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1.
  • Discovery of GSK1070916, a ... Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase
    Adams, Nicholas D; Adams, Jerry L; Burgess, Joelle L ... Journal of medicinal chemistry, 05/2010, Volume: 53, Issue: 10
    Journal Article
    Peer reviewed

    The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of ...
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Available for: PNG, UM
2.
  • GSK1070916, a potent Aurora... GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models
    Hardwicke, Mary Ann; Oleykowski, Catherine A; Plant, Ramona ... Molecular cancer therapeutics, 07/2009, Volume: 8, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    The protein kinases, Aurora A, B, and C have critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. GSK1070916, is a novel ATP competitive ...
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Available for: NUK, UL, UM, UPUK

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3.
  • Perfluoroalkyl and polyfluo... Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in groundwater: current understandings and challenges to overcome
    Zhao, Zhen; Li, Jie; Zhang, Xianming ... Environmental science and pollution research international, 07/2022, Volume: 29, Issue: 33
    Journal Article
    Peer reviewed

    Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been frequently detected in groundwater globally. With the phase-out of perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) due to ...
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4.
  • Purification processes of l... Purification processes of live virus vaccine candidates expressed in adherent Vero cell lines via multimodal chromatography in flowthrough mode
    Konstantinidis, Spyridon; Poplyk, Murphy R.; Ma, Wanli (Justin) ... Biotechnology and bioengineering, August 2024, Volume: 121, Issue: 8
    Journal Article
    Peer reviewed
    Open access

    Live virus vaccine (LVV) purification, employing chromatography, can be challenged by low binding capacities and elution yields. Alternatively, processes relying solely on enzymatic digestion steps ...
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Available for: BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
5.
  • Structural basis for functi... Structural basis for functional tetramerization of lentiviral integrase
    Hare, Stephen; Di Nunzio, Francesca; Labeja, Alfred ... PLoS pathogens, 07/2009, Volume: 5, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Experimental evidence suggests that a tetramer of integrase (IN) is the protagonist of the concerted strand transfer reaction, whereby both ends of retroviral DNA are inserted into a host cell ...
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6.
  • Small molecule blockade of ... Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
    Kung, Andrew L; Zabludoff, Sonya D; France, Dennis S ... Cancer cell, 07/2004, Volume: 6, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Homeostasis under hypoxic conditions is maintained through a coordinated transcriptional response mediated by the hypoxia-inducible factor (HIF) pathway and requires coactivation by the CBP and p300 ...
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Available for: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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  • Effects of H2O2 on protein ... Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells
    Sullivan, S G; Chiu, D T; Errasfa, M ... Free radical biology & medicine, 03/1994, Volume: 16, Issue: 3
    Journal Article
    Peer reviewed

    Oxidative stress has been implicated in protein phosphorylation and dephosphorylation in cells. In our current studies, H2O2 was shown to reversibly inhibit protein tyrosine phosphatase (PTPase) ...
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Available for: SBJE
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  • Abstract C63: Biological ch... Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3-kinase and the mammalian target of rapamycin (mTOR)
    Hardwicke, Mary Ann; Lu, Hong; Luo, Lusong ... Molecular cancer therapeutics, 12/2009, Volume: 8, Issue: 12_Supplement
    Journal Article
    Peer reviewed

    Abstract The phosphoinositide 3-kinase (PI3K) pathway is among the most commonly activated pathways in human cancer. The biological role of PI3K in growth and survival of cancer cells and the ...
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9.
  • Red Cell Vitamin E and Oxid... Red Cell Vitamin E and Oxidative Damage: A Dual Role of Reducing Agents
    Wang, Jamin; Huang, Ching-Jang; Chow, Ching K. Free radical research, 01/1996, Volume: 24, Issue: 4
    Journal Article
    Peer reviewed

    The purpose of this study was to determine the role of reducing agents in maintaining the integrity of vitamin E-deficient red cells. Three groups of one-month-old male Wistar rats were fed a basal ...
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  • Transglutaminase is essenti... Transglutaminase is essential for IgA nephropathy development acting through IgA receptors
    Berthelot, Laureline; Papista, Christina; Maciel, Thiago T ... The Journal of experimental medicine, 04/2012, Volume: 209, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    IgA nephropathy (IgAN) is a common cause of renal failure worldwide. Treatment is limited because of a complex pathogenesis, including unknown factors favoring IgA1 deposition in the glomerular ...
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