Background Long-term secondary preventive programs in coronary heart disease (CHD) are of highest efficacy but numerous logistical problems often compromise their implementation. Contemporary remote ...technologies have a potential to overcome these barriers.
To assess the impact of 2 preventive counselling programs with subsequent remote support in CHD patients with concomitant obesity.
A prospective randomized parallel-group study in 120 stable CHD patients hospitalized for elective coronary revascularization who were from 40 to 65 years old and had concomitant obesity. Patients were randomized (1:1:1) into 3 groups (n=40 each). Before discharge, Groups 1 and 2 received a single-session comprehensive counselling with focus on diet followed by remote counselling by phone (Group 1) or via text messages (Group 2). Remote counselling was delivered weekly (Months 1-3) and then monthly (Months 4-6). Group 3 received only standard advice from their attending physicians. The patients were followed for 12 months with assessment of adiposity measures, self-reported dietary patterns, physical activity (IPAQ questionnaire), smoking status, blood pressure (BP), fasting blood glucose, lipids and C-reactive protein (CRP) levels, as well as of clinical events.
At 1 year of follow-up, the patients from both intervention groups showed a marked improvement of several risk factors including obesity: the body mass index was reduced by 1.48±0.13 kg/m² in Group 1 and by 1.53±0.18 kg/m² in Group 2; the waist circumference went down by 7.62±0.49 and by 7.41±0.74 cm, respectively; the height-normalized fat mass decreased by 4.66±0.40 kg and 5.98±0.63 kg, respectively (all P values are <0.01 vs corresponding changes in the control group). These changes were coupled with more healthy dietary patterns and less sedentary lifestyles in both intervention groups: the proportion of patients with low activity level fell from 87.5% to 2.5% in Group 1 and from 80% to 10% in Group 2 (both p values <0.01 vs control). In Group 1, BP decreased by 18.08±2.20 mmHg (systolic) and 8.56±1.61 mmHg (diastolic); both р values <0.01 vs Group 3. In Group 2 systolic BP dropped by only 11.95±2.50 mmHg (non-significant) and diastolic BP by 6.33±1.52 mmHg (р<0.05 vs control). The proportion of smokers went down from 30% to 5% in Group 1 and from 22.5% to 0% in Group 2 (both p values <0.01 vs control). The fasting glucose levels decreased by 0.21±0.20 mmol/L in Group 1 and by 0.48±0.25 mmol/L in Group 2 (<0.01 vs control, both), but there were no meaningful improvements in blood lipids or CRP.
Long-term (6 months) secondary prevention programs incorporating remote support technologies result into sustained improvement of key secondary prevention indicators in obese CHD patients, irrespective of the support modality (by phone or via electronic messaging).
Quality of life, which is determined both by the physical symptoms and by psychosocial risk factors, is among the primary treatment goals in coronary heart disease (CHD). Therefore, it is reasonable ...to assess the impact of any therapeutic interventions in CHD on these measures.
To assess the changes of psychological status and quality of life in patients with CHD and abdominal obesity (AO) over time during 2 secondary prevention programs using two different modalities of remote support.
An open-label randomized study with 3 parallel groups enrolling hospitalized patients with stable CHD and AO (most hospitalizations were due to elective revascularization procedures). The patients were randomized into 2 intervention groups (Group I and Group II) and into Group III (control). Both intervention groups received secondary prevention programs including one in-hospital preventive counselling session with focus on healthy eating habits and subsequent remote support for 6 months (Month 1 to 3: once a week; Month 4 to 6: once a month). Group I received this subsequent counselling via phone calls and Group II received text messages via different platforms according to patient preferences. Group III received standard advice at discharge only. During 1 year of follow-up motivation for lifestyle changes and continued participation in secondary prevention programs, anxiety and depression symptoms (HADS), stress levels (10-point VAS) and quality of life (HeartQol) were assessed.
A total of 120 patients were enrolled (mean age±SD, 57.75±6.25 years; men, 83.4%) who had a high baseline motivation to participate in preventive programs. At 1 year of follow-up there was a substantial improvement in anxiety and depression symptoms in Groups I and II which was absent in Group III. As a result, the proportion of patients with HADS-A score ≥8 dropped from 45.0% to 10.0% in Group I and from 40.0% to 7.5% in Group II (both р values <0.01 vs control), and the proportion of participants with HADS-D ≥8 decreased from 30.0% to 10.0% (р<0.01 vs control) and from 12.5% to 0% (р<0.05 vs control), respectively. Stress level decreased in Groups I and II by 3.95±0.38 and 3.56±0.39 баллов, respectively (both р values <0.01 vs control). The HeartQol global score increased by 1.07±0.08 points in Group I and by 0.98±0.13 points in Group (both р values <0.01 vs control).
Both secondary prevention programs with long-term remote support targeting obese CHD patients resulted in improvement of pivotal measures of their psychological status i.e. into a decline of anxiety and depression symptomatology, stress reduction and into a better quality of life.
We present a measurement of the geo-neutrino signal obtained from 1353 days of data with the Borexino detector at Laboratori Nazionali del Gran Sasso in Italy. With a fiducial exposure of ...(3.69±0.16)×1031 proton × year after all selection cuts and background subtraction, we detected (14.3±4.4) geo-neutrino events assuming a fixed chondritic mass Th/U ratio of 3.9. This corresponds to a geo-neutrino signal Sgeo=(38.8±12.0) TNU with just a 6×10−6 probability for a null geo-neutrino measurement. With U and Th left as free parameters in the fit, the relative signals are STh=(10.6±12.7) TNU and SU=(26.5±19.5) TNU. Borexino data alone are compatible with a mantle geo-neutrino signal of (15.4±12.3) TNU, while a combined analysis with the KamLAND data allows to extract a mantle signal of (14.1±8.1) TNU. Our measurement of 31.2−6.1+7.0 reactor anti-neutrino events is in agreement with expectations in the presence of neutrino oscillations.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Borexino is a liquid scintillation detector located deep underground at the Laboratori Nazionali del Gran Sasso (LNGS, Italy). Thanks to the unmatched radio purity of the scintillator, and to the ...well understood detector response at low energy, a new limit on the stability of the electron for decay into a neutrino and a single monoenergetic photon was obtained. This new bound, τ≥6.6×10^{28} yr at 90% C.L., is 2 orders of magnitude better than the previous limit.
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CMK, CTK, FMFMET, IJS, NUK, PNG, UM
We describe the Monte Carlo (MC) simulation of the Borexino detector and the agreement of its output with data. The Borexino MC “ab initio” simulates the energy loss of particles in all detector ...components and generates the resulting scintillation photons and their propagation within the liquid scintillator volume. The simulation accounts for absorption, reemission, and scattering of the optical photons and tracks them until they either are absorbed or reach the photocathode of one of the photomultiplier tubes. Photon detection is followed by a comprehensive simulation of the readout electronics response. The MC is tuned using data collected with radioactive calibration sources deployed inside and around the scintillator volume. The simulation reproduces the energy response of the detector, its uniformity within the fiducial scintillator volume relevant to neutrino physics, and the time distribution of detected photons to better than 1% between 100 keV and several MeV. The techniques developed to simulate the Borexino detector and their level of refinement are of possible interest to the neutrino community, especially for current and future large-volume liquid scintillator experiments such as Kamland–Zen, SNO+, and Juno.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Abstract
Cosmogenic radio-nuclei are an important source of background for low-energy neutrino experiments. In Borexino, cosmogenic
$$^{11}$$
11
C decays outnumber solar
pep
and CNO neutrino events ...by about ten to one. In order to extract the flux of these two neutrino species, a highly efficient identification of this background is mandatory. We present here the details of the most consolidated strategy, used throughout Borexino solar neutrino measurements. It hinges upon finding the space-time correlations between
$$^{11}$$
11
C decays, the preceding parent muons and the accompanying neutrons. This article describes the working principles and evaluates the performance of this Three-Fold Coincidence (TFC) technique in its two current implementations: a hard-cut and a likelihood-based approach. Both show stable performances throughout Borexino Phases II (2012–2016) and III (2016–2020) data sets, with a
$$^{11}$$
11
C tagging efficiency of
$$\sim 90$$
∼
90
% and
$$\sim $$
∼
63–66 % of the exposure surviving the tagging. We present also a novel technique that targets specifically
$$^{11}$$
11
C produced in high-multiplicity during major spallation events. Such
$$^{11}$$
11
C appear as a
burst
of events, whose space-time correlation can be exploited. Burst identification can be combined with the TFC to obtain about the same tagging efficiency of
$$\sim 90\%$$
∼
90
%
but with a higher fraction of the exposure surviving, in the range of
$$\sim $$
∼
66–68 %.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Precision measurements of solar neutrinos emitted by specific nuclear reaction chains in the Sun are of great interest for developing an improved understanding of star formation and evolution. Given ...the expected neutrino fluxes and known detection reactions, such measurements require detectors capable of collecting neutrino-electron scattering data in exposures on the order of 1 ktonne-yr, with good energy resolution and extremely low background. Two-phase liquid argon time projection chambers (LAr TPCs) are under development for direct Dark Matter WIMP searches, which possess very large sensitive mass, high scintillation light yield, good energy resolution, and good spatial resolution in all three cartesian directions. While enabling Dark Matter searches with sensitivity extending to the ''neutrino floor'' (given by the rate of nuclear recoil events from solar neutrino coherent scattering), such detectors could also enable precision measurements of solar neutrino fluxes using the neutrino-electron elastic scattering events. Modeling results are presented for the cosmogenic and radiogenic backgrounds affecting solar neutrino detection in a 300 tonne (100 tonne fiducial) LAr TPC operating at LNGS depth (3,800 meters of water equivalent). The results show that such a detector could measure the CNO neutrino rate with ∼15% precision, and significantly improve the precision of the {sup 7}Be and pep neutrino rates compared to the currently available results from the Borexino organic liquid scintillator detector.
Abstract
Directional sensitivity to nuclear recoils would provide a smoking gun for a possible discovery of dark matter in the form of WIMPs (Weakly Interacting Massive Particles). A hint of ...directional dependence of the response of a dual-phase argon Time Projection Chamber (TPC) was found in the SCENE experiment. Given the potential importance of such a capability in the framework of dark matter searches, a new dedicated experiment, ReD (Recoil Directionality), was designed by the Global Argon Dark Matter Collaboration, in order to scrutinise this hint. A small dual-phase argon TPC was irradiated with neutrons produced by the p(
7
Li,
7
Be)n reaction using the 15 MV TANDEM accelerator of the INFN - Laboratori Nazionali del Sud, Catania, Italy, so as to produce argon nuclear recoils in the range (20 - 100) keV of interest for dark matter searches. Energy and direction of nuclear recoils are inferred by the detection of the elastically-scattered neutron by a set of scintillation detectors. Events were selected by gating of the associated
7
Be, which is detected by a telescope of Si detectors.
The solar neutrino experiment Borexino, which is located in the Gran Sasso underground laboratories, is in a unique position to study muon-induced backgrounds in an organic liquid scintillator. In ...this study, a large sample of cosmic muons is identified and tracked by a muon veto detector external to the liquid scintillator, and by the specific light patterns observed when muons cross the scintillator volume. The yield of muon-induced neutrons is found to be Y sub(n) = (3.10 + or - 0.11) times 10 super(-4) sub(n)/( mu times (g/cm super(2))). The distance prole between the parent muon track and the neutron capture point has the average value lambda = (81.5 + or - 2.7) cm. Additionally the yields of a number of cosmogenic radioisotopes are measured for super(12)N, super(12)B, super(8)He, super(9)C, super(9)Li, super(8)B, super(6)He, super(8)Li, super(11)Be, super(10)C and super(11)C. All results are compared with Monte Carlo simulation predictions using the Fluka and GEANT4 packages. General agreement between data and simulation is observed for the cosmogenic production yields with a few exceptions, the most prominent case being super(11)C yield for which both codes return about 50% lower values. The predicted mu -n distance prole and the neutron multiplicity distribution are found to be overall consistent with data.
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