale dataset, YouTube-Dance3D, from open data source. Extensive experiments on currently available music-dance datasets and our YouTube-Dance3D dataset demonstrate that our approach effectively captures the correlation between music and dance and can be used to choreograph appropriate dance sequences.
With the rise of low-carbon concept and the trend of low-carbon planning, the evaluation of low-carbon planning has been paid more and more attention by the academic and planning circles. Carbon ...evaluation has become a hot topic after “environmental evaluation” and “green evaluation.” In order to promote the important content of energy conservation and sustainable development in the construction of low-carbon cities, this paper constructs and plans the content of low-carbon city planning and construction. On the basis of the effectiveness evaluation index system, this paper discusses the linkage between analytic hierarchy process and fuzzy comprehensive evaluation method and makes a comprehensive quantitative evaluation on the effectiveness of case planning EIA. Combining the advantages of analytic hierarchy process and fuzzy comprehensive evaluation method, the subobjectives and weights of each index are determined by the analytic hierarchy process. The multi-level fuzzy comprehensive evaluation method is used to evaluate the factors that affect the low-carbon effect of urban high-rise residential district planning. This study leads the new trend of future urban construction, and the construction of low-carbon residential areas, as an important part of promoting urban sustainable development, is the core component of future low-carbon urban planning and construction.
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FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, UL, UM, UPUK
The current virtual machine(VM) resources scheduling in cloud computing environment mainly considers the current state of the system but seldom considers system variation and historical data, which ...always leads to load imbalance of the system. In view of the load balancing problem in VM resources scheduling, this paper presents a scheduling strategy on load balancing of VM resources based on genetic algorithm. According to historical data and current state of the system and through genetic algorithm, this strategy computes ahead the influence it will have on the system after the deployment of the needed VM resources and then chooses the least-affective solution, through which it achieves the best load balancing and reduces or avoids dynamic migration. This strategy solves the problem of load imbalance and high migration cost by traditional algorithms after scheduling. Experimental results prove that this method is able to realize load balancing and reasonable resources utilization both when system load is stable and variant.
The trade-off between water permeability and selectivity is considered as the biggest challenge during membrane fabrication for water purification. The aquaporin (AQP)-based biomimetic membrane has ...been proven to have both enhanced water permeability and improved selectivity due to the unique features of the AQP protein water channel that permits water molecules and rejects all other components. In this study, a prototype forward osmosis (FO) Aquaporin Inside™ membrane (AIM) was evaluated in terms of intrinsic filtration properties, membrane surface chemistry and fouling behaviour, and compared with a commercial FO membrane. The surface of the prototype AIM appeared to be a modified semi-aromatic polyamide layer instead of fully-aromatic as in other conventional FO products. As a result, compared to the commercial FO membrane, the prototype AIM shows higher water flux and comparable reverse salt flux (RSF) when tested under identical conditions. Due to the lower RSF, the AIM had less organic fouling by a sodium alginate solution when calcium chloride (CaCl2) was used as the draw solution (DS). The membrane integrity of the prototype AIM was maintained after repeated cycles of fouling by high concentration of gypsum and physical cleaning tests. This demonstrates the possibility of using the AIM membrane for treating harsh feed solutions.
•Performance of a prototype aquaporin-based FO membrane (AIM) was investigated.•Remarkable filtration performance exhibited by AIM.•Lower RSF for AIM diminished membrane fouling when CaCl2 was used as a draw solute.•Mechanical integrity of AIM was superior compared to a conventional FO membrane.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
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