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•A low-toxicity, high-efficiency, and low-cost deep eutectic solvent was synthesized.•Choline chloride-glycerol deep eutectic solvent was applied to separate Al foil and cathode ...materials of spent LIBs.•The deactivation of PVDF can be attributed to an alkali degradation process of PVDF in deep eutectic solvent.
The separation of cathode materials from aluminum (Al) foil is a key issue worthy of attention in the process of resource utilization of spent lithium-ion batteries (LIBs). Traditional technologies for the Al foil and cathode materials separation have the disadvantages of the use of corrosive acid/alkali, release of HF hazards, and environment and healthy risks of the toxicity reagent. In this study, a low-toxicity, high-efficiency, and low-cost deep eutectic solvent (DES), choline chloride-glycerol, was synthesized and applied to solving the separation dilemma of Al foil and cathode materials in spent LIBs. The experimental results show that separation of the Al foil and cathode materials can be achieved under optimal conditions designed by the response surface method: heating temperature 190 ℃, choline chloride: glycerol molar ratio 2.3:1, and heating time 15.0 min; the peeling percentage of cathode material can reach 99.86 wt%. Mechanism analysis results confirm that the separation of Al foil and cathode materials was the result of the deactivation of the organic binder polyvinylidene fluoride (PVDF), which can be attributed to an alkali degradation process caused by the attack of the hydroxide of choline chloride on the acidic hydrogen atom in PVDF.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
Structured output support vector machine (SVM) based tracking algorithms have shown favorable performance recently. Nonetheless, the time-consuming candidate sampling and complex optimization limit ...their real-time applications. In this paper, we propose a novel large margin object tracking method which absorbs the strong discriminative ability from structured output SVM and speeds up by the correlation filter algorithm significantly. Secondly, a multimodal target detection technique is proposed to improve the target localization precision and prevent model drift introduced by similar objects or background noise. Thirdly, we exploit the feedback from high-confidence tracking results to avoid the model corruption problem. We implement two versions of the proposed tracker with the representations from both conventional hand-crafted and deep convolution neural networks (CNNs) based features to validate the strong compatibility of the algorithm. The experimental results demonstrate that the proposed tracker performs superiorly against several state-of-the-art algorithms on the challenging benchmark sequences while runs at speed in excess of 80 frames per second.
Spatiotemporal and motion features are two complementary and crucial information for video action recognition. Recent state-of-the-art methods adopt a 3D CNN stream to learn spatiotemporal features ...and another flow stream to learn motion features. In this work, we aim to efficiently encode these two features in a unified 2D framework. To this end, we first propose a STM block, which contains a Channel-wise SpatioTemporal Module (CSTM) to present the spatiotemporal features and a Channel-wise Motion Module (CMM) to efficiently encode motion features. We then replace original residual blocks in the ResNet architecture with STM blcoks to form a simple yet effective STM network by introducing very limited extra computation cost. Extensive experiments demonstrate that the proposed STM network outperforms the state-of-the-art methods on both temporal-related datasets (i.e., Something-Something v1 & v2 and Jester) and scene-related datasets (i.e., Kinetics-400, UCF-101, and HMDB-51) with the help of encoding spatiotemporal and motion features together.
Electronic waste (e-waste) is one of the relatively fast-growing solid waste streams, with an annual growth rate of 3%–5%. Although international policies have been formulated to better limit the ...global transboundary movement of hazardous waste, the existence of illegal trade and “informal” recycling has exacerbated the global recycling of e-waste. At present, residents in many low-income areas are still illegally and unscientifically disposing of e-waste to profit from it. The toxic and harmful substances produced affect the global ecological environment through the geochemical cycle. In this review, we provide a systematic overview of the status quo of e-waste recycling globally. E-waste is placed into a framework, grouped by product type, quantity, composition, environmental health risk, and global impact. Management measures, legislative policies, current disposal, and transboundary movement are summarized at international, regional, and national levels, illustrating the status and challenges of e-waste collection and disposal. Techniques such as physical dismantling, component recycling, metal extraction, and re-utilization of non-metallic materials are described, which can have long-term impact on the ecosystem. We advocate that the global sustainable recycling of e-waste be supported by regional cooperation, legislative management, technology development, and eco-friendly design. This study provides a global solution for the recycling of e-waste.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
A self‐powered,solution‐processed perovskite photodetector with sub‐nanosecond response time is presented. Eliminating charge trapping and removing the constraints from the resistance–capacitance ...constant increases the response speed, which enables them to be applied in a homemade, time‐resolved photoluminescence system that successfully resolves the decay process of typical fluorescence and phosphorescent materials with a recombination lifetime from several nanoseconds to microseconds.
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BFBNIB, FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique ...mode of action for overcoming current challenges in TNBC treatment.
Different inhibitors were used to study the cell death manner of DMOCPTL. RNA silencing was used to evaluate the functions of GPX4 in ferroptosis and apoptosis of TNBC cells and functions of EGR1 in apoptosis. Immunohistochemical assay of tissue microarray were used for investigating correlation of GPX4 and EGR1 with TNBC. Computer-aided docking and small molecule probe were used for study the binding of DMOCPTL with GPX4.
DMOCPTL, a derivative of natural product parthenolide, exhibited about 15-fold improvement comparing to that of the parent compound PTL for TNBC cells. The cell death manner assay showed that the anti-TNBC effect of DMOCPTL mainly by inducing ferroptosis and apoptosis through ubiquitination of GPX4. The probe of DMOCPTL assay indicated that DMOCPTL induced GPX4 ubiquitination by directly binding to GPX4 protein. To the best of our knowledge, this is the first report of inducing ferroptosis through ubiquitination of GPX4. Moreover, the mechanism of GPX4 regulation of apoptosis is still obscure. Here, we firstly reveal that GPX4 regulated mitochondria-mediated apoptosis through regulation of EGR1 in TNBC cells. Compound 13, the prodrug of DMOCPTL, effectively inhibited the growth of breast tumor and prolonged the lifespan of mice in vivo, and no obvious toxicity was observed.
These findings firstly revealed novel manner to induce ferroptosis through ubiquitination of GPX4 and provided mechanism for GPX4 inducing mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Moreover, compound 13 deserves further studies as a lead compound with novel mode of action for ultimate discovery of effective anti-TNBC drug.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
In recent decades, with the continuous development of high‐throughput sequencing technology, data volume in medical research has increased, at the same time, almost all clinical researchers have ...their own independent omics data, which provided a better condition for data mining and a deeper understanding of gene functions. However, for these large amounts of data, many common and cutting‐edge effective bioinformatics research methods still cannot be widely used. This has encouraged the establishment of many analytical platforms, a portion of databases or platforms were designed to solve the special analysis needs of users, for instance, MG RAST, IMG/M, Qiita, BIGSdb, and TRAPR were developed for specific omics research, and some databases or servers provide solutions for special problems solutions. Metascape was designed to only provide functional annotations of genes as well as function enrichment analysis; BioNumerics and RidomSeqSphere+ perform multilocus sequence typing; CARD provides only antimicrobial resistance annotations. Additionally, some web services are outdated, and inefficient interaction often fails to meet the needs of researchers, such as our previous versions of the platform. Therefore, the demand to complete massive data processing tasks urgently requires a comprehensive bioinformatics analysis platform. Hence, we have developed a website platform, Sangerbox 3.0 (http://vip.sangerbox.com/), a web‐based tool platform. On a user‐friendly interface that also supports differential analysis, the platform provides interactive customizable analysis tools, including various kinds of correlation analyses, pathway enrichment analysis, weighted correlation network analysis, and other common tools and functions, users only need to upload their own corresponding data into Sangerbox 3.0, select required parameters, submit, and wait for the results after the task has been completed. We have also established a new interactive plotting system that allows users to adjust the parameters in the image; moreover, optimized plotting performance enables users to adjust large‐capacity vector maps on the web site. At the same time, we have integrated GEO, TCGA, ICGC, and other databases and processed data in batches, greatly reducing the difficulty to obtain data and improving the efficiency of bioimformatics study for users. Finally, we also provide users with rich sources of bioinformatics analysis courses, offering a platform for researchers to share and exchange knowledge.
Sangerbox with a user‐friendly interface supports differential analysis, correlation analyses, pathway enrichment analysis, weighted correlation network analysis, and so on. A new interactive plotting system that allows users to adjust the parameters in the image. It has organized GEO, TCGA, ICGC, and other databases; a rapid batch processing reduces the difficulty in data acquirement, greatly improving the efficiency.
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FZAB, GIS, IJS, KILJ, NLZOH, NUK, OILJ, SAZU, SBCE, SBMB, UL, UM, UPUK
E-waste generation has become a serious environmental challenge worldwide. The global quantity of e-waste was estimated 44.7 million metric tons (Mt) in 2016. The improper recycling of e-waste is ...still a challenging issue in developing countries.
The objectives of this a review article to present comprehensive information of recent studied on environment pollution and effect on human health in China.
The search engines consulted, period of publications reviewed 2015–2018. For search study, we used different key words: ‘improper recycling’, ‘primitive recycling,’ ‘backyard recycling,’ ‘e-waste,’ ‘WEEE’, and the studies related to improper recycling of e-waste.
According to reports, the e-waste recycled by unorganized sectors in China. These unorganized sector workers daily go for work, such as e-waste collection from consumer house and manual dismantling of e-waste by using simple method, at unauthorized workshop. These backyard workshop are reported in small clusters in or around city e.g., Qingyuan village; Taizhou, Longtang Town, Guiyu, nearby Nanyang River and Beigang River in China.
The earlier reported studies directed the heavy metals effect (causing effects both acute and chronic effects; respiratory irritation, reproductive problem, cardiovascular and urinary infection/disease) on human health. According the reports, the improper recycling of e-waste which need to be address for the environment protection and prevention of public health risk. However, if e-waste exposure is not avoided very well, the associated contamination will be continuing, and simultaneously needful to increase the awareness for proper e-waste management in China.
In order to solve the e-waste problem in China, more detail research is needed. Furthermore, for environment protection and health safety, the proper e-waste dismantling techniques, environmentally sound management, and the regular monitoring are very important.
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•This review provides a synopsis of complexity of the e-waste issue.•High pollutant levels in exposed workers derives from relaxed e-waste recycling practices in China.•Exposure media of the pollutants derived from e-waste improper recycling are described.•Body burden of pollutants on the human health are briefly reviewed.•Highlights potential exposure routes and possible for adverse impacts on engaged workers.
Informal e-waste sector sites are significantly polluted with polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) as well as metals in significant concentration levels.
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GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP
Herein, the design for a tunable plasmonic refractive index nanosensor is presented. The sensor is composed of a metal⁻insulator⁻metal waveguide with a baffle and a circular split-ring resonator ...cavity. Analysis of transmission characteristics of the sensor structures was performed using the finite element method, and the influence of the structure parameters on the sensing characteristics of the sensor is studied in detail. The calculation results show that the structure can realize dual Fano resonance, and the structural parameters of the sensor have different effects on Fano resonance. The peak position and the line shape of the resonance can be adjusted by altering the sensitive parameters. The maximum value of structural sensitivity was found to be 1114.3 nm/RIU, with a figure of merit of 55.71. The results indicate that the proposed structure can be applied to optical integrated circuits, particularly in high sensitivity nanosensors.
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IZUM, KILJ, NUK, PILJ, PNG, SAZU, UL, UM, UPUK
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