A high efficiency and great tunability of bandwidth and absorption‐range electromagnetic wave absorber is proposed without precedent. A series of 2D carbon‐based nanocomposites with the loading of ...cerium oxide (CN‐Ce) and other types of rare earth oxides (CN‐REOs) can be successfully synthesized by a simple solvothermal‐sintering method. As‐synthesized 2D nanocomposites with local graphite‐like C3N4 structure and trace N‐doped are identified by transmission electron microscopy, X‐ray photoelectron spectroscopy, X‐ray powder diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy. The CN‐REOs and polyvinylidene fluoride composite absorbers with reflection loss values above −40 dB are obtained in C‐band, X‐band, and Ku‐band, respectively. The empirical rules on effective bandwidth and frequency range are discovered and summarized, which can be successfully realized by simply tuning the doping amount or type of REO. The mechanism is explained by enhanced attenuation and tunable impedance matching. In addition co‐filled samples by two types of CN‐REOs nanocomposites are prepared to support these findings and inspire the preparation of absorber with desirable frequency band in the range of 2–18 GHz.
In the system of composites of PVDF and trace n‐doped carbon nanocomposites loaded with rare earth oxide, a high‐performance electromagnetic wave‐absorbing composite with adjustable electromagnetic wave absorption frequency range and adjustable effective absorption width is obtained. Regular performance is found based on extensive experimental data and analysis of intrinsic performance. In addition, the empirical conclusions are well‐validated by co‐filled (CN‐Ce+CN‐Eu)/PVDF samples.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Bimetallic metal–organic frameworks are rationally synthesized as templates and employed for porous carbons with retained morphology, high graphitization degree, hierarchical porosity, high surface ...area, CoNx moiety and uniform N/Co dopant by pyrolysis. The optimized carbon with additional phosphorus dopant exhibits excellent electrocatalytic performance for the oxygen reduction reaction, which is much better than the benchmark Pt/C in alkaline media.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
We here report that miR‐17‐92 cluster is a novel target for p53‐mediated transcriptional repression under hypoxia. We found the expression levels of miR‐17‐92 cluster were reduced in hypoxia‐treated ...cells containing wild‐type p53, but were unchanged in hypoxia‐treated p53‐deficient cells. The repression of miR‐17‐92 cluster under hypoxia is independent of c‐Myc. Luciferase reporter assays mapped the region responding to p53‐mediated repression to a p53‐binding site in the proximal region of the miR‐17‐92 promoter. Chromatin immunoprecipitation (ChIP), Re‐ChIP and gel retardation assays revealed that the binding sites for p53‐ and the TATA‐binding protein (TBP) overlap within the miR‐17‐92 promoter; these proteins were found to compete for binding. Finally, we show that pri‐miR‐17‐92 expression correlated well with p53 status in colorectal carcinomas. Over‐express miR‐17‐92 cluster markedly inhibits hypoxia‐induced apoptosis, whereas blocked miR‐17‐5p and miR‐20a sensitize the cells to hypoxia‐induced apoptosis. These data indicated that p53‐mediated repression of miR‐17‐92 expression likely has an important function in hypoxia‐induced apoptosis, and thus further our understanding of the tumour suppressive function of p53.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Grain size is an important component trait of grain yield, which is frequently threatened by abiotic stress. However, little is known about how grain yield and abiotic stress tolerance are regulated. ...Here, we characterize GSA1, a quantitative trait locus (QTL) regulating grain size and abiotic stress tolerance associated with metabolic flux redirection. GSA1 encodes a UDP-glucosyltransferase, which exhibits glucosyltransferase activity toward flavonoids and monolignols. GSA1 regulates grain size by modulating cell proliferation and expansion, which are regulated by flavonoid-mediated auxin levels and related gene expression. GSA1 is required for the redirection of metabolic flux from lignin biosynthesis to flavonoid biosynthesis under abiotic stress and the accumulation of flavonoid glycosides, which protect rice against abiotic stress. GSA1 overexpression results in larger grains and enhanced abiotic stress tolerance. Our findings provide insights into the regulation of grain size and abiotic stress tolerance associated with metabolic flux redirection and a potential means to improve crops.
The hematogenous metastatic pattern of gastric cancer (GC) was not fully explored. Here we analyzed the frequency and clinicopathological features of metastasis to liver, lung, bone, and brain from ...GC patients. Data queried for this analysis included GC patients from the Surveillance, Epidemiology, and End Results Program database from 2010 to 2014. All of statistical analyses were performed using the Intercooled Stata 13.0 (Stata Corporation, College Station, TX). All statistical tests were two‐sided. Totally, there were 19 022 eligible patients for analysis. At the time of diagnosis, there were 7792 patients at stage IV, including 3218 (41.30%) patients with liver metastasis, 1126 (14.45%) with lung metastasis, 966 (12.40%) with bone metastasis and 151 (1.94%) with brain metastasis. GC patients with lung or liver metastasis have a higher risk of bone and brain metastasis than those without lung nor liver metastasis. Intestinal subtype had significantly higher rate of liver and lung metastasis, while diffuse type was more likely to have bone metastasis. Proximal stomach had significantly higher risk to develop metastasis than distal stomach. African‐Americans had the highest risk of liver metastasis and Caucasian had the highest prone to develop lung and brain metastasis. The median survival for patients with liver, lung, bone, and brain metastasis was 4 months, 3 months, 4 months and 3 months, respectively. It is important to evaluate the status of bone and brain metastasis in GC patients with lung or liver metastasis. Knowledge of metastatic patterns is helpful for clinicians to design personalized pretreatment imaging evaluation for GC patients.
Metastatic rate to liver, lung, bone, and brain from gastric cancer patients were 16.92%, 5.92%, 5.08%, and 0.79%, respectively. Higher bone and brain metastasis was found in lung or liver metastasis patients.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative disease characterized by eosinophilic intranuclear inclusions in the nervous system and multiple visceral ...organs. The clinical manifestation of NIID varies widely, and both familial and sporadic cases have been reported. Here we have performed genetic linkage analysis and mapped the disease locus to 1p13.3-q23.1; however, whole-exome sequencing revealed no potential disease-causing mutations. We then performed long-read genome sequencing and identified a large GGC repeat expansion within human-specific NOTCH2NLC. Expanded GGC repeats as the cause of NIID was further confirmed in an additional three NIID-affected families as well as five sporadic NIID-affected case subjects. Moreover, given the clinical heterogeneity of NIID, we examined the size of the GGC repeat among 456 families with a variety of neurological conditions with the known pathogenic genes excluded. Surprisingly, GGC repeat expansion was observed in two Alzheimer disease (AD)-affected families and three parkinsonism-affected families, implicating that the GGC repeat expansions in NOTCH2NLC could also contribute to the pathogenesis of both AD and PD. Therefore, we suggest defining a term NIID-related disorders (NIIDRD), which will include NIID and other related neurodegenerative diseases caused by the expanded GGC repeat within human-specific NOTCH2NLC.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A new type of cobalt(II)-doped carbon dots (CCDs) have been fabricated and used successfully for sensing Cr(VI) ions on the basis of photoluminescence quenching. The structural characterization of ...as-obtained CCDs was thoroughly performed by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) and X-ray photoelectron (XPS) spectroscopy. The optical properties were also determined by absorption and fluorescence spectra. By recording 3D fluorescence spectrum, a unique intra-particle Förster resonance energy transfer (FRET) system was investigated. In addition, fluorescence quenching of CCDs was observed in the presence of Cr(VI) ions due to inner filter effect. A good linear relationship between the concentration of Cr(VI) ions and fluorescent intensity was obtained in the range from 5μM to 125μM (R2=0.99), and the limit of detection was calculated as 1.17μM (0.12ppm for Cr(VI)). Importantly, this method was capable of rapidly detecting Cr(VI) ions in tap water and fish samples, which may be helpful in risk reduction of intake Cr(VI) contamination from water and seafood.
•Cobalt(II)-doped carbon dots (CCDs) have been fabricated.•CCDs were used for Cr(VI) sensing based on photoluminescence quenching.•The structural characterization of as-obtained CCDs was thoroughly investigated.•The CCDs was capable of rapidly detecting Cr(VI) in tap water and fish samples.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Nitrogen-doped graphene has been a recent research focus. It is crucial to further utilize the excellent properties of graphene macroscopic assemblies. Herein, we first report a unique and convenient ...hydrothermal process for controlled synthesis and structural adjustment of the nitrogen-doped graphene hydrogel (GN-GH), which can be readily scaled-up for mass production of nitrogen-doped graphene hydrogel by using organic amine and graphene oxide as precursors. The organic amine is not only as nitrogen sources to obtain the nitrogen-doped graphene but also as an important modification to control the assembly of graphene sheets in the 3D structures. Inner structure of the GN-GHs and the content of nitrogen in the graphene are easily adjusted by organic amine. Interestingly, it has been found that the supercapacitor performance of the typical product could be remarkably enhanced. Even at an ultrafast charge/discharge rate of 185.0A/g, a high power density of 205.0kW/kg can be obtained. In addition, at a current density of 100.0A/g, 95.2% of its capacitance was retained for 4000 cycles. The present nitrogen-doped graphene hydrogels may have potential applications as ultrahigh power density capacitors in the vehicle, lift and the other devices at high rates.
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► Macroscopic nitrogen-doped graphene hydrogels can be easily synthesized. ► The organic amine acts as nitrogen source and controls the assembly of graphene sheets. ► Inner structure of the nitrogen-doped graphene hydrogels and the content of nitrogen in the graphene can be easily adjusted by organic amine. ► The supercapacitor performance of the nitrogen-doped graphene hydrogels can be remarkably enhanced. ► A high power density of 205.0kW/kg can be reached even at an ultrafast charge/discharge rate of 185.0A/g.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK
As a generalization of fuzzy sets and intuitionistic fuzzy sets, neutrosophic sets have been developed to represent uncertain, imprecise, incomplete, and inconsistent information existing in the real ...world. And interval neutrosophic sets (INSs) have been proposed exactly to address issues with a set of numbers in the real unit interval, not just a specific number. However, there are fewer reliable operations for INSs, as well as the INS aggregation operators and decision making method. For this purpose, the operations for INSs are defined and a comparison approach is put forward based on the related research of interval valued intuitionistic fuzzy sets (IVIFSs) in this paper. On the basis of the operations and comparison approach, two interval neutrosophic number aggregation operators are developed. Then, a method for multicriteria decision making problems is explored applying the aggregation operators. In addition, an example is provided to illustrate the application of the proposed method.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
Reversibility of hepatic fibrosis is an intrinsic response to chronic injury, and with on-going damage, fibrosis can progress to its end-stage consequence, cirrhosis. Non-invasive and reliable ...biomarkers for early detection of liver fibrosis are needed. Based on the CCl
-induced liver fibrosis rat model, urinary and serum metabolic profiling performed by LC-QTOF-MS associated with histological progression were utilized to identify liver fibrosis-specific potential biomarkers for early prediction and to reveal significant fibrotic pathways and their dynamic changes in different stages of liver fibrosis. Finally, nine differential metabolites in urine and ten in serum were selected and identified involving the most relevant metabolic pathways. Perturbations of tryptophan, valine, leucine, isoleucine, and citrate (TCA) cycle metabolites, along with sphingolipid and glycerophospholipid metabolites, occurred from the onset of liver fibrosis. Furthermore, dysregulation of valine and bile acid biosynthesis metabolites occurred in the intermediate and advanced stages. More importantly, among these metabolites, urinary kynurenic acid, 5-hydroxyindoleacetyl glycine, 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid and serum sphinganine, sphingomyelin, L-leucine, L-tryptophan, and LysoPC(17:0) changed at all time points and may serve as potential early biomarkers for the diagnosis of hepatic fibrosis and as therapeutic targets. Overall, this work evaluates the potential of these metabolites for the early detection of liver fibrosis.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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