Early-stage cancer detection could reduce breast cancer death rates significantly in the long-term. The most critical point for best prognosis is to identify early-stage cancer cells. Investigators ...have studied many breast diagnostic approaches, including mammography, magnetic resonance imaging, ultrasound, computerized tomography, positron emission tomography and biopsy. However, these techniques have some limitations such as being expensive, time consuming and not suitable for young women. Developing a high-sensitive and rapid early-stage breast cancer diagnostic method is urgent. In recent years, investigators have paid their attention in the development of biosensors to detect breast cancer using different biomarkers. Apart from biosensors and biomarkers, microwave imaging techniques have also been intensely studied as a promising diagnostic tool for rapid and cost-effective early-stage breast cancer detection. This paper aims to provide an overview on recent important achievements in breast screening methods (particularly on microwave imaging) and breast biomarkers along with biosensors for rapidly diagnosing breast cancer.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
Breast cancer is the leading cause of death among females, early diagnostic methods with suitable treatments improve the 5-year survival rates significantly. Microwave breast imaging has been ...reported as the most potential to become the alternative or additional tool to the current gold standard X-ray mammography for detecting breast cancer. The microwave breast image quality is affected by the microwave sensor, sensor array, the number of sensors in the array and the size of the sensor. In fact, microwave sensor array and sensor play an important role in the microwave breast imaging system. Numerous microwave biosensors have been developed for biomedical applications, with particular focus on breast tumor detection. Compared to the conventional medical imaging and biosensor techniques, these microwave sensors not only enable better cancer detection and improve the image resolution, but also provide attractive features such as label-free detection. This paper aims to provide an overview of recent important achievements in microwave sensors for biomedical imaging applications, with particular focus on breast cancer detection. The electric properties of biological tissues at microwave spectrum, microwave imaging approaches, microwave biosensors, current challenges and future works are also discussed in the manuscript.
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Terahertz (THz) imaging has the potential to detect breast tumors during breast-conserving surgery accurately. Over the past decade, many research groups have extensively studied THz imaging and ...spectroscopy techniques for identifying breast tumors. This manuscript presents the recent development of THz imaging techniques for breast cancer detection. The dielectric properties of breast tissues in the THz range, THz imaging and spectroscopy systems, THz radiation sources, and THz breast imaging studies are discussed. In addition, numerous chemometrics methods applied to improve THz image resolution and data collection processing are summarized. Finally, challenges and future research directions of THz breast imaging are presented.
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Medical imaging tools are essential in early-stage lung cancer diagnostics and the monitoring of lung cancer during treatment. Various medical imaging modalities, such as chest X-ray, magnetic ...resonance imaging, positron emission tomography, computed tomography, and molecular imaging techniques, have been extensively studied for lung cancer detection. These techniques have some limitations, including not classifying cancer images automatically, which is unsuitable for patients with other pathologies. It is urgently necessary to develop a sensitive and accurate approach to the early diagnosis of lung cancer. Deep learning is one of the fastest-growing topics in medical imaging, with rapidly emerging applications spanning medical image-based and textural data modalities. With the help of deep learning-based medical imaging tools, clinicians can detect and classify lung nodules more accurately and quickly. This paper presents the recent development of deep learning-based imaging techniques for early lung cancer detection.
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Early diagnosis of lung cancer helps to reduce the cancer death rate significantly. Over the years, investigators worldwide have extensively investigated many screening modalities for lung cancer ...detection, including computerized tomography, chest X-ray, positron emission tomography, sputum cytology, magnetic resonance imaging and biopsy. However, these techniques are not suitable for patients with other pathologies. Developing a rapid and sensitive technique for early diagnosis of lung cancer is urgently needed. Biosensor-based techniques have been recently recommended as a rapid and cost-effective tool for early diagnosis of lung tumor markers. This paper reviews the recent development in screening and biosensor-based techniques for early lung cancer detection.
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Medical imaging techniques, including X-ray mammography, ultrasound, and magnetic resonance imaging, play a crucial role in the timely identification and monitoring of breast cancer. However, these ...conventional imaging modalities have their limitations, and there is a need for a more accurate and sensitive alternative. Microwave imaging has emerged as a promising technique for breast cancer detection due to its non-ionizing, non-invasive, and cost-effective nature. Recent advancements in microwave imaging and sensing techniques have opened up new possibilities for the early diagnosis and treatment of breast cancer. By combining microwave sensing with machine learning techniques, microwave imaging approaches can rapidly and affordably identify and classify breast tumors. This manuscript provides a comprehensive overview of the latest developments in microwave imaging and sensing techniques for the early detection of breast cancer. It discusses the principles and applications of microwave imaging and highlights its advantages over conventional imaging modalities. The manuscript also delves into integrating machine learning algorithms to enhance the accuracy and efficiency of microwave imaging in breast cancer detection.
X-ray mammography is currently considered the golden standard method for breast cancer screening, however, it has limitations in terms of sensitivity and specificity. With the rapid advancements in ...deep learning techniques, it is possible to customize mammography for each patient, providing more accurate information for risk assessment, prognosis, and treatment planning. This paper aims to study the recent achievements of deep learning-based mammography for breast cancer detection and classification. This review paper highlights the potential of deep learning-assisted X-ray mammography in improving the accuracy of breast cancer screening. While the potential benefits are clear, it is essential to address the challenges associated with implementing this technology in clinical settings. Future research should focus on refining deep learning algorithms, ensuring data privacy, improving model interpretability, and establishing generalizability to successfully integrate deep learning-assisted mammography into routine breast cancer screening programs. It is hoped that the research findings will assist investigators, engineers, and clinicians in developing more effective breast imaging tools that provide accurate diagnosis, sensitivity, and specificity for breast cancer.
Holographic microwave imaging (HMI) has been proposed for early breast cancer diagnosis. Automatically classifying benign and malignant tumors in microwave images is challenging. Convolutional neural ...networks (CNN) have demonstrated excellent image classification and tumor detection performance. This study investigates the feasibility of using the CNN architecture to identify and classify HMI images. A modified AlexNet with transfer learning was investigated to automatically identify, classify, and quantify four and five different HMI breast images. Various pre-trained networks, including ResNet18, GoogLeNet, ResNet101, VGG19, ResNet50, DenseNet201, SqueezeNet, Inception v3, AlexNet, and Inception-ResNet-v2, were investigated to evaluate the proposed network. The proposed network achieved high classification accuracy using small training datasets (966 images) and fast training times.
Pathological changes in biological tissue are related to the changes in mechanical properties of biological tissue. Conventional medical screening tools such as ultrasound, magnetic resonance imaging ...or computed tomography have failed to produce the elastic properties of biological tissues directly. Ultrasound elasticity imaging (UEI) has been proposed as a promising imaging tool to map the elastic parameters of soft tissues for the clinical diagnosis of various diseases include prostate, liver, breast, and thyroid gland. Existing UEI-based approaches can be classified into three groups: internal physiologic excitation, external excitation, and acoustic radiation force (ARF) excitation methods. Among these methods, ARF has become one of the most popular techniques for the clinical diagnosis and treatment of disease. This paper provides comprehensive information on the recently developed ARF-based UEI techniques and instruments for biomedical applications. The mechanical properties of soft tissue, ARF and displacement estimation methods, working principle and implementation instruments for each ARF-based UEI method are discussed.
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The authors recently developed a two-dimensional (2D) holographic electromagnetic induction imaging (HEI) for biomedical imaging applications. However, this method was unable to detect small ...inclusions accurately. For example, only one of two inclusions can be detected in the reconstructed image if the two inclusions were located at the same XY plane but in different Z-directions. This paper provides a theoretical framework of three-dimensional (3D) HEI to accurately and effectively detect inclusions embedded in a biological object. A numerical system, including a realistic head phantom, a 16-element excitation sensor array, a 16-element receiving sensor array, and image processing model has been developed to evaluate the effectiveness of the proposed method for detecting small stroke. The achieved 3D HEI images have been compared with 2D HEI images. Simulation results show that the 3D HEI method can accurately and effectively identify small inclusions even when two inclusions are located at the same XY plane but in different Z-directions. This preliminary study shows that the proposed method has the potential to develop a useful imaging tool for the diagnosis of neurological diseases and injuries in the future.
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