Ever since the 1999 Kocaeli earthquake, in which the Kandilli Observatory and Earthquake Research Institute (KOERI) was not able to correctly reflect the magnitude size in its preliminary report ...because of the saturation effect, a rapid and accurate determination of the earthquake becomes a very important issue. Therefore, in the framework of this study, an automatic determination of the moment magnitude was performed by using the displacement spectra of selected earthquakes in the Marmara Region. For this purpose, 39 three-component broadband stations from KOERI seismic network which recorded 174 earthquakes with magnitudes 2.5 ≤
M
≤ 5.0 in between 2006–2009 were used. Due to the importance of quality factor in determination of the moment magnitude with spectral analysis method, the quality factor was calculated for the whole region in the beginning. Source spectrum which was obtained by converting the velocity records to displacement spectra and moment magnitudes of earthquakes were determined by fitting this spectrum to classical Brune model. For this aim, an automatic procedure was utilized which based on minimizing the differences between observed and synthetic source spectra identified by the S waves. Besides moment magnitude and location parameters, some source parameters such as seismic moment, spectral level, corner frequency and stress drop were also calculated. Application of the method proves that determining the seismic moment from the source spectra is applicable not only for earthquakes with small magnitude but also moderate earthquakes as well.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
The North Anatolian fault zone that ruptured during the mainshock of theM 7.4 Kocaeli (Izmit) earthquake of 17 August 1999 has beenmonitored using S wave splitting, in order to test a ...hypothesisproposed by Tadokoro et al. (1999). This idea is based on the observationof the M 7.2 1995 Hyogo-ken Nanbu (Kobe) earthquake, Japan.After the Hyogo-ken Nanbu earthquake, a temporal change was detectedin the direction of faster shear wave polarization in 2-3 years after the mainshock (Tadokoro, 1999). Four seismic stations were installed within andnear the fault zone at Kizanlik where the fault offset was 1.5 m, about80 km to the east of the epicenter of the Kocaeli earthquake. Theobservation period was from August 30 to October 27, 1999. Preliminaryresult shows that the average directions of faster shear wave polarization attwo stations were roughly parallel to the fault strike. We expect that thedirection of faster shear wave polarization will change to the same directionas the regional tectonic stress reflecting fault healing process. We havealready carried out a repeated aftershock observation at the same site in2000 for monitoring the fault healing process.PUBLICATION ABSTRACT
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
Background: To assess the role of serum angiotensin converting enzyme (ACE) levels and ACE insertion /deletion (I/D) genetic polymorphism in Turkish age-related macular degeneration (AMD) patients ...and control subjects.
Methods: This prospective study consisted of 78 patients with AMD and 68 control subjects. The I/D polymorphism of the ACE was carried out by polymerase chain reaction. Serum ACE levels were determined by using the ELISA method.
Results: There was no significant difference in the mean serum values of ACE between the control and patient groups (p = 0.107). The genotypic frequencies of ACE polymorphism in the control and patient groups were not significantly different either (p = 0.218).
Conclusion: We could not show a significant role of serum ACE levels and ACE I/D genetic polymorphism in the etiopathogenesis of AMD in the Turkish population, and our findings did not support the idea that serum ACE levels and ACE DD genotype were risk factors for AMD.
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DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
The expression of specific tumor necrosis factor (TNF) membrane receptors and biological effects of recombinant TNF (rTNF)-alpha on normal human T lymphocytes were studied. Although resting T cells ...lacked specific binding capacity for rTNF-alpha, high affinity (Kd 70 pM) TNF receptors were de novo induced upon primary activation of T cells. Comparison of TNF receptor expression with that of high affinity interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) receptors, respectively, revealed similarities to IL 2-receptor expression with respect to kinetics of induction. However, maximum expression of TNF receptors (approximately equal to 5000/cell at day 6) and subsequent decline occurred approximately 3 days after the peak of IL 2-receptor expression. In contrast, no change in the expression of IFN-gamma receptors (Kd 10 pM, 300 to 400 receptors/cell) was found in the course of T cell activation. On activated TNF receptor positive T cells, TNF-alpha exerted multiple stimulatory activities. Thus TNF increased the expression of HLA-DR antigens and high affinity IL 2 receptors. As a consequence, TNF-treated T cells showed an enhanced proliferative response to IL 2. Moreover, TNF-alpha was effective as a co-stimulator of IL 2-dependent IFN-gamma production. These data indicate that TNF-alpha may regulate growth and functional activities of normal T cells.
Zusammenfassung
Hintergrund
Mit der zunehmenden Anzahl eingenommener Arzneimittel steigt die Prävalenz von Medikationsrisiken. Hierzu zählen beispielsweise Arzneimittelwechselwirkungen, welche ...erwünschte und unerwünschte Wirkungen einzelner Arzneistoffe reduzieren aber auch verstärken können.
Fragestellung
Das Verbundvorhaben POLAR (POLypharmazie, Arzneimittelwechselwirkungen und Risiken) hat das Ziel, mit Methoden und Prozessen der Medizininformatikinitiative (MII) auf Basis von „Real World Data“ (stationärer Behandlungsdaten von Universitätskliniken) einen Beitrag zur Detektion von Medikationsrisiken bei Patient:innen mit Polymedikation zu leisten. Im Artikel werden die konkreten klinischen Probleme dargestellt und am konkreten Auswertebeispiel illustriert.
Material und Methoden
Konkrete pharmakologische Fragestellungen werden algorithmisch abgebildet und an 13 Datenintegrationszentren in verteilten Analysen ausgewertet. Eine wesentliche Voraussetzung für die Anwendung dieser Algorithmen ist die Kerndatensatzstruktur der MII, die auf internationale IT-, Interoperabilitäts- und Terminologiestandards setzt.
Ergebnisse
In POLAR konnte erstmals gezeigt werden, dass stationäre Behandlungsdaten standortübergreifend auf der Basis abgestimmter, interoperabler Datenaustauschformate datenschutzkonform für Forschungsfragen zu arzneimittelbezogenen Problemen nutzbar gemacht werden können.
Schlussfolgerungen
Als Zwischenstand in POLAR wird ein erstes vorläufiges Ergebnis einer Analyse gezeigt. Darüber hinaus werden allgemeinere technische, rechtliche, kommunikative Chancen und Herausforderungen dargestellt, wobei der Fokus auf dem Fall der Verwendung stationärer Behandlungsdaten als „Real World Data“ für die Forschung liegt.
Abstract
Background
As the number of concomitantly used drugs increases, the prevalence of medication risks increases. These include, for example, drug interactions which may reduce or increase the desired and undesired effects of individual drugs.
Objectives
The POLypharmacy, drug interActions and Risks (POLAR) project aims to contribute to the detection of medication risks in patients with polymedication using methods and processes of the Medical Informatics Initiative (MII) on the basis of “real world data” (inpatient treatment data of university hospitals). In the article, the specific clinical problems are presented and illustrated based on an evaluation example.
Materials and methods
Specific pharmacological questions are mapped algorithmically and applied in distributed analyses in 13 data integration centers. An essential prerequisite for the application of these algorithms is the core data set structure of the MII, which relies on international information technology, interoperability, and terminology standards.
Results
In POLAR, it was demonstrated for the first time that inpatient treatment data can be made usable across sites for research questions on drug-related problems based on coordinated, interoperable data exchange formats in a privacy-compliant manner.
Conclusions
An interim report from the POLAR project shows the first, preliminary result of an analysis. In addition, more general discussions of technical, legal, communicative opportunities and challenges are presented, with a focus on using inpatient treatment data as “real world data” for research purposes.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OBVAL, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
To evaluate axillary dissection with axillary lymphoscintigraphy (ALS) in postoperative patients with breast carcinoma and its role in adjuvant radiotherapy (RT). Additionally, to define axillary ...dissection as complete and incomplete with ALS and to correlate it with the number of removed lymph nodes.
In the last two years, 121 women were studied four weeks after operation. Bilateral second interdigital subcutaneous injections were performed for ALS. Complete and incomplete axillary dissection were interpreted according to the number of surgically removed lymph nodes. ALS was interpreted as complete if no accumulation was shown.
There was a good correlation between the number of surgically removed lymph nodes and complete and incomplete interpretation on ALS (p < 0.004). The number of removed lymph nodes was equal to or greater than 15 in 72% patients with complete dissection according to ALS. Of 48 patients with surgically incomplete axillary dissection, 18 (38%) showed no accumulation in the axillary region, while 25 of 68 (37%) patients with surgically complete dissection showed accumulation in the axillary region and were interpreted as incomplete according to ALS. Indication of RT was changed after ALS in patients with 1 to 3 involved lymph nodes. While RT was not considered in 12 of these patients before ALS, they were included in RT planning. On the other hand, 17 patients, considered for RT previously, were excluded from RT planning after ALS.
Evaluation of axillary dissection with ALS especially in suspicious patients with 1 to 3 lymph node metastases might prevent unnecessary morbidity and can be useful in selecting patients who truly need axillary irradiation.
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EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ
We have used human-rodent somatic cell hybrids to investigate the regional localization of the IFN-gamma R gene on human chromosome 6 and studied functional and antigenic characteristics of the ...expressed IFN-gamma R by Scatchard analyses of 125I-IFN-gamma binding and binding of an anti-receptor mAb (A6C5). The data obtained revealed coordinate expression of IFN-gamma- and A6C5-binding capacity as well as competition in binding to chromosome 6-positive hybrids and normal cells, indicating that the A6C5-defined protein is by itself capable of high affinity IFN-gamma binding and, thus, is likely to constitute the major IFN-gamma R protein of distinct cell types. The receptor gene could be allocated to region 6q16 to 6q22, which also contains the c-ros oncogene. Genetic linkage of the IFN-gamma R gene to an oncogene located in a region of non-random chromosomal aberrations may have a causal relationship to the deregulated IFN-gamma R expression in several malignancies.
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