One of the most intense air mass transformations on Earth happens when cold air flows from frozen surfaces to much warmer open water in cold-air outbreaks (CAOs), a process captured beautifully in ...satellite imagery. Despite the ubiquity of the CAO cloud regime over high-latitude oceans, we have a rather poor understanding of its properties, its role in energy and water cycles, and its treatment in weather and climate models. The Cold-air Outbreaks in the Marine Boundary Layer Experiment (COMBLE) was conducted to better understand this regime and its representation in models. COMBLE aimed to examine the relations between surface fluxes, boundary-layer structure, aerosol, cloud and precipitation properties, and mesoscale circulations in marine CAOs. Processes affecting these properties largely fall in a range of scales where boundary-layer processes, convection, and precipitation are tightly coupled, which makes accurate representation of the CAO cloud regime in numerical weather prediction and global climate models most challenging. COMBLE deployed an Atmospheric Radiation Measurement Mobile Facility at a coastal site in northern Scandinavia (69°N), with additional instruments on Bear Island (75°N), from December 2019 to May 2020. CAO conditions were experienced 19% (21%) of the time at the main site (on Bear Island). A comprehensive suite of continuous in situ and remote sensing observations of atmospheric conditions, clouds, precipitation, and aerosol were collected. Because of the clouds’ well-defined origin, their shallow depth, and the broad range of observed temperature and aerosol concentrations, the COMBLE dataset provides a powerful modeling test bed for improving the representation of mixed-phase cloud processes in large-eddy simulations and large-scale models.
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Epigenetic variation describes heritable differences that are not attributable to changes in DNA sequence. There is the potential for pure epigenetic variation that occurs in the absence of any ...genetic change or for more complex situations that involve both genetic and epigenetic differences. Methylation of cytosine residues provides one mechanism for the inheritance of epigenetic information. A genome-wide profiling of DNA methylation in two different genotypes of Zea mays (ssp. mays), an organism with a complex genome of interspersed genes and repetitive elements, allowed the identification and characterization of examples of natural epigenetic variation. The distribution of DNA methylation was profiled using immunoprecipitation of methylated DNA followed by hybridization to a high-density tiling microarray. The comparison of the DNA methylation levels in the two genotypes, B73 and Mo17, allowed for the identification of approximately 700 differentially methylated regions (DMRs). Several of these DMRs occur in genomic regions that are apparently identical by descent in B73 and Mo17 suggesting that they may be examples of pure epigenetic variation. The methylation levels of the DMRs were further studied in a panel of near-isogenic lines to evaluate the stable inheritance of the methylation levels and to assess the contribution of cis- and trans- acting information to natural epigenetic variation. The majority of DMRs that occur in genomic regions without genetic variation are controlled by cis-acting differences and exhibit relatively stable inheritance. This study provides evidence for naturally occurring epigenetic variation in maize, including examples of pure epigenetic variation that is not conditioned by genetic differences. The epigenetic differences are variable within maize populations and exhibit relatively stable trans-generational inheritance. The detected examples of epigenetic variation, including some without tightly linked genetic variation, may contribute to complex trait variation.
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State-of-the-art research on brain asymmetry, explained from molecular to clinical levels.
Hemispheric asymmetry is one of the basic aspects of perception and cognitive processing. The different ...functions of the left and right hemispheres of the brain have been studied with renewed interest in recent years, as scholars explore applications to new areas, new measuring techniques, and new theoretical approaches. This volume provides a comprehensive view of the latest research in brain asymmetry, offering not only recent empirical and clinical findings but also a coherent theoretical approach to the subject. In chapters that report on the field at levels from the molecular to the clinical, leading researchers address such topics as the evolution and genetics of brain asymmetry; animal models; findings from structural and functional neuroimaging techniques and research; sex differences and hormonal effects; sleep asymmetry; cognitive asymmetry in visual and auditory perception; and auditory laterality and speech perception, memory, and asymmetry in the context of developmental, neurological, and psychiatric disorders.
Contributors
Katrin Amunts, Ulrike Bayer, Alfredo Brancucci, Vince D. Calhoun, Maria Casagrande, Marco Catani, Michael C. Corballis, Patricia E. Cowell, Timothy J. Crow, Tom Eichele, Stephanie Forkel, Patrick J. Gannon, Isabelle George, Onur Güntürkün, Heikki Hämäläinen, Markus Hausmann, Joseph B. Hellige, Kenneth Hugdahl, Masud Husain, Grégoria Kalpouzos, Bruno Laeng, Martina Manns, Chikashi Michimata, Deborah W. Moncrieff, Lars Nyberg, Godfrey Pearlson, Stefan Pollmann, Victoria Singh-Curry, Iris E.C. Sommer, Tao Sun, Nathan Swanson, Fiia Takio, Michel Thiebaut de Schotten, René Westerhausen
Demand for viable human organs for transplantation continues to exceed the supply. To expand supply, the criteria for identification and management of suitable donors must continue to evolve. ...Poisoned patients are often excluded as potential organ donors due to perceived risks of transmittable agents and/or physiologically compromised organs. In this report, a patient succumbed after an intentional ingestion of cyanide and multiple Pharmaceuticals. Donor organ viability was determined by lack of significant injury beyond the central nervous system. Following standard procurement procedures, the heart, liver, corneas, 16 skin grafts and 16 bone grafts were deemed suitable and successfully transplanted. All organ recipients were doing well eight months post transplantation. The focus of procurement personnel should be on tissue injury and not on the mere presence of clinical effect of a toxic agent. With the paucity of organs available, poison centers need to be cognizant of this dilemma when faced with a toxicologically compromised potential organ donor.
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