We correct an overestimation of the production rate of
137
Xe in the DARWIN detector operated at LNGS. This formerly dominant intrinsic background source is now at a level similar to the irreducible ...background from solar
8
B neutrinos, thus unproblematic at the LNGS depth. The projected half-life sensitivity for the neutrinoless double beta decay (
0
ν
β
β
) of
136
Xe improves by
22
%
compared to the previously reported number and is now
T
1
/
2
0
ν
=
3.0
×
10
27
yr
(90% C.L.) after 10 years of DARWIN operation.
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We have searched for periodic variations of the electronic recoil event rate in the (2-6) keV energy range recorded between February 2011 and March 2012 with the XENON100 detector, adding up to 224.6 ...live days in total. Following a detailed study to establish the stability of the detector and its background contributions during this run, we performed an unbinned profile likelihood analysis to identify any periodicity up to 500 days. We find a global significance of less than 1σ for all periods, suggesting no statistically significant modulation in the data. While the local significance for an annual modulation is 2.8σ, the analysis of a multiple-scatter control sample and the phase of the modulation disfavor a dark matter interpretation. The DAMA/LIBRA annual modulation interpreted as a dark matter signature with axial-vector coupling of weakly interacting massive particles to electrons is excluded at 4.8σ.
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In this paper, we describe the XENON100 data analyses used to assess the target-intrinsic background sources radon (
), thoron (
) and krypton (
). We detail the event selections of high-energy alpha ...particles and decay-specific delayed coincidences. We derive distributions of the individual radionuclides inside the detector and quantify their abundances during the main three science runs of the experiment over a period of
∼
4
years
, from January 2010 to January 2014. We compare our results to external measurements of radon emanation and krypton concentrations where we find good agreement. We report an observed reduction in concentrations of radon daughters that we attribute to the plating-out of charged ions on the negatively biased cathode.
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Ictal epileptic headache, characterized by headache as the sole symptom of a seizure attack, is a rare condition. In this case report, we present a 52‐year‐old female with a history of systemic lupus ...erythematosus who sought medical attention at the headache clinic due to a new type of headache. The headache was described as an intense painful wave followed by a dull headache, without autonomic symptoms or migrainous features. Magnetic resonance imaging revealed an enhancing lesion in the left hippocampus in addition to two other lesions in the corpus callosum and left parieto‐occipital lobe. Electroencephalography during the headache episodes showed epileptic discharges originating from the left fronto‐temporal region. The patient was initiated on levetiracetam, which resulted in the resolution of both the epileptic discharges and the headaches. This case underscores the significance of considering ictal epileptic headache as a potential secondary cause for headaches, particularly in patients with underlying conditions that may predispose them to epilepsy, such as systemic lupus erythematosus.
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The selection of low-radioactive construction materials is of utmost importance for the success of low-energy rare event search experiments. Besides radioactive contaminants in the bulk, the ...emanation of radioactive radon atoms from material surfaces attains increasing relevance in the effort to further reduce the background of such experiments. In this work, we present the
222
Rn emanation measurements performed for the XENON1T dark matter experiment. Together with the bulk impurity screening campaign, the results enabled us to select the radio-purest construction materials, targeting a
222
Rn activity concentration of
10
μ
Bq
/
kg
in
3.2
t
of xenon. The knowledge of the distribution of the
222
Rn sources allowed us to selectively eliminate problematic components in the course of the experiment. The predictions from the emanation measurements were compared to data of the
222
Rn activity concentration in XENON1T. The final
222
Rn activity concentration of
(
4.5
±
0.1
)
μ
Bq
/
kg
in the target of XENON1T is the lowest ever achieved in a xenon dark matter experiment.
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Immune-modifying medications are widely available and recognized as valuable by most gastroenterologists. However, approximately 40% of patients with Crohn's disease (CD) do not comply with regimens ...using these medications, resulting in complications, hospitalization, and surgeries. We sought to identify factors that motivate adherence or nonadherence with medication recommendations for CD.
We conducted qualitative interviews with patients living with CD who were identified as adherent or nonadherent to immune-modifying medication recommendations by their treating gastroenterologist. Semistructured interview guides were developed based on an established framework for understanding health behaviors. We conducted content analysis of the resulting qualitative data using an inductive-deductive approach to identify emergent themes that influence medication decision-making.
Twenty-five patients with CD completed interviews for this study. Interviews were independently coded and analyzed for thematic content. Two broad domains emerged comprising (1) themes reflected in the Theoretical Domains Framework and (2) novel themes specific to medication decision-making in CD. Adherent patients conveyed a sense of trust in science and healthcare provider expertise, while nonadherent patients were more likely to express beliefs in their ability to self-manage CD, concern about risks associated with medication, and a general ambivalence to treatment.
There are clear cognitive, behavioral, and relational factors that guide patients' medication-related decision-making. Several of the factors share features of other behavioral change and decision-making processes, while others are specific to the experience of patients with CD. A fuller understanding of these factors is essential to developing effective behavioral interventions to improve adherence to evidence-based treatment recommendations.
In preparation for the XENON1T Dark Matter data acquisition, we have prototyped and implemented a new computing model. The XENON signal and data processing software is developed fully in Python 3, ...and makes extensive use of generic scientific data analysis libraries, such as the SciPy stack. A certain tension between modern "Big Data" solutions and existing HEP frameworks is typically experienced in smaller particle physics experiments. ROOT is still the "standard" data format in our field, defined by large experiments (ATLAS, CMS). To ease the transition, our computing model caters to both analysis paradigms, leaving the choice of using ROOT-specific C++ libraries, or alternatively, Python and its data analytics tools, as a front-end choice of developing physics algorithms. We present our path on harmonizing these two ecosystems, which allowed us to use off-the-shelf software libraries (e.g., NumPy, SciPy, scikit-learn, matplotlib) and lower the cost of development and maintenance. To analyse the data, our software allows researchers to easily create "mini-trees"; small, tabular ROOT structures for Python analysis, which can be read directly into pandas DataFrame structures. One of our goals was making ROOT available as a cross-platform binary for an easy installation from the Anaconda Cloud (without going through the "dependency hell"). In addition to helping us discover dark matter interactions, lowering this barrier helps shift the particle physics toward non-domain-specific code.
MAUS: the MICE analysis user software Asfandiyarov, R.; Bayes, R.; Blackmore, V. ...
Journal of instrumentation,
04/2019, Volume:
14, Issue:
4
Journal Article
Peer reviewed
Open access
The Muon Ionization Cooling Experiment (MICE) collaboration has developed the MICE Analysis User Software (MAUS) to simulate and analyze experimental data. It serves as the primary codebase for the ...experiment, providing for offline batch simulation and reconstruction as well as online data quality checks. The software provides both traditional particle-physics functionalities such as track reconstruction and particle identification, and accelerator physics functions, such as calculating transfer matrices and emittances. The code design is object orientated, but has a top-level structure based on the Map-Reduce model. This allows for parallelization to support live data reconstruction during data-taking operations. MAUS allows users to develop in either Python or C++ and provides APIs for both. Various software engineering practices from industry are also used to ensure correct and maintainable code, including style, unit and integration tests, continuous integration and load testing, code reviews, and distributed version control. The software framework and the simulation and reconstruction capabilities are described.
Background
During videoscope‐assisted minimally invasive surgery which uses a high magnification videoscope to treat periodontal defects, small areas resembling calculus are detected remaining on ...root surfaces following scaling. These are clinically termed microislands of calculus, which are removed by the use of a chelating agent. This material has not been verified as calculus and the ability of a chelating agent to remove calculus has not been proven. The purpose of this ex vivo study is to verify if the material is calculus and to determine if calculus is removed with a chelating agent.
Methods
Extracted teeth (n = 22) with heavy calculus on root surfaces were selected. A 5‐mm2 area containing calculus was scribed on each root. Digital videoscope images were made of the marked areas using only white light and also with only a 655‐nm diode laser that causes calculus to fluoresce. The marked areas were root planed until no calculus was visible with 3.5× surgical loupes. Digital images were again made. The test area was then burnished with a chelating agent (EDTA) for 30 seconds and images again made. Using the images, the percentage of the marked root surface containing calculus was calculated.
Results
Calculus remained on the roots surfaces after they were judged to be clean using 3.5× loupe magnification. Remaining calculus was reduced after burnishing for 30 seconds with EDTA.
Conclusions
Calculus remains on root surfaces judged to be calculus free using surgical loupes for visualization. Small areas of calculus are reduced or eliminated with a chelating agent.
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