The paper presents the results of a population-based, geneticoepidemiological, and immunological study conducted in two regions of Tatarstan. The population-based risks for tuberculosis were ...established for males and females. Based on the population and family data, the authors calculated the genetic liability to tuberculosis, namely hereditability that is in the range of 0.8 to 1.0 and includes the contribution of nongenetic and environmental factors. Analysis of the results of immunogenetic studies of the northwestern region of Tatarstan has ascertained that patients have an association with the HLA antigen B22, in the Kama Region there is an association with other HLA antigens: B12 and B16. The higher frequency of the HLA antigens B28 and CW1 in healthy individuals as compared with that in patients with pulmonary tuberculosis (PT) suggests the resistance of PT carriers of these antigens for the disease. A study of the distribution of HLA genes by polymerase chain reaction has established the association of the disease with the DR-B1-15 genes in the Kama Region.
Experimental abdominal aorta ligation at the bifurcation site was performed in anesthetized mongrel dogs (body mass 12-17 kg) under controlled respiration. Aortic ligation produced a significant ...effect on the physiological indices of cardiac function, ultrastructure of the myocardium, liver and musculus quadriceps femoris, as well as on the content of macroergic compounds in these organs. One-hour aortic occlusion caused mainly reversible dystrophic changes in the tissues studied; 2-8-hour aortic ligation led to much more severe changes in the skeletal musculature, liver, and heart, while reperfusion, as a rule, impaired the cardiac and hepatic status. The latter may be attributed to the release of neuromediators and intermediate metabolism products from the ischemic skeletal muscles.
