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31.
  • Predicting changes in the p... Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes
    Ladumor, Mayur K.; Storelli, Flavia; Liang, Xiaomin ... CPT: pharmacometrics and systems pharmacology, February 2023, Volume: 12, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the ...
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Available for: FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
32.
  • Pharmacometrics in pregnancy: An unmet need
    Ke, Alice Ban; Rostami-Hodjegan, Amin; Zhao, Ping ... Annual review of pharmacology and toxicology, 01/2014, Volume: 54
    Journal Article
    Peer reviewed
    Open access

    Pregnant women and their fetuses are orphan populations with respect to the safety and efficacy of drugs. Physiological and absorption, distribution, metabolism, and excretion (ADME) changes during ...
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  • Prediction of Pregnancy-Ind... Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters
    Peng, Jinfu; Ladumor, Mayur K; Unadkat, Jashvant D Drug metabolism and disposition, 10/2021, Volume: 49, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    Pregnancy can significantly change the pharmacokinetics of drugs, including those renally secreted by organic anion transporters (OATs). Quantifying these changes in pregnant women is logistically ...
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  • Estimation of Fetal-to-Mate... Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model
    Peng, Jinfu; Ladumor, Mayur K; Unadkat, Jashvant D Drug metabolism and disposition, 05/2022, Volume: 50, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Pregnant women are frequently prescribed drugs to treat chronic diseases such as human immunodeficiency virus infection, but little is known about the benefits and risks of these drugs to the fetus ...
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  • Increased renal elimination... Increased renal elimination of endogenous and synthetic pyrimidine nucleosides in concentrative nucleoside transporter 1 deficient mice
    Persaud, Avinash K; Bernier, Matthew C; Massey, Michael A ... Nature communications, 06/2023, Volume: 14, Issue: 1
    Journal Article
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    Open access

    Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 ...
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36.
  • A Physiologically-Based Pha... A Physiologically-Based Pharmacokinetic Model for Cannabidiol in Healthy Adults, Hepatically-Impaired Adults, and Children
    Bansal, Sumit; Ladumor, Mayur K; Paine, Mary F ... Drug metabolism and disposition, 06/2023, Volume: 51, Issue: 6
    Journal Article
    Peer reviewed
    Open access

    Cannabidiol (CBD) is available as a prescription oral drug that is indicated for the treatment of some types of epilepsy in children and adults. CBD is also available over-the-counter and is used to ...
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  • Successful Prediction of Hu... Successful Prediction of Human Hepatic Concentrations of Transported Drugs Using the Proteomics‐Informed Relative Expression Factor Approach
    Yin, Mengyue; Balhara, Ankit; Marie, Solène ... Clinical pharmacology and therapeutics, March 2024, 2024-03-00, 20240301, Volume: 115, Issue: 3
    Journal Article
    Peer reviewed

    Tissue drug concentrations determine the efficacy and toxicity of drugs. When a drug is the substrate of transporters that are present at the blood:tissue barrier, the steady‐state unbound tissue ...
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Available for: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
38.
  • Predicting Regional Respira... Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model
    Ladumor, Mayur K; Unadkat, Jashvant D Drug metabolism and disposition, 05/2022, Volume: 50, Issue: 5
    Journal Article
    Peer reviewed

    Oral inhalation (OI) of drugs is the route of choice to treat respiratory diseases or for recreational drug use (e.g., cannabis). After OI, the drug is deposited in and systemically absorbed from ...
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  • Abundance of Phase 1 and 2 ... Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study
    Prasad, Bhagwat; Bhatt, Deepak Kumar; Johnson, Katherine ... Drug metabolism and disposition, 07/2018, Volume: 46, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based pharmacokinetic (PBPK) modeling, we compared the protein abundance of various phase 1 and phase 2 ...
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  • Positron Emission Tomograph... Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A
    Billington, Sarah; Shoner, Steven; Lee, Scott ... Clinical pharmacology and therapeutics, November 2019, Volume: 106, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Using positron emission tomography imaging, we determined the hepatic concentrations and hepatobiliary transport of 11Crosuvastatin (RSV; i.v. injection) in the absence (n = 6) and presence (n = 4 of ...
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Available for: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK

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