To characterize spermatogenesis in the estrogenized transgender patient.
This is a retrospective, single-center, cross-sectional study. Seventy-two transgender women underwent gender-affirming ...orchiectomy between May 2015 and January 2017. All were on long-term (>1 year) cross-sex hormonal therapy prior to orchiectomy. Patient data were obtained via chart review. Histologic analysis was performed by a pathology resident under the supervision of a genitourinary pathologist. The main outcome is histologic presence of germ cells and presence of spermatids (a proxy for preserved spermatogenesis) in orchiectomy specimens.
There were 141 pathologic specimens available for analysis. Germ cells were present in 114 out of 141 (81%) testicles. Spermatids were present in 57 (40%) testicles. Presence of germ cells was associated with older age (43 vs 35 years, P = .007) and increased testicular weight (28.6 g vs 19.3 g, P <.001). Presence of spermatids was associated with increased weight (31.5 g vs 23.3 g, P <.001) and volume (20.3 mL vs 12.6 mL, P <.001). There was a linear correlation between testis volume and preserved spermatogenesis (Pearson's r = 0.448, P <.001).
Despite long-term hormone therapy, the majority (80%) of transgender women have germ cells present in the testicle. Spermatogenesis is preserved in approximately 40% of these individuals. Duration of hormonal therapy did not affect the degree of preservation of germ cells or spermatogenesis but starting hormonal treatment at a younger age may be associated with decreased germ cells in the testicle. Volume of testicles predict presence of preserved spermatogenesis.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
When optical navigation images acquired by the OSIRIS‐REx (Origins, Spectral Interpretation, Resource Identification, and Security‐Regolith Explorer) mission revealed the periodic ejection of ...particles from asteroid (101955) Bennu, it became a mission priority to quickly identify and track these objects for both spacecraft safety and scientific purposes. The large number of particles and the mission criticality rendered time‐intensive manual inspection impractical. We present autonomous techniques for particle detection and tracking that were developed in response to the Bennu phenomenon but that have the capacity for general application to particles in motion about a celestial body. In an example OSIRIS‐REx data set, our autonomous techniques identified 93.6% of real particle tracks and nearly doubled the number of tracks detected versus manual inspection alone.
Key Points
We describe autonomous techniques for the identification and tracking of particles in motion about a celestial body
We demonstrate these techniques using images from the OSIRIS‐REx mission to the active asteroid (101955) Bennu
In the OSIRIS‐REx dataset, our autonomous algorithms detected 93.6% of real particle tracks, including 244 tracks not identified by manual inspection
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
Abstract
The Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission collected a sample from the rubble-pile asteroid (101955) Bennu for return ...to Earth. For the successful Touch And Go sample acquisition maneuver, the shape and mass of the asteroid needed to be known precisely. Here we use a combination of radiometric, image landmark, and laser altimetry data to determine Bennu’s mass, shape, and orientation simultaneously and to verify existing models thereof. Our shape determination consists of estimating a scale factor and three frame rotation angles that apply to both the global digital terrain model (GDTM) and the landmark coordinates. We use a data type called image constraints, where we take the difference of the observation of the same landmark in images taken at two different times. We analyze data from two phases of the OSIRIS-REx mission, Orbital B and Recon B, and show that interphase image constraints greatly reduce interdependencies between estimated parameters for mass, GDTM scale, and biases on the altimetry data. This results in an improved solution for the mass and shape relative to considering a single mission phase. We find Bennu’s gravitational parameter
GM
to be 4.89256 ± 0.00035 m
3
s
−2
, and we find a scale factor of 1.000896 ± 0.00036 for the altimetry-based GDTM. Using the scaled volume, this results in a bulk density of 1191.57 ± 1.74 kg m
−3
, which is within the uncertainties of previous analyses but more precise.
The Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer (OSIRIS-REx) GoddardSpace Flight Center (GSFC) Independent Navigation Team (INT) performs center-finding and ...landmark-basedOptical Navigation (OpNav), Orbit Determination (OD), maneuver verification, and additional analyses in support ofnavigation operations motivated by a stringent set of science requirements. The INT has adopted a streamlined andagile approach to navigation operations support via a virtual operations environment, known as \"OREX-NAV\",which leverages existing capabilities of the Space Science Mission Operations (SSMO) virtual Multi-MissionOperations Center (vMMOC). The virtual environment architecture of OREX-NAV enables the INT to perform dailyoperational tasks and seamlessly interface with external mission networks, regardless of physical location. Throughthe automation and process adopted, the INT is able to keep pace with the rapid cadence of required deliverables.
While plasma biomarkers have been proposed to aid in the clinical diagnosis of Alzheimer disease (AD), few biomarkers have been validated in independent patient cohorts. Here we aim to determine ...plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI).
Using a targeted proteomic approach, we measured levels of 190 plasma proteins and peptides in 600 participants from 2 independent centers (University of Pennsylvania, Philadelphia; Washington University, St. Louis, MO), and identified 17 analytes associated with the diagnosis of very mild dementia/mild cognitive impairment (MCI) or AD. Four analytes (apoE, B-type natriuretic peptide, C-reactive protein, pancreatic polypeptide) were also found to be altered in clinical MCI/AD in the ADNI cohort (n = 566). Regression analysis showed CSF Aβ42 levels and t-tau/Aβ42 ratios to correlate with the number of APOE4 alleles and plasma levels of B-type natriuretic peptide and pancreatic polypeptide.
Four plasma analytes were consistently associated with the diagnosis of very mild dementia/MCI/AD in 3 independent clinical cohorts. These plasma biomarkers may predict underlying AD through their association with CSF AD biomarkers, and the association between plasma and CSF amyloid biomarkers needs to be confirmed in a prospective study.
During its initial orbital phase in early 2019, the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) asteroid sample return mission detected ...small particles apparently emanating from the surface of the near-Earth asteroid (101955) Bennu in optical navigation images. Identification and characterization of the physical and dynamical properties of these objects became a mission priority in terms of both spacecraft safety and scientific investigation. Traditional techniques for particle identification and tracking typically rely on manual inspection and are often time-consuming. The large number of particles associated with the Bennu events and the mission criticality rendered manual inspection techniques infeasible for long-term operational support. In this work, we present techniques for autonomously detecting potential particles in monocular images and providing initial correspondences between observations in sequential images, as implemented for the OSIRIS-REx mission.
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