•This was the first report on analysis of amicarthiazol residues by UPLC-MS/MS.•The method has been successfully developed and validated with the good sensitivity and selectivity, and met the current ...requirements for the analysis of pesticide residue.•The method be a helpful tool for the controlling and monitoring of the risks posed by amicarthiazol to human health and environment safety.
A reliable and rapid method has been optimized to determine the residue of amicarthiazol in soil and environmental water samples. After extraction and evaporation, the extraction was carried out with solid phase extraction (SPE) cleanup using HLB cartridge (only soil samples) and for the quantitative determination by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The resulting residues of amicarthiazol were analyzed by a gradient separation performed on a UPLC system with a C18 column, methanol and water containing 0.1% (v v−1) formic acid as the mobile phase in the mode of electrospray positive ionization (ESI+) and multiple reaction monitoring (MRM). Results showed that the recoveries for spiked samples were 74.4–97.1% and 72.1–109.9% for soil and water, respectively, with the relative standard deviation (RSD) less than 10.2% when fortified at 10, 100 and 1000μgL−1. The limits of detection (LODs) and the limits of quantification (LOQs) for matrix matched standards ranged from 0.073–0.425μgL−1 and 0.243–1.42μgL−1. The intra-day precision (n=5) and the inter-day precision over 10 days (n=10) for the amicarthiazol in soils and water samples spiked at 100μgL−1 was 7.9% and 15.9%, respectively. Results indicated that the developed method could be a helpful tool for the controlling and monitoring of the risks posed by amicarthiazol to human health and environment safety.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
Stroke is one of the leading causes of disability and death globally.It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue.（＋）-Borneol,a simple ...bicyclic monoterpene extracted from traditional Chinese medicine,is widely used in various types of diseases.However,no study has proved the effects of（＋）-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown.Here,we report that in the rat model of permanent cerebral ischemia,we found that（＋）-borneol（1.0 mg/kg） significantly ameliorated infarct size and neurological scores via reducing the expression of inducible nitric oxide synthase（iNOS）and tumor necrosis factor-alpha（TNF-α） in a dose dependent manner.Notably,（＋）-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke,which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task,at least in part through reducing loss of dendritic spines in the length,brunch number and density.These findings suggest that（＋）-borneol could serve as a therapeutic target for ischemic stroke.
In NC milling tool path reflects all the processing process, the tool path is reasonable or not, related to the workpiece processing quality and production efficiency, through several parts of the ...typical contour shape analysis, determination method of NC machining tool path, determined by the combination of NC milling tool path, to reduce the surface roughness of the workpiece, improve workpiece processing quality objective.
The surface of workpiece in NC turning process, often encounter the workpiece surface cross quadrant arc, if the use of the same processing methods and ordinary arc, often leads to the emergence of ...cross quadrant arc machining shape error, through the research of the NC machining of workpiece surface cross quadrant arc, CNC turning reasonable go knife and tool path in NC turning, solve cross quadrant arc, some defects in the surface of the workpiece processing, ensure the machining with circular arc profile theory demands, so as to improve the machining quality and the machining accuracy requirements.
Through the process of NC machining analysis, summed up the points of NC machining process analysis, through the process of a comprehensive and reasonable analysis procedure for CNC turning and CNC ...programming formulation provides an important basis and guarantee, so as to improve the machining quality and the machining accuracy requirements.
Practice and theory are equally important in prosthodontics. Although the current training mode of residents in prosthodontics has made some achievements, there are still some challenges in the ...training. How to help residents master the essential elements of dental prosthodontics practice in a short term of training program, improve the quality of clinical training, and to provide more high-level prosthodontics doctors to the society are all important topics in the current dental prosthodontics traning. We designed a systematic head simulation teaching program to improve the clinical operating ability of residents in prosthodontics.
Pure tungsten （PW） and W-1 wt% La203 （WL10） were prepared by powder metallurgical route fol- lowed by the swaging ＋ rolling process. The logarithmic strains are 0, 0.37, 0.58, and 0.98 for WL10 and ...0, 0.58 for PW. Heat treatments were performed at temperatures var- ied from 1,573 to 2,173 K to determine the recrystalliza- tion temperature. Recrystallization temperatures are 1,973 and 2,173 K for WL1 （logarithmic strain of 0.37） and WL3 （logarithmic strain of 0.98）, respectively. But in the case of WL2 （logarithmic strain of 0.58）, full recrystallization is not achieved at temperature of above 2,173 K. Further- more, the recrystallization temperature of PW with loga- rithmic strain of 0.58 is at least 300 K lower than that of the equivalent WLI0 sample. Moreover, the increase of recrystallization temperature inhibits the strength degra- dation of WL2： samples lose 4 % and 22 % strength when annealed at 1,573 and 1,973 K compared with room tem- perature （RT） sample. Finally, the texture evolution for the swaged ＋ rolled WL10 is significantly related to the deformation degree： the dominated orientation is （001） for WL2 while （110） for WL3.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Objective The common differentially expressed mRNAs in brain, heart and liver tissues of deceased sudden infant death syndrome （SIDS） and infectious sudden death in infancy （ISDI） confirmed by ...autopsy was screened by bioinformatics to explore the common molecular markers and pathogenesis of SIDS and ISDI. Methods The datasets of GSE70422 and GSE136992 were downloaded, the limma of R software was used to screen differentially expressed mRNA in different tissue samples of SIDS and ISDI decedents for overlapping analysis. The clusterProfiler of R software was used to conduct gene ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） enrichment analysis. The protein-protein interaction （PPI） network was constructed by STRING database, while the hub gene was screened by cytoHubba plug-in. Results Compared with the control group, there were 19 significant differentially expressed genes in the tissue samples of SIDS and ISDI decedents, among which 16 in the heart tissue and 3 in the liver tissue, and the
Proton exchange membrane fuel cell (PEMFC) with hydrogen energy as the main energy, has the advantages of high energy conversion efficiency, environmental friendliness, and low working temperature, ...indicating the broad application prospects. However, PEMFC technology still faces severe challenges in cost and performance index. Bipolar plate is an important part of PEMFC, which accounts for a large proportion in its weight and cost, and has many irreplaceable functions. Three kinds of commonly used bipolar plate substrate materials (graphite material, composite material, and metal material) and the characteristics of several commonly used modification methods were summarized. And the stainless steel bipolar plate with more applications and low cost in recent years and its common modification methods were summarized emphatically.
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