The Bristol CMIP6 Data Hackathon Mitchell, Dann M.; Stone, Emma J.; Andrews, Oliver D. ...
Weather,
June 2022, 2022-06-00, 20220601, Volume:
77, Issue:
6
Journal Article
Peer reviewed
Open access
The Bristol CMIP6 Data Hackathon formed part of the Met Office Climate Data Challenge Hackathon series during 2021, bringing together around 100 UK early career researchers from a wide range of ...environmental disciplines. The purpose was to interrogate the under‐utilised but currently most advanced climate model inter‐comparison project datasets to develop new research ideas, create new networks and outreach opportunities in the lead up to COP26. Experts in different science fields, supported by a core team of scientists and data specialists at Bristol, had the unique opportunity to explore together interdisciplinary environmental topics summarised in this article.
Full text
Available for:
BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Studies of physiology can provide important insight into how animals are coping with challenges in their environment and can signal the potential effects of exposure to human activity in both the ...short and long term. In this study, we measured the physiological and behavioural response of little penguins (Eudyptula minor) that were naïve to human activity over 30 min of capture and handling. We assessed relationships between corticosterone secretion, behaviour, sex and time of day in order to characterize the determinants of the natural stress response. We then compared the response of these naïve penguins with the responses of female little penguins that had been exposed to research activity (bimonthly nest check and weighing) and to both research activity (monthly nest check and weighing) and evening viewing by tourists. We found that corticosterone concentrations increased significantly over 30 min of capture, with naïve penguins demonstrating a more acute stress response during the day than at night. Penguins that had previously been exposed to handling at the research and research/visitor sites showed elevated corticosterone concentrations and consistently more aggressive behaviour after 30 min compared with naïve birds, although there were no significant differences in baseline corticosterone concentrations. Our findings demonstrate that these little penguins have not habituated to routine capture, but rather mount a heightened physiological and behavioural response to handling by humans. Less invasive research monitoring techniques, such as individual identification with PIT tags and automatic recording and weighing, and a reduction in handling during the day should be considered to mitigate some of the potentially negative effects of disturbance. Given the paucity of data on the long-term consequences of heightened stress on animal physiology, our study highlights the need for further investigation of the relationship between the corticosterone stress response and fitness outcomes, such as breeding success and survival.
Anti-TNF drugs, such as infliximab, are associated with attenuated antibody responses after SARS-CoV-2 vaccination. We aimed to determine how the anti-TNF drug infliximab and the anti-integrin drug ...vedolizumab affect vaccine-induced neutralising antibodies against highly transmissible omicron (B.1.1.529) BA.1, and BA.4 and BA.5 (hereafter BA.4/5) SARS-CoV-2 variants, which possess the ability to evade host immunity and, together with emerging sublineages, are now the dominating variants causing current waves of infection.
CLARITY IBD is a prospective, multicentre, observational cohort study investigating the effect of infliximab and vedolizumab on SARS-CoV-2 infection and vaccination in patients with inflammatory bowel disease (IBD). Patients aged 5 years and older with a diagnosis of IBD and being treated with infliximab or vedolizumab for 6 weeks or longer were recruited from infusion units at 92 hospitals in the UK. In this analysis, we included participants who had received uninterrupted biological therapy since recruitment and without a previous SARS-CoV-2 infection. The primary outcome was neutralising antibody responses against SARS-CoV-2 wild-type and omicron subvariants BA.1 and BA.4/5 after three doses of SARS-CoV-2 vaccine. We constructed Cox proportional hazards models to investigate the risk of breakthrough infection in relation to neutralising antibody titres. The study is registered with the ISRCTN registry, ISRCTN45176516, and is closed to accrual.
Between Sept 22 and Dec 23, 2020, 7224 patients with IBD were recruited to the CLARITY IBD study, of whom 1288 had no previous SARS-CoV-2 infection after three doses of SARS-CoV-2 vaccine and were established on either infliximab (n=871) or vedolizumab (n=417) and included in this study (median age was 46·1 years IQR 33·6–58·2, 610 47·4% were female, 671 52·1% were male, 1209 93·9% were White, and 46 3·6% were Asian). After three doses of SARS-CoV-2 vaccine, 50% neutralising titres (NT50s) were significantly lower in patients treated with infliximab than in those treated with vedolizumab, against wild-type (geometric mean 2062 95% CI 1720–2473 vs 3440 2939–4026; p<0·0001), BA.1 (107·3 86·40–133·2 vs 648·9 523·5–804·5; p<0·0001), and BA.4/5 (40·63 31·99–51·60 vs 223·0 183·1–271·4; p<0·0001) variants. Breakthrough infection was significantly more frequent in patients treated with infliximab (119 13·7%; 95% CI 11·5–16·2 of 871) than in those treated with vedolizumab (29 7·0% 4·8–10·0 of 417; p=0·00040). Cox proportional hazards models of time to breakthrough infection after the third dose of vaccine showed infliximab treatment to be associated with a higher hazard risk than treatment with vedolizumab (hazard ratio HR 1·71 95% CI 1·08–2·71; p=0·022). Among participants who had a breakthrough infection, we found that higher neutralising antibody titres against BA.4/5 were associated with a lower hazard risk and, hence, a longer time to breakthrough infection (HR 0·87 0·79–0·95; p=0·0028).
Our findings underline the importance of continued SARS-CoV-2 vaccination programmes, including second-generation bivalent vaccines, especially in patient subgroups where vaccine immunogenicity and efficacy might be reduced, such as those on anti-TNF therapies.
Royal Devon University Healthcare NHS Foundation Trust; Hull University Teaching Hospital NHS Trust; NIHR Imperial Biomedical Research Centre; Crohn's and Colitis UK; Guts UK; National Core Studies Immunity Programme, UK Research and Innovation; and unrestricted educational grants from F Hoffmann-La Roche, Biogen, Celltrion Healthcare, Takeda, and Galapagos.
Management of marine mega-fauna in a changing climate is constrained by a series of uncertainties, often related to climate change projections, ecological responses, and the effectiveness of ...strategies in alleviating climate change impacts. Uncertainties can be reduced over time through adaptive management. Adaptive management is a framework for resource conservation that promotes iterative learning-based decision making. To successfully implement the adaptive management cycle, different steps (planning, designing, learning and adjusting) need to be systematically implemented to inform earlier steps in an iterative way. Despite the critical role that adaptive management is likely to play in addressing the impacts of climate change on marine mega-fauna few managers have successfully implemented an adaptive management approach. We discuss the approaches necessary to implement each step of an adaptive management cycle to manage marine mega-fauna in a changing climate, highlighting the steps that require further attention to fully implement the process. Examples of sharks and rays (Selachimorpha and Batoidea) on the Great Barrier Reef and little penguins, Eudyptula minor, in south-eastern Australia are used as case studies. We found that successful implementation of the full adaptive management cycle to marine mega-fauna needs managers and researchers to: (1) obtain a better understanding of the capacity of species to adapt to climate change to inform the planning step; (2) identify strategies to directly address impacts in the marine environment to inform the designing step; and (3) develop systematic evaluation and monitoring programs to inform the learning step. Further, legislation needs to flexible to allow for management to respond.
Full text
Available for:
CEKLJ, EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Studies of physiology can provide important insight into how animals are coping with challenges in their environment and can signal the potential effects of exposure to human activity in both the ...short and long term. In this study, we measured the physiological and behavioural response of little penguins (Eudyptula minor) that were naive to human activity over 30 min of capture and handling. We assessed relationships between corticosterone secretion, behaviour, sex and time of day in order to characterize the determinants of the natural stress response. We then compared the response of these naive penguins with the responses of female little penguins that had been exposed to research activity (bimonthly nest check and weighing) and to both research activity (monthly nest check and weighing) and evening viewing by tourists. We found that corticosterone concentrations increased significantly over 30 min of capture, with naive penguins demonstrating a more acute stress response during the day than at night. Penguins that had previously been exposed to handling at the research and research/visitor sites showed elevated corticosterone concentrations and consistently more aggressive behaviour after 30 min compared with naive birds, although there were no significant differences in baseline corticosterone concentrations. Our findings demonstrate that these little penguins have not habituated to routine capture, but rather mount a heightened physiological and behavioural response to handling by humans. Less invasive research monitoring techniques, such as individual identification with PIT tags and automatic recording and weighing, and a reduction in handling during the day should be considered to mitigate some of the potentially negative effects of disturbance. Given the paucity of data on the long-term consequences of heightened stress on animal physiology, our study highlights the need for further investigation of the relationship between the corticosterone stress response and fitness outcomes, such as breeding success and survival.
The properties of the recently discovered extrasolar planets were not anticipated by theoretical work on the formation of planetary systems, most models for which were developed to explain our Solar ...System. Indeed, the observational technique used to detect these planets (measurement of radial-velocity shifts in stellar spectral lines) do not yet have the sensitivity to detect planetary systems like our own. Here we report observations and modelling of the gravitational microlensing event MACHO-97-BLG-41. We infer that the lens system consists of a planet of about 3 Jupiter masses orbiting a binary stellar system consisting of a late-K dwarf star and an M dwarf. The stars are separated by ∼1.8 astronomical units (1 AU is the Earth-Sun distance), and the planet is orbiting them at a distance of about 7 AU. We had expected to find first the microlensing signature of jovian planets around single stars, so this result suggests that such planets orbiting short-period binary stars may be common.
Full text
Available for:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
EXPLAINING EXTREME EVENTS OF 2016 Herring, Stephanie C.; Christidi, Nikolaos; Hoell, Andrew ...
Bulletin of the American Meteorological Society,
01/2018, Volume:
99, Issue:
1
Journal Article
Peer reviewed
This sixth edition of explaining extreme events of the previous year (2016) from a climate perspective is the first of these reports to find that some extreme events were not possible in a ...preindustrial climate. The events were the 2016 record global heat, the heat across Asia, as well as a marine heat wave off the coast of Alaska. While these results are novel, they were not unexpected. Climate attribution scientists have been predicting that eventually the influence of human-caused climate change would become sufficiently strong as to push events beyond the bounds of natural variability alone. It was also predicted that we would first observe this phenomenon for heat events where the climate change influence is most pronounced. Additional retrospective analysis will reveal if, in fact, these are the first events of their kind or were simply some of the first to be discovered.
Last year, the editors emphasized the need for additional papers in the area of “impacts attribution” that investigate whether climate change’s influence on the extreme event can subsequently be directly tied to a change in risk of the socio-economic or environmental impacts. Several papers in this year’s report address this challenge, including Great Barrier Reef bleaching, living marine resources in the Pacific, and ecosystem productivity on the Iberian Peninsula. This is an increase over the number of impact attribution papers than in the past, and are hopefully a sign that research in this area will continue to expand in the future.
Other extreme weather event types in this year’s edition include ocean heat waves, forest fires, snow storms, and frost, as well as heavy precipitation, drought, and extreme heat and cold events over land. There were a number of marine heat waves examined in this year’s report, and all but one found a role for climate change in increasing the severity of the events. While human-caused climate change caused China’s cold winter to be less likely, it did not influence U.S. storm Jonas which hit the mid-Atlantic in winter 2016.
As in past years, the papers submitted to this report are selected prior to knowing the final results of whether human-caused climate change influenced the event. The editors have and will continue to support the publication of papers that find no role for human-caused climate change because of their scientific value in both assessing attribution methodologies and in enhancing our understanding of how climate change is, and is not, impacting extremes. In this report, twenty-one of the twenty-seven papers in this edition identified climate change as a significant driver of an event, while six did not. Of the 131 papers now examined in this report over the last six years, approximately 65% have identified a role for climate change, while about 35% have not found an appreciable effect.
Looking ahead, we hope to continue to see improvements in how we assess the influence of human-induced climate change on extremes and the continued inclusion of stakeholder needs to inform the growth of the field and how the results can be applied in decision making. While it represents a considerable challenge to provide robust results that are clearly communicated for stakeholders to use as part of their decision-making processes, these annual reports are increasingly showing their potential to help meet such growing needs.
Full text
Available for:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Dihydrofolate reductase has been purified from a methotrexate-resistant strain of Lactobacillus casei NCB 6375. By careful attention to growth conditions, up to 2.5 g of enzyme is obtained from a 400 ...litre culture. The purification procedure, involving poly-ethyleneimine treatment, DEAE-cellulose chromatography and affinity chromatography on methotrexate-aminohexyl-Sepharose, operates on the gram scale, with overall yields of 50-60%. Elution of the affinity column by reverse (upward) flow was used, as it led to recovery of the enzyme in a much smaller volume. The enzyme obtained appears to be more than 98% pure, as judged by gel electrophoresis, isoelectric focusing, and gel filtration. It has a mol.wt. of approx. 17900 and a turnover number of 4s-1 (50mM-triethanolamine/400mM-KCl, pH 7.2, 25 degrees C) with dihydrofolate and NADPH as substrates. The turnover number for folate is 0.02s-1. Michaelis constants for a variety of substrates have been measured by using a new fluorimetric assay (0.36 muM-dihydrofolate; 0.78 muM-NADPH), and binding constants determined by using the quenching of protein fluorescence (dihydrofolate, 2.25 X 10(6)M-1; NADPH, greater than 10(8)M-1). The pH/activity profile shows a single maximum at pH 7.3; at this pH, marked activation by 0.5M-NaCl is observed.
Nature, 402, 57, (1999) The study of extra-solar planetary systems has emerged as a new discipline of
observational astronomy in the past few years with the discovery of a number of
extra-solar ...planets. The properties of most of these extra-solar planets were
not anticipated by theoretical work on the formation of planetary systems. Here
we report observations and light curve modeling of gravitational microlensing
event MACHO-97-BLG-41, which indicates that the lens system consists of a
planet orbiting a binary star system. According to this model, the mass ratio
of the binary star system is 3.8:1 and the stars are most likely to be a late K
dwarf and an M dwarf with a separation of about 1.8 AU. A planet of about 3
Jupiter masses orbits this system at a distance of about 7 AU. If our
interpretation of this light curve is correct, it represents the first
discovery of a planet orbiting a binary star system and the first detection of
a Jovian planet via the gravitational microlensing technique. It suggests that
giant planets may be common in short period binary star systems.
The study of extra-solar planetary systems has emerged as a new discipline of observational astronomy in the past few years with the discovery of a number of extra-solar planets. The properties of ...most of these extra-solar planets were not anticipated by theoretical work on the formation of planetary systems. Here we report observations and light curve modeling of gravitational microlensing event MACHO-97-BLG-41, which indicates that the lens system consists of a planet orbiting a binary star system. According to this model, the mass ratio of the binary star system is 3.8:1 and the stars are most likely to be a late K dwarf and an M dwarf with a separation of about 1.8 AU. A planet of about 3 Jupiter masses orbits this system at a distance of about 7 AU. If our interpretation of this light curve is correct, it represents the first discovery of a planet orbiting a binary star system and the first detection of a Jovian planet via the gravitational microlensing technique. It suggests that giant planets may be common in short period binary star systems.
PDF
