The mean and variability of the Atlantic meridional overturning circulation (AMOC), as represented in six ocean reanalysis products, are analyzed over the period 1960–2007. Particular focus is on ...multi-decadal trends and interannual variability at 26.5°N and 45°N. For four of the six reanalysis products, corresponding reference simulations obtained from the same models and forcing datasets but without the imposition of subsurface data constraints are included for comparison. An emphasis is placed on identifying general characteristics of the reanalysis representation of AMOC relative to their reference simulations without subsurface data constraints. The AMOC as simulated in these two sets are presented in the context of results from the Coordinated Ocean-ice Reference Experiments phase II (CORE-II) effort, wherein a common interannually varying atmospheric forcing data set was used to force a large and diverse set of global ocean-ice models. Relative to the reference simulations and CORE-II forced model simulations it is shown that (1) the reanalysis products tend to have greater AMOC mean strength and enhanced variance and (2) the reanalysis products are
less
consistent in their year-to-year AMOC changes. We also find that relative to the reference simulations (but not the CORE-II forced model simulations) the reanalysis products tend to have enhanced multi-decadal trends (from 1975–1995 to 1995–2007) in the mid to high latitudes of the northern hemisphere.
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DOBA, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, IZUM, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, SIK, UILJ, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The impact of resolving western boundary currents and mesoscale eddies on a carbon circulation simulation for the North Pacific Ocean is investigated to evaluate the merits of using high‐resolution ...ocean biogeochemical models for climate projections. Simulations by a 100‐km resolution global ocean biogeochemical model with and without embedding a 10‐km resolution model in the North Pacific Ocean are compared. The major improvement in the high‐resolution simulation is the representation of the Kuroshio, its extension current, and the recirculation gyres formed to its south and north, resulting in a proper representation of the North Pacific subtropical mode water (STMW) and an increase in storage of the anthropogenic CO2 (Canth) in STMW by about two‐thirds. The larger storage rate in STMW is caused by supply of a larger amount of warm surface water containing rich Canth to the formation region by the intensified Kuroshio. A huge buoyancy loss from this warm water results in the increased formation of STMW that occupies a vast area in the western subtropical gyre. The surface uptake of Canth in the formation region of STMW is slightly increased but is largely comparable to that of the low‐resolution model. Moreover, there is no structural difference in Canth uptake in other parts of the subtropical region. Thus, the improvement of Canth distribution can be understood as a redistribution of water mass in the subtropical gyre by the improved circulation. The present assessment motivates the use of a high horizontal resolution ocean model in next‐generation projection experiments with carbon cycles.
Plain Language Summary
Accurately representing absorption and accumulation of anthropogenic CO2 (Canth) by the ocean in Earth system models is important to reliably project future climate change. This study investigates the impact of realistically expressing the Kuroshio, which is not expressed adequately in the majority of current Earth system models, on a carbon circulation simulation for the North Pacific Ocean. Two simulations differing in the horizontal grid spacing, about 100 and 10 km, are compared. The intensified Kuroshio in the fine resolution model results in an improved oceanic structure for the upper 500‐m depths in the western North Pacific Ocean, and more Canth is accumulated there, which is closer to observations. Budget analysis suggests that source for the increased Canth accumulation is not local surface flux but a supply of Canth‐rich surface water from low latitudes by the intensified Kuroshio. Such improvements would give more fidelity to projections of regional subsurface water acidification rate. Overall, the use of a fine horizontal resolution ocean model can be recommended in next‐generation projection experiments with carbon cycles for the North Pacific Ocean.
Key Points
Storage of anthropogenic carbon in the western North Pacific Ocean is improved by using a 10‐km horizontal resolution ocean model
Improvement in the formation and distribution of the North Pacific subtropical mode water is a key
Use of 10‐km class high horizontal resolution ocean models is recommended as part of Earth system models with carbon cycles
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DOBA, FZAB, GIS, IJS, IZUM, KILJ, NLZOH, NUK, OILJ, PILJ, PNG, SAZU, SBCE, SBMB, SIK, UILJ, UKNU, UL, UM, UPUK
Using an ocean carbon cycle model embedded in an ocean general circulation model, we examine how the budget of anthropogenic CO2 (Cant) is controlled by ocean dynamics. To complement recent studies ...showing only vertically integrated budgets, we provide a step‐by‐step description by making use of three different coarse grainings of the full vertical resolution of the ocean model in our budget analysis. For the 11 subdomains of the global ocean, these coarse grainings are (1) a one‐layer (vertically integrated) budget, (2) a three‐layer budget, and (3) an 11‐layer budget. We largely focus on the Pacific circulation. We identify and quantify substantial carbon transport associated with the subtropical cells (STCs), which are dominant contributors to the meridional overturning circulation in the upper ocean in the tropics and subtropics, as playing a fundamental role in governing the ocean interior distribution of Cant. The upper branch of the STCs transports Cant‐rich water from the tropics to the subtropics, contributing to the precondition for the high Cant inventory in mode waters. The lower branch of the STCs carries about two thirds of the transported Cant back to the tropics, while it largely excludes Subtropical Mode Waters. This work implies that the reemergence of Cant through recirculation within the STCs may lead to a reduced capacity for further Cant uptake via gas exchange into the surface ocean, potentially contributing to a positive carbon‐climate feedback.
Key Points
Three‐dimensional carbon budget is estimated using a biogeochemical model
Subtropical cells are important for determining the anthropogenic CO2 budget
Anthropogenic CO2 budget in mode waters is also discussed
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
The coastal ocean contributes to regulating atmospheric greenhouse gas concentrations by taking up carbon dioxide (CO2) and releasing nitrous oxide (N2O) and methane (CH4). In this second phase of ...the Regional Carbon Cycle Assessment and Processes (RECCAP2), we quantify global coastal ocean fluxes of CO2, N2O and CH4 using an ensemble of global gap‐filled observation‐based products and ocean biogeochemical models. The global coastal ocean is a net sink of CO2 in both observational products and models, but the magnitude of the median net global coastal uptake is ∼60% larger in models (−0.72 vs. −0.44 PgC year−1, 1998–2018, coastal ocean extending to 300 km offshore or 1,000 m isobath with area of 77 million km2). We attribute most of this model‐product difference to the seasonality in sea surface CO2 partial pressure at mid‐ and high‐latitudes, where models simulate stronger winter CO2 uptake. The coastal ocean CO2 sink has increased in the past decades but the available time‐resolving observation‐based products and models show large discrepancies in the magnitude of this increase. The global coastal ocean is a major source of N2O (+0.70 PgCO2‐e year−1 in observational product and +0.54 PgCO2‐e year−1 in model median) and CH4 (+0.21 PgCO2‐e year−1 in observational product), which offsets a substantial proportion of the coastal CO2 uptake in the net radiative balance (30%–60% in CO2‐equivalents), highlighting the importance of considering the three greenhouse gases when examining the influence of the coastal ocean on climate.
Plain Language Summary
The coastal ocean regulates greenhouse gases. It acts as a sink of carbon dioxide (CO2) but also releases nitrous oxide (N2O) and methane (CH4) into the atmosphere. This synthesis contributes to the second phase of the Regional Carbon Cycle Assessment and Processes (RECCAP2) and provides a comprehensive view of the coastal air‐sea fluxes of these three greenhouse gases at the global scale. We use a multi‐faceted approach combining gap‐filled observation‐based products and ocean biogeochemical models. We show that the global coastal ocean is a net sink of CO2 in both observational products and models, but the coastal uptake of CO2 is ∼60% larger in models than in observation‐based products due to model‐product differences in seasonality. The coastal CO2 sink is strengthening but the magnitude of this strengthening is poorly constrained. We also find that the coastal emissions of N2O and CH4 counteract a substantial part of the effect of coastal CO2 uptake in the atmospheric radiative balance (by 30%–60% in CO2‐equivalents), highlighting the need to consider these three gases together to understand the influence of the coastal ocean on climate.
Key Points
We synthesize air‐sea fluxes of CO2, nitrous oxide and methane in the global coastal ocean using observation‐based products and ocean models
The coastal ocean CO2 sink is 60% larger in ocean models than in observation‐based products due to systematic differences in seasonality
Coastal nitrous oxide and methane emissions offset 30%–60% of the CO2 coastal uptake in the net radiative balance
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Triple-negative breast cancer (TNBC) can be divided into six subtypes. Among these subtypes, the basal-like 2 (BL2) subtype shows the lowest five-year survival rate and highest risk of metastasis. ...Alpha-crystallin B chains (αB-crystallin), a small heat shock protein that is known
to be involved in breast cancer metastasis, is highly expressed in the basal-like subtype but not in the other non-basal subtypes. Thus, we hypothesized that αB-crystallin may be an important factor involved in the worse prognosis of the BL2 subtype compared with those of the other TNBC
subtypes. Here, we examined the role of αB-crystallin in cell motility in two TNBC cell lines: HCC1806 (BL2 subtype) and, as control, MDA-MB-436 (mesenchymal stem-like subtype). HCC1806 showed greater cell migration capacity and a higher expression level of the gene encoding αB-crystallin
(CRYAB) than did MDA-MB-436. Short interfering RNA-mediated silencing of CRYAB expression significantly reduced the cell migration capacity of HCC1806 cells, whereas it had no effect in MDA-MB-436 cells, indicating that αB-crystallin is essential for the migration
of HCC1806 cells. Thus, high αB-crystallin expression may be a contributing factor to the poor prognosis of BL2 TNBC.
Understanding the impacts of high‐resolution ocean model provides valuable insights for future research. However, the outcomes of sea surface state changes in both the tropics and mid‐latitudes ...remain unclear, and initialized seasonal forecasts have not been studied extensively. This study investigates the impact of ocean model resolution with the first long‐term hindcast experiment of an eddy‐resolving (0.1°) ocean model used for global seasonal forecasting. We show that using the high‐resolution ocean model significantly changes boreal winter jet streams in the atmosphere, based on the comparison of 30‐year hindcasts with ocean resolutions ranging from 1° to 0.1° for the Japan Meteorological Agency/Meteorological Research Institute Coupled Prediction System version 3. In boreal winters, the cold sea surface bias in the equatorial Pacific is significantly reduced, leading to an equatorward shift in the intertropical convergence zone (ITCZ) and enhanced convective activity in the western equatorial Pacific. The subtropical jet shifts equatorward due to the ITCZ shift and the weakening of equatorward propagation of mid‐latitude atmospheric eddies. The enhanced convective activity in the tropics has a remote influence in the mid‐latitudes, significantly reducing the upward eddy propagation of zonal wavenumber 1. Sea surface warm‐up in the mid‐latitudes partially cancels the reduction impact by enhancing the zonal wavenumber 2. Overall, the polar night jet accelerates due to the reduced supply of eddy forcing.
Plain Language Summary
Atmospheric and oceanic eddies play an important role in shaping the climate. In numerical climate simulations, the Earth is divided into a grid of discrete boxes, and the exchange of energy and mass between the boxes is computed step‐by‐step. Coarse grids are often used to reduce the computational cost, but recent studies have suggested that resolving fine ocean phenomena can make a significant difference. In this study, numerical seasonal forecasting experiments with ocean resolutions of 100 km, 25 km, and 10 km are compared to investigate the high‐resolution effects on the atmospheric flow for boreal winter. This is the first 30‐year‐long, retrospective seasonal forecast experiment for the past winters using a global eddy‐resolving (10 km) ocean model. The high‐resolution ocean model greatly warms the surface seawater in the tropical Pacific and in the mid‐latitude oceans. These changes in the sea surface influence atmospheric convection and eddies, with far‐reaching effects on distant regions and altitudes. Such effects on the westerly jet streams, which flow several kilometers to tens of kilometers above the sea surface, are observed in the southward shift of the subtropical jet and the strengthening of the polar night jet.
Key Points
Altering the ocean model resolution from 1° to 0.1° in a seasonal forecast model shifts and enhances the subtropical and polar night jets
Atmospheric responses to both tropical and mid‐latitude oceans are observed
Wave‐mean flow diagnostics indicates that the jet stream responses are more strongly influenced by the tropics
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a favorable treatment outcome in patients with EGFR mutation-positive non-small cell lung cancer. However, most of such ...patients become resistant to EGFR-TKIs within a year. Thus, clarifying the mechanism
of acquired resistance to EGFR-TKIs has been a research focus. Here, we demonstrated that the expression of progesterone receptor membrane component 2 (PGRMC2) was upregulated in an erlotinib-resistant cell line, PC9/ER, compared with the parental PC9 lung cancer cells. Our previous study
showed that PGRMC1 is responsible for acquired resistance to erlotinib; however, PGRMC2 has not been discussed yet. Thus, the aim of this study was to determine the role of PGRMC2 in acquired resistance to erlotinib. Transfection with PGRMC2 siRNA significantly enhanced the sensitivity to
erlotinib in PC9/ER cells. Furthermore, knockdown of PGRMC2 reduced the expression of p21, which is known as cell-cycle inhibitor and antiproliferative effector. These results suggest that PGRMC2 partially contributes to erlotinib resistance in PC9/ER cells, and that investigation into the
effect of PGRMC2 on apoptosis and the cell cycle are warranted.
We present an analysis of annual and seasonal mean characteristics of the Indian Ocean circulation and water masses from 16 global ocean–sea-ice model simulations that follow the Coordinated ...Ocean-ice Reference Experiments (CORE) interannual protocol (CORE-II). All simulations show a similar large-scale tropical current system, but with differences in the Equatorial Undercurrent. Most CORE-II models simulate the structure of the Cross Equatorial Cell (CEC) in the Indian Ocean. We uncover a previously unidentified secondary pathway of northward cross-equatorial transport along 75 °E, thus complementing the pathway near the Somali Coast. This secondary pathway is most prominent in the models which represent topography realistically, thus suggesting a need for realistic bathymetry in climate models. When probing the water mass structure in the upper ocean, we find that the salinity profiles are closer to observations in geopotential (level) models than in isopycnal models. More generally, we find that biases are model dependent, thus suggesting a grouping into model lineage, formulation of the surface boundary, vertical coordinate and surface salinity restoring. Refinement in model horizontal resolution (one degree versus 14 degree) does not significantly improve simulations, though there are some marginal improvements in the salinity and barrier layer results. The results in turn suggest that a focus on improving physical parameterizations (e.g. boundary layer processes) may offer more near-term advances in Indian Ocean simulations than refined grid resolution.
•Assessment of the Indian Ocean simulation from global forced sea- ice models.•SST biases are ∼2 times smaller in forced simulations than the coupled simulations.•Coupled model shows large inter-model spread over the eastern equatorial Indian Ocean.•Refinement in model horizontal resolution does not significantly improve simulations.•Uncover a secondary pathway of northward cross-equatorial transport along 75 °E.•Models are unable to capture the observed thick barrier layer in the north Bay of Bengal.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Activating transcription factor 3 (ATF3), a member of ATF/CREB family of transcription factors, is induced in a variety of stressed tissue. ATF3 regulates transcription by binding to DNA sites as a ...homodimer or heterodimer with Jun proteins. The purpose of this study was to examine the expression and regulation of ATF3 after axonal injury in neurons in dorsal root ganglia (DRG) and spinal cord. In naive rats, ATF3 was not expressed in the DRG and spinal cord. Following the cut of peripheral nerve, ATF3 was immediately induced in virtually all DRG neurons and motoneurons that were axotomized, and the time course of induction was dependent on the distance between the injury site and the cell body. Double labeling using immunohistochemistry revealed that the population of DRG neurons expressing ATF3 included those expressing c-jun, and in motoneurons ATF3 and c-jun were concurrently expressed after axotomy. In contrast to c-jun, ATF3 was not induced transsynaptically in spinal dorsal horn neurons. We conclude that ATF3 is specifically induced in sensory and motoneurons in the spinal cord following nerve injury and should be regarded as an unique neuronal marker of nerve injury in the nervous system.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
A practical scheme is proposed to explicitly introduce tides into ocean general circulation models (OGCM). In this scheme, barotropic linear response to the tidal forcing is calculated by the time ...differential equations modified for ocean tides, instead of the original barotropic equations of an OGCM. This allows for the usage of various parameterizations specified for tides, such as the self-attraction/loading (SAL) effect and energy dissipation due to internal tides, without unintentional violation of the original dynamical balances in an OGCM. Meanwhile, secondary nonlinear effects of tides, e.g., excitation of internal tides and advection by tidal currents, are fully represented within the framework of the original OGCM equations. That is, this scheme drives the OGCM by the barotropic linear tidal currents which are predicted progressively by a tuned tide model, instead of the equilibrium tide potential, without large additional numerical costs. We incorporated this scheme into Meteorological Research Institute Community Ocean Model and executed test experiments with a low-resolution global model. The results showed that the model can simulate both the non-tidal circulations and the tidal motion simultaneously. Owing to the usage of tidal parameterizations such as a SAL term, a root-mean-squared error in the tidal heights is found to be as small as 10.0 cm, which is comparable to that of elaborately tuned tide models. In addition, analysis of the speed and energy of the barotropic tidal currents is found to be consistent with that of past tide studies. The model also showed active excitement of internal tides and tidal mixing. In the future, the impacts of internal tides and tidal mixing should be examined using a model with a finer resolution, since explicit and precise introduction of tides into an OGCM is a significant step toward the improvement of ocean models.
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