We present ADIOS 2, the latest version of the Adaptable Input Output (I/O) System. ADIOS 2 addresses scientific data management needs ranging from scalable I/O in supercomputers, to data analysis in ...personal computer and cloud systems. Version 2 introduces a unified application programming interface (API) that enables seamless data movement through files, wide-area-networks, and direct memory access, as well as high-level APIs for data analysis. The internal architecture provides a set of reusable and extendable components for managing data presentation and transport mechanisms for new applications. ADIOS 2 bindings are available in C++11, C, Fortran, Python, and Matlab and are currently used across different scientific communities. ADIOS 2 provides a communal framework to tackle data management challenges as we approach the exascale era of supercomputing.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
We designed a retrospective cohort study using the Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan, to examine whether recent global ...diagnostic criteria for preeclampsia, phenotypes of hypertensive disorders of pregnancy (HDP) and features of the disease are useful as predictors of placental abruption and whether other risk factors are associated with the onset of placental abruption. A total of 85,858 hospitalized patients with a diagnosis of HDP who gave birth during hospitalization between July 2010 and March 2018 were included in this study. We examined the associations between the occurrence of placental abruption after hospitalization and several factors, including gestational age (GA) at placental abruption onset, HDP subtypes, GA on admission, maternal age, body mass index, smoking, multiple pregnancy, prelabor rupture of membranes, diabetes mellitus, emergency admission by ambulance, and consciousness, using a multivariate logistic regression analysis. Placental abruption occurred in 541 patients (0.63%) after hospital admission, and the occurrence increased acutely after 32 weeks GA. A decrease in abruption was significantly associated with maternal BMI on admission (≥30 kg/m
; odds ratio OR, 0.54; 95% confidence interval CI, 0.41-0.70) and multiple pregnancy (OR, 0.29; 95% CI, 0.18-0.46). An increase in abruption was associated with earlier GA on admission (<34 weeks' GA; OR, 3.77; 95% CI, 3.13-4.53) and emergency admission by ambulance (OR, 1.34; 95% CI, 1.09-1.65). Individual features of severe PE showed no significant associations with the occurrence of abruption. In conclusion, HDP at an earlier GA was suggested to be a risk factor for placental abruption, and we recommend hospitalization and careful management of such patients to improve their prognosis.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
For leukotriene receptor antagonists (LTRAs), especially pranlukast, safety data during pregnancy is limited. Therefore, we conducted a prospective, two‐centered cohort study using data from ...teratogen information services in Japan to clarify the effects of LTRA exposure during pregnancy on maternal and fetal outcomes. Pregnant women who being counseled on drug use during pregnancy at two facilities were enrolled. The primary outcome of this study was major congenital anomalies. The incidence of major congenital anomalies in women exposed to montelukast or pranlukast during the first trimester of pregnancy was compared with that of controls. Logistic regression analysis was performed to analyze the effects of maternal LTRA use during the first trimester of pregnancy on major congenital anomalies. The outcomes of 231 pregnant women exposed to LTRAs (montelukast n = 122; pranlukast n = 106; both n = 3) and 212 live births were compared with those of controls. The rate of major congenital anomalies in the LTRA group was 1.9%. Multivariable logistic regression analysis revealed that LTRA exposure was not a risk factor for major congenital anomalies (adjusted odds ratio, 0.78; 95% confidence interval, 0.23–2.05; p = 0.653). In addition, no significant difference was detected in stillbirth, spontaneous abortion, preterm birth, and low birth weight between the two groups. The present study revealed that montelukast and pranlukast were not associated with the risk of major congenital anomalies. Our findings suggest that LTRAs could be safely employed for asthma therapy during pregnancy.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Depressed skull fractures in newborn occur in about 1 to 2.5 per 10,000 births. The depressed skull fractures are caused by prolonged pressure applied to the fetal head in uterus or traumatic ...factors, for example forceps delivery or digital pressure from the hand of obstetricians during caesarian sections. We report a case of a depressed skull fractures in neonate born by cesarian section. A 2, 096 g female was born by cesarean delivery performed in advanced labor, when the cervix is 9 cm dilated at 37 weeks gestation. Because of the fetal head had deeply engaged into the pelvis, an assistant pushed up the fetal head from the vagina, but we failed to deliver the fetal head. After all, we delivered the fetus by reverse breech extraction after hysterotomy extension superiorly in an inverse T. At birth, she was noted to have a depression of skull measuring 5×3 cm in the left side of the parietal bone. A computed tomography scan showed subarachnoid hemorrhage, and magnetic resonance imaging showed cerebral contusion. Because of the presence of multiple intracranial lesions, the depressed skull fracture was estimated to be caused by traumatic factors. During the 25 days follow up, she did not show any abnormal neurological symptoms. The depressed fracture was followed up without surgery. At cesarian section when the fetal head is deeply engaged, we need to be careful about pushing the fetal head up deeply from the vagina and might consider extending incision or to relax the uterus and revers breech extraction to reduce fetal and maternal morbidity.
Combustion chamber of liquid-propellant rocket engine is developed mainly based on tests using subscale chamber with single and multiple injectors and full-scale engine. Understanding the combustion ...phenomena only from the test is difficult, and the knowledge obtained in the subscale test is not always applicable to the full-scale chamber. Development of numerical simulation technique to predict the onset of combustion instability and evaluate wall heat flux is required. In this article, the compressible Large-Eddy Simulation was applied to the subscale chambers to validate the numerical method. Mechanism of combustion instability was also discussed. Then, present challenge for the analysis of the full-scale rocket chamber by the compressible Large-Eddy Simulation was also presented.
Group A streptococcus infection during pregnancy can be concerning. It may cause toxic shock syndrome, which can be fatal. Here, we report a rare case of a pregnant woman who developed infectious ...sacroiliitis due to group A streptococcus infection. To the best of our knowledge, this case is the first of its kind to be reported.
A 32-year-old multiparous Japanese woman presented with fever and right buttock pain at 28 weeks of gestation. Based on our clinical findings and investigations, she was diagnosed with group A streptococcus bacteremia and infectious sacroiliitis caused by group A streptococcus. A cardiotocography performed to assess the fetal status showed fetal tachycardia. To prevent the patient from progressing to toxic shock syndrome caused by group A streptococcus, we performed an emergency cesarean section. The patient and her infant had a good course after the cesarean section.
A pregnant woman diagnosed with group A streptococcus infection needs to be monitored closely because a timely decision to deliver the fetus before rapid deterioration to toxic shock syndrome is crucial.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
We report two pregnant women with COVID-19. Case 1 was a 34-year-old, multigravida woman with COVID-19 at 28+3 weeks of gestation. High fever didn’t improve, furthermore, respiratory symptoms and ...thrombocytopenia progressed. Because the antiviral drug use was necessary, we performed cesarean section at 29+5 weeks of gestation with spinal anesthesia. Treatment with the antiviral drug was started after delivery. She requested breastfeeding, so started milking with taking measures against infection. SARS-CoV-2 was negative in her milk. There was no COVID-19 infection in the baby. Case 2 was a 29-year-old, primigravid woman. She went into labor at 38+6 weeks, then she was diagnosed with COVID-19. She was transported to our hospital and underwent a cesarean section with general anesthesia. Mother and child were separated until 8 days after delivery. There was no hope of breastfeeding during separation, and mixed feeding was started after separation. It was considered that even pregnant women with COVID-19 could perform breastfeeding, if measures to prevent the spread of the infection are taken.
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