All‐solid‐state lithium batteries (ASSLBs) have the potential to revolutionize battery systems for electric vehicles due to their benefits in safety, energy density, packaging, and operable ...temperature range. As the key component in ASSLBs, inorganic lithium‐ion‐based solid‐state electrolytes (SSEs) have attracted great interest, and advances in SSEs are vital to deliver the promise of ASSLBs. Herein, a survey of emerging SSEs is presented, and ion‐transport mechanisms are briefly discussed. Techniques for increasing the ionic conductivity of SSEs, including substitution and mechanical strain treatment, are highlighted. Recent advances in various classes of SSEs enabled by different preparation methods are described. Then, the issues of chemical stabilities, electrochemical compatibility, and the interfaces between electrodes and SSEs are focused on. A variety of research addressing these issues is outlined accordingly. Given their importance for next‐generation battery systems and transportation style, a perspective on the current challenges and opportunities is provided, and suggestions for future research directions for SSEs and ASSLBs are suggested.
Inorganic solid‐state electrolytes (SSEs) offer numerous advantages for the development of next‐generation batteries. The most promising advantages are the safety that benefits from the nonflammable nature of SSEs and the possibility of using a Li‐metal anode, which has highest capacity, lowest anodic potential, and is indispensable to the future success of high‐energy‐density Li–S batteries and Li–O2 battery systems.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Although organic–inorganic halide perovskites continue to generate considerable interest due to great potentials for various optoelectronic devices, there are some critical obstacles to practical ...applications, including lead toxicity, relatively low field-effect mobility, and strong hysteresis during operation. This paper proposes a universal approach to significantly improve mobility and operational stability with reduced dual-sweep hysteresis for perovskite-based thin film transistors (TFTs) by coupling low-dimensional lead-free perovskite material (C6H5C2H4NH3)2SnI4 (hereafter abbreviated as (PEA)2SnI4) with embedded conjugated polymer wrapped semiconducting carbon nanotubes (semi-CNTs). In (PEA)2SnI4/semi-CNT hybrid TFTs, semi-CNTs can provide highway-like transport paths, enabling smoother carrier transport with less trapping and scattering. We also demonstrate the performance of (PEA)2SnI4/semi-CNT hybrid phototransistors with ultrahigh photoresponsivity (R) of 6.3 × 104 A/W and detectivity (D*) of 1.12 × 1017 Jones, which is about 2 or 3 orders of magnitude higher than that of the best devices available to date. The results indicate promising potentials for solution-processed perovskite/semi-CNT hybrid platforms, and the developed strategy can be applied for high-performance perovskite nanomaterial optoelectronics.
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IJS, KILJ, NUK, PNG, UL, UM
Forkhead box protein O1 (FOXO1), a key member of the FOXO family of transcription factors, acts as a tumor suppressor and has been associated with various key cellular functions, including cell ...growth, differentiation, apoptosis and angiogenesis. Therefore, it is puzzling why FOXO protein expression is downregulated in cancer cells. MicroRNAs, non-coding 20~22 nucleotide single-stranded RNAs, result in translational repression or degradation and gene silencing of their target genes, and significantly contribute to the regulation of gene expression. In the current study, we report that miR-370 expression was significantly upregulated in five prostate cancer cell lines, compared to normal prostatic epithelial (PrEC) cells. Ectopic expression of miR-370 induced proliferation and increased the anchorage-independent growth and colony formation ability of DU145 and LNCaP prostate cancer cells, while inhibition of miR-370 reduced proliferation, anchorage-independent growth and colony formation ability. Furthermore, upregulation of miR-370 promoted the entry of DU145 and LNCaP prostate cancer cells into the G1/S cell cycle transition, which was associated with downregulation of the cyclin-dependent kinase (CDK) inhibitors, p27(Kip1) and p21(Cip1), and upregulation of the cell-cycle regulator cyclin D1 mRNA. Additionally, we demonstrated that miR-370 can downregulate expression of FOXO1 by directly targeting the FOXO1 3'-untranslated region. Taken together, our results suggest that miR-370 plays an important role in the proliferation of human prostate cancer cells, by directly suppressing the tumor suppressor FOXO1.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Schottky Barrier in Organic Transistors Xu, Yong; Sun, Huabin; Noh, Yong-Young
IEEE transactions on electron devices,
05/2017, Volume:
64, Issue:
5
Journal Article
Peer reviewed
Organic FETs (OFETs) are essential devices in future flexible electronics. Yet, a crucial issue associated with electronic contact is still unsolved and our fundamental understanding remains very ...limited. Unlike many other previous reports talking about the contact resistance, in this paper, we specifically discuss its major root: the Schottky barrier, by comparison of the conventional metal-silicon contacts, and the unconventional metal-organic contacts, where the special features in OFETs are underlined. We not only examine the basics of the Schottky barrier but also the extrinsic effects as well as the characterization methods. The key factors in device fabrication are also reviewed in order to minimize the detrimental impacts of the Schottky barrier for obtaining optimum device performance.
The donor-acceptor (D-A)-type diketopyrrolopyrrole (DPP)-based small molecules (LGC-D117 and LGC-D118) were synthesized and used as the active layer of solution-processable organic field-effect ...transistors (OFETs). Both LGC-D117 and LGC-D118 contain silaindacenodithiophene as electron-donor units with DPP as an electron-accepting linker, and octylrhodanine as the electron-accepting end group. The molecules were functionalized with different side chains to study their effects on OFET characteristics. LGC-D117 has a simple branched alkyl side chain, whereas LGC-D118 features a bulky siloxane-terminated hybrid alkyl chain. The siloxane side chains of LGC-D118 account for its better crystallinity, leading to significantly high field-effect mobility (max 3.04 cm
V
s
). In particular, LGC-D118 is well soluble and sustains the high mobility in the environmentally friendly 2-methyltetrahydrofuran solvent with low temperature annealing at 100 °C due to the bulky siloxane-terminated alkyl side chain.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
The reliability of mobility has come to be a critical issue to the development of new electronics especially for organic electronics, since mobility is typically extracted from field‐effect ...transistors containing various extrinsic effects and overestimation is popular in the literature. Recently, this issue is emphasized and a reliability factor (r) is proposed by pioneers to gauge the mobility reported. Albeit many factors discussed, how much the extrinsic effects influence r remains unrevealed and a facile solution by using organic transistors is still lacking. Here, it is shown that the widely used extraction method based on the saturation transfer characteristics is sensitive to contact effect and temperature with r dropping to 43%, indeed leading to large mobility overestimation. By contrast, the linear‐regime methods are more reliable particularly the Y‐function method that demonstrates great reliability (r ≈ 100%) even for short‐channel transistors at ultralow temperatures. In addition, operating in saturation regime induces ambipolar conduction further deteriorating reliability if contact doping is absent. High Schottky barriers, on the other side, distort device characteristics making extraction impossible. The results of this study reveal that, aside from device optimizations, selecting a right method is essential for reliable and precise evaluation of the carrier mobility by using organic transistors.
This paper systematically addresses the essential effects on the mobility extraction reliability. The effects related to specific dielectric capacitance, operating regime, channel length, temperature, ambipolar conduction, and Schottky barrier are examined in a quantitative way. The results of this study show that, aside from device optimizations, selecting a proper extraction method is important to reliable mobility evaluation using organic transistors.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Conjugated polymers came to an unprecedented epoch that the charge transport is limited only by small disorder within aggregated domains. Accurate evaluation of transport performance is thus vital to ...optimizing further molecule design. Yet, the routine method by means of the conventional field‐effect transistors may not satisfy such a requirement. Here, it is shown that the extrinsic effects of Schottky barrier, access transport through semiconductor bulk, and concurrent ambipolar conduction seriously influence transport analysis. The planar transistors incorporating ohmic contacts free of access and ambipolar conduction afford an ideal access to charge transport. It is found, however, that only the planar transistors operating in low‐field regime are reliable to explore the inherent transport properties due to the energetic disorder lowering by the lateral field induced by high drain voltage. This work opens up a robust approach to comprehend the delicate charge transport in conjugated polymers so as to develop high‐performance semiconducting polymers for promising plastic electronics.
Conventional and planar polymer transistors are compared to explore the charge transport in conjugated polymers. The former is found to suffer from extrinsic effects of Schottky barrier, access transport, and ambipolar conduction. The latter is free from such issues so is more reliable for transport exploration. However, only those operating in the low‐field regime are reliable to explore the charge transport.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Ni-rich layered oxides (LiNi1-x-yCoxMnyO2, 1-x-y ≥ 0.5) are attracting great attention due to their high capacity and operating voltage. However, Ni-rich layered oxides still face long-standing ...challenges, such as incomplete capacity release and fast capacity fade, especially at high C rates. Herein, we implement a wet chemical method to dope Ti into LiNi0.8Co0.1Mn0.1O2 (NCM811). We discover that NCM811 with the homogeneously distributed Ti can effectively enhance ion transfer kinetics and thus greatly improve capacity delivery at high C rates. The Ti-doped NCM811 exhibits a capacity of 196 mAh/g and 157 mAh/g at 0.5C and 2C in voltage range of 2.8–4.6 V, 5% higher (188 mAh/g at 0.5C) and 15% higher (136 mAh/g at 2C) than the pristine NCM811. Ti-doped NCM811 cathodes also exhibit enhanced cycling stability with capacity retention of 84% after 100 cycles at 1C, which shows that our methodology for Ti doping is potentially competitive for a practical production of Ni-rich layered oxides.
•A simple, low cost and scalable hydrolysis method has been developed to uniformly dope Ti into Ni-rich layered oxide.•Ni2+/Li+ cation mixing degree has been decreased.•Fast Li ion transport kinetics and stable structure has been enabled.•A much better rate capability and significantly enhanced cycle stability have been offered.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Organic field-effect transistors (OFETs) are fundamental building blocks for various state-of-the-art electronic devices. Solution-processed organic crystals are appreciable materials for these ...applications because they facilitate large-scale, low-cost fabrication of devices with high performance. Patterning organic crystal transistors into well-defined geometric features is necessary to develop these crystals into practical semiconductors. This review provides an update on recentdevelopment in patterning technology for solution-processed organic crystals and their applications in field-effect transistors. Typical demonstrations are discussed and examined. In particular, our latest research progress on the spin-coating technique from mixture solutions is presented as a promising method to efficiently produce large organic semiconducting crystals on various substrates for high-performance OFETs. This solution-based process also has other excellent advantages, such as phase separation for self-assembled interfaces via one-step spin-coating, self-flattening of rough interfaces, and in situ purification that eliminates the impurity influences. Furthermore, recommendations for future perspectives are presented, and key issues for further development are discussed.
Chimeric antigen receptor (CAR) T cells targeting B‐cell maturation antigen have shown positive responses in patients with multiple myeloma (MM). The phase 2 portion of the CARTITUDE‐1 study of ...ciltacabtagene autoleucel (cilta‐cel) included a cohort of Japanese patients with relapsed/refractory MM. Following a conditioning regimen of cyclophosphamide (300 mg/m2) and fludarabine (30 mg/m2), patients received a single cilta‐cel infusion at a target dose of 0.75 × 106 (range, 0.5–1.0 × 106CAR‐positive viable T cells/kg). The primary endpoint was overall response rate (ORR; defined as partial response or better) by International Myeloma Working Group criteria. A key secondary endpoint was the rate of very good partial response (VGPR) or better (defined as VGPR, complete response, stringent complete response). This first analysis was performed at 6 months after the last patient received cilta‐cel. Thirteen patients underwent apheresis, nine of whom received cilta‐cel infusion. Eight patients who received cilta‐cel at the target dose responded, yielding an ORR of 100%. Seven of eight (87.5%) patients achieved a VGPR or better. One additional patient who received a below‐target dose of cilta‐cel also achieved a best response of VGPR. MRD negativity (10−5 threshold) was achieved in all six evaluable patients. Eight of nine (88.9%) patients who received cilta‐cel infusion experienced a grade 3 or 4 adverse event, and eight (88.9%) patients experienced cytokine release syndrome (all grade 1 or 2). No CAR‐T cell neurotoxicity was reported. A positive benefit/risk profile for cilta‐cel was established for heavily pretreated Japanese patients with relapsed or refractory MM.
CARTITUDE‐1, a phase 1b and 2 open‐label study of ciltacabtageneautoleucel (cilta‐cel) in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM), had a protocol‐specified separate Japanese cohort to characterize cilta‐cel efficacy and safety in Japanese patients. All eight of eight patients responded, yielding an overall response rate of 100% and safety was manageable and comparable to the main cohort. A positive benefit/risk profile for cilta‐cel was established for heavily pretreated Japanese patients with RRMM.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
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