At present, there are few studies exploring the impact of market-based environmental regulation on ESG performance based on the perspective of carbon emission trading scheme (CETS). This paper aims ...to supplement this research field through empirical analysis. Taking Shanghai-Shenzhen A-share listed companies from 2012 to 2022 as the research object, this paper studies the impact of CETS, a market-based environmental regulation tool, on the ESG performance of enterprises by constructing a time-varying DID model and examines the mediating roles of green technology innovation, agency cost and analyst attention. The results show that the implementation of CETS can significantly boost ESG performance, and green technology innovation, agency cost, and analyst attention play a partial intermediary role between the two, while the mediating effects of green total factor productivity and green total factor energy efficiency are not significant. In terms of heterogeneity analysis, the study shows that CETS implementation has a more substantial promotion effect on ESG performance in non-state-owned enterprises, non-politically connected enterprises and non-high-tech enterprises. In this paper, the robustness test was carried out through PSM-DID, placebo test and replacement of explained variables, and the test results further supported the hypothesis in this paper. This study enriched the research on the impact of market-based environmental regulation on ESG from the perspective of CETS. It provided enlightenment for enterprises to improve ESG performance to a strategic level, improve the level of green technology innovation, and the government to implement differentiated environmental governance policies.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
S-adenosylmethionine (SAM) is a naturally occurring physiologic molecule found ubiquitously in all mammalian cells and an essential compound in many metabolic pathways. It has been reported to ...possess many pharmacological properties including cancer-preventive and anticancer effects. However, the precise molecular mechanism involved in its anticancer effect is not yet clear. The present study is conducted to investigate the anticancer activity and the underlying mechanisms of SAM on human gallbladder cancer cells (GBC-SD and SGC-996) in vitro and in vivo. Cells were dealt with SAM and subjected to cell viability, colony formation, Hoechst staining, apoptosis, cycle arrest, western blot, and xenograft tumorigenicity assay. Experimental results showed that SAM could significantly inhibit the growth and proliferation and induce the apoptosis as well as cell cycle arrest in G0/G1 phase of GBC-SD and SGC-996 cells in a dose-dependent manner in vitro. The expression levels of p-JAK2, p-STAT3, Mcl-1, and Bcl-XL were significantly downregulated. In addition, inhibition of the JAK2/STAT3 pathway significantly enhanced the anti-apoptotic effect of SAM, suggesting the key roles of JAK2/STAT3 in the process. More importantly, our in vivo studies demonstrated that administration of SAM could significantly decrease the tumor weight and volume and immunohistochemistry analysis proved the downregulation of p-JAK2 and p-STAT3 in tumor tissues following SAM treatment, consistent with our in vitro results. In summary, our findings indicated that SAM can inhibit cell proliferation and induce apoptosis as well as cycle arrest of GBC cells by suppression of JAK2/STAT3 pathways and the dramatic effects of SAM hinting that SAM might be a useful therapeutic option for patients suffering from gallbladder cancer.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Building retailer equity increases revenue and profitability by insulating retailers from competitors. Store image is the basis of retailer equity, but extant literature offers little insight into ...the empirical research which takes store image dimensions as antecedents of retailer equity. This paper establishes a theoretical and empirical basis that shows the impact of selected store image dimensions on retailer equity. The authors propose a conceptual framework in which store image dimensions are related to three dimensions of retailer equity, i.e., retailer awareness, retailer associations, retailer perceived quality. These dimensions are then related to retailer loyalty. The empirical tests using a structural equation model support the research hypotheses. The results indicate the positive effect of convenience, perceived price, physical facilities, employee service, and institutional factors on retailer equity dimensions as antecedents of retailer equity.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
JUNO and IZUMO1 are the first receptor-ligand protein pairs discovered to be essential for sperm-oocyte fusion; their interaction is indispensable for fertilization.
PCR was used to clone the ...full-length DNA sequence of the Juno gene in sheep. The single nucleotide polymorphism (SNP) loci of Juno were genotyped by Sequenom MassARRAY®. PCR combined with rapid amplification of cDNA Ends were used to clone the full-length cDNA sequence of Juno and Izumo1. Reverse transcriptase-PCR (RT-PCR) and real time-quantitative-PCR (RT-qPCR) were used to analyze the genes' expression in tissues of sheep, and single cell RNA-seq was used to analyze the genes' expression in oocytes, granulosa cells and follicular theca of polytocous and monotocous Small Tail Han ewes. Bioinformatics was used to analyze advanced structure and phylogeny of JUNO and IZUMO1 proteins.
The full-length DNA sequence of the Juno gene in sheep was cloned and nine SNPs were screened. We found a significant association between the g.848253 C > A locus of Juno and litter size of Small Tail Han sheep (P < 0.05). The full-length cDNA sequence of Juno and Izumo1 genes from Small Tail Han sheep were obtained. We found a new segment of the Izumo1 CDS consisting of 35 bp, and we confirmed the Izumo1 gene has 9 exons, not 8. RT-qPCR showed that Juno and Izumo1 genes were highly expressed in ovarian and testicular tissues, respectively (P < 0.01). Single cell RNA-seq showed Juno was specifically expressed in oocytes, but not in granulosa cells or follicular theca, while Izumo1 displayed little to no expression in all three cell types. There was no difference in expression of the Juno gene in oocyte and ovarian tissue in sheep with different litter sizes, indicating expression of Juno is not related to litter size traits. Bioinformatic analysis revealed the g.848253 C > A locus of Juno results in a nonconservative missense point mutation leading to a change from Phe to Leu at position 219 in the amino acid sequence.
For the first time, this study systematically analyzed the expression, structure and function of Juno and Izumo1 genes and their encoded proteins in Small Tail Han sheep, providing the basis for future studies of the regulatory mechanisms of Juno and Izumo1 genes.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
This research explores how consumers respond to Corporate Social Responsibility (CSR) in China with a multiproduct, comparative survey. Empirical results conclude that (1) Chinese consumers, who show ...a high level of awareness and trust of CSR, are more likely to transform a good CSR record into positive corporate evaluation, product association, and purchase intention; (2) Consumer responses to CSR vary across different product categories. Those firms selling experience products (vs. search and credence products) are more likely to gain consumers' positive product associations and purchase support through CSR practices; and (3) The relationships between consumer demographics and their CSR responses are not linear, and those consumers with a middle level of age and income would respond to CSR more positively. Managerial implications are provided.
This study was conducted to investigate the effects of dietary supplementation with different types of
(
) on the growth and gut health of weaned piglets. A total of 160 piglets were randomly ...assigned into four groups: control group (a basal diet), BS-A group (a basal diet supplemented with
A at 1 × 10
CFU/g feed), BS-B group (a basal diet supplemented with
B at 1 × 10
CFU/g feed), and BS-C group (a basal diet supplemented with
C at 1 × 10
CFU/g feed). All groups had five replicates with eight piglets per replicate. On days 7, 21, and 42 of the trial, blood plasma and intestinal tissues and digesta samples were collected to determine plasma cytokine concentrations, intestinal morphology, gut microbiota community and metabolic activity, and the expression of genes related to gut physiology and metabolism. The results showed that dietary
supplementation improved (
< 0.05) the body weight and average daily gain (in BS-B and BS-C groups) of weaned piglets and decreased (
< 0.05) the diarrhea rates (in BS-A, BS-B, and BS-C groups). In the intestinal morphology analysis,
supplementation improved (
< 0.05) the size of villus height and villus height to crypt depth ratio in the ileum of weaned piglets.
, and
were the most dominant microflora in piglets' colon whatever the trial group and time of analysis. Dietary BS-C supplementation increased (
< 0.05) the relative abundances of
and
and decreased (
< 0.05) the relative abundances of
and
compared with the control group. In addition, dietary
supplementation increased (
< 0.05) the indicators of intestinal health, including plasma levels of interleukin (IL)-2 and IL-10, as well as the colonic levels of short-chain fatty acids. Furthermore, dietary
supplementation also up-regulated (
< 0.05) the expression of genes involved in metabolic pathways related to intestinal microbiota maturation. In conclusion, these findings suggest that a diet containing BS-B or BS-C can efficiently promote growth performance, decrease diarrhea incidence, and ameliorate several indicators of intestinal health through the modulation of gut microbiota composition and metabolic activity in weaned piglets.
The new-generation lithium metal batteries require polymer electrolytes with high ionic conductivity and mechanical properties. However, the performance of the polymer electrolytes is severely ...influenced by the lithium bond formation between the functional groups and lithium ions (Li
), which has barely been considered in the past. Herein, a lithium bond enriched polymer gel (PAEV) is elaborately designed by copolymerizing 4-acryloylmorpholine (ACMO) and 1-vinyl-3-ethyl imidazolium bis(trifluoromethylsulfonyl)imide (VEIMTFSI) in 1-ethyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide (EMIMTFSI) with the presence of LiFSI. The lithium bonds formed between LiFSI and carbonyl groups in PACMO can be regulated by the Li
coordination number, and further weakened by the hydrogen bonds with EMIMTFSI and polyVEIMTFSI, to effectively render the polymer electrolyte with adjustable ionic conductivity and tunable mechanical property. In addition, with the regulated coordination environment of Li
, the LiF and Li
N layer can be uniformly formed on the Li surface to facilitate Li
nucleation and deposition. As a consequence, the PAEV electrolyte confers the Li/LiFePO
(LFP) battery with high capacity of 124 mA h g
at 1 C under 25 °C, and 152 mA h g
under 50 °C. This work can promote the development of high performance polymer electrolyte via lithium bond manipulation.
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IJS, KILJ, NUK, PNG, UL, UM
This article offers a rare study of the content and performance of political strategies in China’s highly institutionalized setting. A conceptual framework based on institutional theory findings is ...proposed to develop a set of expected political behavior. This is then confronted to data from a convenient sample of 233 firms. The results show that there are indeed recognizable patterns of political strategy, most of which are bent by the strong institutional environment toward accommodation rather than confrontation or defiance. The strategies identified were found to be related to the nature of the firms’ available resources and to the firms’ ability to extract benefits or bend the government’s behavior in their favor.
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NUK, OILJ, SAZU, UKNU, UL, UM, UPUK
The determination of gallic acid (GA) content by a graphene modified glassy carbon electrode (graphene/GCE) was studied. The electrochemical behavior of GA on this electrode was studied by cyclic ...voltammetry (CV), and the standard curve was constructed by differential pulse voltammetry (DPV). The results indicate that graphene has a good catalytic effect on GA in phosphate buffer (PBS) and shows a linear response toward GA in the 8.0x10-8 to 2.0x10-5 mo∙L-1 concentration range. The detection limit is 1.2x10’9 mol∙L-1. This proposed determination for GA on graphene/GCE was carried out in the presence of potentially interfering compounds such as sorbic acid, tartaric acid, ascorbic acid and glucose. The content of GA in green tea was determined by this method, and the recovery was 97.9% ’ 100.6% with satisfactory results.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
This research examines the mechanism of consumer responses to CSR under multiindustry context in China. Data is collected by a three-industry comparative survey. The empirical results show that: 1) ...Two positive influences of consumers’ perceiving CSR performance on their corporate associations and product associations are respectively partially and fully mediated by consumers’ CSR trust; 2) Product category is a moderator of the relationship between consumers’ CSR trust and product association, and the positive path from product association to purchase intention. This study could help managers to understand how consumers think about CSR, and provides them strategic guidance to implement CSR programme in China.
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