The European Space Agency has invested heavily in two cornerstones missions; Herschel and Planck. The legacy data from these missions provides us with an unprecedented opportunity to study cosmic ...dust in galaxies so that we can answer fundamental questions about, for example: the origin of the chemical elements, physical processes in the interstellar medium (ISM), its effect on stellar radiation, its relation to star formation and how this relates to the cosmic far infrared background. In this paper we describe the DustPedia project, which is enabling us to develop tools and computer models that will help us relate observed cosmic dust emission to its physical properties (chemical composition, size distribution, temperature), to its origins (evolved stars, super novae, growth in the ISM) and the processes that destroy it (high energy collisions and shock heated gas). To carry out this research we will combine the Herschel/Planck data with that from other sources of data, providing observations at numerous wavelengths (< 41) across the spectral energy distribution, thus creating the DustPedia database. To maximise our spatial resolution and sensitivity to cosmic dust we limit our analysis to 4231 local galaxies (v < 3000 km/s) selected via their near infrared luminosity (stellar mass). To help us interpret the data we have developed a new physical model for dust (THEMIS), a new Bayesian method of fitting and interpreting spectral energy distributions (HerBIE) and a state-of-the-art Monte Carlo photon tracing radiative transfer model (SKIRT). In this the first of the DustPedia papers we describe the project objectives, data sets used and provide an insight into the new scientific methods we plan to implement.
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world and infected hundreds of millions of people with coronavirus disease 2019 (COVID-19). While this viral ...species was unknown prior to January 2020, its similarity to other coronaviruses that infect humans has allowed for rapid insight into the mechanisms that it uses to infect human hosts, as well as the ways in which the human immune system can respond. Here, we contextualize SARS-CoV-2 among other coronaviruses and identify what is known and what can be inferred about its behavior once inside a human host. Because the genomic content of coronaviruses, which specifies the virus's structure, is highly conserved, early genomic analysis provided a significant head start in predicting viral pathogenesis and in understanding potential differences among variants. The pathogenesis of the virus offers insights into symptomatology, transmission, and individual susceptibility. Additionally, prior research into interactions between the human immune system and coronaviruses has identified how these viruses can evade the immune system's protective mechanisms. We also explore systems-level research into the regulatory and proteomic effects of SARS-CoV-2 infection and the immune response. Understanding the structure and behavior of the virus serves to contextualize the many facets of the COVID-19 pandemic and can influence efforts to control the virus and treat the disease.
COVID-19 involves a number of organ systems and can present with a wide range of symptoms. From how the virus infects cells to how it spreads between people, the available research suggests that these patterns are very similar to those seen in the closely related viruses SARS-CoV-1 and possibly Middle East respiratory syndrome-related CoV (MERS-CoV). Understanding the pathogenesis of the SARS-CoV-2 virus also contextualizes how the different biological systems affected by COVID-19 connect. Exploring the structure, phylogeny, and pathogenesis of the virus therefore helps to guide interpretation of the broader impacts of the virus on the human body and on human populations. For this reason, an in-depth exploration of viral mechanisms is critical to a robust understanding of SARS-CoV-2 and, potentially, future emergent human CoVs (HCoVs).
Aims. This work investigates the potential of using the wavelength-dependence of galaxy structural parameters (Sérsic index, n, and effective radius, Re) to separate galaxies into distinct types. ...Methods. A sample of nearby galaxies with reliable visual morphologies is considered, for which we measure structural parameters by fitting multi-wavelength single-Sérsic models. Additionally, we use a set of artificially redshifted galaxies to test how these classifiers behave when the signal-to-noise decreases. Results. We show that the wavelength-dependence of n may be employed to separate visually-classified early- and late-type galaxies, in a manner similar to the use of colour and n. Furthermore, we find that the wavelength variation of n can recover galaxies that are misclassified by these other morphological proxies. Roughly half of the spiral galaxies that contaminate an early-type sample selected using (u-r) versus n can be correctly identified as late-types by N, the ratio of n measured in two different bands. Using a set of artificially-redshifted images, we show that this technique remains effective up to z ~ 0.1. N can therefore be used to achieve purer samples of early-types and more complete samples of late-types than using a colour-n cut alone. We also study the suitability of R, the ratio of Re in two different bands, as a morphological classifier, but find that the average sizes of both early- and late-type galaxies do not change substantially over optical wavelengths.
Variations in intervention rates, without subsequent reductions in adverse outcomes, can indicate overuse. We studied variations in and associations between commonly used childbirth interventions and ...adverse outcomes, adjusted for population characteristics.
In this multinational cross-sectional study, existing data on 4,729,307 singleton births at ≥37 weeks in 2013 from Finland, Sweden, Norway, Denmark, Iceland, Ireland, England, the Netherlands, Belgium, Germany (Hesse), Malta, the United States, and Chile were used to describe variations in childbirth interventions and outcomes. Numbers of births ranged from 3,987 for Iceland to 3,500,397 for the USA. Crude data were analysed in the Netherlands, or analysed data were shared with the principal investigator. Strict variable definitions were used and information on data quality was collected. Intervention rates were described for each country and stratified by parity. Uni- and multivariable analyses were performed, adjusted for population characteristics, and associations between rates of interventions, population characteristics, and outcomes were assessed using Spearman's rank correlation coefficients. Considerable intercountry variations were found for all interventions, despite adjustments for population characteristics. Adjustments for ethnicity and body mass index changed odds ratios for augmentation of labour and episiotomy. Largest variations were found for augmentation of labour, pain relief, episiotomy, instrumental birth, and cesarean section (CS). Percentages of births at ≥42 weeks varied from 0.1% to 6.7%. Rates among nulliparous versus multiparous women varied from 56% to 80% versus 51% to 82% for spontaneous onset of labour; 14% to 36% versus 8% to 28% for induction of labour; 3% to 13% versus 7% to 26% for prelabour CS; 16% to 48% versus 12% to 50% for overall CS; 22% to 71% versus 7% to 38% for augmentation of labour; 50% to 93% versus 25% to 86% for any intrapartum pain relief, 19% to 83% versus 10% to 64% for epidural anaesthesia; 6% to 68% versus 2% to 30% for episiotomy in vaginal births; 3% to 30% versus 1% to 7% for instrumental vaginal births; and 42% to 70% versus 50% to 84% for spontaneous vaginal births. Countries with higher rates of births at ≥42 weeks had higher rates of births with a spontaneous onset (rho = 0.82 for nulliparous/rho = 0.83 for multiparous women) and instrumental (rho = 0.67) and spontaneous (rho = 0.66) vaginal births among multiparous women and lower rates of induction of labour (rho = -0.71/-0.66), prelabour CS (rho = -0.61/-0.65), overall CS (rho = -0.61/-0.67), and episiotomy (multiparous: rho = -0.67). Variation in CS rates was mainly due to prelabour CS (rho = 0.96). Countries with higher rates of births with a spontaneous onset had lower rates of emergency CS (nulliparous: rho = -0.62) and higher rates of spontaneous vaginal births (multiparous: rho = 0.70). Prelabour and emergency CS were positively correlated (nulliparous: rho = 0.74). Higher rates of obstetric anal sphincter injury following vaginal birth were found in countries with higher rates of spontaneous birth (nulliparous: rho = 0.65). In countries with higher rates of epidural anaesthesia (nulliparous) and spontaneous births (multiparous), higher rates of Apgar score < 7 were found (rhos = 0.64). No statistically significant variation was found for perinatal mortality. Main limitations were varying quality of data and missing information.
Considerable intercountry variations were found for all interventions, even after adjusting for population characteristics, indicating overuse of interventions in some countries. Multivariable analyses are essential when comparing intercountry rates. Implementation of evidence-based guidelines is crucial in optimising intervention use and improving quality of maternity care worldwide.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background Previous studies have reported comorbid disease, including hypertension, diabetes mellitus, chronic cardiac and renal disease, malignancy, HIV, tuberculosis (TB) and obesity, to be ...associated with COVID-19 mortality. National demographic surveys have reported a high proportion of undiagnosed and untreated comorbid disease in South Africa (SA).Objectives To determine the number of individuals with previously undiagnosed HIV, TB and non-communicable diseases (NCDs) among patients hospitalised with COVID-19, and the level of medical control of these chronic diseases.Methods We conducted a sentinel surveillance study to collect enhanced data on HIV, TB and NCDs among individuals with COVID-19 admitted to 16 secondary-level public hospitals in six of the nine provinces of SA. Trained surveillance officers approached all patients who met the surveillance case definition for inclusion in the study, and consenting patients were enrolled. The data collection instrument included questions on past medical history to determine the self-reported presence of comorbidities. The results of clinical and laboratory testing introduced as part of routine clinical care for hospitalised COVID-19 patients were collected for the study, to objectively determine the presence of hypertension, diabetes, HIV and TB and the levels of control of diabetes and HIV.Results On self-reported history, the most prevalent comorbidities were hypertension (n=1 658; 51.5%), diabetes (n=855; 26.6%) and HIV (n=603; 18.7%). The prevalence of self-reported active TB was 3.1%, and that of previous TB 5.5%. There were 1 254 patients admitted with COVID-19 (39.0%) who met the body mass index criteria for obesity. On clinical and laboratory testing, 87 patients were newly diagnosed with HIV, 29 with TB, 215 with diabetes and 40 with hypertension during their COVID-19 admission. There were 151/521 patients living with HIV (29.0%) with a viral load >1 000 copies/mL and 309/570 (54.2%) with a CD4 count
In this paper, we demonstrate a new method for fitting galaxy profiles which makes use of the full multiwavelength data provided by modern large optical-near-infrared imaging surveys. We present a ...new version of galapagos, which utilizes a recently developed multiwavelength version of galfit, and enables the automated measurement of wavelength-dependent Sérsic profile parameters for very large samples of galaxies. Our new technique is extensively tested to assess the reliability of both pieces of software, galfit and galapagos on both real ugrizY JHK imaging data from the Galaxy And Mass Assembly survey and simulated data made to the same specifications. We find that fitting galaxy light profiles with multiwavelength data increases the stability and accuracy of the measured parameters, and hence produces more complete and meaningful multiwavelength photometry than has been available previously. The improvement is particularly significant for magnitudes in low-S/N bands and for structural parameters like half-light radius r
e and Sérsic index n for which a prior is used by constraining these parameters to a polynomial as a function of wavelength. This allows the fitting routines to push the magnitude of galaxies for which sensible values can be derived to fainter limits. The technique utilizes a smooth transition of galaxy parameters with wavelength, creating more physically meaningful transitions than single-band fitting and allows accurate interpolation between passbands, perfect for derivation of rest-frame values.
Objective. To describe the background characteristics of women who gave birth to their first child at an advanced and very advanced maternal age, including their sociodemographic background, social ...relationships, health behavior, physical and mental health, and reproductive history. Design. Cross‐sectional data from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Setting. Norway. Sample. 41 236 Norwegian‐speaking nulliparous women. Methods. Data were collected by the first questionnaire distributed in week 17 of pregnancy during the recruitment period 1999–2008. The distribution of descriptive variables in relation to age was investigated, by means of bivariate and multivariate logistic regression analyses. Main outcome measures. Advanced (33–37 years) and very advanced (≥38 years) maternal age. Results. Women who had their first baby at an advanced or very advanced age differed from the younger women with regard to a wide range of background characteristics, and this difference was most pronounced for the very advanced group. Problems related to physical aging were more common (infertility, physical health problems, sleep problems, depression and fatigue). Of the sociodemographic factors; high annual income and low level of education were most strongly correlated with high maternal age, followed by single status, unemployment, unsatisfactory relationship with partner and unplanned pregnancy. Conclusions. Besides having more age‐related reproductive and physical health problems, women who had their first baby at an advanced or very advanced age constituted a heterogeneous group characterized by either socioeconomic prosperity or vulnerability.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SBCE, SBMB, UL, UM, UPUK
We provide the basic integrated physical properties of all the galaxies contained in the full Cornell Atlas of Spitzer/IRS Sources (CASSIS) with available broad-band photometry from UV to 22 μm. We ...have collected broad-band photometric measurements in 14 wavelengths from available public surveys in order to study the spectral energy distribution (SED) of each galaxy in CASSIS, thus constructing a final sample of 1146 galaxies in the redshift range 0 < z < 2.5. The SEDs are modelled with the CIGALE code which relies on the energy balance between the absorbed stellar and the dust emission while taking into account the possible contribution due to the presence of an active galactic nucleus (AGN). We split the galaxies in three groups, a low-redshift (z < 0.1), a mid-redshift (0.1 ≤ z < 0.5) and a high-redshift (z ≥ 0.5) sub-sample and find that the vast majority of the Spitzer/IRS galaxies are star-forming and lie on or above the star-forming main sequence of the corresponding redshift. Moreover, the emission of Spitzer/IRS galaxies with z < 0.1 is mostly dominated by star-formation, galaxies in the mid-redshift bin are a mixture of star forming and AGN galaxies, while half of the galaxies with z ≥ 0.5 show moderate or high AGN activity. Additionally, using rest-frame NUV−r colour, Sérsic indices, optical OIII and NII emission lines we explore the nature of these galaxies by investigating further their structure as well as their star-formation and AGN activity. Using a colour magnitude diagram we confirm that 97% of the galaxies with redshift smaller than 0.5 have experienced a recent star-formation episode. For a sub-sample of galaxies with available structural information and redshift smaller than 0.3 we find that early-type galaxies are placed below the main sequence, while late-type galaxies are found on the main-sequence as expected. Finally, for all the galaxies with redshift smaller than 0.5 and available optical spectral line measurements we compare the ability of CIGALE to detect the presence of an AGN in contrast to the optical spectra classification. We find that galaxies with high AGN luminosity, as calculated by CIGALE, are most likely to be classified as composite or AGNs by optical spectral lines.
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IntroductionThere are growing concerns about the increase in rates of commonly used childbirth interventions. When indicated, childbirth interventions are crucial for preventing maternal and ...perinatal morbidity and mortality, but their routine use in healthy women and children leads to avoidable maternal and neonatal harm. Establishing ideal rates of interventions can be challenging. This study aims to describe the range of variations in the use of commonly used childbirth interventions in high-income countries around the world, and in outcomes in nulliparous and multiparous women.Methods and analysisThis multinational cross-sectional study will use data from births in 2013 with national population data or representative samples of the population of pregnant women in high-income countries. Data from women who gave birth to a single child from 37 weeks gestation onwards will be included and the results will be presented for nulliparous and multiparous women separately. Anonymised individual level data will be analysed. Primary outcomes are rates of commonly used childbirth interventions, including induction and/or augmentation of labour, intrapartum antibiotics, epidural and pharmacological pain relief, episiotomy in vaginal births, instrument-assisted birth (vacuum or forceps), caesarean section and use of oxytocin postpartum. Secondary outcomes are maternal and perinatal mortality, Apgar score below 7 at 5 min, postpartum haemorrhage and obstetric anal sphincter injury. Univariable and multivariable logistic regression analyses will be conducted to investigate variations among countries, adjusted for maternal age, body mass index, gestational weight gain, ethnic background, socioeconomic status and infant birth weight. The overall mean rates will be considered as a reference category, weighted for the size of the study population per country.Ethics and disseminationThe Medical Ethics Review Committee of VU University Medical Center Amsterdam confirmed that an official approval of this study was not required. Results will be disseminated at national and international conferences and published in peer-reviewed journals.
One type of Non-Timber Forest Products (NTFP) that sap can use is pine stands. Pine stands must be tapped to get the sap and of course it requires a lot of labor to work as sap tappers. One of the ...efforts made is to involve communities around the forest. Public interest in getting involved in pine sap tapping is still low. The cause of the low interest in the community to be involved in pine sap tapping is thought to be due to the low contribution of income from pine sap tapping to farmers’ income. This study aims to determine the income of pine sap tappers and the factors that influence the income of pine sap tappers in KPH Mamasa Tengah, West Sulawesi. The data analysis used in this research is quantitative descriptive analysis. The results showed that the income of pine sap tappers was Rp. 1,577,500 / month if the tools and materials were borne by the company and the income of the pine sap tappers was Rp. 30,020 / month if the tools and materials were borne by the farmers. The results of multiple regression analysis indicate that the factor that affects the income of pine sap tappers is the area of tapping.
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