New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the ...in vitro activity of Casiopeínas® copper-based compounds (CasIIIia, CasIIIEa, and CasIIgly) alone and combined with isoniazid (INH), rifampicin, or ethambutol (EMB) against resistant and susceptible Mycobacterium tuberculosis. Seventeen clinical M. tuberculosis isolates (5 multi-drug resistant and 2 resistant to INH and/or EMB) were subjected to determination of the minimal inhibitory concentration (MIC) by the resazurin microtiter assay and combination assessment by the resazurin drug combination microtiter assay. The Casiopeínas® alone showed a remarkable effect against resistant isolates with MIC values from 0.78 to 12.50 μg/ml. Furthermore, a synergistic effect mainly with EMB is shown for both resistant and susceptible clinical isolates. Casiopeínas® are promising candidates for future investigation into the development of antituberculosis drugs, being one of the first examples of essential metal-based drugs used in this field.
Presentación Toledano Magaña, Yanis; Vázquez Duhalt, Rafael; Acosta Torres, Laura
Mundo nano (en línea),
06/2018, Volume:
11, Issue:
21
Journal Article
Peer reviewed
La nanotecnología ha avanzado vertiginosamente alcanzando un nivel multi e interdisciplinario al interactuar con otras disciplinas, especialmente con la biomedicina, la fisicoquímica, la ciencia de ...materiales, y, en el área de las humanidades, con la bioética, por mencionar algunas. En este sentido, como ya lo señalábamos en el número anterior de Mundo Nano, el diseño de nuevos materiales a escala nanométrica puede generar potenciales riesgos considerando sus posibles aplicaciones.
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